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Protein Ontology report - transient receptor potential cation channel TRPC3/6/7
PR:000000718 - http://purl.obolibrary.org/obo/PR_000000718
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000718   
  PRO nametransient receptor potential cation channel TRPC3/6/7 
  Synonyms
PRO-Short-label: EXACT:fam:TRPC[3/6/7]
Other: RELATED:DAG-sensitive TRPC
  Definition"A transient receptor potential cation channel TRPC that is a member of a subgroup of subfamily C containing the very similar TRPC3, TRPC6, and TRPC7. They form homomeric or heteromeric nonselective cation channels that generate double-rectifying currents and are activated by diacylglycerol." [PMID:16382100, PMID:16460286, PMID:17579562
  PRO Categoryfamily 
  ParentPR:000000680 transient receptor potential cation channel TRPC
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 8                                        
         Sequence2                                                  Organism-Sequence 10                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500999
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000718

transient receptor potential cation channel TRPC3/6/7

fam:TRPC[3/6/7]


"A transient receptor potential cation channel TRPC that is a member of a subgroup of subfamily C containing the very similar TRPC3, TRPC6, and TRPC7. They form homomeric or heteromeric nonselective cation channels that generate double-rectifying currents and are activated by diacylglycerol." [PMID:16382100, PMID:16460286, PMID:17579562]


gene



PR:000000775

short transient receptor potential cation channel TRPC3

TRPC3


"A transient receptor potential cation channel TRPC3/6/7 that is a translation product of the human TRPC3 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P34586

transient-receptor-potential-like protein (worm)

TRPC3 (worm)


"A short transient receptor potential cation channel TRPC3 that is encoded in the genome of worm." [PRO:CNA]


organism-gene



PR:Q13507

short transient receptor potential channel 3 (human)

hTRPC3


"A short transient receptor potential cation channel TRPC3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13507]


organism-sequence



PR:Q13507-1

short transient receptor potential channel 3 isoform 1 (human)

hTRPC3/iso:1


"A short transient receptor potential cation channel TRPC3 isoform 1 that is encoded in the genome of human." [PRO:HJD]

Yes

organism-sequence



PR:Q13507-2

short transient receptor potential channel 3 isoform h1 (human)

hTRPC3/iso:h1


"A short transient receptor potential channel 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13507-2." [PRO:DNx, UniProtKB:Q13507]


organism-sequence



PR:Q13507-3

short transient receptor potential channel 3 isoform h2 (human)

hTRPC3/iso:h2


"A short transient receptor potential channel 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13507-3." [PRO:DNx, UniProtKB:Q13507]


organism-gene



PR:Q9JMI9

short transient receptor potential channel 3 (rat)

rTRPC3


"A short transient receptor potential cation channel TRPC3 that is encoded in the genome of rat." [OMA:Q9JMI9, PRO:DNx]


organism-gene



PR:Q9QZC1

short transient receptor potential channel 3 (mouse)

mTRPC3


"A short transient receptor potential cation channel TRPC3 that is encoded in the genome of mouse." [OMA:Q9QZC1, PRO:DNx]


sequence



PR:000000937

short transient receptor potential cation channel TRPC3 isoform 1

TRPC3/iso:1


"A short transient receptor potential cation channel TRPC3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13507-1 or a 1:1 ortholog thereof." [PRO:DAN, PRO:HJD]


organism-sequence



PR:Q13507-1

short transient receptor potential channel 3 isoform 1 (human)

hTRPC3/iso:1


"A short transient receptor potential cation channel TRPC3 isoform 1 that is encoded in the genome of human." [PRO:HJD]

Yes

gene



PR:000001080

short transient receptor potential cation channel TRPC7

TRPC7


"A transient receptor potential cation channel TRPC3/6/7 that is a translation product of the human TRPC7 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q9HCX4

short transient receptor potential channel 7 (human)

hTRPC7


"A short transient receptor potential cation channel TRPC7 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HCX4]

Yes

organism-sequence



PR:Q9HCX4-1

short transient receptor potential channel 7 isoform 1 (human)

hTRPC7/iso:1


"A short transient receptor potential cation channel TRPC7 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HCX4]


organism-sequence



PR:Q9HCX4-2

short transient receptor potential channel 7 isoform h2 (human)

hTRPC7/iso:h2


"A short transient receptor potential channel 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCX4-2." [PRO:DNx, UniProtKB:Q9HCX4]


organism-sequence



PR:Q9HCX4-3

short transient receptor potential channel 7 isoform h3 (human)

hTRPC7/iso:h3


"A short transient receptor potential channel 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCX4-3." [PRO:DNx, UniProtKB:Q9HCX4]


organism-gene



PR:Q9WVC5

short transient receptor potential channel 7 (mouse)

mTRPC7


"A short transient receptor potential cation channel TRPC7 that is encoded in the genome of mouse." [OMA:Q9WVC5, PRO:DNx]


organism-sequence



PR:Q9WVC5-1

short transient receptor potential channel 7 isoform 1 (mouse)

mTRPC7/iso:1


"A short transient receptor potential cation channel TRPC7 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9WVC5]

Yes

sequence



PR:000001081

short transient receptor potential cation channel TRPC7 isoform 1

TRPC7/iso:1


"A short transient receptor potential cation channel TRPC7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WVC5-1 or a 1:1 ortholog thereof." [PMID:10488066]


organism-sequence



PR:Q9HCX4-1

short transient receptor potential channel 7 isoform 1 (human)

hTRPC7/iso:1


"A short transient receptor potential cation channel TRPC7 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HCX4]


organism-sequence



PR:Q9WVC5-1

short transient receptor potential channel 7 isoform 1 (mouse)

mTRPC7/iso:1


"A short transient receptor potential cation channel TRPC7 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9WVC5]

Yes

gene



PR:000016696

short transient receptor potential channel 6

TRPC6


"A transient receptor potential cation channel TRPC3/6/7 that is a translation product of the human TRPC6 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q61143

short transient receptor potential channel 6 (mouse)

mTRPC6


"A short transient receptor potential channel 6 that is encoded in the genome of mouse." [OMA:Q61143, PRO:DNx]


organism-gene



PR:Q9Y210

short transient receptor potential channel 6 (human)

hTRPC6


"A short transient receptor potential channel 6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9Y210]


organism-sequence



PR:Q9Y210-1

short transient receptor potential channel 6 isoform h1 (human)

hTRPC6/iso:h1


"A short transient receptor potential channel 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y210-1." [PRO:DNx, UniProtKB:Q9Y210]


organism-sequence



PR:Q9Y210-2

short transient receptor potential channel 6 isoform h2 (human)

hTRPC6/iso:h2


"A short transient receptor potential channel 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y210-2." [PRO:DNx, UniProtKB:Q9Y210]


organism-sequence



PR:Q9Y210-3

short transient receptor potential channel 6 isoform h3 (human)

hTRPC6/iso:h3


"A short transient receptor potential channel 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y210-3." [PRO:DNx, UniProtKB:Q9Y210]


organism-modification



PR:000058350

short transient receptor potential channel 6 N-glycosylated 1 (human)

hTRPC6/NGlyco:1


"A short transient receptor potential channel 6 (human) that has been N-glycosylated at the residue equivalent to Asn-473 of the amino acid sequence represented by UniProtKB:Q9Y210-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:Q9Y210-1, Asn-473, MOD:00160~GNO:G08293MJ." [GlyGen:Q9Y210-1, PMID:29671580, PRO:DNx]


organism-modification



PR:000058351

short transient receptor potential channel 6 N-glycosylated 2 (human)

hTRPC6/NGlyco:2


"A short transient receptor potential channel 6 (human) that has been N-glycosylated at the residue equivalent to Asn-473 of the amino acid sequence represented by UniProtKB:Q9Y210-1, in which the glycan composition is represented by GlyTouCan:G12580WI. Example: UniProtKB:Q9Y210-1, Asn-473, MOD:00160~GNO:G12580WI." [GlyGen:Q9Y210-1, PMID:29671580, PRO:DNx]


organism-modification



PR:000072935

short transient receptor potential channel 6 phosphorylated 1 (human)

hTRPC6/Phos:1


"A short transient receptor potential channel 6 (human) that has been phosphorylated on the residue at the position equivalent to Thr-402 of the amino acid sequence represented by UniProtKB:Q9Y210-1. Example: UniProtKB:Q9Y210-1, Thr-402, MOD:00047." [IEDB_epitope:2148183, PRO:DNx]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006816 calcium ion transportPR:Q9WVC5-1 mTRPC7/iso:1 PMID:10488066
GO:0007602 phototransductionPR:Q13507-1 hTRPC3/iso:1 PMID:9215637

Molecular Function GO Term

Protein Forms & Complexes

Evidence
contributes_to GO:0005262 calcium channel activityPR:Q9WVC5-1 mTRPC7/iso:1 PMID:10488066
GO:0005515 protein bindingPR:Q13507-1 hTRPC3/iso:1 PMID:15744307
PR:Q9HCX4 hTRPC7 PMID:15757897
contributes_to GO:0006828 manganese ion transportPR:Q9WVC5-1 mTRPC7/iso:1 PMID:10488066
GO:0015279 store-operated calcium channel activityPR:Q13507-1 hTRPC3/iso:1 PMID:9215637

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005886 plasma membranePR:Q13507-1 hTRPC3/iso:1 PMID:9368034
GO:0016020 membranePR:Q9WVC5-1 mTRPC7/iso:1 PMID:10488066