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Protein Ontology report - voltage-gated potassium channel KCNV1
PR:000000725 - http://purl.obolibrary.org/obo/PR_000000725
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000725   
  PRO namevoltage-gated potassium channel KCNV1 
  Synonyms
PRO-Short-label: EXACT:KCNV1
Other: EXACT:neuronal potassium channel alpha subunit HNKA | voltage-gated potassium channel subunit Kv8.1
  Definition"A voltage-gated potassium channel alpha subunit that is a translation product of the human KCNV1 gene or a 1:1 ortholog thereof. It has an atypical S6 segment containing the structural elements that modify inactivation of Kv2 channels. Similarly to KCNF1, KCNV1 and KCNS, KCNV2 subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIA. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits. It modulates the activity of KCNB1 and KCNB2 channels by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarized values." [PMID:16382104] 
  PRO Categorygene 
  ParentPR:000000685 voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:565
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000725 voltage-gated potassium channel KCNV1
KCNV1
Yes
organism-gene


PR:P97557 potassium voltage-gated channel subfamily V member 1 (rat)
rKCNV1

organism-gene


PR:Q6PIU1 potassium voltage-gated channel subfamily V member 1 (human)
hKCNV1

organism-sequence


PR:Q6PIU1-1 potassium voltage-gated channel subfamily V member 1 isoform 1 (human)
hKCNV1/iso:1

organism-gene


PR:Q8BZN2 potassium voltage-gated channel subfamily V member 1 (mouse)
mKCNV1

organism-gene


PR:Q9XXD1 probable voltage-gated potassium channel subunit kvs-4 (worm)
KCNV1 (worm)

organism-sequence


PR:Q9XXD1-1 probable voltage-gated potassium channel subunit kvs-4 isoform a (worm)
KCNV1/iso:a (worm)

organism-sequence


PR:Q9XXD1-2 probable voltage-gated potassium channel subunit kvs-4 isoform b (worm)
KCNV1/iso:b (worm)

sequence


PR:000000801 voltage-gated potassium channel KCNV1 isoform 1
KCNV1/iso:1

organism-sequence


PR:Q6PIU1-1 potassium voltage-gated channel subfamily V member 1 isoform 1 (human)
hKCNV1/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000725 KCNV1
It modulates the activity of KCNB1 and KCNB2 channels by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarized values		 enablesGO:0015459 potassium channel regulator activity PANTHER:PTHR11537