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Protein Ontology report - voltage-gated potassium channel KCNV1
PR:000000725 - http://purl.obolibrary.org/obo/PR_000000725
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000725   
  PRO namevoltage-gated potassium channel KCNV1 
  Synonyms
PRO-Short-label: EXACT:KCNV1
Other: EXACT:neuronal potassium channel alpha subunit HNKA | voltage-gated potassium channel subunit Kv8.1
  Definition"A voltage-gated potassium channel alpha subunit that is a translation product of the human KCNV1 gene or a 1:1 ortholog thereof. It has an atypical S6 segment containing the structural elements that modify inactivation of Kv2 channels. Similarly to KCNF1, KCNV1 and KCNS, KCNV2 subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIA. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits. It modulates the activity of KCNB1 and KCNB2 channels by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarized values." [PMID:16382104
  PRO Categorygene 
  ParentPR:000000685 voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:565
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000725

voltage-gated potassium channel KCNV1

KCNV1


"A voltage-gated potassium channel alpha subunit that is a translation product of the human KCNV1 gene or a 1:1 ortholog thereof. It has an atypical S6 segment containing the structural elements that modify inactivation of Kv2 channels. Similarly to KCNF1, KCNV1 and KCNS, KCNV2 subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIA. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits. It modulates the activity of KCNB1 and KCNB2 channels by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarized values." [PMID:16382104]

Yes

organism-gene



PR:P97557

potassium voltage-gated channel subfamily V member 1 (rat)

rKCNV1


"A voltage-gated potassium channel KCNV1 that is encoded in the genome of rat." [OMA:P97557, PRO:DNx]


organism-gene



PR:Q6PIU1

potassium voltage-gated channel subfamily V member 1 (human)

hKCNV1


"A voltage-gated potassium channel KCNV1 that is encoded in the genome of human." []


organism-sequence



PR:Q6PIU1-1

potassium voltage-gated channel subfamily V member 1 isoform 1 (human)

hKCNV1/iso:1


"A voltage-gated potassium channel KCNV1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-gene



PR:Q8BZN2

potassium voltage-gated channel subfamily V member 1 (mouse)

mKCNV1


"A voltage-gated potassium channel KCNV1 that is encoded in the genome of mouse." [OMA:Q8BZN2, PRO:DNx]


organism-gene



PR:Q9XXD1

probable voltage-gated potassium channel subunit kvs-4 (worm)

KCNV1 (worm)


"A voltage-gated potassium channel KCNV1 that is encoded in the genome of worm." [OMA:Q9XXD1, PRO:DNx]


organism-sequence



PR:Q9XXD1-1

probable voltage-gated potassium channel subunit kvs-4 isoform a (worm)

KCNV1/iso:a (worm)


"A probable voltage-gated potassium channel subunit kvs-4 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9XXD1-1." [PRO:DNx, UniProtKB:Q9XXD1]


organism-sequence



PR:Q9XXD1-2

probable voltage-gated potassium channel subunit kvs-4 isoform b (worm)

KCNV1/iso:b (worm)


"A probable voltage-gated potassium channel subunit kvs-4 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9XXD1-2." [PRO:DNx, UniProtKB:Q9XXD1]


sequence



PR:000000801

voltage-gated potassium channel KCNV1 isoform 1

KCNV1/iso:1


"A voltage-gated potassium channel KCNV1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6PIU1-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q6PIU1-1

potassium voltage-gated channel subfamily V member 1 isoform 1 (human)

hKCNV1/iso:1


"A voltage-gated potassium channel KCNV1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0015459 potassium channel regulator activityPR:000000725 KCNV1 PANTHER:PTHR11537