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Protein Ontology report - voltage-gated potassium channel KCNV2
PR:000000726 - http://purl.obolibrary.org/obo/PR_000000726
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000726   
  PRO namevoltage-gated potassium channel KCNV2 
  Synonyms
PRO-Short-label: EXACT:KCNV2
Other: EXACT:voltage-gated potassium channel subunit Kv8.2
  Definition"A voltage-gated potassium channel alpha subunit that is a translation product of the human KCNV2 gene or a 1:1 ortholog thereof. Similarly to KCNF1, KCNV1 and KCNS, KCNV2 subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIS. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000685 voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:566
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000726
voltage-gated potassium channel KCNV2
KCNV2
"A voltage-gated potassium channel alpha subunit that is a translation product of the human KCNV2 gene or a 1:1 ortholog thereof. Similarly to KCNF1, KCNV1 and KCNS, KCNV2 subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIS. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits." [PRO:CNA]
Yes
organism-gene


PR:Q8CFS6
potassium voltage-gated channel subfamily V member 2 (mouse)
mKCNV2
"A voltage-gated potassium channel KCNV2 that is encoded in the genome of mouse." [OMA:Q8CFS6, PRO:DNx]

organism-gene


PR:Q8TDN2
potassium voltage-gated channel subfamily V member 2 (human)
hKCNV2
"A voltage-gated potassium channel KCNV2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8TDN2]

organism-sequence


PR:000000803
voltage-gated potassium channel KCNV2 sequence variant G459D (human)
hKCNV2/var:G459D
"A potassium voltage-gated channel subfamily V member 2 (human) that has an Asp residue at the position equivalent to Gly-459 of the amino acid sequence represented by UniProtKB:Q8TDN2. UniProtKB:Q8TDN2, Gly-459, CHEBI:29958." [PMID:16909397, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000804
voltage-gated potassium channel KCNV2 sequence variant A259V (human)
hKCNV2/var:A259V
"A potassium voltage-gated channel subfamily V member 2 (human) that has a Val residue at the position equivalent to Ala-259 of the amino acid sequence represented by UniProtKB:Q8TDN2. UniProtKB:Q8TDN2, Ala-259, CHEBI:30015." [PMID:16909397, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000805
voltage-gated potassium channel KCNV2 sequence variant L126Q (human)
hKCNV2/var:L126Q
"A potassium voltage-gated channel subfamily V member 2 (human) that has a Gln residue at the position equivalent to Leu-126 of the amino acid sequence represented by UniProtKB:Q8TDN2. UniProtKB:Q8TDN2, Leu-126, CHEBI:30011." [PMID:16909397, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000806
voltage-gated potassium channel KCNV2 sequence variant 4 (human)
hKCNV2/var:4
"A potassium voltage-gated channel subfamily V member 2 (human) that has a three-residue deletion at the positions equivalent to 339-341 of the amino acid sequence represented by UniProtKB:Q8TDN2. These residues are part of segment S3. UniProtKB:Q8TDN2, 1-338, 342-545." [PMID:16909397, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000807
voltage-gated potassium channel KCNV2 sequence variant S256W (human)
hKCNV2/var:S256W
"A potassium voltage-gated channel subfamily V member 2 (human) that has a Trp residue at the position equivalent to Ser-256 of the amino acid sequence represented by UniProtKB:Q8TDN2. UniProtKB:Q8TDN2, Ser-256, CHEBI:29954." [PMID:16909397, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000808
voltage-gated potassium channel KCNV2 sequence variant W188C (human)
hKCNV2/var:W188C
"A potassium voltage-gated channel subfamily V member 2 (human) that has a Cys residue at the position equivalent to Trp-188 of the amino acid sequence represented by UniProtKB:Q8TDN2. UniProtKB:Q8TDN2, Trp-188, CHEBI:29950." [PMID:16909397, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:Q8TDN2-1
potassium voltage-gated channel subfamily V member 2 isoform 1 (human)
hKCNV2/iso:1
"A voltage-gated potassium channel KCNV2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

sequence


PR:000000802
voltage-gated potassium channel KCNV2 isoform 1
KCNV2/iso:1
"A voltage-gated potassium channel KCNV2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TDN2-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:Q8TDN2-1
potassium voltage-gated channel subfamily V member 2 isoform 1 (human)
hKCNV2/iso:1
"A voltage-gated potassium channel KCNV2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000726 KCNV2
The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits		 enablesGO:0015459 potassium channel regulator activity PANTHER:PTHR11537
PR:000000803 hKCNV2/var:G459D
UniProtKB:Q8TDN2, Gly-459, CHEBI:29958		 associated_with_disease_progressionDO:0050795 cone dystrophy PMID:16909397
PR:000000804 hKCNV2/var:A259V
UniProtKB:Q8TDN2, Ala-259, CHEBI:30015		 associated_with_disease_progressionDO:0050795 cone dystrophy PMID:16909397
PR:000000805 hKCNV2/var:L126Q
UniProtKB:Q8TDN2, Leu-126, CHEBI:30011		 associated_with_disease_progressionDO:0050795 cone dystrophy PMID:16909397
PR:000000806 hKCNV2/var:4
UniProtKB:Q8TDN2, 1-338, 342-545		 associated_with_disease_progressionDO:0050795 cone dystrophy PMID:16909397
PR:000000807 hKCNV2/var:S256W
UniProtKB:Q8TDN2, Ser-256, CHEBI:29954		 associated_with_disease_progressionDO:0050795 cone dystrophy PMID:16909397
PR:000000808 hKCNV2/var:W188C
UniProtKB:Q8TDN2, Trp-188, CHEBI:29950		 associated_with_disease_progressionDO:0050795 cone dystrophy PMID:16909397