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Protein Ontology report - voltage-gated potassium channel subunit KCNQ2
PR:000000729 - http://purl.obolibrary.org/obo/PR_000000729
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000729   
  PRO namevoltage-gated potassium channel subunit KCNQ2 
  Synonyms
PRO-Short-label: EXACT:KCNQ2
Gene-based: RELATED:Kqt2
Other: EXACT:KQT-like 2 | neuroblastoma-specific potassium channel subunit alpha KvLQT2 | potassium channel subunit alpha KvLQT2 | voltage-gated potassium channel subunit Kv7.2
  Definition"A voltage-gated potassium channel subunit KQT that is a translation product of the human KCNQ2 gene or a 1:1 ortholog thereof. Most of the isoforms are generated by splicing that is restricted to a region that encodes the intracellular C-terminal domain of the channel (exons 7-16 in rat). From these, there are two main classes, one containing exon 16 in-frame, and others with an alternative splice junction in exon 14 that results in a frameshift and early termination. In addition, exons 12 and 13 have alternative splice junctions, and exons 8,11, and 15a are subject to splicing. Many members of this class can form heteromeric channels with members of the class KCNQ3 (PR:000000730). Some forms of KCNQ2 contain two binding calmodulin binding sites and calmodulin is tethered constitutively to KCNQ channels." [PMID:11230508, PMID:12223552
  PRO Categorygene 
  ParentPR:000000684 voltage-gated potassium channel subunit KQT
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence16                                                  Organism-Sequence 38                                        
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500965;IUPHARobj:561
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000729

voltage-gated potassium channel subunit KCNQ2

KCNQ2


"A voltage-gated potassium channel subunit KQT that is a translation product of the human KCNQ2 gene or a 1:1 ortholog thereof. Most of the isoforms are generated by splicing that is restricted to a region that encodes the intracellular C-terminal domain of the channel (exons 7-16 in rat). From these, there are two main classes, one containing exon 16 in-frame, and others with an alternative splice junction in exon 14 that results in a frameshift and early termination. In addition, exons 12 and 13 have alternative splice junctions, and exons 8,11, and 15a are subject to splicing. Many members of this class can form heteromeric channels with members of the class KCNQ3 (PR:000000730). Some forms of KCNQ2 contain two binding calmodulin binding sites and calmodulin is tethered constitutively to KCNQ channels." [PMID:11230508, PMID:12223552]


organism-gene



PR:O43526

potassium voltage-gated channel subfamily KQT member 2 (human)

hKCNQ2


"A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of human." []


organism-sequence



PR:000000907

voltage-gated potassium channel subunit KCNQ2 sequence variant S247W (human)

hKCNQ2/var:S247W


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Trp residue at the position equivalent to Ser-247 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Ser-247, CHEBI:29954." [PMID:12742592, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000908

voltage-gated potassium channel subunit KCNQ2 sequence variant H228Q (human)

hKCNQ2/var:H228Q


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Gln residue at the position equivalent to His-228 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, His-228, CHEBI:30011." [PMID:14534157, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000909

voltage-gated potassium channel subunit KCNQ2 sequence variant R207W (human)

hKCNQ2/var:R207W


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Trp residue at the position equivalent to Arg-207 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Arg-207, CHEBI:29954." [PMID:11572947, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000910

voltage-gated potassium channel subunit KCNQ2 sequence variant L243F (human)

hKCNQ2/var:L243F


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Phe residue at the position equivalent to Leu-243 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Leu-243, CHEBI:29997." [PMID:14534157, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000911

voltage-gated potassium channel subunit KCNQ2 sequence variant 4 (human)

hKCNQ2/var:4


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a change of one of the innermost Arg residues of the key functional voltage sensor (S4) region. Example: UniProtKB:O43526-1, Arg-214, CHEBI:29954." [PMID:11175290, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000912

voltage-gated potassium channel subunit KCNQ2 sequence variant Y284C (human)

hKCNQ2/var:Y284C


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Cys residue at the position equivalent to Tyr-284 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Tyr-284, CHEBI:29950." [PMID:10788442, PMID:9425895, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000913

voltage-gated potassium channel subunit KCNQ2 sequence variant A306T (human)

hKCNQ2/var:A306T


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Thr residue at the position equivalent to Ala-306 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Ala-306, CHEBI:30013." [PMID:10788442, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000914

voltage-gated potassium channel subunit KCNQ2 sequence variant R333Q (human)

hKCNQ2/var:R333Q


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Gln residue at the position equivalent to Arg-333 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Arg-333, CHEBI:30011." [PMID:14534157, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000915

voltage-gated potassium channel subunit KCNQ2 sequence variant M208V (human)

hKCNQ2/var:M208V


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Val residue at the position equivalent to Met-208 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Met-208, CHEBI:30015." [PMID:14534157, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:O43526-1

potassium voltage-gated channel subfamily KQT member 2 isoform 1 (human)

hKCNQ2/iso:1


"A voltage-gated potassium channel subunit KCNQ2 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


organism-sequence



PR:O43526-2

potassium voltage-gated channel subfamily KQT member 2 isoform 2 (human)

hKCNQ2/iso:2


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:O43526-3

potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human)

hKCNQ2/iso:3


"A voltage-gated potassium channel subunit KCNQ2 isoform 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


organism-sequence



PR:000000916

voltage-gated potassium channel subunit KCNQ2 isoform 3 sequence variant K526N (human)

hKCNQ2/iso:3/var:K526N


"A potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human) that has an Asn residue at the position equivalent to Lys-526 of the amino acid sequence represented by UniProtKB:O43526-3. UniProtKB:O43526-3, Lys-526, CHEBI:50347." [PMID:15249611, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:O43526-4

potassium voltage-gated channel subfamily KQT member 2 isoform 4 (human)

hKCNQ2/iso:4


"A voltage-gated potassium channel subunit KCNQ2 isoform 4 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:O43526-5

potassium voltage-gated channel subfamily KQT member 2 isoform 5 (human)

hKCNQ2/iso:5


"A voltage-gated potassium channel subunit KCNQ2 isoform 5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


organism-sequence



PR:O43526-6

potassium voltage-gated channel subfamily KQT member 2 isoform 6 (human)

hKCNQ2/iso:6


"A voltage-gated potassium channel subunit KCNQ2 isoform 6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]

Yes

organism-modification



PR:000076442

potassium voltage-gated channel subfamily KQT member 2 acetylated 1 (human)

hKCNQ2/Ac:1


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has been acetylated on the residue at the position equivalent to Lys-69 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Lys-69, MOD:00723." [IEDB_epitope:1779391, PRO:DNx]


organism-modification



PR:000079703

potassium voltage-gated channel subfamily KQT member 2 phosphorylated 1 (human)

hKCNQ2/Phos:1


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-74 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Tyr-74, MOD:00048." [IEDB_epitope:2147317, PRO:DNx]


organism-gene



PR:O88943

potassium voltage-gated channel subfamily KQT member 2 (rat)

rKCNQ2


"A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of rat." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-1

potassium voltage-gated channel subfamily KQT member 2 isoform A (rat)

rKCNQ2/iso:A


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-sequence



PR:O88943-2

potassium voltage-gated channel subfamily KQT member 2 isoform B (rat)

rKCNQ2/iso:B


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-2." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-3

potassium voltage-gated channel subfamily KQT member 2 isoform C (rat)

rKCNQ2/iso:C


"A voltage-gated potassium channel subunit KCNQ2 isoform 3 that is encoded in the genome of rat." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-4

potassium voltage-gated channel subfamily KQT member 2 isoform D (rat)

rKCNQ2/iso:D


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-4." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-5

potassium voltage-gated channel subfamily KQT member 2 isoform E (rat)

rKCNQ2/iso:E


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-5." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-6

potassium voltage-gated channel subfamily KQT member 2 isoform F (rat)

rKCNQ2/iso:F


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-6." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-7

potassium voltage-gated channel subfamily KQT member 2 isoform G (rat)

rKCNQ2/iso:G


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-7." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-8

potassium voltage-gated channel subfamily KQT member 2 isoform H (rat)

rKCNQ2/iso:H


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-8." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-9

potassium voltage-gated channel subfamily KQT member 2 isoform I (rat)

rKCNQ2/iso:I


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-9." [PRO:DNx, UniProtKB:O88943]


organism-gene



PR:Q9Z351

potassium voltage-gated channel subfamily KQT member 2 (mouse)

mKCNQ2


"A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of mouse." [OMA:Q9Z351, PRO:DNx]


organism-sequence



PR:Q9Z351-1

potassium voltage-gated channel subfamily KQT member 2 isoform 1 (mouse)

mKCNQ2/iso:1


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-10

potassium voltage-gated channel subfamily KQT member 2 isoform 10 (mouse)

mKCNQ2/iso:10


"A voltage-gated potassium channel subunit KCNQ2 isoform 10 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

organism-sequence



PR:Q9Z351-11

potassium voltage-gated channel subfamily KQT member 2 isoform 11 (mouse)

mKCNQ2/iso:11


"A voltage-gated potassium channel subunit KCNQ2 isoform 11 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

organism-sequence



PR:Q9Z351-12

potassium voltage-gated channel subfamily KQT member 2 isoform 12 (mouse)

mKCNQ2/iso:12


"A voltage-gated potassium channel subunit KCNQ2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

organism-sequence



PR:Q9Z351-13

potassium voltage-gated channel subfamily KQT member 2 isoform m13 (mouse)

mKCNQ2/iso:m13


"A potassium voltage-gated channel subfamily KQT member 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-13." [PRO:DNx, UniProtKB:Q9Z351]


organism-sequence



PR:Q9Z351-2

potassium voltage-gated channel subfamily KQT member 2 isoform 2 (mouse)

mKCNQ2/iso:2


"A voltage-gated potassium channel subunit KCNQ2 isoform 12 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-3

potassium voltage-gated channel subfamily KQT member 2 isoform 3 (mouse)

mKCNQ2/iso:3


"A voltage-gated potassium channel subunit KCNQ2 isoform 13 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-4

potassium voltage-gated channel subfamily KQT member 2 isoform 4 (mouse)

mKCNQ2/iso:4


"A voltage-gated potassium channel subunit KCNQ2 isoform 14 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-5

potassium voltage-gated channel subfamily KQT member 2 isoform 5 (mouse)

mKCNQ2/iso:5


"A voltage-gated potassium channel subunit KCNQ2 isoform 15 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-6

potassium voltage-gated channel subfamily KQT member 2 isoform 6 (mouse)

mKCNQ2/iso:6


"A voltage-gated potassium channel subunit KCNQ2 isoform 16 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-7

potassium voltage-gated channel subfamily KQT member 2 isoform 7 (mouse)

mKCNQ2/iso:7


"A voltage-gated potassium channel subunit KCNQ2 isoform 7 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-8

potassium voltage-gated channel subfamily KQT member 2 isoform 8 (mouse)

mKCNQ2/iso:8


"A voltage-gated potassium channel subunit KCNQ2 isoform 8 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-9

potassium voltage-gated channel subfamily KQT member 2 isoform 9 (mouse)

mKCNQ2/iso:9


"A voltage-gated potassium channel subunit KCNQ2 isoform 9 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

sequence



PR:000000891

voltage-gated potassium channel subunit KCNQ2 isoform 1

KCNQ2/iso:1


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-12 or a 1:1 ortholog thereof." [PMID:11230508, PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-1

potassium voltage-gated channel subfamily KQT member 2 isoform 1 (human)

hKCNQ2/iso:1


"A voltage-gated potassium channel subunit KCNQ2 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


organism-sequence



PR:Q9Z351-12

potassium voltage-gated channel subfamily KQT member 2 isoform 12 (mouse)

mKCNQ2/iso:12


"A voltage-gated potassium channel subunit KCNQ2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

sequence



PR:000000892

voltage-gated potassium channel subunit KCNQ2 isoform 10

KCNQ2/iso:10


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-10 with unique C-terminus sequence VSLSPC or a 1:1 ortholog thereof." [PMID:9666519, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-10

potassium voltage-gated channel subfamily KQT member 2 isoform 10 (mouse)

mKCNQ2/iso:10


"A voltage-gated potassium channel subunit KCNQ2 isoform 10 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

sequence



PR:000000893

voltage-gated potassium channel subunit KCNQ2 isoform 11

KCNQ2/iso:11


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-11 or a 1:1 ortholog thereof." [PMID:9666519, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-11

potassium voltage-gated channel subfamily KQT member 2 isoform 11 (mouse)

mKCNQ2/iso:11


"A voltage-gated potassium channel subunit KCNQ2 isoform 11 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

sequence



PR:000000894

voltage-gated potassium channel subunit KCNQ2 isoform 12

KCNQ2/iso:12


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-2

potassium voltage-gated channel subfamily KQT member 2 isoform 2 (mouse)

mKCNQ2/iso:2


"A voltage-gated potassium channel subunit KCNQ2 isoform 12 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000895

voltage-gated potassium channel subunit KCNQ2 isoform 13

KCNQ2/iso:13


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-3

potassium voltage-gated channel subfamily KQT member 2 isoform 3 (mouse)

mKCNQ2/iso:3


"A voltage-gated potassium channel subunit KCNQ2 isoform 13 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000896

voltage-gated potassium channel subunit KCNQ2 isoform 14

KCNQ2/iso:14


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-4 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-4

potassium voltage-gated channel subfamily KQT member 2 isoform 4 (mouse)

mKCNQ2/iso:4


"A voltage-gated potassium channel subunit KCNQ2 isoform 14 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000897

voltage-gated potassium channel subunit KCNQ2 isoform 15

KCNQ2/iso:15


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-5 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-5

potassium voltage-gated channel subfamily KQT member 2 isoform 5 (mouse)

mKCNQ2/iso:5


"A voltage-gated potassium channel subunit KCNQ2 isoform 15 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000898

voltage-gated potassium channel subunit KCNQ2 isoform 16

KCNQ2/iso:16


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-6 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-6

potassium voltage-gated channel subfamily KQT member 2 isoform 6 (mouse)

mKCNQ2/iso:6


"A voltage-gated potassium channel subunit KCNQ2 isoform 16 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000899

voltage-gated potassium channel subunit KCNQ2 isoform 2

KCNQ2/iso:2


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-2

potassium voltage-gated channel subfamily KQT member 2 isoform 2 (human)

hKCNQ2/iso:2


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:O88943-1

potassium voltage-gated channel subfamily KQT member 2 isoform A (rat)

rKCNQ2/iso:A


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-sequence



PR:Q9Z351-1

potassium voltage-gated channel subfamily KQT member 2 isoform 1 (mouse)

mKCNQ2/iso:1


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000002632

voltage-gated potassium channel subunit KCNQ2 isoform 2 unmodified form

KCNQ2/iso:2/UnMod


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


sequence



PR:000000900

voltage-gated potassium channel subunit KCNQ2 isoform 3

KCNQ2/iso:3


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-3 or a 1:1 ortholog thereof." [PMID:9430594, PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-3

potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human)

hKCNQ2/iso:3


"A voltage-gated potassium channel subunit KCNQ2 isoform 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


organism-sequence



PR:000000916

voltage-gated potassium channel subunit KCNQ2 isoform 3 sequence variant K526N (human)

hKCNQ2/iso:3/var:K526N


"A potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human) that has an Asn residue at the position equivalent to Lys-526 of the amino acid sequence represented by UniProtKB:O43526-3. UniProtKB:O43526-3, Lys-526, CHEBI:50347." [PMID:15249611, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:O88943-3

potassium voltage-gated channel subfamily KQT member 2 isoform C (rat)

rKCNQ2/iso:C


"A voltage-gated potassium channel subunit KCNQ2 isoform 3 that is encoded in the genome of rat." [PRO:DNx, UniProtKB:O88943]


sequence



PR:000000901

voltage-gated potassium channel subunit KCNQ2 isoform 4

KCNQ2/iso:4


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-4 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-4

potassium voltage-gated channel subfamily KQT member 2 isoform 4 (human)

hKCNQ2/iso:4


"A voltage-gated potassium channel subunit KCNQ2 isoform 4 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000902

voltage-gated potassium channel subunit KCNQ2 isoform 5

KCNQ2/iso:5


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-5 or a 1:1 ortholog thereof." [PMID:11230508, PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-5

potassium voltage-gated channel subfamily KQT member 2 isoform 5 (human)

hKCNQ2/iso:5


"A voltage-gated potassium channel subunit KCNQ2 isoform 5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


sequence



PR:000000903

voltage-gated potassium channel subunit KCNQ2 isoform 6

KCNQ2/iso:6


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-6 or a 1:1 ortholog thereof." [PMID:9039501, PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-6

potassium voltage-gated channel subfamily KQT member 2 isoform 6 (human)

hKCNQ2/iso:6


"A voltage-gated potassium channel subunit KCNQ2 isoform 6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]

Yes

sequence



PR:000000904

voltage-gated potassium channel subunit KCNQ2 isoform 7

KCNQ2/iso:7


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-7 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-7

potassium voltage-gated channel subfamily KQT member 2 isoform 7 (mouse)

mKCNQ2/iso:7


"A voltage-gated potassium channel subunit KCNQ2 isoform 7 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000905

voltage-gated potassium channel subunit KCNQ2 isoform 8

KCNQ2/iso:8


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-8 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-8

potassium voltage-gated channel subfamily KQT member 2 isoform 8 (mouse)

mKCNQ2/iso:8


"A voltage-gated potassium channel subunit KCNQ2 isoform 8 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000906

voltage-gated potassium channel subunit KCNQ2 isoform 9

KCNQ2/iso:9


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-9 or a 1:1 ortholog thereof." [PMID:9666519, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-9

potassium voltage-gated channel subfamily KQT member 2 isoform 9 (mouse)

mKCNQ2/iso:9


"A voltage-gated potassium channel subunit KCNQ2 isoform 9 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000907 hKCNQ2/var:S247W
Example: UniProtKB:O43526-1, Ser-247, CHEBI:29954
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:12742592
enablesdecreased GO:0005249 voltage-gated potassium channel activity relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:12742592
PR:000000908 hKCNQ2/var:H228Q
Example: UniProtKB:O43526-1, His-228, CHEBI:30011
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000909 hKCNQ2/var:R207W
Example: UniProtKB:O43526-1, Arg-207, CHEBI:29954
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:11572947
enablesdecreased GO:0005249 voltage-gated potassium channel activity relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:11572947
PR:000000910 hKCNQ2/var:L243F
Example: UniProtKB:O43526-1, Leu-243, CHEBI:29997
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000911 hKCNQ2/var:4
Example: UniProtKB:O43526-1, Arg-214, CHEBI:29954
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:11175290
PR:000000912 hKCNQ2/var:Y284C
Example: UniProtKB:O43526-1, Tyr-284, CHEBI:29950
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:10788442
located_inGO:0009986 cell surface PMID:10788442
PR:000000913 hKCNQ2/var:A306T
Example: UniProtKB:O43526-1, Ala-306, CHEBI:30013
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:10788442
located_inGO:0009986 cell surface PMID:10788442
PR:000000914 hKCNQ2/var:R333Q
Example: UniProtKB:O43526-1, Arg-333, CHEBI:30011
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000915 hKCNQ2/var:M208V
Example: UniProtKB:O43526-1, Met-208, CHEBI:30015
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000916 hKCNQ2/iso:3/var:K526N
UniProtKB:O43526-3, Lys-526, CHEBI:50347
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:15249611
PR:O43526-2 hKCNQ2/iso:2 enablescontributes_to GO:0005249 voltage-gated potassium channel activity PMID:11160379
PR:O43526-4 hKCNQ2/iso:4 enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9836639
PR:O43526-6 hKCNQ2/iso:6 enablesdecreased|contributes_to GO:0005249 voltage-gated potassium channel activity relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:9039501
PR:O88943-1 rKCNQ2/iso:A enablescontributes_to GO:0005249 voltage-gated potassium channel activity PMID:11038262
PR:Q9Z351-10 mKCNQ2/iso:10 enablesNOT GO:0022832 voltage-gated channel activity PMID:9666519
PR:Q9Z351-11 mKCNQ2/iso:11 enablesNOT GO:0022832 voltage-gated channel activity PMID:9666519
PR:Q9Z351-12 mKCNQ2/iso:12 enablesGO:0005516 calmodulin binding PMID:12223552
located_inGO:0008076 voltage-gated potassium channel complex PMID:12223552
GO:0009986 cell surface PMID:12223552
PR:Q9Z351-9 mKCNQ2/iso:9 enablesNOT GO:0022832 voltage-gated channel activity PMID:9666519