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Protein Ontology report - voltage-gated potassium channel subunit KCNQ2
PR:000000729 - http://purl.obolibrary.org/obo/PR_000000729
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000729   
  PRO namevoltage-gated potassium channel subunit KCNQ2 
  Synonyms
PRO-Short-label: EXACT:KCNQ2
Gene-based: RELATED:Kqt2
Other: EXACT:KQT-like 2 | neuroblastoma-specific potassium channel subunit alpha KvLQT2 | potassium channel subunit alpha KvLQT2 | voltage-gated potassium channel subunit Kv7.2
  Definition"A voltage-gated potassium channel subunit KQT that is a translation product of the human KCNQ2 gene or a 1:1 ortholog thereof. Most of the isoforms are generated by splicing that is restricted to a region that encodes the intracellular C-terminal domain of the channel (exons 7-16 in rat). From these, there are two main classes, one containing exon 16 in-frame, and others with an alternative splice junction in exon 14 that results in a frameshift and early termination. In addition, exons 12 and 13 have alternative splice junctions, and exons 8,11, and 15a are subject to splicing. Many members of this class can form heteromeric channels with members of the class KCNQ3 (PR:000000730). Some forms of KCNQ2 contain two binding calmodulin binding sites and calmodulin is tethered constitutively to KCNQ channels." [PMID:11230508, PMID:12223552] 
  PRO Categorygene 
  ParentPR:000000684 voltage-gated potassium channel subunit KQT
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence16                                                  Organism-Sequence 38                                        
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500965;IUPHARobj:561
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000729 voltage-gated potassium channel subunit KCNQ2
KCNQ2

organism-gene


PR:O43526 potassium voltage-gated channel subfamily KQT member 2 (human)
hKCNQ2

organism-sequence


PR:000000907 voltage-gated potassium channel subunit KCNQ2 sequence variant S247W (human)
hKCNQ2/var:S247W
Yes
organism-sequence


PR:000000908 voltage-gated potassium channel subunit KCNQ2 sequence variant H228Q (human)
hKCNQ2/var:H228Q
Yes
organism-sequence


PR:000000909 voltage-gated potassium channel subunit KCNQ2 sequence variant R207W (human)
hKCNQ2/var:R207W
Yes
organism-sequence


PR:000000910 voltage-gated potassium channel subunit KCNQ2 sequence variant L243F (human)
hKCNQ2/var:L243F
Yes
organism-sequence


PR:000000911 voltage-gated potassium channel subunit KCNQ2 sequence variant 4 (human)
hKCNQ2/var:4
Yes
organism-sequence


PR:000000912 voltage-gated potassium channel subunit KCNQ2 sequence variant Y284C (human)
hKCNQ2/var:Y284C
Yes
organism-sequence


PR:000000913 voltage-gated potassium channel subunit KCNQ2 sequence variant A306T (human)
hKCNQ2/var:A306T
Yes
organism-sequence


PR:000000914 voltage-gated potassium channel subunit KCNQ2 sequence variant R333Q (human)
hKCNQ2/var:R333Q
Yes
organism-sequence


PR:000000915 voltage-gated potassium channel subunit KCNQ2 sequence variant M208V (human)
hKCNQ2/var:M208V
Yes
organism-sequence


PR:O43526-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (human)
hKCNQ2/iso:1

organism-sequence


PR:O43526-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (human)
hKCNQ2/iso:2
Yes
organism-sequence


PR:O43526-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human)
hKCNQ2/iso:3

organism-sequence


PR:000000916 voltage-gated potassium channel subunit KCNQ2 isoform 3 sequence variant K526N (human)
hKCNQ2/iso:3/var:K526N
Yes
organism-sequence


PR:O43526-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (human)
hKCNQ2/iso:4
Yes
organism-sequence


PR:O43526-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (human)
hKCNQ2/iso:5

organism-sequence


PR:O43526-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (human)
hKCNQ2/iso:6
Yes
organism-modification


PR:000076442 potassium voltage-gated channel subfamily KQT member 2 acetylated 1 (human)
hKCNQ2/Ac:1

organism-modification


PR:000079703 potassium voltage-gated channel subfamily KQT member 2 phosphorylated 1 (human)
hKCNQ2/Phos:1

organism-gene


PR:O88943 potassium voltage-gated channel subfamily KQT member 2 (rat)
rKCNQ2

organism-sequence


PR:O88943-1 potassium voltage-gated channel subfamily KQT member 2 isoform A (rat)
rKCNQ2/iso:A
Yes
organism-sequence


PR:O88943-2 potassium voltage-gated channel subfamily KQT member 2 isoform B (rat)
rKCNQ2/iso:B

organism-sequence


PR:O88943-3 potassium voltage-gated channel subfamily KQT member 2 isoform C (rat)
rKCNQ2/iso:C

organism-sequence


PR:O88943-4 potassium voltage-gated channel subfamily KQT member 2 isoform D (rat)
rKCNQ2/iso:D

organism-sequence


PR:O88943-5 potassium voltage-gated channel subfamily KQT member 2 isoform E (rat)
rKCNQ2/iso:E

organism-sequence


PR:O88943-6 potassium voltage-gated channel subfamily KQT member 2 isoform F (rat)
rKCNQ2/iso:F

organism-sequence


PR:O88943-7 potassium voltage-gated channel subfamily KQT member 2 isoform G (rat)
rKCNQ2/iso:G

organism-sequence


PR:O88943-8 potassium voltage-gated channel subfamily KQT member 2 isoform H (rat)
rKCNQ2/iso:H

organism-sequence


PR:O88943-9 potassium voltage-gated channel subfamily KQT member 2 isoform I (rat)
rKCNQ2/iso:I

organism-gene


PR:Q9Z351 potassium voltage-gated channel subfamily KQT member 2 (mouse)
mKCNQ2

organism-sequence


PR:Q9Z351-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (mouse)
mKCNQ2/iso:1

organism-sequence


PR:Q9Z351-10 potassium voltage-gated channel subfamily KQT member 2 isoform 10 (mouse)
mKCNQ2/iso:10
Yes
organism-sequence


PR:Q9Z351-11 potassium voltage-gated channel subfamily KQT member 2 isoform 11 (mouse)
mKCNQ2/iso:11
Yes
organism-sequence


PR:Q9Z351-12 potassium voltage-gated channel subfamily KQT member 2 isoform 12 (mouse)
mKCNQ2/iso:12
Yes
organism-sequence


PR:Q9Z351-13 potassium voltage-gated channel subfamily KQT member 2 isoform m13 (mouse)
mKCNQ2/iso:m13

organism-sequence


PR:Q9Z351-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (mouse)
mKCNQ2/iso:2

organism-sequence


PR:Q9Z351-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (mouse)
mKCNQ2/iso:3

organism-sequence


PR:Q9Z351-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (mouse)
mKCNQ2/iso:4

organism-sequence


PR:Q9Z351-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (mouse)
mKCNQ2/iso:5

organism-sequence


PR:Q9Z351-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (mouse)
mKCNQ2/iso:6

organism-sequence


PR:Q9Z351-7 potassium voltage-gated channel subfamily KQT member 2 isoform 7 (mouse)
mKCNQ2/iso:7

organism-sequence


PR:Q9Z351-8 potassium voltage-gated channel subfamily KQT member 2 isoform 8 (mouse)
mKCNQ2/iso:8

organism-sequence


PR:Q9Z351-9 potassium voltage-gated channel subfamily KQT member 2 isoform 9 (mouse)
mKCNQ2/iso:9
Yes
sequence


PR:000000891 voltage-gated potassium channel subunit KCNQ2 isoform 1
KCNQ2/iso:1

organism-sequence


PR:O43526-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (human)
hKCNQ2/iso:1

organism-sequence


PR:Q9Z351-12 potassium voltage-gated channel subfamily KQT member 2 isoform 12 (mouse)
mKCNQ2/iso:12
Yes
sequence


PR:000000892 voltage-gated potassium channel subunit KCNQ2 isoform 10
KCNQ2/iso:10

organism-sequence


PR:Q9Z351-10 potassium voltage-gated channel subfamily KQT member 2 isoform 10 (mouse)
mKCNQ2/iso:10
Yes
sequence


PR:000000893 voltage-gated potassium channel subunit KCNQ2 isoform 11
KCNQ2/iso:11

organism-sequence


PR:Q9Z351-11 potassium voltage-gated channel subfamily KQT member 2 isoform 11 (mouse)
mKCNQ2/iso:11
Yes
sequence


PR:000000894 voltage-gated potassium channel subunit KCNQ2 isoform 12
KCNQ2/iso:12

organism-sequence


PR:Q9Z351-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (mouse)
mKCNQ2/iso:2

sequence


PR:000000895 voltage-gated potassium channel subunit KCNQ2 isoform 13
KCNQ2/iso:13

organism-sequence


PR:Q9Z351-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (mouse)
mKCNQ2/iso:3

sequence


PR:000000896 voltage-gated potassium channel subunit KCNQ2 isoform 14
KCNQ2/iso:14

organism-sequence


PR:Q9Z351-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (mouse)
mKCNQ2/iso:4

sequence


PR:000000897 voltage-gated potassium channel subunit KCNQ2 isoform 15
KCNQ2/iso:15

organism-sequence


PR:Q9Z351-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (mouse)
mKCNQ2/iso:5

sequence


PR:000000898 voltage-gated potassium channel subunit KCNQ2 isoform 16
KCNQ2/iso:16

organism-sequence


PR:Q9Z351-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (mouse)
mKCNQ2/iso:6

sequence


PR:000000899 voltage-gated potassium channel subunit KCNQ2 isoform 2
KCNQ2/iso:2

organism-sequence


PR:O43526-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (human)
hKCNQ2/iso:2
Yes
organism-sequence


PR:O88943-1 potassium voltage-gated channel subfamily KQT member 2 isoform A (rat)
rKCNQ2/iso:A
Yes
organism-sequence


PR:Q9Z351-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (mouse)
mKCNQ2/iso:1

modification


PR:000002632 voltage-gated potassium channel subunit KCNQ2 isoform 2 unmodified form
KCNQ2/iso:2/UnMod

sequence


PR:000000900 voltage-gated potassium channel subunit KCNQ2 isoform 3
KCNQ2/iso:3

organism-sequence


PR:O43526-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human)
hKCNQ2/iso:3

organism-sequence


PR:000000916 voltage-gated potassium channel subunit KCNQ2 isoform 3 sequence variant K526N (human)
hKCNQ2/iso:3/var:K526N
Yes
organism-sequence


PR:O88943-3 potassium voltage-gated channel subfamily KQT member 2 isoform C (rat)
rKCNQ2/iso:C

sequence


PR:000000901 voltage-gated potassium channel subunit KCNQ2 isoform 4
KCNQ2/iso:4

organism-sequence


PR:O43526-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (human)
hKCNQ2/iso:4
Yes
sequence


PR:000000902 voltage-gated potassium channel subunit KCNQ2 isoform 5
KCNQ2/iso:5

organism-sequence


PR:O43526-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (human)
hKCNQ2/iso:5

sequence


PR:000000903 voltage-gated potassium channel subunit KCNQ2 isoform 6
KCNQ2/iso:6

organism-sequence


PR:O43526-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (human)
hKCNQ2/iso:6
Yes
sequence


PR:000000904 voltage-gated potassium channel subunit KCNQ2 isoform 7
KCNQ2/iso:7

organism-sequence


PR:Q9Z351-7 potassium voltage-gated channel subfamily KQT member 2 isoform 7 (mouse)
mKCNQ2/iso:7

sequence


PR:000000905 voltage-gated potassium channel subunit KCNQ2 isoform 8
KCNQ2/iso:8

organism-sequence


PR:Q9Z351-8 potassium voltage-gated channel subfamily KQT member 2 isoform 8 (mouse)
mKCNQ2/iso:8

sequence


PR:000000906 voltage-gated potassium channel subunit KCNQ2 isoform 9
KCNQ2/iso:9

organism-sequence


PR:Q9Z351-9 potassium voltage-gated channel subfamily KQT member 2 isoform 9 (mouse)
mKCNQ2/iso:9
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:14264 benign neonatal seizuresPR:000000907 hKCNQ2/var:S247W PMID:12742592
PR:000000908 hKCNQ2/var:H228Q PMID:14534157
PR:000000909 hKCNQ2/var:R207W PMID:11572947
PR:000000910 hKCNQ2/var:L243F PMID:14534157
PR:000000911 hKCNQ2/var:4 PMID:11175290
PR:000000912 hKCNQ2/var:Y284C PMID:10788442
PR:000000913 hKCNQ2/var:A306T PMID:10788442
PR:000000914 hKCNQ2/var:R333Q PMID:14534157
PR:000000915 hKCNQ2/var:M208V PMID:14534157
PR:000000916 hKCNQ2/iso:3/var:K526N PMID:15249611

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005249 voltage-gated potassium channel activityPR:000000907 hKCNQ2/var:S247W PMID:12742592
PR:000000909 hKCNQ2/var:R207W PMID:11572947
contributes_to GO:0005249 voltage-gated potassium channel activityPR:O43526-2 hKCNQ2/iso:2 PMID:11160379
PR:O88943-1 rKCNQ2/iso:A PMID:11038262
decreased|contributes_to GO:0005249 voltage-gated potassium channel activityPR:O43526-6 hKCNQ2/iso:6 PMID:9039501
contributes_to GO:0005251 delayed rectifier potassium channel activityPR:O43526-4 hKCNQ2/iso:4 PMID:9836639
GO:0005516 calmodulin bindingPR:Q9Z351-12 mKCNQ2/iso:12 PMID:12223552
NOT GO:0022832 voltage-gated channel activityPR:Q9Z351-10 mKCNQ2/iso:10 PMID:9666519
PR:Q9Z351-11 mKCNQ2/iso:11 PMID:9666519
PR:Q9Z351-9 mKCNQ2/iso:9 PMID:9666519

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0008076 voltage-gated potassium channel complexPR:Q9Z351-12 mKCNQ2/iso:12 PMID:12223552
GO:0009986 cell surfacePR:000000912 hKCNQ2/var:Y284C PMID:10788442
PR:000000913 hKCNQ2/var:A306T PMID:10788442
PR:Q9Z351-12 mKCNQ2/iso:12 PMID:12223552