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Protein Ontology report - voltage-gated potassium channel KCNC1
PR:000000781 - http://purl.obolibrary.org/obo/PR_000000781
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000781   
  PRO namevoltage-gated potassium channel KCNC1 
  Synonyms
PRO-Short-label: EXACT:KCNC1
Other: EXACT:NGK2 | potassium voltage-gated channel subfamily C member 1 | RAW2 | voltage-gated potassium channel subunit Kv3.1 | voltage-gated potassium channel subunit Kv4
  Definition"A shaw-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNC1 gene or a 1:1 ortholog thereof. They contain an ATM motif at the C-terminus, following the S6 segment that allows interaction with axonal targeting machinery when exposed." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000711 shaw-related voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 6                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:548
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000781

voltage-gated potassium channel KCNC1

KCNC1


"A shaw-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNC1 gene or a 1:1 ortholog thereof. They contain an ATM motif at the C-terminus, following the S6 segment that allows interaction with axonal targeting machinery when exposed." [PRO:CNA]


organism-gene



PR:P15388

voltage-gated potassium channel KCNC1 (mouse)

mKCNC1


"A voltage-gated potassium channel KCNC1 that is encoded in the genome of mouse." [OMA:P15388, PRO:DNx]


organism-sequence



PR:P15388-1

voltage-gated potassium channel KCNC1, isoform Short (mouse)

mKCNC1/iso:Short


"A voltage-gated potassium channel KCNC1 isoform Short that is encoded in the genome of mouse." [PMID:2599109, PRO:HJD]


organism-sequence



PR:P15388-3

voltage-gated potassium channel KCNC1, isoform Long (mouse)

mKCNC1/iso:Long


"A voltage-gated potassium channel KCNC1 isoform Long that is encoded in the genome of mouse." [PMID:2599109, PRO:HJD, RefSeq:NP_001106210]


organism-gene



PR:P25122

voltage-gated potassium channel KCNC1 (rat)

rKCNC1


"A voltage-gated potassium channel KCNC1 that is encoded in the genome of rat." [OMA:P25122, PRO:DNx]


organism-sequence



PR:P25122-1

voltage-gated potassium channel KCNC1 isoform Long (rat)

rKCNC1/iso:Long


"A voltage-gated potassium channel KCNC1 isoform Long that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-modification



PR:000036575

voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1 (rat)

rKCNC1/iso:Long/Phos:1


"A voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1 in rat. UniProtKB:P25122-1, Ser-503, MOD:00046." [PMID:16595659, PRO:CNA]

Yes

organism-modification



PR:000045386

voltage-gated potassium channel KCNC1 isoform Long unphosphorylated 1 (rat)

rKCNC1/iso:Long/UnPhos:1


"A voltage-gated potassium channel KCNC1 isoform Long (rat) that lacks phosphorylation on Ser-503. UniProtKB:P25122-1, Ser-503, PR:000026291." [PMID:16595659, PRO:CNA]

Yes

organism-sequence



PR:P25122-2

voltage-gated potassium channel KCNC1 isoform Short (rat)

rKCNC1/iso:Short


"A voltage-gated potassium channel KCNC1 isoform Short that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-gene



PR:P48547

voltage-gated potassium channel KCNC1 (human)

hKCNC1


"A voltage-gated potassium channel KCNC1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P48547]


organism-sequence



PR:P48547-1

voltage-gated potassium channel KCNC1 isoform 1 (human)

hKCNC1/iso:1


"A voltage-gated potassium channel KCNC1 isoform Short that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P48547-2

voltage-gated potassium channel KCNC1 isoform h2 (human)

hKCNC1/iso:h2


"A voltage-gated potassium channel KCNC1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48547-2." [PRO:DNx, UniProtKB:P48547]


sequence



PR:000000939

voltage-gated potassium channel KCNC1 isoform Short

KCNC1/iso:Short


"A voltage-gated potassium channel KCNC1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48547-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P15388-1

voltage-gated potassium channel KCNC1, isoform Short (mouse)

mKCNC1/iso:Short


"A voltage-gated potassium channel KCNC1 isoform Short that is encoded in the genome of mouse." [PMID:2599109, PRO:HJD]


organism-sequence



PR:P25122-2

voltage-gated potassium channel KCNC1 isoform Short (rat)

rKCNC1/iso:Short


"A voltage-gated potassium channel KCNC1 isoform Short that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-sequence



PR:P48547-1

voltage-gated potassium channel KCNC1 isoform 1 (human)

hKCNC1/iso:1


"A voltage-gated potassium channel KCNC1 isoform Short that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000940

voltage-gated potassium channel KCNC1 isoform Long

KCNC1/iso:Long


"A voltage-gated potassium channel KCNC1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25122-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P15388-3

voltage-gated potassium channel KCNC1, isoform Long (mouse)

mKCNC1/iso:Long


"A voltage-gated potassium channel KCNC1 isoform Long that is encoded in the genome of mouse." [PMID:2599109, PRO:HJD, RefSeq:NP_001106210]


organism-sequence



PR:P25122-1

voltage-gated potassium channel KCNC1 isoform Long (rat)

rKCNC1/iso:Long


"A voltage-gated potassium channel KCNC1 isoform Long that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-modification



PR:000036575

voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1 (rat)

rKCNC1/iso:Long/Phos:1


"A voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1 in rat. UniProtKB:P25122-1, Ser-503, MOD:00046." [PMID:16595659, PRO:CNA]

Yes

organism-modification



PR:000045386

voltage-gated potassium channel KCNC1 isoform Long unphosphorylated 1 (rat)

rKCNC1/iso:Long/UnPhos:1


"A voltage-gated potassium channel KCNC1 isoform Long (rat) that lacks phosphorylation on Ser-503. UniProtKB:P25122-1, Ser-503, PR:000026291." [PMID:16595659, PRO:CNA]

Yes

modification



PR:000000986

voltage-gated potassium channel KCNC1 isoform Long phosphorylated form

KCNC1/iso:Long/PhosRes+


"A voltage-gated potassium channel KCNC1 isoform Long that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000992

voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1

KCNC1/iso:Long/Phos:1


"A voltage-gated potassium channel KCNC1 isoform Long phosphorylated form in which the phosphorylation occurs by the action of PKC at the Ser residue within the DSKL motif located in the C-terminal tail. In resting neurons, basal phosphorylation at this site decreases Kv3.1 channel current, reducing neuronal ability to follow high frequency stimulation. Example: UniProtKB:P25122-1, Ser-503, MOD:00046." [PMID:16595659]


organism-modification



PR:000036575

voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1 (rat)

rKCNC1/iso:Long/Phos:1


"A voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1 in rat. UniProtKB:P25122-1, Ser-503, MOD:00046." [PMID:16595659, PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Molecular Function GO Term

Protein Forms & Complexes

Evidence
contributes_to GO:0005249 voltage-gated potassium channel activityPR:000045386 rKCNC1/iso:Long/UnPhos:1 PMID:16595659
decreased|contributes_to GO:0005249 voltage-gated potassium channel activityPR:000036575 rKCNC1/iso:Long/Phos:1 PMID:16595659
GO:0030506 ankyrin bindingPR:P25122-1 rKCNC1/iso:Long PMID:18094255

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0016020 membranePR:000036575 rKCNC1/iso:Long/Phos:1 PMID:16595659
GO:0030424 axonPR:P25122-1 rKCNC1/iso:Long PMID:18094255
GO:0032809 neuronal cell body membranePR:P25122-2 rKCNC1/iso:Short PMID:18094255