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Protein Ontology report - A-type voltage-gated potassium channel KCND2
PR:000000785 - http://purl.obolibrary.org/obo/PR_000000785
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000785   
  PRO nameA-type voltage-gated potassium channel KCND2 
  Synonyms
PRO-Short-label: EXACT:KCND2
Gene-based: RELATED:KIAA1044
Other: EXACT:potassium voltage-gated channel subfamily D member 2 | voltage-gated potassium channel subunit Kv4.2
  Definition"A shal-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCND2 gene or a 1:1 ortholog thereof. Kv4.2 potassium channels play a critical role in postsynaptic excitability. They are modulated by phosphorylation as well as by association with Kv4 Channel Interacting Proteins (KChIPs). The N terminus contains an ER retention motif RKR that seems to be masked when associated to KChiPs. This masking increases surface expression." [PMID:12829703, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000710 shal-related voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:553
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000785 A-type voltage-gated potassium channel KCND2
KCND2

organism-gene


PR:Q5VSI1 A-type voltage-gated potassium channel KCND2 (zebrafish)
z-KCND2

organism-gene


PR:Q9NZV8 A-type voltage-gated potassium channel KCND2 (human)
hKCND2

organism-sequence


PR:Q9NZV8-1 A-type voltage-gated potassium channel KCND2 isoform 1 (human)
hKCND2/iso:1
Yes
organism-modification


PR:000084839 A-type voltage-gated potassium channel KCND2 deaminated 1 (human)
hKCND2/Deam:1

organism-gene


PR:Q9Z0V2 A-type voltage-gated potassium channel KCND2 (mouse)
mKCND2

organism-sequence


PR:Q9Z0V2-1 A-type voltage-gated potassium channel KCND2 isoform 1 (mouse)
mKCND2/iso:1
Yes
organism-modification


PR:000036577 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse)
mKCND2/iso:1/Phos:1

organism-modification


PR:000036578 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse)
mKCND2/iso:1/Phos:2
Yes
organism-modification


PR:000036579 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse)
mKCND2/iso:1/Phos:3
Yes
organism-modification


PR:000036580 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse)
mKCND2/iso:1/Phos:4
Yes
organism-modification


PR:000045389 A-type voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 3 (mouse)
mKCND2/iso:1/UnPhos:3
Yes
organism-modification


PR:000045390 A-type voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 4 (mouse)
mKCND2/iso:1/UnPhos:4
Yes
sequence


PR:000000947 A-type voltage-gated potassium channel KCND2 isoform 1
KCND2/iso:1

organism-sequence


PR:Q9NZV8-1 A-type voltage-gated potassium channel KCND2 isoform 1 (human)
hKCND2/iso:1
Yes
organism-sequence


PR:Q9Z0V2-1 A-type voltage-gated potassium channel KCND2 isoform 1 (mouse)
mKCND2/iso:1
Yes
organism-modification


PR:000036577 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse)
mKCND2/iso:1/Phos:1

organism-modification


PR:000036578 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse)
mKCND2/iso:1/Phos:2
Yes
organism-modification


PR:000036579 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse)
mKCND2/iso:1/Phos:3
Yes
organism-modification


PR:000036580 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse)
mKCND2/iso:1/Phos:4
Yes
organism-modification


PR:000045389 A-type voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 3 (mouse)
mKCND2/iso:1/UnPhos:3
Yes
organism-modification


PR:000045390 A-type voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 4 (mouse)
mKCND2/iso:1/UnPhos:4
Yes
modification


PR:000000988 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated form
KCND2/iso:1/PhosRes+

modification


PR:000000994 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1
KCND2/iso:1/Phos:1

organism-modification


PR:000036577 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse)
mKCND2/iso:1/Phos:1

modification


PR:000000995 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2
KCND2/iso:1/Phos:2

organism-modification


PR:000036578 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse)
mKCND2/iso:1/Phos:2
Yes
modification


PR:000000996 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3
KCND2/iso:1/Phos:3

organism-modification


PR:000036579 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse)
mKCND2/iso:1/Phos:3
Yes
modification


PR:000000997 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4
KCND2/iso:1/Phos:4

organism-modification


PR:000036580 A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse)
mKCND2/iso:1/Phos:4
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036578 mKCND2/iso:1/Phos:2
UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047		 located_inGO:0030425 dendrite PMID:11040264
PR:000036579 mKCND2/iso:1/Phos:3
UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046		 located_inGO:0030425 dendrite PMID:11040264
PR:000036580 mKCND2/iso:1/Phos:4
UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046		 enablesdecreased|contributes_to GO:0005250 A-type (transient outward) potassium channel activity relative to PR:000002656 PMID:16251476
located_inGO:0009986 cell surface PMID:16251476
GO:0030425 dendrite PMID:11040264
PR:000045389 mKCND2/iso:1/UnPhos:3
UniProtKB:Q9Z0V2-1, Ser-552, PR:000026291		 located_inGO:0009986 cell surface PMID:12829703; PMID:16251476
PR:000045390 mKCND2/iso:1/UnPhos:4
UniProtKB:Q9Z0V2-1, Thr-602/Thr-607/Ser-616, PR:000026291		 enablescontributes_to GO:0005250 A-type (transient outward) potassium channel activity PMID:16251476
PR:Q9NZV8-1 hKCND2/iso:1 acts_upstream_of_or_withinGO:0001508 action potential PMID:11102480
GO:0007268 chemical synaptic transmission PMID:11102480
located_inGO:0009986 cell surface PMID:12493773
PR:Q9Z0V2-1 mKCND2/iso:1 located_inGO:0005783 endoplasmic reticulum PMID:12829703