Protein Ontology

Home

Linked Open Data

Browse

Statistics

Download

RACE-PRO

PRO tracker

Community

PRO Consortium

Publications

Documentation

Protein Ontology report - voltage-gated inwardly rectifying potassium channel KCNH2

PR:000000791 - http://purl.obolibrary.org/obo/PR_000000791

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000791

PRO name

voltage-gated inwardly rectifying potassium channel KCNH2

Synonyms

PRO-Short-label:	EXACT:	KCNH2
Gene-based:	RELATED:	ERG \| ERG1 \| HERG
Other:	EXACT:	Eag homolog \| Eag-related protein 1 \| ERG-1 \| ether-a-go-go-related gene potassium channel 1 \| ether-a-go-go-related protein 1 \| potassium voltage-gated channel subfamily H member 2 \| voltage-gated potassium channel subunit KCNH2 \| voltage-gated potassium channel subunit Kv11.1
	RELATED:	KHCN2

Definition

"A voltage-gated potassium channel Erg alpha subunit that is a translation product of the human KCNH2 gene or a 1:1 ortholog thereof." [PRO:CNA]

PRO Category

gene

Parent

PR:000000721 voltage-gated potassium channel Erg alpha subunit

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	3
Sequence	4	Organism-Sequence	9
Modification	6	Organism-Modification	5

Term Hierarchy
Visualization

DAG:

OLS:

Back to top

Related Cross References
Db identifiers	IUPHARobj:572

Back to top

Protein Forms

Switch to Extended View

Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000000791 voltage-gated inwardly rectifying potassium channel KCNH2

KCNH2

organism-gene

PR:O08962 voltage-gated inwardly rectifying potassium channel KCNH2 (rat)

rKCNH2

organism-gene

PR:O35219 voltage-gated inwardly rectifying potassium channel KCNH2 (mouse)

mKCNH2

organism-sequence

PR:O35219-1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (mouse)

mKCNH2/iso:A

Yes

organism-modification

PR:000036582 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)

mKCNH2/iso:A/NGlyco:1

Yes

organism-sequence

PR:O35219-2 voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' (mouse)

mKCNH2/iso:1A'

Yes

organism-sequence

PR:O35219-3 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (mouse)

mKCNH2/iso:B

Yes

organism-gene

PR:Q12809 voltage-gated inwardly rectifying potassium channel KCNH2 (human)

hKCNH2

Yes

organism-sequence

PR:Q12809-1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)

hKCNH2/iso:A

Yes

organism-modification

PR:000036581 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1

Yes

organism-modification

PR:000036583 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1

Yes

organism-modification

PR:000045392 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1

Yes

organism-modification

PR:000045393 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-

Yes

organism-sequence

PR:Q12809-2 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (human)

hKCNH2/iso:B

Yes

organism-sequence

PR:Q12809-4 voltage-gated inwardly rectifying potassium channel KCNH2 isoform h4 (human)

hKCNH2/iso:h4

organism-sequence

PR:Q12809-5 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO (human)

hKCNH2/iso:A-USO

Yes

organism-sequence

PR:Q12809-6 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B-USO (human)

hKCNH2/iso:B-USO

organism-sequence

PR:Q12809-7 voltage-gated inwardly rectifying potassium channel KCNH2 isoform h3.1 (human)

hKCNH2/iso:h3.1

sequence

PR:000000957 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A

KCNH2/iso:A

organism-sequence

PR:O35219-1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (mouse)

mKCNH2/iso:A

Yes

organism-modification

PR:000036582 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)

mKCNH2/iso:A/NGlyco:1

Yes

organism-sequence

PR:Q12809-1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)

hKCNH2/iso:A

Yes

organism-modification

PR:000036581 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1

Yes

organism-modification

PR:000036583 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1

Yes

organism-modification

PR:000045392 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1

Yes

organism-modification

PR:000045393 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-

Yes

modification

PR:000000989 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A glycosylated form

KCNH2/iso:A/GlycoRes+

modification

PR:000000998 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1

KCNH2/iso:A/NGlyco:1

organism-modification

PR:000036581 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1

Yes

organism-modification

PR:000036582 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)

mKCNH2/iso:A/NGlyco:1

Yes

modification

PR:000000990 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated form

KCNH2/iso:A/PhosRes+

modification

PR:000000999 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1

KCNH2/iso:A/Phos:1

organism-modification

PR:000036583 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1

Yes

modification

PR:000002666 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unmodified form

KCNH2/iso:A/UnMod

organism-modification

PR:000045393 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-

Yes

modification

PR:000045391 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1

KCNH2/iso:A/UnGlyco:1

organism-modification

PR:000045392 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1

Yes

sequence

PR:000000958 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B

KCNH2/iso:B

organism-sequence

PR:O35219-3 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (mouse)

mKCNH2/iso:B

Yes

organism-sequence

PR:Q12809-2 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (human)

hKCNH2/iso:B

Yes

sequence

PR:000000959 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO

KCNH2/iso:A-USO

organism-sequence

PR:Q12809-5 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO (human)

hKCNH2/iso:A-USO

Yes

sequence

PR:000000960 voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A'

KCNH2/iso:1A'

organism-sequence

PR:O35219-2 voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' (mouse)

mKCNH2/iso:1A'

Yes

Back to top

Functional Annotation (PRO-centric view)

Switch to GO Centric View

PRO Term	GO Annotation		Evidence
PR:000036581 hKCNH2/iso:A/NGlyco:1 UniProtKB:Q12809-1, Asn-598, MOD:00160	located_in	GO:0008076 voltage-gated potassium channel complex	PMID:12063277
	located_in	GO:0009986 cell surface	PMID:12063277
PR:000036582 mKCNH2/iso:A/NGlyco:1 UniProtKB:O35219-1, Asn-600, MOD:00160	located_in	GO:0005886 plasma membrane	MGI_ref:3040012; PMID:14668215
PR:000036583 hKCNH2/iso:A/Phos:1	enables	decreased GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod	PMID:10837251
PR:000036583 hKCNH2/iso:A/Phos:1	located_in	GO:0008076 voltage-gated potassium channel complex	PMID:10837251
PR:000045392 hKCNH2/iso:A/UnGlyco:1 UniProtKB:Q12809-1, Asn-598, PR:000026291	located_in	GO:0009986 cell surface	PMID:12063277
PR:000045393 hKCNH2/iso:A/PhosRes-	enables	contributes_to GO:0005251 delayed rectifier potassium channel activity	PMID:10837251; PMID:9351446
PR:O35219-1 mKCNH2/iso:A	enables	contributes_to GO:0005251 delayed rectifier potassium channel activity	PMID:9351446; PMID:9351462
	located_in	GO:0005635 nuclear envelope	MGI_ref:3040012; PMID:14668215
		GO:0005635 nuclear envelope	MGI_ref:3040012; PMID:14668215
		GO:0005737 cytoplasm	MGI_ref:3040012; PMID:14668215
		GO:0005737 cytoplasm	MGI_ref:3040012; PMID:14668215
		GO:0005886 plasma membrane	MGI_ref:3040012; PMID:14668215
		GO:0008076 voltage-gated potassium channel complex	PMID:9351462
PR:O35219-2 mKCNH2/iso:1A'	enables	GO:0005251 delayed rectifier potassium channel activity	PMID:9351462
PR:O35219-2 mKCNH2/iso:1A'	located_in	GO:0008076 voltage-gated potassium channel complex	PMID:9351462
PR:O35219-3 mKCNH2/iso:B	enables	contributes_to GO:0005251 delayed rectifier potassium channel activity	PMID:9351446; PMID:9351462
PR:O35219-3 mKCNH2/iso:B	located_in	GO:0008076 voltage-gated potassium channel complex	PMID:9351462
PR:Q12809 hKCNH2	acts_upstream_of_or_within	GO:0006936 muscle contraction	PMID:7736582
PR:Q12809 hKCNH2	acts_upstream_of_or_within	GO:0008016 regulation of heart contraction	PMID:7736582
PR:Q12809-1 hKCNH2/iso:A	enables	GO:0030552 cAMP binding	PMID:10837251
PR:Q12809-2 hKCNH2/iso:B	enables	contributes_to GO:0005251 delayed rectifier potassium channel activity	PMID:9351446
PR:Q12809-5 hKCNH2/iso:A-USO	enables	altered\|contributes_to GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod	PMID:9765245
PR:Q12809-5 hKCNH2/iso:A-USO	located_in	GO:0008076 voltage-gated potassium channel complex	PMID:9765245