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Protein Ontology report - voltage-gated inwardly rectifying potassium channel KCNH2
PR:000000791 - http://purl.obolibrary.org/obo/PR_000000791
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000791   
  PRO namevoltage-gated inwardly rectifying potassium channel KCNH2 
  Synonyms
PRO-Short-label: EXACT:KCNH2
Gene-based: RELATED:ERG | ERG1 | HERG
Other: EXACT:Eag homolog | Eag-related protein 1 | ERG-1 | ether-a-go-go-related gene potassium channel 1 | ether-a-go-go-related protein 1 | potassium voltage-gated channel subfamily H member 2 | voltage-gated potassium channel subunit KCNH2 | voltage-gated potassium channel subunit Kv11.1
RELATED:KHCN2
  Definition"A voltage-gated potassium channel Erg alpha subunit that is a translation product of the human KCNH2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000721 voltage-gated potassium channel Erg alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence4                                                  Organism-Sequence 9                                        
         Modification6                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:572
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000791

voltage-gated inwardly rectifying potassium channel KCNH2

KCNH2


"A voltage-gated potassium channel Erg alpha subunit that is a translation product of the human KCNH2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O08962

voltage-gated inwardly rectifying potassium channel KCNH2 (rat)

rKCNH2


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is encoded in the genome of rat." [OMA:O08962, PRO:DNx]


organism-gene



PR:O35219

voltage-gated inwardly rectifying potassium channel KCNH2 (mouse)

mKCNH2


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is encoded in the genome of mouse." [OMA:O35219, PRO:DNx]


organism-sequence



PR:O35219-1

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (mouse)

mKCNH2/iso:A


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036582

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)

mKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in mouse. UniProtKB:O35219-1, Asn-600, MOD:00160." [PMID:14668215, PRO:CNA]

Yes

organism-sequence



PR:O35219-2

voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' (mouse)

mKCNH2/iso:1A'


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O35219]

Yes

organism-sequence



PR:O35219-3

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (mouse)

mKCNH2/iso:B


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform B that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O35219]

Yes

organism-gene



PR:Q12809

voltage-gated inwardly rectifying potassium channel KCNH2 (human)

hKCNH2


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q12809]

Yes

organism-sequence



PR:Q12809-1

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)

hKCNH2/iso:A


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036581

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000036583

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 in human." [PMID:10837251, PRO:CNA]

Yes

organism-modification



PR:000045392

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000045393

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human) that lacks phosphorylated residues." [PMID:10837251, PRO:CNA]

Yes

organism-sequence



PR:Q12809-2

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (human)

hKCNH2/iso:B


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]

Yes

organism-sequence



PR:Q12809-4

voltage-gated inwardly rectifying potassium channel KCNH2 isoform h4 (human)

hKCNH2/iso:h4


"A voltage-gated inwardly rectifying potassium channel KCNH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-4." [PRO:DNx, UniProtKB:Q12809]


organism-sequence



PR:Q12809-5

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO (human)

hKCNH2/iso:A-USO


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]

Yes

organism-sequence



PR:Q12809-6

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B-USO (human)

hKCNH2/iso:B-USO


"A voltage-gated inwardly rectifying potassium channel KCNH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-6." [PRO:DNx, UniProtKB:Q12809]


organism-sequence



PR:Q12809-7

voltage-gated inwardly rectifying potassium channel KCNH2 isoform h3.1 (human)

hKCNH2/iso:h3.1


"A voltage-gated inwardly rectifying potassium channel KCNH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-7." [PRO:DNx, UniProtKB:Q12809]


sequence



PR:000000957

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A

KCNH2/iso:A


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O35219-1

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (mouse)

mKCNH2/iso:A


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036582

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)

mKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in mouse. UniProtKB:O35219-1, Asn-600, MOD:00160." [PMID:14668215, PRO:CNA]

Yes

organism-sequence



PR:Q12809-1

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)

hKCNH2/iso:A


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036581

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000036583

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 in human." [PMID:10837251, PRO:CNA]

Yes

organism-modification



PR:000045392

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000045393

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human) that lacks phosphorylated residues." [PMID:10837251, PRO:CNA]

Yes

modification



PR:000000989

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A glycosylated form

KCNH2/iso:A/GlycoRes+


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that includes at least one glycosylated residue." [PRO:CNA]


modification



PR:000000998

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1

KCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A glycosylated form that has been glycosylated at the Asn residue within the Nx[T/S] motif located approximately 26 amino acids downstream of the S5 transmembrane domain. Example: UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277]


organism-modification



PR:000036581

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000036582

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)

mKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in mouse. UniProtKB:O35219-1, Asn-600, MOD:00160." [PMID:14668215, PRO:CNA]

Yes

modification



PR:000000990

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated form

KCNH2/iso:A/PhosRes+


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000999

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1

KCNH2/iso:A/Phos:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated form in which the phosphorylation occurs at Ser and Thr residues located in the intracellular loops by PKA." [PMID:10837251]


organism-modification



PR:000036583

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 in human." [PMID:10837251, PRO:CNA]

Yes

modification



PR:000002666

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unmodified form

KCNH2/iso:A/UnMod


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


organism-modification



PR:000045393

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human) that lacks phosphorylated residues." [PMID:10837251, PRO:CNA]

Yes

modification



PR:000045391

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1

KCNH2/iso:A/UnGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that lacks a glycosylated Asn residue in the Nx[T/S] motif located approximately 26 amino acids downstream of the S5 transmembrane domain. Example: UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277]


organism-modification



PR:000045392

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277, PRO:CNA]

Yes

sequence



PR:000000958

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B

KCNH2/iso:B


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-2 or a 1:1 ortholog thereof." [PMID:9351446, PMID:9351462, PRO:CNA, PRO:DAN]


organism-sequence



PR:O35219-3

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (mouse)

mKCNH2/iso:B


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform B that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O35219]

Yes

organism-sequence



PR:Q12809-2

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (human)

hKCNH2/iso:B


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]

Yes

sequence



PR:000000959

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO

KCNH2/iso:A-USO


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-5 or a 1:1 ortholog thereof." [PMID:9765245, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q12809-5

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO (human)

hKCNH2/iso:A-USO


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]

Yes

sequence



PR:000000960

voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A'

KCNH2/iso:1A'


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35219-2 or a 1:1 ortholog thereof." [PMID:9351462, PRO:CNA, PRO:DAN]


organism-sequence



PR:O35219-2

voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' (mouse)

mKCNH2/iso:1A'


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O35219]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036581 hKCNH2/iso:A/NGlyco:1
UniProtKB:Q12809-1, Asn-598, MOD:00160
located_inGO:0008076 voltage-gated potassium channel complex PMID:12063277
GO:0009986 cell surface PMID:12063277
PR:000036582 mKCNH2/iso:A/NGlyco:1
UniProtKB:O35219-1, Asn-600, MOD:00160
located_inGO:0005886 plasma membrane MGI_ref:3040012; PMID:14668215
PR:000036583 hKCNH2/iso:A/Phos:1 enablesdecreased GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod PMID:10837251
located_inGO:0008076 voltage-gated potassium channel complex PMID:10837251
PR:000045392 hKCNH2/iso:A/UnGlyco:1
UniProtKB:Q12809-1, Asn-598, PR:000026291
located_inGO:0009986 cell surface PMID:12063277
PR:000045393 hKCNH2/iso:A/PhosRes- enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:10837251; PMID:9351446
PR:O35219-1 mKCNH2/iso:A enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9351446; PMID:9351462
located_inGO:0005635 nuclear envelope MGI_ref:3040012; PMID:14668215
GO:0005635 nuclear envelope MGI_ref:3040012; PMID:14668215
GO:0005737 cytoplasm MGI_ref:3040012; PMID:14668215
GO:0005737 cytoplasm MGI_ref:3040012; PMID:14668215
GO:0005886 plasma membrane MGI_ref:3040012; PMID:14668215
GO:0008076 voltage-gated potassium channel complex PMID:9351462
PR:O35219-2 mKCNH2/iso:1A' enablesGO:0005251 delayed rectifier potassium channel activity PMID:9351462
located_inGO:0008076 voltage-gated potassium channel complex PMID:9351462
PR:O35219-3 mKCNH2/iso:B enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9351446; PMID:9351462
located_inGO:0008076 voltage-gated potassium channel complex PMID:9351462
PR:Q12809 hKCNH2 acts_upstream_of_or_withinGO:0006936 muscle contraction PMID:7736582
GO:0008016 regulation of heart contraction PMID:7736582
PR:Q12809-1 hKCNH2/iso:A enablesGO:0030552 cAMP binding PMID:10837251
PR:Q12809-2 hKCNH2/iso:B enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9351446
PR:Q12809-5 hKCNH2/iso:A-USO enablesaltered|contributes_to GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod PMID:9765245
located_inGO:0008076 voltage-gated potassium channel complex PMID:9765245