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Protein Ontology report - voltage-gated potassium channel subunit KCNA2
PR:000000810 - http://purl.obolibrary.org/obo/PR_000000810
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000810   
  PRO namevoltage-gated potassium channel subunit KCNA2 
  Synonyms
PRO-Short-label: EXACT:KCNA2
Other: EXACT:NGK1 | voltage-gated K(+) channel HuKIV | voltage-gated potassium channel HBK5 | voltage-gated potassium channel subunit Kv1.2
RELATED:MK2
  Definition"A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA2 gene or a 1:1 ortholog thereof. The Kv1.2 channel is involved in maintaining membrane potential, modulating electrical excitability in neurons and muscle. It can coassemble with other Kv1 subunits." [PMID:16382104
  PRO Categorygene 
  ParentPR:000000709 shaker-related voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 11                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:539
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000810

voltage-gated potassium channel subunit KCNA2

KCNA2


"A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA2 gene or a 1:1 ortholog thereof. The Kv1.2 channel is involved in maintaining membrane potential, modulating electrical excitability in neurons and muscle. It can coassemble with other Kv1 subunits." [PMID:16382104]


organism-gene



PR:P16389

potassium voltage-gated channel subfamily A member 2 (human)

hKCNA2


"A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of human." []


organism-sequence



PR:P16389-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (human)

hKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036584

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 (human)

hKCNA2/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 in human. UniProtKB:P16389-1, Tyr-132, MOD:00048." [PMID:15215309, PRO:CNA]

Yes

organism-modification



PR:000036587

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (human)

hKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in human. UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA]

Yes

organism-sequence



PR:P16389-2

potassium voltage-gated channel subfamily A member 2 isoform h2 (human)

hKCNA2/iso:h2


"A potassium voltage-gated channel subfamily A member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16389-2." [PRO:DNx, UniProtKB:P16389]


organism-gene



PR:P63141

potassium voltage-gated channel subfamily A member 2 (mouse)

mKCNA2


"A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of mouse." [OMA:P63141, PRO:DNx]


organism-sequence



PR:P63141-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (mouse)

mKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036585

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (mouse)

mKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in mouse. UniProtKB:P63141-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-gene



PR:P63142

potassium voltage-gated channel subfamily A member 2 (rat)

rKCNA2


"A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of rat." [OMA:P63142, PRO:DNx]


organism-sequence



PR:P63142-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (rat)

rKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-modification



PR:000036586

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (rat)

rKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in rat. UniProtKB:P63142-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-gene



PR:Q8I4B0

potassium voltage-gated channel protein shk-1 (worm)

KCNA2 (worm)


"A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of worm." [OMA:Q8I4B0, PRO:DNx]


organism-sequence



PR:Q8I4B0-1

potassium voltage-gated channel protein shk-1 isoform c (worm)

KCNA2/iso:c (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-1." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-2

potassium voltage-gated channel protein shk-1 isoform b (worm)

KCNA2/iso:b (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-2." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-3

potassium voltage-gated channel protein shk-1 isoform d (worm)

KCNA2/iso:d (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-3." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-4

potassium voltage-gated channel protein shk-1 isoform a (worm)

KCNA2/iso:a (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-4." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-5

potassium voltage-gated channel protein shk-1 isoform e (worm)

KCNA2/iso:e (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-5." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-6

potassium voltage-gated channel protein shk-1 isoform f (worm)

KCNA2/iso:f (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-6." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-7

potassium voltage-gated channel protein shk-1 isoform g (worm)

KCNA2/iso:g (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-7." [PRO:DNx, UniProtKB:Q8I4B0]


sequence



PR:000000972

voltage-gated potassium channel subunit KCNA2 isoform 1

KCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16389-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P16389-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (human)

hKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036584

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 (human)

hKCNA2/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 in human. UniProtKB:P16389-1, Tyr-132, MOD:00048." [PMID:15215309, PRO:CNA]

Yes

organism-modification



PR:000036587

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (human)

hKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in human. UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA]

Yes

organism-sequence



PR:P63141-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (mouse)

mKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036585

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (mouse)

mKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in mouse. UniProtKB:P63141-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P63142-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (rat)

rKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-modification



PR:000036586

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (rat)

rKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in rat. UniProtKB:P63142-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000991

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated form

KCNA2/iso:1/PhosRes+


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000001000

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1

KCNA2/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the REDEGYIK sequence located adjacent to the tetramerization domain. Phosphorylation at this site promotes endocytosis and suppresses the channel activity. Example: UniProtKB:P16389-1, Tyr-132, MOD:00048." [PRO:CNA]


organism-modification



PR:000036584

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 (human)

hKCNA2/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 in human. UniProtKB:P16389-1, Tyr-132, MOD:00048." [PMID:15215309, PRO:CNA]

Yes

modification



PR:000001001

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2

KCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated form in which the phosphorylation occurs at the pair of Ser residues within the SSPD motif at the C terminus. Phosphorylation at this site promotes cell surface localization. Example: UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633]


organism-modification



PR:000036585

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (mouse)

mKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in mouse. UniProtKB:P63141-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036586

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (rat)

rKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in rat. UniProtKB:P63142-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036587

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (human)

hKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in human. UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036584 hKCNA2/iso:1/Phos:1
UniProtKB:P16389-1, Tyr-132, MOD:00048
enablesNOT GO:0005251 delayed rectifier potassium channel activity PMID:15215309
located_inGO:0005768 endosome PMID:15215309
PR:000036585 mKCNA2/iso:1/Phos:2
UniProtKB:P63141-1, Ser-440/Ser-441, MOD:00046
located_inGO:0008076 voltage-gated potassium channel complex PMID:18056633
GO:0009986 cell surface PMID:18056633
PR:000036586 rKCNA2/iso:1/Phos:2
UniProtKB:P63142-1, Ser-440/Ser-441, MOD:00046
located_inGO:0008076 voltage-gated potassium channel complex PMID:18056633
GO:0009986 cell surface PMID:18056633
PR:000036587 hKCNA2/iso:1/Phos:2
UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046
located_inGO:0008076 voltage-gated potassium channel complex PMID:18056633
GO:0009986 cell surface PMID:18056633
PR:P16389-1 hKCNA2/iso:1 enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:1715584
located_inGO:0008076 voltage-gated potassium channel complex PMID:2251283
GO:0009986 cell surface PMID:15215309
PR:P63142-1 rKCNA2/iso:1 enablesGO:0005515 protein binding with PR:P78352 DLG4 PMID:17959782