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Protein Ontology report - voltage-gated potassium channel subunit KCNA5
PR:000000812 - http://purl.obolibrary.org/obo/PR_000000812
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000812   
  PRO namevoltage-gated potassium channel subunit KCNA5 
  Synonyms
PRO-Short-label: EXACT:KCNA5
Other: EXACT:HPCN1 | KV1-5 | voltage-gated potassium channel HK2 | voltage-gated potassium channel subunit Kv1.5
  Definition"A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA5 gene or a 1:1 ortholog thereof. The voltage-gated potassium channel Kv1.5 mediates the ultrarapid-activating potassium current (IKur) in heart, and also plays a critical role in the regulation of arterial tone." [PMID:10575199, PMID:16772329, PMID:18344374
  PRO Categorygene 
  ParentPR:000000709 shaker-related voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 6                                        
         Modification1                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:542
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000812

voltage-gated potassium channel subunit KCNA5

KCNA5


"A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA5 gene or a 1:1 ortholog thereof. The voltage-gated potassium channel Kv1.5 mediates the ultrarapid-activating potassium current (IKur) in heart, and also plays a critical role in the regulation of arterial tone." [PMID:10575199, PMID:16772329, PMID:18344374]


organism-gene



PR:P19024

potassium voltage-gated channel subfamily A member 5 (rat)

rKCNA5


"A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of rat." [OMA:P19024, PRO:DNx]


organism-gene



PR:P22460

potassium voltage-gated channel subfamily A member 5 (human)

hKCNA5


"A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human." []


organism-sequence



PR:P22460-1

potassium voltage-gated channel subfamily A member 5 isoform 1 (human)

hKCNA5/iso:1


"A voltage-gated potassium channel subunit KCNA5 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:000036568

potassium voltage-gated channel subfamily A member 5 isoform 1 sequence variant E375* (human)

hKCNA5/iso:1/var:E375*


"A potassium voltage-gated channel subfamily A member 5 isoform 1 (human) that has a C-terminal truncation and thus lacks the S4-S6 voltage sensor, pore region and C terminus, but preserves the N terminus and S1-S3 transmembrane domains that secure tetrameric subunit assembly. UniProtKB:P22460-1, 1-374." [PMID:16772329, PRO:CNA]

Yes

organism-sequence



PR:P22460-2

potassium voltage-gated channel subfamily A member 5 isoform h2 (human)

hKCNA5/iso:h2


"A potassium voltage-gated channel subfamily A member 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22460-2." [PRO:DNx, UniProtKB:P22460]


organism-gene



PR:Q61762

potassium voltage-gated channel subfamily A member 5 (mouse)

mKCNA5


"A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of mouse." [OMA:Q61762, PRO:DNx]


organism-sequence



PR:Q61762-1

potassium voltage-gated channel subfamily A member 5 isoform 1 (mouse)

mKCNA5/iso:1


"A voltage-gated potassium channel subunit KCNA5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q61762-2

potassium voltage-gated channel subfamily A member 5 isoform 2 (mouse)

mKCNA5/iso:2


"A voltage-gated potassium channel subunit KCNA5 isoform 2 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q61762]

Yes

organism-sequence



PR:Q61762-3

potassium voltage-gated channel subfamily A member 5 isoform 3 (mouse)

mKCNA5/iso:3


"A voltage-gated potassium channel subunit KCNA5 isoform 3 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q61762]

Yes

sequence



PR:000000974

voltage-gated potassium channel subunit KCNA5 isoform 1

KCNA5/iso:1


"A voltage-gated potassium channel subunit KCNA5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22460-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P22460-1

potassium voltage-gated channel subfamily A member 5 isoform 1 (human)

hKCNA5/iso:1


"A voltage-gated potassium channel subunit KCNA5 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:000036568

potassium voltage-gated channel subfamily A member 5 isoform 1 sequence variant E375* (human)

hKCNA5/iso:1/var:E375*


"A potassium voltage-gated channel subfamily A member 5 isoform 1 (human) that has a C-terminal truncation and thus lacks the S4-S6 voltage sensor, pore region and C terminus, but preserves the N terminus and S1-S3 transmembrane domains that secure tetrameric subunit assembly. UniProtKB:P22460-1, 1-374." [PMID:16772329, PRO:CNA]

Yes

organism-sequence



PR:Q61762-1

potassium voltage-gated channel subfamily A member 5 isoform 1 (mouse)

mKCNA5/iso:1


"A voltage-gated potassium channel subunit KCNA5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

sequence



PR:000000975

voltage-gated potassium channel subunit KCNA5 isoform 2

KCNA5/iso:2


"A voltage-gated potassium channel subunit KCNA5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61762-2 or a 1:1 ortholog thereof." [PMID:11524461, PMID:8226976, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q61762-2

potassium voltage-gated channel subfamily A member 5 isoform 2 (mouse)

mKCNA5/iso:2


"A voltage-gated potassium channel subunit KCNA5 isoform 2 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q61762]

Yes

modification



PR:000002684

voltage-gated potassium channel subunit KCNA5 isoform 2 unmodified form

KCNA5/iso:2/UnMod


"A voltage-gated potassium channel subunit KCNA5 isoform 2 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]

Yes

sequence



PR:000000976

voltage-gated potassium channel subunit KCNA5 isoform 3

KCNA5/iso:3


"A voltage-gated potassium channel subunit KCNA5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61762-3 or a 1:1 ortholog thereof." [PMID:8226976, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q61762-3

potassium voltage-gated channel subfamily A member 5 isoform 3 (mouse)

mKCNA5/iso:3


"A voltage-gated potassium channel subunit KCNA5 isoform 3 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q61762]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006813 potassium ion transportPR:Q61762-1 mKCNA5/iso:1 MGI_ref:63618; PMID:8226976
PR:Q61762-2 mKCNA5/iso:2 MGI_ref:63618; PMID:8226976
GO:0043267 negative regulation of potassium ion transportPR:Q61762-3 mKCNA5/iso:3 MGI_ref:63618; PMID:8226976

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005249 voltage-gated potassium channel activityPR:Q61762-1 mKCNA5/iso:1 MGI_ref:63618; PMID:8226976
PR:Q61762-2 mKCNA5/iso:2 MGI_ref:63618; PMID:8226976
contributes_to GO:0005251 delayed rectifier potassium channel activityPR:P22460-1 hKCNA5/iso:1 PMID:1986382
NOT|contributes_to GO:0005251 delayed rectifier potassium channel activityPR:000036568 hKCNA5/iso:1/var:E375* PMID:16772329
GO:0019870 potassium channel inhibitor activityPR:Q61762-3 mKCNA5/iso:3 MGI_ref:63618; PMID:8226976

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005886 plasma membranePR:000002684 KCNA5/iso:2/UnMod MGI_ref:63618; PMID:8226976
PR:Q61762-1 mKCNA5/iso:1 MGI_ref:63618; PMID:8226976
PR:Q61762-2 mKCNA5/iso:2 MGI_ref:63618; PMID:8226976