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Protein Ontology report - voltage-gated potassium channel subunit KCNA5
PR:000000812 - http://purl.obolibrary.org/obo/PR_000000812
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000812   
  PRO namevoltage-gated potassium channel subunit KCNA5 
  Synonyms
PRO-Short-label: EXACT:KCNA5
Other: EXACT:HPCN1 | KV1-5 | voltage-gated potassium channel HK2 | voltage-gated potassium channel subunit Kv1.5
  Definition"A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA5 gene or a 1:1 ortholog thereof. The voltage-gated potassium channel Kv1.5 mediates the ultrarapid-activating potassium current (IKur) in heart, and also plays a critical role in the regulation of arterial tone." [PMID:10575199, PMID:16772329, PMID:18344374] 
  PRO Categorygene 
  ParentPR:000000709 shaker-related voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 6                                        
         Modification1                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:542
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000812 voltage-gated potassium channel subunit KCNA5
KCNA5

organism-gene


PR:P19024 potassium voltage-gated channel subfamily A member 5 (rat)
rKCNA5

organism-gene


PR:P22460 potassium voltage-gated channel subfamily A member 5 (human)
hKCNA5

organism-sequence


PR:P22460-1 potassium voltage-gated channel subfamily A member 5 isoform 1 (human)
hKCNA5/iso:1
Yes
organism-sequence


PR:000036568 potassium voltage-gated channel subfamily A member 5 isoform 1 sequence variant E375* (human)
hKCNA5/iso:1/var:E375*
Yes
organism-sequence


PR:P22460-2 potassium voltage-gated channel subfamily A member 5 isoform h2 (human)
hKCNA5/iso:h2

organism-gene


PR:Q61762 potassium voltage-gated channel subfamily A member 5 (mouse)
mKCNA5

organism-sequence


PR:Q61762-1 potassium voltage-gated channel subfamily A member 5 isoform 1 (mouse)
mKCNA5/iso:1
Yes
organism-sequence


PR:Q61762-2 potassium voltage-gated channel subfamily A member 5 isoform 2 (mouse)
mKCNA5/iso:2
Yes
organism-sequence


PR:Q61762-3 potassium voltage-gated channel subfamily A member 5 isoform 3 (mouse)
mKCNA5/iso:3
Yes
sequence


PR:000000974 voltage-gated potassium channel subunit KCNA5 isoform 1
KCNA5/iso:1

organism-sequence


PR:P22460-1 potassium voltage-gated channel subfamily A member 5 isoform 1 (human)
hKCNA5/iso:1
Yes
organism-sequence


PR:000036568 potassium voltage-gated channel subfamily A member 5 isoform 1 sequence variant E375* (human)
hKCNA5/iso:1/var:E375*
Yes
organism-sequence


PR:Q61762-1 potassium voltage-gated channel subfamily A member 5 isoform 1 (mouse)
mKCNA5/iso:1
Yes
sequence


PR:000000975 voltage-gated potassium channel subunit KCNA5 isoform 2
KCNA5/iso:2

organism-sequence


PR:Q61762-2 potassium voltage-gated channel subfamily A member 5 isoform 2 (mouse)
mKCNA5/iso:2
Yes
modification


PR:000002684 voltage-gated potassium channel subunit KCNA5 isoform 2 unmodified form
KCNA5/iso:2/UnMod
Yes
sequence


PR:000000976 voltage-gated potassium channel subunit KCNA5 isoform 3
KCNA5/iso:3

organism-sequence


PR:Q61762-3 potassium voltage-gated channel subfamily A member 5 isoform 3 (mouse)
mKCNA5/iso:3
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006813 potassium ion transportPR:Q61762-1 mKCNA5/iso:1 MGI_ref:63618; PMID:8226976
PR:Q61762-2 mKCNA5/iso:2 MGI_ref:63618; PMID:8226976
GO:0043267 negative regulation of potassium ion transportPR:Q61762-3 mKCNA5/iso:3 MGI_ref:63618; PMID:8226976

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005249 voltage-gated potassium channel activityPR:Q61762-1 mKCNA5/iso:1 MGI_ref:63618; PMID:8226976
PR:Q61762-2 mKCNA5/iso:2 MGI_ref:63618; PMID:8226976
contributes_to GO:0005251 delayed rectifier potassium channel activityPR:P22460-1 hKCNA5/iso:1 PMID:1986382
NOT|contributes_to GO:0005251 delayed rectifier potassium channel activityPR:000036568 hKCNA5/iso:1/var:E375* PMID:16772329
GO:0019870 potassium channel inhibitor activityPR:Q61762-3 mKCNA5/iso:3 MGI_ref:63618; PMID:8226976

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886 plasma membranePR:000002684 KCNA5/iso:2/UnMod MGI_ref:63618; PMID:8226976
PR:Q61762-1 mKCNA5/iso:1 MGI_ref:63618; PMID:8226976
PR:Q61762-2 mKCNA5/iso:2 MGI_ref:63618; PMID:8226976