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Protein Ontology report - voltage-gated inwardly rectifying potassium channel KCNH2 isoform A

PR:000000957 - http://purl.obolibrary.org/obo/PR_000000957

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000957

PRO name

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A

Synonyms

PRO-Short-label:	EXACT:	KCNH2/iso:A
Other:	EXACT:	voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1

Definition

"A voltage-gated inwardly rectifying potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

PRO Category

sequence

Parent

PR:000000791 voltage-gated inwardly rectifying potassium channel KCNH2

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Sequence	1	Organism-Sequence	2
Modification	6	Organism-Modification	5

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

sequence

PR:000000957 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A

KCNH2/iso:A

organism-sequence

PR:O35219-1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (mouse)

mKCNH2/iso:A

Yes

organism-modification

PR:000036582 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)

mKCNH2/iso:A/NGlyco:1

Yes

organism-sequence

PR:Q12809-1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)

hKCNH2/iso:A

Yes

organism-modification

PR:000036581 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1

Yes

organism-modification

PR:000036583 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1

Yes

organism-modification

PR:000045392 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1

Yes

organism-modification

PR:000045393 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-

Yes

modification

PR:000000989 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A glycosylated form

KCNH2/iso:A/GlycoRes+

modification

PR:000000998 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1

KCNH2/iso:A/NGlyco:1

organism-modification

PR:000036581 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1

Yes

organism-modification

PR:000036582 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)

mKCNH2/iso:A/NGlyco:1

Yes

modification

PR:000000990 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated form

KCNH2/iso:A/PhosRes+

modification

PR:000000999 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1

KCNH2/iso:A/Phos:1

organism-modification

PR:000036583 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1

Yes

modification

PR:000002666 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unmodified form

KCNH2/iso:A/UnMod

organism-modification

PR:000045393 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-

Yes

modification

PR:000045391 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1

KCNH2/iso:A/UnGlyco:1

organism-modification

PR:000045392 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000036581 hKCNH2/iso:A/NGlyco:1 UniProtKB:Q12809-1, Asn-598, MOD:00160	located_in	GO:0008076 voltage-gated potassium channel complex	PMID:12063277
	located_in	GO:0009986 cell surface	PMID:12063277
PR:000036582 mKCNH2/iso:A/NGlyco:1 UniProtKB:O35219-1, Asn-600, MOD:00160	located_in	GO:0005886 plasma membrane	MGI_ref:3040012; PMID:14668215
PR:000036583 hKCNH2/iso:A/Phos:1	enables	decreased GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod	PMID:10837251
PR:000036583 hKCNH2/iso:A/Phos:1	located_in	GO:0008076 voltage-gated potassium channel complex	PMID:10837251
PR:000045392 hKCNH2/iso:A/UnGlyco:1 UniProtKB:Q12809-1, Asn-598, PR:000026291	located_in	GO:0009986 cell surface	PMID:12063277
PR:000045393 hKCNH2/iso:A/PhosRes-	enables	contributes_to GO:0005251 delayed rectifier potassium channel activity	PMID:10837251; PMID:9351446
PR:O35219-1 mKCNH2/iso:A	enables	contributes_to GO:0005251 delayed rectifier potassium channel activity	PMID:9351446; PMID:9351462
	located_in	GO:0005635 nuclear envelope	MGI_ref:3040012; PMID:14668215
		GO:0005635 nuclear envelope	MGI_ref:3040012; PMID:14668215
		GO:0005737 cytoplasm	MGI_ref:3040012; PMID:14668215
		GO:0005737 cytoplasm	MGI_ref:3040012; PMID:14668215
		GO:0005886 plasma membrane	MGI_ref:3040012; PMID:14668215
		GO:0008076 voltage-gated potassium channel complex	PMID:9351462
PR:Q12809-1 hKCNH2/iso:A	enables	GO:0030552 cAMP binding	PMID:10837251