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Documentation
Protein Ontology report - voltage-gated inwardly rectifying potassium channel KCNH2 isoform A
PR:000000957 -
http://purl.obolibrary.org/obo/PR_000000957
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000957
PRO name
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A
Synonyms
PRO-Short-label
:
EXACT:
KCNH2/iso:A
Other
:
EXACT:
voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1
Definition
"A voltage-gated inwardly rectifying potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by
UniProtKB:Q12809-1
or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
PRO Category
sequence
Parent
PR:000000791
voltage-gated inwardly rectifying potassium channel KCNH2
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
1
Organism-Sequence
2
Modification
6
Organism-Modification
5
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
sequence
PR:000000957
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A
KCNH2/iso:A
"A voltage-gated inwardly rectifying potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
organism-sequence
PR:O35219-1
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (mouse)
mKCNH2/iso:A
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification
PR:000036582
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)
mKCNH2/iso:A/NGlyco:1
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in mouse. UniProtKB:O35219-1, Asn-600, MOD:00160." [PMID:14668215, PRO:CNA]
Yes
organism-sequence
PR:Q12809-1
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)
hKCNH2/iso:A
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000036581
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)
hKCNH2/iso:A/NGlyco:1
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277, PRO:CNA]
Yes
organism-modification
PR:000036583
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)
hKCNH2/iso:A/Phos:1
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 in human." [PMID:10837251, PRO:CNA]
Yes
organism-modification
PR:000045392
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)
hKCNH2/iso:A/UnGlyco:1
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277, PRO:CNA]
Yes
organism-modification
PR:000045393
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)
hKCNH2/iso:A/PhosRes-
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human) that lacks phosphorylated residues." [PMID:10837251, PRO:CNA]
Yes
modification
PR:000000989
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A glycosylated form
KCNH2/iso:A/GlycoRes+
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that includes at least one glycosylated residue." [PRO:CNA]
modification
PR:000000998
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1
KCNH2/iso:A/NGlyco:1
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A glycosylated form that has been glycosylated at the Asn residue within the Nx[T/S] motif located approximately 26 amino acids downstream of the S5 transmembrane domain. Example: UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277]
organism-modification
PR:000036581
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)
hKCNH2/iso:A/NGlyco:1
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277, PRO:CNA]
Yes
organism-modification
PR:000036582
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)
mKCNH2/iso:A/NGlyco:1
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in mouse. UniProtKB:O35219-1, Asn-600, MOD:00160." [PMID:14668215, PRO:CNA]
Yes
modification
PR:000000990
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated form
KCNH2/iso:A/PhosRes+
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that includes at least one phosphorylated residue." [PRO:CNA]
modification
PR:000000999
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1
KCNH2/iso:A/Phos:1
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated form in which the phosphorylation occurs at Ser and Thr residues located in the intracellular loops by PKA." [PMID:10837251]
organism-modification
PR:000036583
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)
hKCNH2/iso:A/Phos:1
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 in human." [PMID:10837251, PRO:CNA]
Yes
modification
PR:000002666
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unmodified form
KCNH2/iso:A/UnMod
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
organism-modification
PR:000045393
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)
hKCNH2/iso:A/PhosRes-
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human) that lacks phosphorylated residues." [PMID:10837251, PRO:CNA]
Yes
modification
PR:000045391
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1
KCNH2/iso:A/UnGlyco:1
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that lacks a glycosylated Asn residue in the Nx[T/S] motif located approximately 26 amino acids downstream of the S5 transmembrane domain. Example: UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277]
organism-modification
PR:000045392
voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)
hKCNH2/iso:A/UnGlyco:1
"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277, PRO:CNA]
Yes
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005251
delayed rectifier potassium channel activity
PR:000036583
hKCNH2/iso:A/Phos:1
PMID:10837251
contributes_to
GO:0005251
delayed rectifier potassium channel activity
PR:000045393
hKCNH2/iso:A/PhosRes-
PMID:10837251
;
PMID:9351446
PR:O35219-1
mKCNH2/iso:A
PMID:9351446
;
PMID:9351462
GO:0030552
cAMP binding
PR:Q12809-1
hKCNH2/iso:A
PMID:10837251
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005635
nuclear envelope
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
GO:0005737
cytoplasm
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
GO:0005886
plasma membrane
PR:000036582
mKCNH2/iso:A/NGlyco:1
MGI_ref:3040012;
PMID:14668215
PR:O35219-1
mKCNH2/iso:A
MGI_ref:3040012;
PMID:14668215
GO:0008076
voltage-gated potassium channel complex
PR:000036581
hKCNH2/iso:A/NGlyco:1
PMID:12063277
PR:000036583
hKCNH2/iso:A/Phos:1
PMID:10837251
PR:O35219-1
mKCNH2/iso:A
PMID:9351462
GO:0009986
cell surface
PR:000036581
hKCNH2/iso:A/NGlyco:1
PMID:12063277
PR:000045392
hKCNH2/iso:A/UnGlyco:1
PMID:12063277
