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Protein Ontology report - receptor-type tyrosine-protein phosphatase C
PR:000001006 - http://purl.obolibrary.org/obo/PR_000001006
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001006   
  PRO namereceptor-type tyrosine-protein phosphatase C 
  Synonyms
PRO-Short-label: EXACT:PTPRC
Gene-based: RELATED:CD45
Other: EXACT:L-CA | leukocyte common antigen | ly-5 | lymphocyte antigen 5
  Definition"A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule." [PMID:1351092, PRO:CNA] 
  CommentRequested by=CL. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence8                                                  Organism-Sequence 22                                        
         Modification17                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF002004;IUPHARobj:1852
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001006 receptor-type tyrosine-protein phosphatase C
PTPRC

organism-gene


PR:P04157 receptor-type tyrosine-protein phosphatase C (rat)
rPTPRC

organism-sequence


PR:P04157-1 receptor-type tyrosine-protein phosphatase C isoform r1 (rat)
rPTPRC/iso:r1

organism-sequence


PR:P04157-2 receptor-type tyrosine-protein phosphatase C isoform r2 (rat)
rPTPRC/iso:r2

organism-sequence


PR:P04157-3 receptor-type tyrosine-protein phosphatase C isoform r3 (rat)
rPTPRC/iso:r3

organism-sequence


PR:P04157-4 receptor-type tyrosine-protein phosphatase C isoform r4 (rat)
rPTPRC/iso:r4

organism-sequence


PR:P04157-5 receptor-type tyrosine-protein phosphatase C isoform r5 (rat)
rPTPRC/iso:r5

organism-gene


PR:P06800 receptor-type tyrosine-protein phosphatase C (mouse)
mPTPRC

organism-sequence


PR:000050324 receptor-type tyrosine-protein phosphatase C isoform x1 (mouse)
mPtprc/iso:x1
Yes
organism-sequence


PR:000050325 receptor-type tyrosine-protein phosphatase C isoform 2 (mouse)
mPtprc/iso:2

organism-sequence


PR:P06800-4 receptor-type tyrosine-protein phosphatase C isoform m1 (mouse)
mPTPRC/iso:m1

organism-sequence


PR:P06800-5 receptor-type tyrosine-protein phosphatase C isoform m2 (mouse)
mPTPRC/iso:m2

organism-sequence


PR:P06800-6 receptor-type tyrosine-protein phosphatase C isoform m3 (mouse)
mPTPRC/iso:m3

organism-gene


PR:P08575 receptor-type tyrosine-protein phosphatase C (human)
hPTPRC

organism-sequence


PR:P08575-10 receptor-type tyrosine-protein phosphatase C isoform CD45RC (human)
hPTPRC/iso:CD45RC

organism-sequence


PR:P08575-3 receptor-type tyrosine-protein phosphatase C isoform CD45RABC (human)
hPTPRC/iso:CD45RABC

organism-sequence


PR:P08575-4 receptor-type tyrosine-protein phosphatase C isoform CD45RO (human)
hPTPRC/iso:CD45RO

organism-sequence


PR:P08575-5 receptor-type tyrosine-protein phosphatase C isoform CD45RAB (human)
hPTPRC/iso:CD45RAB

organism-sequence


PR:P08575-6 receptor-type tyrosine-protein phosphatase C isoform CD45RAC (human)
hPTPRC/iso:CD45RAC

organism-sequence


PR:P08575-7 receptor-type tyrosine-protein phosphatase C isoform CD45RBC (human)
hPTPRC/iso:CD45RBC

organism-sequence


PR:P08575-8 receptor-type tyrosine-protein phosphatase C isoform CD45RA (human)
hPTPRC/iso:CD45RA

organism-sequence


PR:P08575-9 receptor-type tyrosine-protein phosphatase C isoform CD45RB (human)
hPTPRC/iso:CD45RB

organism-modification


PR:000048962 receptor-type tyrosine-protein phosphatase C, signal peptide removed form (human)
hPTPRC/SigPep-

organism-modification


PR:000054484 receptor-type tyrosine-protein phosphatase C O-glycosylated 1 (human)
hPTPRC/OGlyco:1

organism-modification


PR:000054485 receptor-type tyrosine-protein phosphatase C O-glycosylated 2 (human)
hPTPRC/OGlyco:2

organism-modification


PR:000054486 receptor-type tyrosine-protein phosphatase C O-glycosylated 3 (human)
hPTPRC/OGlyco:3

organism-modification


PR:000066498 receptor-type tyrosine-protein phosphatase C cysteinylated 1 (human)
hPTPRC/Cyst:1

organism-modification


PR:000070055 receptor-type tyrosine-protein phosphatase C glutathionylated 1 (human)
hPTPRC/SGlt:1

organism-modification


PR:000081963 receptor-type tyrosine-protein phosphatase C deaminated 1 (human)
hPTPRC/Deam:1

organism-modification


PR:000082529 receptor-type tyrosine-protein phosphatase C cysteinylated 2 (human)
hPTPRC/Cyst:2

organism-modification


PR:000083575 receptor-type tyrosine-protein phosphatase C phosphorylated 1 (human)
hPTPRC/Phos:1

organism-modification


PR:000083798 receptor-type tyrosine-protein phosphatase C cysteinylated 3 (human)
hPTPRC/Cyst:3

organism-modification


PR:000084837 receptor-type tyrosine-protein phosphatase C cysteinylated 4 (human)
hPTPRC/Cyst:4

organism-gene


PR:P35832 tyrosine-protein phosphatase 99A (fruit fly)
fly-PTPRC

organism-sequence


PR:P35832-1 tyrosine-protein phosphatase 99A isoform B (fruit fly)
fly-PTPRC/iso:B

organism-sequence


PR:P35832-2 tyrosine-protein phosphatase 99A isoform A (fruit fly)
fly-PTPRC/iso:A

organism-sequence


PR:P35832-3 tyrosine-protein phosphatase 99A isoform C (fruit fly)
fly-PTPRC/iso:C

organism-sequence


PR:P35832-4 tyrosine-protein phosphatase 99A isoform D (fruit fly)
fly-PTPRC/iso:D

sequence


PR:000001014 receptor-type tyrosine-protein phosphatase C isoform CD45RABC
PTPRC/iso:CD45RABC

organism-sequence


PR:P08575-3 receptor-type tyrosine-protein phosphatase C isoform CD45RABC (human)
hPTPRC/iso:CD45RABC

modification


PR:000025805 receptor-type tyrosine-protein phosphatase C isoform CD45RABC, signal peptide removed form
PTPRC/iso:CD45RABC/SigPep-

modification


PR:000025813 receptor-type tyrosine-protein phosphatase C isoform CD45RABC, signal peptide removed glycosylated form
PTPRC/iso:CD45R/SigPep-/GlycoRes+

sequence


PR:000001016 receptor-type tyrosine-protein phosphatase C isoform CD45RB
PTPRC/iso:CD45RB

organism-sequence


PR:P08575-9 receptor-type tyrosine-protein phosphatase C isoform CD45RB (human)
hPTPRC/iso:CD45RB

modification


PR:000025807 receptor-type tyrosine-protein phosphatase C isoform CD45RB, signal peptide removed form
PTPRC/iso:CD45RB/SigPep-

modification


PR:000025815 receptor-type tyrosine-protein phosphatase C isoform CD45RB, signal peptide removed glycosylated form
PTPRC/iso:CD45RB/SigPep-/GlycoRes+

sequence


PR:000001017 receptor-type tyrosine-protein phosphatase C isoform CD45RO
PTPRC/iso:CD45RO

organism-sequence


PR:P08575-4 receptor-type tyrosine-protein phosphatase C isoform CD45RO (human)
hPTPRC/iso:CD45RO

modification


PR:000025808 receptor-type tyrosine-protein phosphatase C isoform CD45RO, signal peptide removed form
PTPRC/iso:CD45RO/SigPep-

modification


PR:000025816 receptor-type tyrosine-protein phosphatase C isoform CD45RO, signal peptide removed glycosylated form
PTPRC/iso:CD45RO/SigPep-/GlycoRes+

sequence


PR:000025801 receptor-type tyrosine-protein phosphatase C isoform CD45RC
PTPRC/iso:CD45RC

organism-sequence


PR:P08575-10 receptor-type tyrosine-protein phosphatase C isoform CD45RC (human)
hPTPRC/iso:CD45RC

modification


PR:000025809 receptor-type tyrosine-protein phosphatase C isoform CD45RC, signal peptide removed form
PTPRC/iso:CD45RC/SigPep-

modification


PR:000025817 receptor-type tyrosine-protein phosphatase C isoform CD45RC, signal peptide removed glycosylated form
PTPRC/iso:CD45RC/SigPep-/GlycoRes+

sequence


PR:000025804 receptor-type tyrosine-protein phosphatase C isoform CD45RBC
PTPRC/iso:CD45RBC

organism-sequence


PR:P08575-7 receptor-type tyrosine-protein phosphatase C isoform CD45RBC (human)
hPTPRC/iso:CD45RBC

modification


PR:000025812 receptor-type tyrosine-protein phosphatase C isoform CD45RBC, signal peptide removed form
PTPRC/iso:CD45RBC/SigPep-

modification


PR:000025820 receptor-type tyrosine-protein phosphatase C isoform CD45RBC, signal peptide removed glycosylated form
PTPRC/iso:CD45RBC/SigPep-/GlycoRes+

seqgroup


PR:000050216 receptor-type tyrosine-protein phosphatase C isoform CD45R
PTPRC/iso:CD45R

sequence


PR:000001015 receptor-type tyrosine-protein phosphatase C isoform CD45RA
PTPRC/iso:CD45RA

organism-sequence


PR:P08575-8 receptor-type tyrosine-protein phosphatase C isoform CD45RA (human)
hPTPRC/iso:CD45RA

modification


PR:000025806 receptor-type tyrosine-protein phosphatase C isoform CD45RA, signal peptide removed form
PTPRC/iso:CD45RA/SigPep-

modification


PR:000025814 receptor-type tyrosine-protein phosphatase C isoform CD45RA, signal peptide removed glycosylated form
PTPRC/iso:CD45RA/SigPep-/GlycoRes+

sequence


PR:000025802 receptor-type tyrosine-protein phosphatase C isoform CD45RAB
PTPRC/iso:CD45RAB

organism-sequence


PR:P08575-5 receptor-type tyrosine-protein phosphatase C isoform CD45RAB (human)
hPTPRC/iso:CD45RAB

modification


PR:000025810 receptor-type tyrosine-protein phosphatase C isoform CD45RAB, signal peptide removed form
PTPRC/iso:CD45RAB/SigPep-

modification


PR:000025818 receptor-type tyrosine-protein phosphatase C isoform CD45RAB, signal peptide removed glycosylated form
PTPRC/iso:CD45RAB/SigPep-/GlycoRes+

sequence


PR:000025803 receptor-type tyrosine-protein phosphatase C isoform CD45RAC
PTPRC/iso:CD45RAC

organism-sequence


PR:P08575-6 receptor-type tyrosine-protein phosphatase C isoform CD45RAC (human)
hPTPRC/iso:CD45RAC

modification


PR:000025811 receptor-type tyrosine-protein phosphatase C isoform CD45RAC, signal peptide removed form
PTPRC/iso:CD45RAC/SigPep-

modification


PR:000025819 receptor-type tyrosine-protein phosphatase C isoform CD45RAC, signal peptide removed glycosylated form
PTPRC/iso:CD45RAC/SigPep-/GlycoRes+

modification


PR:000018306 receptor-type tyrosine-protein phosphatase C, signal peptide removed form
PTPRC/SigPep-

modification


PR:000025805 receptor-type tyrosine-protein phosphatase C isoform CD45RABC, signal peptide removed form
PTPRC/iso:CD45RABC/SigPep-

modification


PR:000025813 receptor-type tyrosine-protein phosphatase C isoform CD45RABC, signal peptide removed glycosylated form
PTPRC/iso:CD45R/SigPep-/GlycoRes+

modification


PR:000025806 receptor-type tyrosine-protein phosphatase C isoform CD45RA, signal peptide removed form
PTPRC/iso:CD45RA/SigPep-

modification


PR:000025814 receptor-type tyrosine-protein phosphatase C isoform CD45RA, signal peptide removed glycosylated form
PTPRC/iso:CD45RA/SigPep-/GlycoRes+

modification


PR:000025807 receptor-type tyrosine-protein phosphatase C isoform CD45RB, signal peptide removed form
PTPRC/iso:CD45RB/SigPep-

modification


PR:000025815 receptor-type tyrosine-protein phosphatase C isoform CD45RB, signal peptide removed glycosylated form
PTPRC/iso:CD45RB/SigPep-/GlycoRes+

modification


PR:000025808 receptor-type tyrosine-protein phosphatase C isoform CD45RO, signal peptide removed form
PTPRC/iso:CD45RO/SigPep-

modification


PR:000025816 receptor-type tyrosine-protein phosphatase C isoform CD45RO, signal peptide removed glycosylated form
PTPRC/iso:CD45RO/SigPep-/GlycoRes+

modification


PR:000025809 receptor-type tyrosine-protein phosphatase C isoform CD45RC, signal peptide removed form
PTPRC/iso:CD45RC/SigPep-

modification


PR:000025817 receptor-type tyrosine-protein phosphatase C isoform CD45RC, signal peptide removed glycosylated form
PTPRC/iso:CD45RC/SigPep-/GlycoRes+

modification


PR:000025810 receptor-type tyrosine-protein phosphatase C isoform CD45RAB, signal peptide removed form
PTPRC/iso:CD45RAB/SigPep-

modification


PR:000025818 receptor-type tyrosine-protein phosphatase C isoform CD45RAB, signal peptide removed glycosylated form
PTPRC/iso:CD45RAB/SigPep-/GlycoRes+

modification


PR:000025811 receptor-type tyrosine-protein phosphatase C isoform CD45RAC, signal peptide removed form
PTPRC/iso:CD45RAC/SigPep-

modification


PR:000025819 receptor-type tyrosine-protein phosphatase C isoform CD45RAC, signal peptide removed glycosylated form
PTPRC/iso:CD45RAC/SigPep-/GlycoRes+

modification


PR:000025812 receptor-type tyrosine-protein phosphatase C isoform CD45RBC, signal peptide removed form
PTPRC/iso:CD45RBC/SigPep-

modification


PR:000025820 receptor-type tyrosine-protein phosphatase C isoform CD45RBC, signal peptide removed glycosylated form
PTPRC/iso:CD45RBC/SigPep-/GlycoRes+

organism-modification


PR:000048962 receptor-type tyrosine-protein phosphatase C, signal peptide removed form (human)
hPTPRC/SigPep-

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000050324 mPtprc/iso:x1
UniProtKB:P06800-4, 3-1293		 located_inGO:0009897 external side of plasma membrane MGI_ref:77755; PMID:8566025