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Protein Ontology report - integrin alpha-X
PR:000001013 - http://purl.obolibrary.org/obo/PR_000001013
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000001013   
  PRO nameintegrin alpha-X 
  Synonyms
PRO-Short-label: EXACT:ITGAX
Gene-based: RELATED:CD11C
Other: EXACT:CD11 antigen-like family member C | CD11c | Leu M5 | leukocyte adhesion glycoprotein p150,95 alpha chain | leukocyte adhesion receptor p150,95
  Definition"An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis." [UniProtKB:P20702
  CommentRequested by=CL. 
  PRO Categorygene 
  ParentPR:000001005 integrin alpha with A domain
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification1                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2454
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001013

integrin alpha-X

ITGAX


"An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis." [UniProtKB:P20702]


organism-gene



PR:P20702

integrin alpha-X (human)

hITGAX


"An integrin alpha-X that is encoded in the genome of human." []


organism-modification



PR:000048068

integrin alpha-X, signal peptide removed form (human)

hITGAX/SigPep-


"An integrin alpha-X (human) that has had the signal peptide removed. UniProtKB:P20702, 20-1163." [PRO:DNx, Reactome:R-HSA-202764]


organism-modification



PR:000067455

integrin alpha-X deaminated 1 (human)

hITGAX/Deam:1


"An integrin alpha-X (human) that has been deaminated on the residue at the position equivalent to Gln-148 of the amino acid sequence represented by UniProtKB:P20702. UniProtKB:P20702, Gln-148, MOD:00685." [IEDB_epitope:1562933, PRO:DNx]


organism-modification



PR:000072290

integrin alpha-X phosphorylated 1 (human)

hITGAX/Phos:1


"An integrin alpha-X (human) that has been phosphorylated on the residue at the position equivalent to Ser-668 of the amino acid sequence represented by UniProtKB:P20702. UniProtKB:P20702, Ser-668, MOD:00046." [IEDB_epitope:2149007, PRO:DNx]


organism-modification



PR:000072421

integrin alpha-X deaminated 2 (human)

hITGAX/Deam:2


"An integrin alpha-X (human) that has been deaminated on the residue at the position equivalent to Asn-798 of the amino acid sequence represented by UniProtKB:P20702. UniProtKB:P20702, Asn-798, MOD:00684." [IEDB_epitope:1362041, PRO:DNx]


organism-modification



PR:000079771

integrin alpha-X deaminated 3 (human)

hITGAX/Deam:3


"An integrin alpha-X (human) that has been deaminated on the residue at the position equivalent to Gln-570 of the amino acid sequence represented by UniProtKB:P20702. UniProtKB:P20702, Gln-570, MOD:00685." [IEDB_epitope:1381600, PRO:DNx]


organism-modification



PR:000082347

integrin alpha-X cysteinylated 1 (human)

hITGAX/Cyst:1


"An integrin alpha-X (human) that has been cysteinylated on the residue at the position equivalent to Cys-126 of the amino acid sequence represented by UniProtKB:P20702. UniProtKB:P20702, Cys-126, MOD:00765." [IEDB_epitope:1582475, PRO:DNx]


organism-gene



PR:Q9QXH4

integrin alpha-X (mouse)

mITGAX


"An integrin alpha-X that is encoded in the genome of mouse." [OMA:Q9QXH4, PRO:DNx]


organism-modification



PR:000067248

integrin alpha-X cysteinylated 1 (mouse)

mITGAX/Cyst:1


"An integrin alpha-X (mouse) that has been cysteinylated on the residue at the position equivalent to Cys-126 of the amino acid sequence represented by UniProtKB:Q9QXH4. UniProtKB:Q9QXH4, Cys-126, MOD:00765." [IEDB_epitope:2097914, PRO:DNx]


modification



PR:000018317

integrin alpha-X, signal peptide removed form

ITGAX/SigPep-


"An integrin alpha-X that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000048068

integrin alpha-X, signal peptide removed form (human)

hITGAX/SigPep-


"An integrin alpha-X (human) that has had the signal peptide removed. UniProtKB:P20702, 20-1163." [PRO:DNx, Reactome:R-HSA-202764]