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Protein Ontology report - CD3 subunit with immunoglobulin domain
PR:000001018 - http://purl.obolibrary.org/obo/PR_000001018
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001018   
  PRO nameCD3 subunit with immunoglobulin domain 
  Synonyms
Other: EXACT:CD3 subunit with Ig-like domain
  Definition"A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." [PMID:16473826, PMID:1724736] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 8                                        
         Sequence3                                                  Organism-Sequence 7                                        
         Modification7                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF001993
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000001018 CD3 subunit with immunoglobulin domain
PTPRC/iso:CD45RO

gene


PR:000001019 CD3 delta
CD3D

organism-gene


PR:P04234 T-cell surface glycoprotein CD3 delta chain (human)
hCD3D

organism-sequence


PR:P04234-1 T-cell surface glycoprotein CD3 delta chain isoform h1 (human)
hCD3D/iso:h1

organism-sequence


PR:P04234-2 T-cell surface glycoprotein CD3 delta chain isoform h2 (human)
hCD3D/iso:h2

organism-modification


PR:000046637 T-cell surface glycoprotein CD3 delta chain, signal peptide removed form (human)
hCD3D/SigPep-

organism-modification


PR:000046638 T-cell surface glycoprotein CD3 delta chain, signal peptide removed phosphorylated 1 (human)
hCD3D/SigPep-/Phos:1

organism-gene


PR:P04235 T-cell surface glycoprotein CD3 delta chain (mouse)
mCD3D

organism-sequence


PR:P04235-1 T-cell surface glycoprotein CD3 delta chain isoform 1 (mouse)
mCD3D/iso:1

organism-gene


PR:P19377 T-cell surface glycoprotein CD3 delta chain (rat)
rCD3D

organism-sequence


PR:P19377-1 T-cell surface glycoprotein CD3 delta chain isoform 1 (rat)
rCD3D/iso:1

sequence


PR:000038652 CD3 delta isoform 1
CD3D/iso:1

organism-sequence


PR:P04235-1 T-cell surface glycoprotein CD3 delta chain isoform 1 (mouse)
mCD3D/iso:1

organism-sequence


PR:P19377-1 T-cell surface glycoprotein CD3 delta chain isoform 1 (rat)
rCD3D/iso:1

modification


PR:000018319 CD3 delta, signal peptide removed form
CD3D/SigPep-

organism-modification


PR:000046637 T-cell surface glycoprotein CD3 delta chain, signal peptide removed form (human)
hCD3D/SigPep-

organism-modification


PR:000046638 T-cell surface glycoprotein CD3 delta chain, signal peptide removed phosphorylated 1 (human)
hCD3D/SigPep-/Phos:1

gene


PR:000001020 CD3 epsilon
CD3E

organism-gene


PR:P07766 T-cell surface glycoprotein CD3 epsilon chain (human)
hCD3E

organism-sequence


PR:P07766-1 T-cell surface glycoprotein CD3 epsilon chain isoform 1 (human)
hCD3E/iso:1

organism-modification


PR:000025777 CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3E/iso:1/SigPep-/Phos:1

Yes
organism-modification


PR:000046639 T-cell surface glycoprotein CD3 epsilon chain, signal peptide removed form (human)
hCD3E/SigPep-

organism-modification


PR:000025777 CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3E/iso:1/SigPep-/Phos:1

Yes
organism-gene


PR:P22646 T-cell surface glycoprotein CD3 epsilon chain (mouse)
mCD3E

sequence


PR:000025775 CD3 epsilon isoform 1
CD3E/iso:1

organism-sequence


PR:P07766-1 T-cell surface glycoprotein CD3 epsilon chain isoform 1 (human)
hCD3E/iso:1

organism-modification


PR:000025777 CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3E/iso:1/SigPep-/Phos:1

Yes
modification


PR:000026691 CD3 epsilon isoform 1, signal peptide removed form
CD3E/iso:1/SigPep-

modification


PR:000025776 CD3 epsilon isoform 1, signal peptide removed phosphorylated 1
CD3E/iso:1/SigPep-/Phos:1

Yes
organism-modification


PR:000025777 CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3E/iso:1/SigPep-/Phos:1

Yes
modification


PR:000018321 CD3 epsilon, signal peptide removed form
CD3E/SigPep-

modification


PR:000026691 CD3 epsilon isoform 1, signal peptide removed form
CD3E/iso:1/SigPep-

modification


PR:000025776 CD3 epsilon isoform 1, signal peptide removed phosphorylated 1
CD3E/iso:1/SigPep-/Phos:1

Yes
organism-modification


PR:000025777 CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3E/iso:1/SigPep-/Phos:1

Yes
organism-modification


PR:000046639 T-cell surface glycoprotein CD3 epsilon chain, signal peptide removed form (human)
hCD3E/SigPep-

organism-modification


PR:000025777 CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3E/iso:1/SigPep-/Phos:1

Yes
gene


PR:000001021 CD3 gamma
CD3G

organism-gene


PR:P09693 T-cell surface glycoprotein CD3 gamma chain (human)
hCD3G

organism-sequence


PR:P09693-1 T-cell surface glycoprotein CD3 gamma chain isoform 1 (human)
hCD3G/iso:1

organism-modification


PR:000025780 CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3G/iso:1/SigPep-/Phos:1
Yes
Yes
organism-modification


PR:000046640 T-cell surface glycoprotein CD3 gamma chain, signal peptide removed form (human)
hCD3G/SigPep-

organism-modification


PR:000025780 CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3G/iso:1/SigPep-/Phos:1
Yes
Yes
organism-modification


PR:000070129 T-cell surface glycoprotein CD3 gamma chain phosphorylated 1 (human)
hCD3G/Phos:1

organism-modification


PR:000074695 T-cell surface glycoprotein CD3 gamma chain phosphorylated 2 (human)
hCD3G/Phos:2

organism-gene


PR:P11942 T-cell surface glycoprotein CD3 gamma chain (mouse)
mCD3G

organism-sequence


PR:P11942-1 T-cell surface glycoprotein CD3 gamma chain isoform 1 (mouse)
mCD3G/iso:1

organism-gene


PR:Q64159 T-cell surface glycoprotein CD3 gamma chain (rat)
rCD3G

sequence


PR:000025778 CD3 gamma isoform 1
CD3G/iso:1

organism-sequence


PR:P09693-1 T-cell surface glycoprotein CD3 gamma chain isoform 1 (human)
hCD3G/iso:1

organism-modification


PR:000025780 CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3G/iso:1/SigPep-/Phos:1
Yes
Yes
organism-sequence


PR:P11942-1 T-cell surface glycoprotein CD3 gamma chain isoform 1 (mouse)
mCD3G/iso:1

modification


PR:000025779 CD3 gamma isoform 1, signal peptide removed phosphorylated 1
CD3G/iso:1/SigPep-/Phos:1

Yes
organism-modification


PR:000025780 CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3G/iso:1/SigPep-/Phos:1
Yes
Yes
modification


PR:000026575 CD3 gamma isoform 1, signal peptide removed form
CD3G/iso:1/SigPep-

modification


PR:000025779 CD3 gamma isoform 1, signal peptide removed phosphorylated 1
CD3G/iso:1/SigPep-/Phos:1

Yes
organism-modification


PR:000025780 CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3G/iso:1/SigPep-/Phos:1
Yes
Yes
modification


PR:000018323 CD3 gamma, signal peptide removed form
CD3G/SigPep-

modification


PR:000026575 CD3 gamma isoform 1, signal peptide removed form
CD3G/iso:1/SigPep-

modification


PR:000025779 CD3 gamma isoform 1, signal peptide removed phosphorylated 1
CD3G/iso:1/SigPep-/Phos:1

Yes
organism-modification


PR:000025780 CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3G/iso:1/SigPep-/Phos:1
Yes
Yes
organism-modification


PR:000046640 T-cell surface glycoprotein CD3 gamma chain, signal peptide removed form (human)
hCD3G/SigPep-

organism-modification


PR:000025780 CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)
hCD3G/iso:1/SigPep-/Phos:1
Yes
Yes
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PTPRC/iso:CD45RO forms found in complexes   

PTPRC/iso:CD45RO Component
 Complexes
PR:000025776 CD3E/iso:1/SigPep-/Phos:1 PR:000025781 CD3 epsilon:CD3 gamma with phosphorylated ITAM
PR:000025777 hCD3E/iso:1/SigPep-/Phos:1 PR:000025782 CD3 epsilon:CD3 gamma with phosphorylated ITAM (human)
PR:000025779 CD3G/iso:1/SigPep-/Phos:1 PR:000025781 CD3 epsilon:CD3 gamma with phosphorylated ITAM
PR:000025780 hCD3G/iso:1/SigPep-/Phos:1 PR:000025782 CD3 epsilon:CD3 gamma with phosphorylated ITAM (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025780 hCD3G/iso:1/SigPep-/Phos:1
UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048		 located_inGO:0005886 plasma membrane Reactome:REACT_13072