back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - CD3 subunit with immunoglobulin domain
PR:000001018 - http://purl.obolibrary.org/obo/PR_000001018
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001018   
  PRO nameCD3 subunit with immunoglobulin domain 
  Synonyms
Other: EXACT:CD3 subunit with Ig-like domain
  Definition"A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." [PMID:16473826, PMID:1724736
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 8                                        
         Sequence3                                                  Organism-Sequence 7                                        
         Modification7                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF001993
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000001018

CD3 subunit with immunoglobulin domain

PTPRC/iso:CD45RO


"A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." [PMID:16473826, PMID:1724736]


gene



PR:000001019

CD3 delta

CD3D


"A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3D gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P04234

T-cell surface glycoprotein CD3 delta chain (human)

hCD3D


"A CD3 delta that is encoded in the genome of human." [PRO:CNA, UniProtKB:P04234]


organism-sequence



PR:P04234-1

T-cell surface glycoprotein CD3 delta chain isoform h1 (human)

hCD3D/iso:h1


"A T-cell surface glycoprotein CD3 delta chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04234-1." [PRO:DNx, UniProtKB:P04234]


organism-sequence



PR:P04234-2

T-cell surface glycoprotein CD3 delta chain isoform h2 (human)

hCD3D/iso:h2


"A T-cell surface glycoprotein CD3 delta chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04234-2." [PRO:DNx, UniProtKB:P04234]


organism-modification



PR:000046637

T-cell surface glycoprotein CD3 delta chain, signal peptide removed form (human)

hCD3D/SigPep-


"A T-cell surface glycoprotein CD3 delta chain (human) that has had the signal peptide removed. UniProtKB:P04234, 22-171." [PRO:DNx, Reactome:R-HSA-198171, Reactome:R-HSA-8869079]


organism-modification



PR:000046638

T-cell surface glycoprotein CD3 delta chain, signal peptide removed phosphorylated 1 (human)

hCD3D/SigPep-/Phos:1


"A T-cell surface glycoprotein CD3 delta chain (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 149 and 160 of the amino acid sequence represented by UniProtKB:P04234. UniProtKB:P04234, 22-171, Tyr-149/Tyr-160, MOD:00048." [PRO:DNx, Reactome:R-HSA-202329]


organism-gene



PR:P04235

T-cell surface glycoprotein CD3 delta chain (mouse)

mCD3D


"A CD3 delta that is encoded in the genome of mouse." [OMA:P04235, PRO:DNx]


organism-sequence



PR:P04235-1

T-cell surface glycoprotein CD3 delta chain isoform 1 (mouse)

mCD3D/iso:1


"A CD3 delta isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:P19377

T-cell surface glycoprotein CD3 delta chain (rat)

rCD3D


"A CD3 delta that is encoded in the genome of rat." [OMA:P19377, PRO:DNx]


organism-sequence



PR:P19377-1

T-cell surface glycoprotein CD3 delta chain isoform 1 (rat)

rCD3D/iso:1


"A CD3 delta isoform 1 that is encoded in the genome of rat." [PRO:DNx]


sequence



PR:000038652

CD3 delta isoform 1

CD3D/iso:1


"A CD3 delta that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04235-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P04235-1

T-cell surface glycoprotein CD3 delta chain isoform 1 (mouse)

mCD3D/iso:1


"A CD3 delta isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P19377-1

T-cell surface glycoprotein CD3 delta chain isoform 1 (rat)

rCD3D/iso:1


"A CD3 delta isoform 1 that is encoded in the genome of rat." [PRO:DNx]


modification



PR:000018319

CD3 delta, signal peptide removed form

CD3D/SigPep-


"A CD3 delta that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000046637

T-cell surface glycoprotein CD3 delta chain, signal peptide removed form (human)

hCD3D/SigPep-


"A T-cell surface glycoprotein CD3 delta chain (human) that has had the signal peptide removed. UniProtKB:P04234, 22-171." [PRO:DNx, Reactome:R-HSA-198171, Reactome:R-HSA-8869079]


organism-modification



PR:000046638

T-cell surface glycoprotein CD3 delta chain, signal peptide removed phosphorylated 1 (human)

hCD3D/SigPep-/Phos:1


"A T-cell surface glycoprotein CD3 delta chain (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 149 and 160 of the amino acid sequence represented by UniProtKB:P04234. UniProtKB:P04234, 22-171, Tyr-149/Tyr-160, MOD:00048." [PRO:DNx, Reactome:R-HSA-202329]


gene



PR:000001020

CD3 epsilon

CD3E


"A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P07766

T-cell surface glycoprotein CD3 epsilon chain (human)

hCD3E


"A CD3 epsilon that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07766]


organism-sequence



PR:P07766-1

T-cell surface glycoprotein CD3 epsilon chain isoform 1 (human)

hCD3E/iso:1


"A CD3 epsilon isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000025777

CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3E/iso:1/SigPep-/Phos:1


"A CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P07766-1, 23-207, Tyr-188/Tyr-199, MOD:00048." [PRO:DNx, UniProtKB:P07766]


Yes
organism-modification



PR:000046639

T-cell surface glycoprotein CD3 epsilon chain, signal peptide removed form (human)

hCD3E/SigPep-


"A T-cell surface glycoprotein CD3 epsilon chain (human) that has had the signal peptide removed. UniProtKB:P07766, 23-207." [PRO:DNx, Reactome:R-HSA-197906]


organism-modification



PR:000025777

CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3E/iso:1/SigPep-/Phos:1


"A CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P07766-1, 23-207, Tyr-188/Tyr-199, MOD:00048." [PRO:DNx, UniProtKB:P07766]


Yes
organism-gene



PR:P22646

T-cell surface glycoprotein CD3 epsilon chain (mouse)

mCD3E


"A CD3 epsilon that is encoded in the genome of mouse." [OMA:P22646, PRO:DNx]


sequence



PR:000025775

CD3 epsilon isoform 1

CD3E/iso:1


"A CD3 epsilon that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07766-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P07766-1

T-cell surface glycoprotein CD3 epsilon chain isoform 1 (human)

hCD3E/iso:1


"A CD3 epsilon isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000025777

CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3E/iso:1/SigPep-/Phos:1


"A CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P07766-1, 23-207, Tyr-188/Tyr-199, MOD:00048." [PRO:DNx, UniProtKB:P07766]


Yes
modification



PR:000026691

CD3 epsilon isoform 1, signal peptide removed form

CD3E/iso:1/SigPep-


"A CD3 epsilon isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000025776

CD3 epsilon isoform 1, signal peptide removed phosphorylated 1

CD3E/iso:1/SigPep-/Phos:1


"A CD3 epsilon isoform 1 that has had the signal peptide removed and has been phosphorylated on two Tyr residues within the ITAM domain. Example: UniProtKB:P07766-1, 23-207, Tyr-188/Tyr-199, MOD:00048." [PMID:20516133, PMID:8647168, PRO:CNA, PRO:DAN]


Yes
organism-modification



PR:000025777

CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3E/iso:1/SigPep-/Phos:1


"A CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P07766-1, 23-207, Tyr-188/Tyr-199, MOD:00048." [PRO:DNx, UniProtKB:P07766]


Yes
modification



PR:000018321

CD3 epsilon, signal peptide removed form

CD3E/SigPep-


"A CD3 epsilon that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026691

CD3 epsilon isoform 1, signal peptide removed form

CD3E/iso:1/SigPep-


"A CD3 epsilon isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000025776

CD3 epsilon isoform 1, signal peptide removed phosphorylated 1

CD3E/iso:1/SigPep-/Phos:1


"A CD3 epsilon isoform 1 that has had the signal peptide removed and has been phosphorylated on two Tyr residues within the ITAM domain. Example: UniProtKB:P07766-1, 23-207, Tyr-188/Tyr-199, MOD:00048." [PMID:20516133, PMID:8647168, PRO:CNA, PRO:DAN]


Yes
organism-modification



PR:000025777

CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3E/iso:1/SigPep-/Phos:1


"A CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P07766-1, 23-207, Tyr-188/Tyr-199, MOD:00048." [PRO:DNx, UniProtKB:P07766]


Yes
organism-modification



PR:000046639

T-cell surface glycoprotein CD3 epsilon chain, signal peptide removed form (human)

hCD3E/SigPep-


"A T-cell surface glycoprotein CD3 epsilon chain (human) that has had the signal peptide removed. UniProtKB:P07766, 23-207." [PRO:DNx, Reactome:R-HSA-197906]


organism-modification



PR:000025777

CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3E/iso:1/SigPep-/Phos:1


"A CD3 epsilon isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P07766-1, 23-207, Tyr-188/Tyr-199, MOD:00048." [PRO:DNx, UniProtKB:P07766]


Yes
gene



PR:000001021

CD3 gamma

CD3G


"A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3G gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P09693

T-cell surface glycoprotein CD3 gamma chain (human)

hCD3G


"A CD3 gamma that is encoded in the genome of human." [PRO:CNA, UniProtKB:P09693]


organism-sequence



PR:P09693-1

T-cell surface glycoprotein CD3 gamma chain isoform 1 (human)

hCD3G/iso:1


"A CD3 gamma isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000025780

CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3G/iso:1/SigPep-/Phos:1


"A CD3 gamma isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048." [PRO:CNA]

Yes

Yes
organism-modification



PR:000046640

T-cell surface glycoprotein CD3 gamma chain, signal peptide removed form (human)

hCD3G/SigPep-


"A T-cell surface glycoprotein CD3 gamma chain (human) that has had the signal peptide removed. UniProtKB:P09693, 23-182." [PRO:DNx, Reactome:R-HSA-197917, Reactome:R-HSA-8869080]


organism-modification



PR:000025780

CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3G/iso:1/SigPep-/Phos:1


"A CD3 gamma isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048." [PRO:CNA]

Yes

Yes
organism-modification



PR:000070129

T-cell surface glycoprotein CD3 gamma chain phosphorylated 1 (human)

hCD3G/Phos:1


"A T-cell surface glycoprotein CD3 gamma chain (human) that has been phosphorylated on the residue at the position equivalent to Tyr-171 of the amino acid sequence represented by UniProtKB:P09693. UniProtKB:P09693, Tyr-171, MOD:00048." [IEDB_epitope:2146099, PRO:DNx]


organism-modification



PR:000074695

T-cell surface glycoprotein CD3 gamma chain phosphorylated 2 (human)

hCD3G/Phos:2


"A T-cell surface glycoprotein CD3 gamma chain (human) that has been phosphorylated on the residue at the position equivalent to Ser-172 of the amino acid sequence represented by UniProtKB:P09693. UniProtKB:P09693, Ser-172, MOD:00046." [IEDB_epitope:2146098, IEDB_epitope:2146100, IEDB_epitope:2146172, PRO:DNx]


organism-gene



PR:P11942

T-cell surface glycoprotein CD3 gamma chain (mouse)

mCD3G


"A CD3 gamma that is encoded in the genome of mouse." [OMA:P11942, PRO:DNx]


organism-sequence



PR:P11942-1

T-cell surface glycoprotein CD3 gamma chain isoform 1 (mouse)

mCD3G/iso:1


"A CD3 gamma isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q64159

T-cell surface glycoprotein CD3 gamma chain (rat)

rCD3G


"A CD3 gamma that is encoded in the genome of rat." [OMA:Q64159, PRO:DNx]


sequence



PR:000025778

CD3 gamma isoform 1

CD3G/iso:1


"A CD3 gamma that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09693-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P09693-1

T-cell surface glycoprotein CD3 gamma chain isoform 1 (human)

hCD3G/iso:1


"A CD3 gamma isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000025780

CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3G/iso:1/SigPep-/Phos:1


"A CD3 gamma isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048." [PRO:CNA]

Yes

Yes
organism-sequence



PR:P11942-1

T-cell surface glycoprotein CD3 gamma chain isoform 1 (mouse)

mCD3G/iso:1


"A CD3 gamma isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000025779

CD3 gamma isoform 1, signal peptide removed phosphorylated 1

CD3G/iso:1/SigPep-/Phos:1


"A CD3 gamma isoform 1 that has had the signal peptide removed and has been phosphorylated on two Tyr residues within the ITAM domain. Example: UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048." [PMID:20516133, PRO:CNA, PRO:DAN]


Yes
organism-modification



PR:000025780

CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3G/iso:1/SigPep-/Phos:1


"A CD3 gamma isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048." [PRO:CNA]

Yes

Yes
modification



PR:000026575

CD3 gamma isoform 1, signal peptide removed form

CD3G/iso:1/SigPep-


"A CD3 gamma isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000025779

CD3 gamma isoform 1, signal peptide removed phosphorylated 1

CD3G/iso:1/SigPep-/Phos:1


"A CD3 gamma isoform 1 that has had the signal peptide removed and has been phosphorylated on two Tyr residues within the ITAM domain. Example: UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048." [PMID:20516133, PRO:CNA, PRO:DAN]


Yes
organism-modification



PR:000025780

CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3G/iso:1/SigPep-/Phos:1


"A CD3 gamma isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048." [PRO:CNA]

Yes

Yes
modification



PR:000018323

CD3 gamma, signal peptide removed form

CD3G/SigPep-


"A CD3 gamma that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026575

CD3 gamma isoform 1, signal peptide removed form

CD3G/iso:1/SigPep-


"A CD3 gamma isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000025779

CD3 gamma isoform 1, signal peptide removed phosphorylated 1

CD3G/iso:1/SigPep-/Phos:1


"A CD3 gamma isoform 1 that has had the signal peptide removed and has been phosphorylated on two Tyr residues within the ITAM domain. Example: UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048." [PMID:20516133, PRO:CNA, PRO:DAN]


Yes
organism-modification



PR:000025780

CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3G/iso:1/SigPep-/Phos:1


"A CD3 gamma isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048." [PRO:CNA]

Yes

Yes
organism-modification



PR:000046640

T-cell surface glycoprotein CD3 gamma chain, signal peptide removed form (human)

hCD3G/SigPep-


"A T-cell surface glycoprotein CD3 gamma chain (human) that has had the signal peptide removed. UniProtKB:P09693, 23-182." [PRO:DNx, Reactome:R-HSA-197917, Reactome:R-HSA-8869080]


organism-modification



PR:000025780

CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)

hCD3G/iso:1/SigPep-/Phos:1


"A CD3 gamma isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048." [PRO:CNA]

Yes

Yes
Back to top
PTPRC/iso:CD45RO forms found in complexes   

PTPRC/iso:CD45RO Component
Complexes
PR:000025776 CD3E/iso:1/SigPep-/Phos:1 PR:000025781 CD3 epsilon:CD3 gamma with phosphorylated ITAM
PR:000025777 hCD3E/iso:1/SigPep-/Phos:1 PR:000025782 CD3 epsilon:CD3 gamma with phosphorylated ITAM (human)
PR:000025779 CD3G/iso:1/SigPep-/Phos:1 PR:000025781 CD3 epsilon:CD3 gamma with phosphorylated ITAM
PR:000025780 hCD3G/iso:1/SigPep-/Phos:1 PR:000025782 CD3 epsilon:CD3 gamma with phosphorylated ITAM (human)
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025780 hCD3G/iso:1/SigPep-/Phos:1
UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048
located_inGO:0005886 plasma membrane Reactome:REACT_13072