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Protein Ontology report - T-cell surface glycoprotein CD3 isoform CD3 zeta
PR:000001029 - http://purl.obolibrary.org/obo/PR_000001029
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001029   
  PRO nameT-cell surface glycoprotein CD3 isoform CD3 zeta 
  Synonyms
PRO-Short-label: EXACT:CD247/iso:CD3 zeta
Other: EXACT:CD-3-zeta | CD3Z | TCRZ
  Definition"A T-cell surface glycoprotein CD3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24161-1 or a 1:1 ortholog thereof." [PMID:2150596, PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000001027 T-cell surface glycoprotein CD3
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000001029

T-cell surface glycoprotein CD3 isoform CD3 zeta

CD247/iso:CD3 zeta


"A T-cell surface glycoprotein CD3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24161-1 or a 1:1 ortholog thereof." [PMID:2150596, PRO:CNA, PRO:DAN]


organism-sequence



PR:P20963-1

T-cell surface glycoprotein CD3 zeta chain (human)

hCD247/iso:CD3 zeta


"A T-cell surface glycoprotein CD3 isoform CD3 zeta that is encoded in the genome of human." [PRO:DNx, UniProtKB:P20963]


organism-modification



PR:000036628

T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1 (human)

hCD247/iso:CD3 zeta/Phos:1


"A T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1 in human." [PMID:9043947, PRO:CL]

Yes

organism-modification



PR:000061848

T-cell surface glycoprotein CD3 zeta chain, signal peptide removed form (human)

hCD247/iso:CD3 zeta/SigPep-


"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed. UniProtKB:P20963-1, 22-164." [PRO:DNx, Reactome:R-HSA-198166]


organism-modification



PR:000063475

T-cell surface glycoprotein CD3 zeta chain, signal peptide removed phosphorylated 1 (human)

hCD247/iso:CD3 zeta/SigPep-/Phos:1


"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-72, Tyr-83, Tyr-111, Tyr-123, Tyr-142, and Tyr-153 of the amino acid sequence represented by UniProtKB:P20963-1. UniProtKB:P20963-1, 22-164, Tyr-72/Tyr-83/Tyr-111/Tyr-123/Tyr-142/Tyr-153, MOD:00048." [PRO:DNx, Reactome:R-HSA-202166]


organism-sequence



PR:P24161-1

T-cell surface glycoprotein CD3 zeta chain (mouse)

mCD247/iso:CD3 zeta


"A T-cell surface glycoprotein CD3 isoform CD3 zeta that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P24161]


modification



PR:000003061

T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated form

CD247/iso:CD3 zeta/PhosRes+


"A T-cell surface glycoprotein CD3 isoform CD3 zeta that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003062

T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1

CD247/iso:CD3 zeta/Phos:1


"A T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated form in which the phosphorylation occurs at the Tyr residues of the tyrosine-based activation motifs (TAMs, also known as Reth motifs), a 15-16 amino acid module containing two tyrosine residues." [PMID:2927501, PMID:7528772, PMID:8195151, PRO:CL]


organism-modification



PR:000036628

T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1 (human)

hCD247/iso:CD3 zeta/Phos:1


"A T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1 in human." [PMID:9043947, PRO:CL]

Yes

organism-modification



PR:000063475

T-cell surface glycoprotein CD3 zeta chain, signal peptide removed phosphorylated 1 (human)

hCD247/iso:CD3 zeta/SigPep-/Phos:1


"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-72, Tyr-83, Tyr-111, Tyr-123, Tyr-142, and Tyr-153 of the amino acid sequence represented by UniProtKB:P20963-1. UniProtKB:P20963-1, 22-164, Tyr-72/Tyr-83/Tyr-111/Tyr-123/Tyr-142/Tyr-153, MOD:00048." [PRO:DNx, Reactome:R-HSA-202166]


modification



PR:000026560

T-cell surface glycoprotein CD3 isoform CD3 zeta, signal peptide removed form

CD247/iso:CD3 zeta/SigPep-


"A T-cell surface glycoprotein CD3 isoform CD3 zeta that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000061848

T-cell surface glycoprotein CD3 zeta chain, signal peptide removed form (human)

hCD247/iso:CD3 zeta/SigPep-


"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed. UniProtKB:P20963-1, 22-164." [PRO:DNx, Reactome:R-HSA-198166]


organism-modification



PR:000063475

T-cell surface glycoprotein CD3 zeta chain, signal peptide removed phosphorylated 1 (human)

hCD247/iso:CD3 zeta/SigPep-/Phos:1


"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-72, Tyr-83, Tyr-111, Tyr-123, Tyr-142, and Tyr-153 of the amino acid sequence represented by UniProtKB:P20963-1. UniProtKB:P20963-1, 22-164, Tyr-72/Tyr-83/Tyr-111/Tyr-123/Tyr-142/Tyr-153, MOD:00048." [PRO:DNx, Reactome:R-HSA-202166]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036628 hCD247/iso:CD3 zeta/Phos:1 acts_upstream_of_or_withinGO:0050852 T cell receptor signaling pathway PMID:9043947
located_inGO:0005886 plasma membrane PMID:9043947