back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - erm protein
PR:000001030 - http://purl.obolibrary.org/obo/PR_000001030
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000001030   
  PRO nameerm protein 
  Definition"A protein that contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain, and a charged C-terminal domain. Ezrin, radixin and merlin also contain a polyproline region between the helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily. ERM proteins are involved in crosslinking actin filaments with plasma membranes." [InterPro:IPR011259
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 14                                        
         Sequence7                                                  Organism-Sequence 29                                        
         Modification20                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF002305
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000001030

erm protein

CD247/iso:CD3 zeta


"A protein that contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain, and a charged C-terminal domain. Ezrin, radixin and merlin also contain a polyproline region between the helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily. ERM proteins are involved in crosslinking actin filaments with plasma membranes." [InterPro:IPR011259]

Yes

gene



PR:000001031

ezrin

EZR


"An erm protein that is a translation product of the human EZR gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P15311

ezrin (human)

hEZR


"An ezrin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P15311]


organism-sequence



PR:P15311-1

ezrin isoform 1 (human)

hEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036588

ezrin isoform 1 phosphorylated 1 (human)

hEZR/iso:1/Phos:1


"An ezrin isoform 1 phosphorylated 1 in human. UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048." [PMID:1382070, PRO:CNA]


organism-modification



PR:000036589

ezrin isoform 1 phosphorylated 2 (human)

hEZR/iso:1/Phos:2


"An ezrin isoform 1 phosphorylated 2 in human. UniProtKB:P15311-1, Ser-66, MOD:00046." [PMID:12840026, PMID:16438931, PRO:CNA]

Yes

organism-modification



PR:000036590

ezrin isoform 1 phosphorylated 3 (human)

hEZR/iso:1/Phos:3


"An ezrin isoform 1 phosphorylated 3 in human. UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PRO:CNA]

Yes

organism-modification



PR:000036591

ezrin isoform 1 phosphorylated 4 (human)

hEZR/iso:1/Phos:4


"An ezrin isoform 1 phosphorylated 4 in human. UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047." [PMID:15647376, PRO:CNA]


organism-modification



PR:000036592

ezrin isoform 1 phosphorylated 5 (human)

hEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in human. UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865, PMID:18025306, PRO:AL, PRO:CNA]

Yes

organism-modification



PR:000036625

ezrin isoform 1 phosphorylated 6 (human)

hEZR/iso:1/Phos:6


"An ezrin isoform 1 phosphorylated 6 in human. UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]

Yes

organism-modification



PR:000047345

ezrin, initiator methionine removed phosphorylated 5 (human)

hEZR/InitMet-/Phos:5


"An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 567 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Thr-567, MOD:00047." [PRO:DNx, Reactome:R-HSA-374559]


organism-modification



PR:000047346

ezrin, initiator methionine removed phosphorylated 1 (human)

hEZR/InitMet-/Phos:1


"An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 146 and 354 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Tyr-146/Tyr-354, MOD:00048." [PRO:DNx, Reactome:R-HSA-374572]


organism-gene



PR:P26040

ezrin (mouse)

mEZR


"An ezrin that is encoded in the genome of mouse." [OMA:P26040, PRO:DNx]


organism-sequence



PR:P26040-1

ezrin isoform 1 (mouse)

mEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000044790

ezrin isoform 1 phosphorylated 5 (mouse)

mEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in mouse. UniProtKB:P26040-1, Thr-567, MOD:00047." [PRO:DAN]


organism-gene



PR:P31977

ezrin (rat)

rEZR


"An ezrin that is encoded in the genome of rat." [OMA:P31977, PRO:DNx]


organism-sequence



PR:P31977-1

ezrin isoform 1 (rat)

rEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of rat." [PRO:CNA]


organism-gene



PR:P46150

moesin/ezrin/radixin homolog 1 (fruit fly)

fly-EZR


"An ezrin that is encoded in the genome of fruit fly." [PRO:CNA]


organism-sequence



PR:P46150-1

moesin/ezrin/radixin homolog 1 isoform J (fruit fly)

fly-EZR/iso:J


"A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-1." [PRO:DNx, UniProtKB:P46150]


organism-sequence



PR:P46150-2

moesin/ezrin/radixin homolog 1 isoform D (fruit fly)

fly-EZR/iso:D


"A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-2." [PRO:DNx, UniProtKB:P46150]


organism-sequence



PR:P46150-3

moesin/ezrin/radixin homolog 1 isoform A (fruit fly)

fly-EZR/iso:A


"A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-3." [PRO:DNx, UniProtKB:P46150]


organism-sequence



PR:P46150-4

moesin/ezrin/radixin homolog 1 isoform B (fruit fly)

fly-EZR/iso:B


"A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-4." [PRO:DNx, UniProtKB:P46150]


organism-sequence



PR:P46150-5

moesin/ezrin/radixin homolog 1 isoform C (fruit fly)

fly-EZR/iso:C


"A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-5." [PRO:DNx, UniProtKB:P46150]


sequence



PR:000001032

ezrin isoform 1

EZR/iso:1


"An ezrin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15311-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P15311-1

ezrin isoform 1 (human)

hEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036588

ezrin isoform 1 phosphorylated 1 (human)

hEZR/iso:1/Phos:1


"An ezrin isoform 1 phosphorylated 1 in human. UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048." [PMID:1382070, PRO:CNA]


organism-modification



PR:000036589

ezrin isoform 1 phosphorylated 2 (human)

hEZR/iso:1/Phos:2


"An ezrin isoform 1 phosphorylated 2 in human. UniProtKB:P15311-1, Ser-66, MOD:00046." [PMID:12840026, PMID:16438931, PRO:CNA]

Yes

organism-modification



PR:000036590

ezrin isoform 1 phosphorylated 3 (human)

hEZR/iso:1/Phos:3


"An ezrin isoform 1 phosphorylated 3 in human. UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PRO:CNA]

Yes

organism-modification



PR:000036591

ezrin isoform 1 phosphorylated 4 (human)

hEZR/iso:1/Phos:4


"An ezrin isoform 1 phosphorylated 4 in human. UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047." [PMID:15647376, PRO:CNA]


organism-modification



PR:000036592

ezrin isoform 1 phosphorylated 5 (human)

hEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in human. UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865, PMID:18025306, PRO:AL, PRO:CNA]

Yes

organism-modification



PR:000036625

ezrin isoform 1 phosphorylated 6 (human)

hEZR/iso:1/Phos:6


"An ezrin isoform 1 phosphorylated 6 in human. UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]

Yes

organism-sequence



PR:P26040-1

ezrin isoform 1 (mouse)

mEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000044790

ezrin isoform 1 phosphorylated 5 (mouse)

mEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in mouse. UniProtKB:P26040-1, Thr-567, MOD:00047." [PRO:DAN]


organism-sequence



PR:P31977-1

ezrin isoform 1 (rat)

rEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of rat." [PRO:CNA]


modification



PR:000001033

ezrin isoform 1 phosphorylated form

EZR/iso:1/PhosRes+


"An ezrin isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000001034

ezrin isoform 1 phosphorylated 1

EZR/iso:1/Phos:1


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs upon EGF stimulation. Example: UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048." [PMID:1382070]


organism-modification



PR:000036588

ezrin isoform 1 phosphorylated 1 (human)

hEZR/iso:1/Phos:1


"An ezrin isoform 1 phosphorylated 1 in human. UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048." [PMID:1382070, PRO:CNA]


modification



PR:000001035

ezrin isoform 1 phosphorylated 2

EZR/iso:1/Phos:2


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs by the action of protein kinase A (PKA). Example: UniProtKB:P15311-1, Ser-66, MOD:00046." [PhosphoSitePlus:28933, PMID:12840026, PMID:16438931]


organism-modification



PR:000036589

ezrin isoform 1 phosphorylated 2 (human)

hEZR/iso:1/Phos:2


"An ezrin isoform 1 phosphorylated 2 in human. UniProtKB:P15311-1, Ser-66, MOD:00046." [PMID:12840026, PMID:16438931, PRO:CNA]

Yes

modification



PR:000001038

ezrin isoform 1 phosphorylated 3

EZR/iso:1/Phos:3


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs at the first Tyr residue within the ITAM-like motif EYLKIAQDLEMYGINYFEI. Example: UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PMID:9052872]


organism-modification



PR:000036590

ezrin isoform 1 phosphorylated 3 (human)

hEZR/iso:1/Phos:3


"An ezrin isoform 1 phosphorylated 3 in human. UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PRO:CNA]

Yes

modification



PR:000001039

ezrin isoform 1 phosphorylated 4

EZR/iso:1/Phos:4


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs both in a Tyr residue within the FERM central domain, and the first Tyr residue within the ITAM-like motif EYLKIAQDLEMYGINYFEI. Example: UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047." [PMID:15647376]


organism-modification



PR:000036591

ezrin isoform 1 phosphorylated 4 (human)

hEZR/iso:1/Phos:4


"An ezrin isoform 1 phosphorylated 4 in human. UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047." [PMID:15647376, PRO:CNA]


modification



PR:000001040

ezrin isoform 1 phosphorylated 5

EZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs at a Thr residue located within the C-terminal domain. Example: UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865]


organism-modification



PR:000036592

ezrin isoform 1 phosphorylated 5 (human)

hEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in human. UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865, PMID:18025306, PRO:AL, PRO:CNA]

Yes

organism-modification



PR:000044790

ezrin isoform 1 phosphorylated 5 (mouse)

mEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in mouse. UniProtKB:P26040-1, Thr-567, MOD:00047." [PRO:DAN]


modification



PR:000003042

ezrin isoform 1 phosphorylated 6

EZR/iso:1/Phos:6


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs at either the C-terminal Thr (Thr-567 in human), through kinases such as Rho-kinase, or the N-terminal tyrosine residue (Tyr-354 in human). Example: UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]


organism-modification



PR:000036625

ezrin isoform 1 phosphorylated 6 (human)

hEZR/iso:1/Phos:6


"An ezrin isoform 1 phosphorylated 6 in human. UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]

Yes

modification



PR:000026720

ezrin isoform 1, initiator methionine removed form

EZR/iso:1/InitMet-


"An ezrin isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000018330

ezrin, initiator methionine removed form

EZR/InitMet-


"An ezrin that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026720

ezrin isoform 1, initiator methionine removed form

EZR/iso:1/InitMet-


"An ezrin isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000047345

ezrin, initiator methionine removed phosphorylated 5 (human)

hEZR/InitMet-/Phos:5


"An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 567 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Thr-567, MOD:00047." [PRO:DNx, Reactome:R-HSA-374559]


organism-modification



PR:000047346

ezrin, initiator methionine removed phosphorylated 1 (human)

hEZR/InitMet-/Phos:1


"An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 146 and 354 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Tyr-146/Tyr-354, MOD:00048." [PRO:DNx, Reactome:R-HSA-374572]


gene



PR:000003008

moesin

MSN


"An erm protein that is a translation product of the human MSN gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O35763

moesin (rat)

rMSN


"A moesin that is encoded in the genome of rat." [OMA:O35763, PRO:DNx]


organism-gene



PR:P26038

moesin (human)

hMSN


"A moesin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P26038]


organism-sequence



PR:P26038-1

moesin isoform 1 (human)

hMSN/iso:1


"A moesin isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036621

moesin isoform 1 phosphorylated 1 (human)

hMSN/iso:1/Phos:1


"A moesin isoform 1 phosphorylated 1 in human. UniProtKB:P26038-1, Thr-558, MOD:00047." [PMID:18025306, PRO:AL]

Yes

organism-modification



PR:000048458

moesin, initiator methionine removed form (human)

hMSN/InitMet-


"A moesin (human) that has had the initiator methionine removed. UniProtKB:P26038, 2-577." [PRO:DNx, Reactome:R-HSA-437350]


organism-modification



PR:000061816

moesin, initiator methionine removed phosphorylated 1 (human)

hMSN/InitMet-/Phos:1


"A moesin (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-558 of the amino acid sequence represented by UniProtKB:P26038. UniProtKB:P26038, 2-577, Thr-558, MOD:00047." [PRO:DNx, Reactome:R-HSA-9663005]


organism-modification



PR:000070075

moesin methylated 1 (human)

hMSN/Me:1


"A moesin (human) that has been methylated on the residue at the position equivalent to Cys-284 of the amino acid sequence represented by UniProtKB:P26038. UniProtKB:P26038, Cys-284, MOD:00660." [IEDB_epitope:1000211, PRO:DNx]


organism-gene



PR:P26041

moesin (mouse)

mMSN


"A moesin that is encoded in the genome of mouse." [OMA:P26041, PRO:DNx]


organism-sequence



PR:P26041-1

moesin isoform 1 (mouse)

mMSN/iso:1


"A moesin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000003010

moesin isoform 1

MSN/iso:1


"A moesin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26038-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P26038-1

moesin isoform 1 (human)

hMSN/iso:1


"A moesin isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036621

moesin isoform 1 phosphorylated 1 (human)

hMSN/iso:1/Phos:1


"A moesin isoform 1 phosphorylated 1 in human. UniProtKB:P26038-1, Thr-558, MOD:00047." [PMID:18025306, PRO:AL]

Yes

organism-sequence



PR:P26041-1

moesin isoform 1 (mouse)

mMSN/iso:1


"A moesin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:P26044-1

radixin isoform 1 (pig)

pig-MSN/iso:1


"A moesin isoform 1 that is encoded in the genome of pig." [PRO:CNA]


modification



PR:000003012

moesin isoform 1 phosphorylated form

MSN/iso:1/PhosRes+


"A moesin isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003013

moesin isoform 1 phosphorylated 1

MSN/iso:1/Phos:1


"A moesin isoform 1 phosphorylated form in which the phosphorylation occurs at a Thr residue located within the C-terminal domain. Example: UniProtKB:P26038-1, Thr-558, MOD:00047." [PMID:18941185, PMID:9456324]


organism-modification



PR:000036621

moesin isoform 1 phosphorylated 1 (human)

hMSN/iso:1/Phos:1


"A moesin isoform 1 phosphorylated 1 in human. UniProtKB:P26038-1, Thr-558, MOD:00047." [PMID:18025306, PRO:AL]

Yes

modification



PR:000026668

moesin isoform 1, initiator methionine removed form

MSN/iso:1/InitMet-


"A moesin isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000018777

moesin, initiator methionine removed form

MSN/InitMet-


"A moesin that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026668

moesin isoform 1, initiator methionine removed form

MSN/iso:1/InitMet-


"A moesin isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000048458

moesin, initiator methionine removed form (human)

hMSN/InitMet-


"A moesin (human) that has had the initiator methionine removed. UniProtKB:P26038, 2-577." [PRO:DNx, Reactome:R-HSA-437350]


organism-modification



PR:000061816

moesin, initiator methionine removed phosphorylated 1 (human)

hMSN/InitMet-/Phos:1


"A moesin (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-558 of the amino acid sequence represented by UniProtKB:P26038. UniProtKB:P26038, 2-577, Thr-558, MOD:00047." [PRO:DNx, Reactome:R-HSA-9663005]


gene



PR:000003009

radixin

RDX


"An erm protein that is a translation product of the human RDX gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P26043

radixin (mouse)

mRDX


"A radixin that is encoded in the genome of mouse." [OMA:P26043, PRO:DNx]


organism-sequence



PR:P26043-1

radixin isoform 1 (mouse)

mRDX/iso:1


"A radixin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:P26044

radixin (pig)

pig-RDX


"A radixin that is encoded in the genome of pig." [PRO:CNA]


organism-gene



PR:P35241

radixin (human)

hRDX


"A radixin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35241]


organism-sequence



PR:P35241-1

radixin isoform 1 (human)

hRDX/iso:1


"A radixin isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P35241-2

radixin isoform h2 (human)

hRDX/iso:h2


"A radixin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35241-2." [PRO:DNx, UniProtKB:P35241]


organism-sequence



PR:P35241-3

radixin isoform h3 (human)

hRDX/iso:h3


"A radixin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35241-3." [PRO:DNx, UniProtKB:P35241]


organism-sequence



PR:P35241-4

radixin isoform h4 (human)

hRDX/iso:h4


"A radixin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35241-4." [PRO:DNx, UniProtKB:P35241]


organism-sequence



PR:P35241-5

radixin isoform h5 (human)

hRDX/iso:h5


"A radixin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35241-5." [PRO:DNx, UniProtKB:P35241]


organism-modification



PR:000062353

radixin phosphorylated 1 (human)

hRDX/Phos:1


"A radixin (human) that has been phosphorylated on the residue at the position equivalent to Thr-564 of the amino acid sequence represented by UniProtKB:P35241-1. Example: UniProtKB:P35241-1, Thr-564, MOD:00047." [PRO:DNx, Reactome:R-HSA-9662922]


organism-modification



PR:000068068

radixin deaminated 1 (human)

hRDX/Deam:1


"A radixin (human) that has been deaminated on the residue at the position equivalent to Gln-77 of the amino acid sequence represented by UniProtKB:P35241-1. Example: UniProtKB:P35241-1, Gln-77, MOD:00685." [IEDB_epitope:774027, PRO:DNx]


organism-gene



PR:Q9PU45

radixin (chicken)

chick-RDX


"A radixin that is encoded in the genome of chicken." [PRO:CNA]


sequence



PR:000003014

radixin isoform 1

RDX/iso:1


"A radixin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35241-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P26043-1

radixin isoform 1 (mouse)

mRDX/iso:1


"A radixin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:P35241-1

radixin isoform 1 (human)

hRDX/iso:1


"A radixin isoform 1 that is encoded in the genome of human." [PRO:CNA]


modification



PR:000003049

radixin isoform 1 phosphorylated form

RDX/iso:1/PhosRes+


"A radixin isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003050

radixin isoform 1 phosphorylated 1

RDX/iso:1/Phos:1


"A radixin isoform 1 phosphorylated form that has been activated though Thr phosphorylation by mitogen-activated protein kinase kinase kinase kinase 4 (Nik). Example: UniProtKB:P26044-1, Thr-564, MOD:00047." [PMID:16938849, PRO:AL]


gene



PR:000003020

merlin

NF2


"An erm protein that is a translation product of the human NF2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P35240

merlin (human)

hNF2


"A merlin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35240]


organism-sequence



PR:P35240-1

merlin isoform 1 (human)

hNF2/iso:1


"A merlin isoform 1 that is encoded in the genome of human." [PMID:9430655, PRO:CNA]

Yes

organism-sequence



PR:P35240-10

merlin isoform h10 (human)

hNF2/iso:h10


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-10." [PRO:DNx, UniProtKB:P35240]


organism-sequence



PR:P35240-2

merlin isoform 3 (human)

hNF2/iso:3


"A merlin isoform 3 that is encoded in the genome of human." [PMID:15467741, PRO:CNA]


organism-sequence



PR:P35240-3

merlin isoform 2 (human)

hNF2/iso:2


"A merlin isoform 2 that is encoded in the genome of human." [PMID:15467741, PRO:CNA]

Yes

organism-sequence



PR:P35240-4

merlin isoform 4 (human)

hNF2/iso:4


"A merlin isoform 4 that is encoded in the genome of human." [PMID:10669747, PRO:CNA]

Yes

organism-sequence



PR:P35240-5

merlin isoform h5 (human)

hNF2/iso:h5


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-5." [PRO:DNx, UniProtKB:P35240]


organism-sequence



PR:P35240-6

merlin isoform h6 (human)

hNF2/iso:h6


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-6." [PRO:DNx, UniProtKB:P35240]


organism-sequence



PR:P35240-7

merlin isoform h7 (human)

hNF2/iso:h7


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-7." [PRO:DNx, UniProtKB:P35240]


organism-sequence



PR:P35240-8

merlin isoform h8 (human)

hNF2/iso:h8


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-8." [PRO:DNx, UniProtKB:P35240]


organism-sequence



PR:P35240-9

merlin isoform h9 (human)

hNF2/iso:h9


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-9." [PRO:DNx, UniProtKB:P35240]


organism-modification



PR:000045760

merlin phosphorylated 1 (human)

hNF2/Phos:1


"A merlin (human) that has been phosphorylated on the residue at the position equivalent to Ser-518 of the amino acid sequence represented by UniProtKB:P35240-1. Example: UniProtKB:P35240-1, Ser-518, MOD:00046." [iPTMnet:P35240, PMID:11719502, PMID:11782491, PMID:14981079, PMID:15378014, PMID:17566081]


organism-modification



PR:000080467

merlin methylated 1 (human)

hNF2/Me:1


"A merlin (human) that has been methylated on the residue at the position equivalent to Cys-51 of the amino acid sequence represented by UniProtKB:P35240-1. Example: UniProtKB:P35240-1, Cys-51, MOD:00660." [IEDB_epitope:1029135, PRO:DNx]


organism-gene



PR:P46662

merlin (mouse)

mNF2


"A merlin that is encoded in the genome of mouse." [OMA:P46662, PRO:DNx]


organism-sequence



PR:P46662-1

merlin isoform 1 (mouse)

mNF2/iso:1


"A merlin isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P46662]


organism-sequence



PR:P46662-2

merlin isoform 2 (mouse)

mNF2/iso:2


"A merlin isoform 2 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P46662]


organism-gene



PR:Q24564

moesin/ezrin/radixin homolog 2 (fruit fly)

fly-NF2


"A merlin that is encoded in the genome of fruit fly." [OMA:Q24564, PRO:DNx]


sequence



PR:000003021

merlin isoform 1

NF2/iso:1


"A merlin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-1 or a 1:1 ortholog thereof." [PMID:18071304]


organism-sequence



PR:P35240-1

merlin isoform 1 (human)

hNF2/iso:1


"A merlin isoform 1 that is encoded in the genome of human." [PMID:9430655, PRO:CNA]

Yes

organism-sequence



PR:P46662-1

merlin isoform 1 (mouse)

mNF2/iso:1


"A merlin isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P46662]


modification



PR:000003024

merlin isoform 1 phosphorylated form

NF2/iso:1/PhosRes+


"A merlin isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003025

merlin isoform 1 phosphorylated 1

NF2/iso:1/Phos:1


"A merlin isoform 1 phosphorylated form that is phosphorylated in a C-terminal Ser residue within the PKA consensus site. Example: UniProtKB:P35240-1, Ser-518, MOD:00046." [PMID:18071304, PRO:AL]


modification



PR:000003026

merlin isoform 1 phosphorylated 2

NF2/iso:1/Phos:2


"A merlin isoform 1 phosphorylated form that is phosphorylated in a Ser residue (PKA consensus site) located within the N-terminal actin binding site, and it is also phosphorylated on a C-terminal Ser residue." [PMID:18071304, PRO:AL]


sequence



PR:000003022

merlin isoform 2

NF2/iso:2


"A merlin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-3 or a 1:1 ortholog thereof." [PMID:18071304]


organism-sequence



PR:P35240-3

merlin isoform 2 (human)

hNF2/iso:2


"A merlin isoform 2 that is encoded in the genome of human." [PMID:15467741, PRO:CNA]

Yes

organism-sequence



PR:P46662-2

merlin isoform 2 (mouse)

mNF2/iso:2


"A merlin isoform 2 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P46662]


modification



PR:000003028

merlin isoform 2 phosphorylated form

NF2/iso:2/PhosRes+


"A merlin isoform 2 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003029

merlin isoform 2 phosphorylated 1

NF2/iso:2/Phos:1


"A merlin isoform 2 phosphorylated form that is phosphorylated in a Ser residue (PKA consensus site) located within the N-terminal actin binding site, and it is also phosphorylated on a C-terminal Ser residue." [PMID:18071304, PRO:AL]


sequence



PR:000026545

merlin isoform 3

NF2/iso:3


"A merlin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-2 or a 1:1 ortholog thereof." [PMID:15467741, PRO:CNA]


organism-sequence



PR:P35240-2

merlin isoform 3 (human)

hNF2/iso:3


"A merlin isoform 3 that is encoded in the genome of human." [PMID:15467741, PRO:CNA]


sequence



PR:000026547

merlin isoform 4

NF2/iso:4


"A merlin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-4 or a 1:1 ortholog thereof." [PMID:10669747, PRO:CNA]


organism-sequence



PR:P35240-4

merlin isoform 4 (human)

hNF2/iso:4


"A merlin isoform 4 that is encoded in the genome of human." [PMID:10669747, PRO:CNA]

Yes

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000001030 CD247/iso:CD3 zeta
ERM proteins are involved in crosslinking actin filaments with plasma membranes
enablesGO:0008092 cytoskeletal protein binding PIRSF:PIRSF002305
PR:000036589 hEZR/iso:1/Phos:2
UniProtKB:P15311-1, Ser-66, MOD:00046
enablesGO:0005515 protein binding with PR:000002696 WWOX/iso:1/UnMod PMID:16438931
PR:000036590 hEZR/iso:1/Phos:3
UniProtKB:P15311-1, Tyr-191, MOD:00048
enablesGO:0005515 protein binding with PR:P00523-1 PMID:15647376
PR:000036592 hEZR/iso:1/Phos:5
UniProtKB:P15311-1, Thr-567, MOD:00047
acts_upstream_of_or_withinGO:0001771 immunological synapse formation PMID:18025306
GO:0051279 regulation of release of sequestered calcium ion into cytosol PMID:18025306
enablesGO:0005515 protein binding with PR:P43403 70 kDa zeta-chain associated protein (human) PMID:18025306
located_inGO:0001772 immunological synapse PMID:18025306
GO:0045177 apical part of cell PMID:16144865
PR:000036621 hMSN/iso:1/Phos:1
UniProtKB:P26038-1, Thr-558, MOD:00047
acts_upstream_of_or_withinGO:0001771 immunological synapse formation PMID:18025306
enablesGO:0005515 protein binding with PR:P16150 CD43 PMID:18025306
located_inGO:0005938 cell cortex PMID:18025306
PR:000036625 hEZR/iso:1/Phos:6
UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047
enablesGO:0003779 actin binding PMID:18852256
located_inGO:0002102 podosome PMID:18852256
GO:0005886 plasma membrane PMID:18852256
PR:P35240-1 hNF2/iso:1 enablesGO:0005515 protein binding with PR:O14745 EBP50 (human) PMID:15467741
GO:0005515 protein binding with PR:Q9H204 EG1 PMID:15467741
located_inGO:0005634 nucleus PMID:20178741
PR:P35240-3 hNF2/iso:2 enablesGO:0005515 protein binding with PR:Q9H204 EG1 PMID:15467741
PR:P35240-4 hNF2/iso:4 enablesGO:0005515 protein binding with PR:P0DPB3-1 PMID:10669747