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Protein Ontology report - ezrin
PR:000001031 - http://purl.obolibrary.org/obo/PR_000001031
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001031   
  PRO nameezrin 
  Synonyms
PRO-Short-label: EXACT:EZR
Gene-based: RELATED:VIL2
Other: EXACT:cytovillin | villin-2
  Definition"An erm protein that is a translation product of the human EZR gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000001030 erm protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 8                                        
         Modification9                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001031

ezrin

EZR


"An erm protein that is a translation product of the human EZR gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P15311

ezrin (human)

hEZR


"An ezrin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P15311]


organism-sequence



PR:P15311-1

ezrin isoform 1 (human)

hEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036588

ezrin isoform 1 phosphorylated 1 (human)

hEZR/iso:1/Phos:1


"An ezrin isoform 1 phosphorylated 1 in human. UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048." [PMID:1382070, PRO:CNA]


organism-modification



PR:000036589

ezrin isoform 1 phosphorylated 2 (human)

hEZR/iso:1/Phos:2


"An ezrin isoform 1 phosphorylated 2 in human. UniProtKB:P15311-1, Ser-66, MOD:00046." [PMID:12840026, PMID:16438931, PRO:CNA]

Yes

organism-modification



PR:000036590

ezrin isoform 1 phosphorylated 3 (human)

hEZR/iso:1/Phos:3


"An ezrin isoform 1 phosphorylated 3 in human. UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PRO:CNA]

Yes

organism-modification



PR:000036591

ezrin isoform 1 phosphorylated 4 (human)

hEZR/iso:1/Phos:4


"An ezrin isoform 1 phosphorylated 4 in human. UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047." [PMID:15647376, PRO:CNA]


organism-modification



PR:000036592

ezrin isoform 1 phosphorylated 5 (human)

hEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in human. UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865, PMID:18025306, PRO:AL, PRO:CNA]

Yes

organism-modification



PR:000036625

ezrin isoform 1 phosphorylated 6 (human)

hEZR/iso:1/Phos:6


"An ezrin isoform 1 phosphorylated 6 in human. UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]

Yes

organism-modification



PR:000047345

ezrin, initiator methionine removed phosphorylated 5 (human)

hEZR/InitMet-/Phos:5


"An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 567 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Thr-567, MOD:00047." [PRO:DNx, Reactome:R-HSA-374559]


organism-modification



PR:000047346

ezrin, initiator methionine removed phosphorylated 1 (human)

hEZR/InitMet-/Phos:1


"An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 146 and 354 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Tyr-146/Tyr-354, MOD:00048." [PRO:DNx, Reactome:R-HSA-374572]


organism-gene



PR:P26040

ezrin (mouse)

mEZR


"An ezrin that is encoded in the genome of mouse." [OMA:P26040, PRO:DNx]


organism-sequence



PR:P26040-1

ezrin isoform 1 (mouse)

mEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000044790

ezrin isoform 1 phosphorylated 5 (mouse)

mEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in mouse. UniProtKB:P26040-1, Thr-567, MOD:00047." [PRO:DAN]


organism-gene



PR:P31977

ezrin (rat)

rEZR


"An ezrin that is encoded in the genome of rat." [OMA:P31977, PRO:DNx]


organism-sequence



PR:P31977-1

ezrin isoform 1 (rat)

rEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of rat." [PRO:CNA]


organism-gene



PR:P46150

moesin/ezrin/radixin homolog 1 (fruit fly)

fly-EZR


"An ezrin that is encoded in the genome of fruit fly." [PRO:CNA]


organism-sequence



PR:P46150-1

moesin/ezrin/radixin homolog 1 isoform J (fruit fly)

fly-EZR/iso:J


"A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-1." [PRO:DNx, UniProtKB:P46150]


organism-sequence



PR:P46150-2

moesin/ezrin/radixin homolog 1 isoform D (fruit fly)

fly-EZR/iso:D


"A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-2." [PRO:DNx, UniProtKB:P46150]


organism-sequence



PR:P46150-3

moesin/ezrin/radixin homolog 1 isoform A (fruit fly)

fly-EZR/iso:A


"A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-3." [PRO:DNx, UniProtKB:P46150]


organism-sequence



PR:P46150-4

moesin/ezrin/radixin homolog 1 isoform B (fruit fly)

fly-EZR/iso:B


"A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-4." [PRO:DNx, UniProtKB:P46150]


organism-sequence



PR:P46150-5

moesin/ezrin/radixin homolog 1 isoform C (fruit fly)

fly-EZR/iso:C


"A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-5." [PRO:DNx, UniProtKB:P46150]


sequence



PR:000001032

ezrin isoform 1

EZR/iso:1


"An ezrin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15311-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P15311-1

ezrin isoform 1 (human)

hEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036588

ezrin isoform 1 phosphorylated 1 (human)

hEZR/iso:1/Phos:1


"An ezrin isoform 1 phosphorylated 1 in human. UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048." [PMID:1382070, PRO:CNA]


organism-modification



PR:000036589

ezrin isoform 1 phosphorylated 2 (human)

hEZR/iso:1/Phos:2


"An ezrin isoform 1 phosphorylated 2 in human. UniProtKB:P15311-1, Ser-66, MOD:00046." [PMID:12840026, PMID:16438931, PRO:CNA]

Yes

organism-modification



PR:000036590

ezrin isoform 1 phosphorylated 3 (human)

hEZR/iso:1/Phos:3


"An ezrin isoform 1 phosphorylated 3 in human. UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PRO:CNA]

Yes

organism-modification



PR:000036591

ezrin isoform 1 phosphorylated 4 (human)

hEZR/iso:1/Phos:4


"An ezrin isoform 1 phosphorylated 4 in human. UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047." [PMID:15647376, PRO:CNA]


organism-modification



PR:000036592

ezrin isoform 1 phosphorylated 5 (human)

hEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in human. UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865, PMID:18025306, PRO:AL, PRO:CNA]

Yes

organism-modification



PR:000036625

ezrin isoform 1 phosphorylated 6 (human)

hEZR/iso:1/Phos:6


"An ezrin isoform 1 phosphorylated 6 in human. UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]

Yes

organism-sequence



PR:P26040-1

ezrin isoform 1 (mouse)

mEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000044790

ezrin isoform 1 phosphorylated 5 (mouse)

mEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in mouse. UniProtKB:P26040-1, Thr-567, MOD:00047." [PRO:DAN]


organism-sequence



PR:P31977-1

ezrin isoform 1 (rat)

rEZR/iso:1


"An ezrin isoform 1 that is encoded in the genome of rat." [PRO:CNA]


modification



PR:000001033

ezrin isoform 1 phosphorylated form

EZR/iso:1/PhosRes+


"An ezrin isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000001034

ezrin isoform 1 phosphorylated 1

EZR/iso:1/Phos:1


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs upon EGF stimulation. Example: UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048." [PMID:1382070]


organism-modification



PR:000036588

ezrin isoform 1 phosphorylated 1 (human)

hEZR/iso:1/Phos:1


"An ezrin isoform 1 phosphorylated 1 in human. UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048." [PMID:1382070, PRO:CNA]


modification



PR:000001035

ezrin isoform 1 phosphorylated 2

EZR/iso:1/Phos:2


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs by the action of protein kinase A (PKA). Example: UniProtKB:P15311-1, Ser-66, MOD:00046." [PhosphoSitePlus:28933, PMID:12840026, PMID:16438931]


organism-modification



PR:000036589

ezrin isoform 1 phosphorylated 2 (human)

hEZR/iso:1/Phos:2


"An ezrin isoform 1 phosphorylated 2 in human. UniProtKB:P15311-1, Ser-66, MOD:00046." [PMID:12840026, PMID:16438931, PRO:CNA]

Yes

modification



PR:000001038

ezrin isoform 1 phosphorylated 3

EZR/iso:1/Phos:3


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs at the first Tyr residue within the ITAM-like motif EYLKIAQDLEMYGINYFEI. Example: UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PMID:9052872]


organism-modification



PR:000036590

ezrin isoform 1 phosphorylated 3 (human)

hEZR/iso:1/Phos:3


"An ezrin isoform 1 phosphorylated 3 in human. UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PRO:CNA]

Yes

modification



PR:000001039

ezrin isoform 1 phosphorylated 4

EZR/iso:1/Phos:4


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs both in a Tyr residue within the FERM central domain, and the first Tyr residue within the ITAM-like motif EYLKIAQDLEMYGINYFEI. Example: UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047." [PMID:15647376]


organism-modification



PR:000036591

ezrin isoform 1 phosphorylated 4 (human)

hEZR/iso:1/Phos:4


"An ezrin isoform 1 phosphorylated 4 in human. UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047." [PMID:15647376, PRO:CNA]


modification



PR:000001040

ezrin isoform 1 phosphorylated 5

EZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs at a Thr residue located within the C-terminal domain. Example: UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865]


organism-modification



PR:000036592

ezrin isoform 1 phosphorylated 5 (human)

hEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in human. UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865, PMID:18025306, PRO:AL, PRO:CNA]

Yes

organism-modification



PR:000044790

ezrin isoform 1 phosphorylated 5 (mouse)

mEZR/iso:1/Phos:5


"An ezrin isoform 1 phosphorylated 5 in mouse. UniProtKB:P26040-1, Thr-567, MOD:00047." [PRO:DAN]


modification



PR:000003042

ezrin isoform 1 phosphorylated 6

EZR/iso:1/Phos:6


"An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs at either the C-terminal Thr (Thr-567 in human), through kinases such as Rho-kinase, or the N-terminal tyrosine residue (Tyr-354 in human). Example: UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]


organism-modification



PR:000036625

ezrin isoform 1 phosphorylated 6 (human)

hEZR/iso:1/Phos:6


"An ezrin isoform 1 phosphorylated 6 in human. UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]

Yes

modification



PR:000026720

ezrin isoform 1, initiator methionine removed form

EZR/iso:1/InitMet-


"An ezrin isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000018330

ezrin, initiator methionine removed form

EZR/InitMet-


"An ezrin that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026720

ezrin isoform 1, initiator methionine removed form

EZR/iso:1/InitMet-


"An ezrin isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000047345

ezrin, initiator methionine removed phosphorylated 5 (human)

hEZR/InitMet-/Phos:5


"An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 567 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Thr-567, MOD:00047." [PRO:DNx, Reactome:R-HSA-374559]


organism-modification



PR:000047346

ezrin, initiator methionine removed phosphorylated 1 (human)

hEZR/InitMet-/Phos:1


"An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 146 and 354 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Tyr-146/Tyr-354, MOD:00048." [PRO:DNx, Reactome:R-HSA-374572]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036589 hEZR/iso:1/Phos:2
UniProtKB:P15311-1, Ser-66, MOD:00046
enablesGO:0005515 protein binding with PR:000002696 WWOX/iso:1/UnMod PMID:16438931
PR:000036590 hEZR/iso:1/Phos:3
UniProtKB:P15311-1, Tyr-191, MOD:00048
enablesGO:0005515 protein binding with PR:P00523-1 PMID:15647376
PR:000036592 hEZR/iso:1/Phos:5
UniProtKB:P15311-1, Thr-567, MOD:00047
acts_upstream_of_or_withinGO:0001771 immunological synapse formation PMID:18025306
GO:0051279 regulation of release of sequestered calcium ion into cytosol PMID:18025306
enablesGO:0005515 protein binding with PR:P43403 70 kDa zeta-chain associated protein (human) PMID:18025306
located_inGO:0001772 immunological synapse PMID:18025306
GO:0045177 apical part of cell PMID:16144865
PR:000036625 hEZR/iso:1/Phos:6
UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047
enablesGO:0003779 actin binding PMID:18852256
located_inGO:0002102 podosome PMID:18852256
GO:0005886 plasma membrane PMID:18852256