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gene
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PR:000001044 |
cystic fibrosis transmembrane conductance regulator
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CFTR
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"A chloride channel protein that is a translation product of the human CFTR gene or a 1:1 ortholog thereof. Involved in the transport of chloride ions. The characteristic domain composition of the functional isoform consists of two modules of a membrane-spanning domain (ABC transporter transmembrane region) followed by a nucleotide-binding domain (ABC transporter domains), separated by an intracellular regulatory domain (R-domain). It also contains a C-terminal PDZ-binding region. The R-domain is an inhibitory domain of CFTR, and phosphorylation of the R-domain removes this inhibition, allowing activation of chloride flux." [PMID:9922375, PRO:CNA]
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organism-gene
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PR:P13569 |
cystic fibrosis transmembrane conductance regulator (human)
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hCFTR
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"A cystic fibrosis transmembrane conductance regulator that is encoded in the genome of human." [PRO:CNA, UniProtKB:P13569]
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organism-sequence
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PR:000063429 |
cystic fibrosis transmembrane conductance regulator sequence variant N1303K (human)
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hCFTR/var:N1303K
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"A cystic fibrosis transmembrane conductance regulator (human) that has a Lys residue at the position equivalent to Asn-1303 of the amino acid sequence represented by UniProtKB:P13569-1. Example: UniProtKB:P13569-1, Asn-1303, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-5678983]
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organism-sequence
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PR:000063523 |
cystic fibrosis transmembrane conductance regulator sequence variant G551D (human)
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hCFTR/var:G551D
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"A cystic fibrosis transmembrane conductance regulator (human) that has an Asp residue at the position equivalent to Gly-551 of the amino acid sequence represented by UniProtKB:P13569-1. Example: UniProtKB:P13569-1, Gly-551, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-5678977]
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organism-sequence
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PR:P13569-1 |
cystic fibrosis transmembrane conductance regulator isoform 1 (human)
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hCFTR/iso:1
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"A cftr isoform 1 that is encoded in the genome of human." [PRO:CNA]
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organism-modification
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PR:000036593 |
cftr isoform 1 N-glycosylated 1 (human)
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hCFTR/iso:1/NGlyco:1
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"A cftr isoform 1 N-glycosylated 1 in human. UniProtKB:P13569-1, Asn-894/Asn-900, MOD:00160." [PMID:7518437, PRO:CNA]
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organism-modification
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PR:000036594 |
cftr isoform 1 phosphorylated 1 (human)
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hCFTR/iso:1/Phos:1
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"A cftr isoform 1 phosphorylated 1 in human. Example: UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PMID:14602047, PMID:1716180, PRO:CNA]
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Yes |
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organism-modification
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PR:000036595 |
cftr isoform 1 phosphorylated 2 (human)
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hCFTR/iso:1/Phos:2
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"A cftr isoform 1 phosphorylated 2 in human. Example: UniProtKB:P13569-1, Ser-686/Ser-737/Ser-768/Ser-790/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PRO:CNA]
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organism-sequence
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PR:P13569-2 |
cystic fibrosis transmembrane conductance regulator isoform 2 (human)
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hCFTR/iso:2
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"A cftr isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P13569]
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organism-sequence
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PR:P13569-3 |
cystic fibrosis transmembrane conductance regulator isoform 3 (human)
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hCFTR/iso:3
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"A cftr isoform 3 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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organism-modification
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PR:000046699 |
cystic fibrosis transmembrane conductance regulator ubiquitinated form (human)
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hCFTR/UbiqLys+
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"A cystic fibrosis transmembrane conductance regulator (human) that includes at least one ubiquitinated lysine. UniProtKB:P13569, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782976, Reactome:R-HSA-8867595, Reactome:R-HSA-8869104]
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organism-modification
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PR:000079746 |
cystic fibrosis transmembrane conductance regulator phosphorylated 1 (human)
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hCFTR/Phos:1
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"A cystic fibrosis transmembrane conductance regulator (human) that has been phosphorylated on the residue at the position equivalent to Ser-573 of the amino acid sequence represented by UniProtKB:P13569-1. Example: UniProtKB:P13569-1, Ser-573, MOD:00046." [IEDB_epitope:1376512, PRO:DNx]
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organism-gene
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PR:P26361 |
cystic fibrosis transmembrane conductance regulator (mouse)
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mCFTR
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"A cystic fibrosis transmembrane conductance regulator that is encoded in the genome of mouse." [OMA:P26361, PRO:DNx]
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organism-sequence
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PR:P26361-1 |
cystic fibrosis transmembrane conductance regulator isoform 1 (mouse)
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mCFTR/iso:1
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"A cftr isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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organism-sequence
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PR:P26361-2 |
cystic fibrosis transmembrane conductance regulator isoform m2 (mouse)
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mCFTR/iso:m2
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"A cystic fibrosis transmembrane conductance regulator (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26361-2." [PRO:DNx, UniProtKB:P26361]
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organism-sequence
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PR:P26361-3 |
cystic fibrosis transmembrane conductance regulator isoform m3 (mouse)
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mCFTR/iso:m3
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"A cystic fibrosis transmembrane conductance regulator (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26361-3." [PRO:DNx, UniProtKB:P26361]
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organism-gene
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PR:P34158 |
cystic fibrosis transmembrane conductance regulator (rat)
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rCFTR
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"A cystic fibrosis transmembrane conductance regulator that is encoded in the genome of rat." [OMA:P34158, PRO:DNx]
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organism-sequence
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PR:P34158-1 |
cystic fibrosis transmembrane conductance regulator isoform 1 (rat)
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rCFTR/iso:1
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"A cftr isoform 1 that is encoded in the genome of rat." [PRO:CNA]
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organism-gene
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PR:Q1LX78 |
cystic fibrosis transmembrane conductance regulator (zebrafish)
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z-CFTR
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"A cystic fibrosis transmembrane conductance regulator that is encoded in the genome of zebrafish." [PRO:CNA]
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sequence
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PR:000001045 |
cftr isoform 1
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CFTR/iso:1
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"A cystic fibrosis transmembrane conductance regulator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13569-1 or a 1:1 ortholog thereof." [PMID:9922375, PRO:CNA, PRO:DAN]
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organism-sequence
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PR:P13569-1 |
cystic fibrosis transmembrane conductance regulator isoform 1 (human)
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hCFTR/iso:1
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"A cftr isoform 1 that is encoded in the genome of human." [PRO:CNA]
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organism-modification
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PR:000036593 |
cftr isoform 1 N-glycosylated 1 (human)
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hCFTR/iso:1/NGlyco:1
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"A cftr isoform 1 N-glycosylated 1 in human. UniProtKB:P13569-1, Asn-894/Asn-900, MOD:00160." [PMID:7518437, PRO:CNA]
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organism-modification
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PR:000036594 |
cftr isoform 1 phosphorylated 1 (human)
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hCFTR/iso:1/Phos:1
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"A cftr isoform 1 phosphorylated 1 in human. Example: UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PMID:14602047, PMID:1716180, PRO:CNA]
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Yes |
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organism-modification
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PR:000036595 |
cftr isoform 1 phosphorylated 2 (human)
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hCFTR/iso:1/Phos:2
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"A cftr isoform 1 phosphorylated 2 in human. Example: UniProtKB:P13569-1, Ser-686/Ser-737/Ser-768/Ser-790/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PRO:CNA]
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organism-sequence
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PR:P26361-1 |
cystic fibrosis transmembrane conductance regulator isoform 1 (mouse)
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mCFTR/iso:1
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"A cftr isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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organism-sequence
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PR:P34158-1 |
cystic fibrosis transmembrane conductance regulator isoform 1 (rat)
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rCFTR/iso:1
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"A cftr isoform 1 that is encoded in the genome of rat." [PRO:CNA]
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modification
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PR:000001048 |
cftr isoform 1 glycosylated form
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CFTR/iso:1/GlycoRes+
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"A cftr isoform 1 that includes at least one glycosylated residue." [PRO:CNA]
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modification
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PR:000001049 |
cftr isoform 1 N-glycosylated 1
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CFTR/iso:1/NGlyco:1
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"A cftr isoform 1 glycosylated form in which the glycosylation is at two Asn residues within the N{P}[ST]{P} motif, located in the fourth extracellular loop. Example: UniProtKB:P13569-1, Asn-894/Asn-900, MOD:00160." [PMID:7518437]
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organism-modification
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PR:000036593 |
cftr isoform 1 N-glycosylated 1 (human)
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hCFTR/iso:1/NGlyco:1
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"A cftr isoform 1 N-glycosylated 1 in human. UniProtKB:P13569-1, Asn-894/Asn-900, MOD:00160." [PMID:7518437, PRO:CNA]
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modification
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PR:000001050 |
cftr isoform 1 phosphorylated form
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CFTR/iso:1/PhosRes+
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"A cftr isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
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modification
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PR:000001051 |
cftr isoform 1 phosphorylated 1
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CFTR/iso:1/Phos:1
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"A cftr isoform 1 phosphorylated form in which the phosphorylation occurs at multiple Ser and/or Thr residues within the PKA consensus sites R[RK]x [ST] located within the regulatory domain (R-domain). Example: UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PMID:14602047]
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organism-modification
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PR:000036594 |
cftr isoform 1 phosphorylated 1 (human)
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hCFTR/iso:1/Phos:1
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"A cftr isoform 1 phosphorylated 1 in human. Example: UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PMID:14602047, PMID:1716180, PRO:CNA]
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Yes |
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modification
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PR:000001052 |
cftr isoform 1 phosphorylated 2
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CFTR/iso:1/Phos:2
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"A cftr isoform 1 phosphorylated form in which the phosphorylation occurs by the action of PKA and PKC at multiple Ser and/or Thr residues within the regulatory domain (R-domain). Example: UniProtKB:P13569-1, Ser-686/Ser-737/Ser-768/Ser-790/Ser-795/Ser-813, MOD:00046." [PMID:1377674]
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organism-modification
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PR:000036595 |
cftr isoform 1 phosphorylated 2 (human)
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hCFTR/iso:1/Phos:2
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"A cftr isoform 1 phosphorylated 2 in human. Example: UniProtKB:P13569-1, Ser-686/Ser-737/Ser-768/Ser-790/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PRO:CNA]
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sequence
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PR:000001046 |
cftr isoform 2
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CFTR/iso:2
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"A cystic fibrosis transmembrane conductance regulator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13569-2 or a 1:1 ortholog thereof." [OMIM:277180, PMID:10766763, PRO:CNA, PRO:DAN]
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organism-sequence
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PR:P13569-2 |
cystic fibrosis transmembrane conductance regulator isoform 2 (human)
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hCFTR/iso:2
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"A cftr isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P13569]
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sequence
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PR:000001047 |
cftr isoform 3
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CFTR/iso:3
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"A cystic fibrosis transmembrane conductance regulator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13569-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
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PR:P13569-3 |
cystic fibrosis transmembrane conductance regulator isoform 3 (human)
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hCFTR/iso:3
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"A cftr isoform 3 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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