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Protein Ontology report - cftr isoform 1
PR:000001045 - http://purl.obolibrary.org/obo/PR_000001045
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001045   
  PRO namecftr isoform 1 
  Synonyms
PRO-Short-label: EXACT:CFTR/iso:1
Other: EXACT:cystic fibrosis transmembrane conductance regulator isoform 1
  Definition"A cystic fibrosis transmembrane conductance regulator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13569-1 or a 1:1 ortholog thereof." [PMID:9922375, PRO:CNA, PRO:DAN] 
  CommentNote: This isoform contains an intracellular regulatory domain (R-domain) that, when unphosphorylated, inhibits CFTR. Phosphorylation of the R-domain removes this inhibition, allowing activation of chloride flux. 
  PRO Categorysequence 
  ParentPR:000001044 cystic fibrosis transmembrane conductance regulator
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 3                                        
         Modification5                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000001045 cftr isoform 1
CFTR/iso:1

organism-sequence


PR:P13569-1 cystic fibrosis transmembrane conductance regulator isoform 1 (human)
hCFTR/iso:1

organism-modification


PR:000036593 cftr isoform 1 N-glycosylated 1 (human)
hCFTR/iso:1/NGlyco:1

organism-modification


PR:000036594 cftr isoform 1 phosphorylated 1 (human)
hCFTR/iso:1/Phos:1
Yes
organism-modification


PR:000036595 cftr isoform 1 phosphorylated 2 (human)
hCFTR/iso:1/Phos:2

organism-sequence


PR:P26361-1 cystic fibrosis transmembrane conductance regulator isoform 1 (mouse)
mCFTR/iso:1

organism-sequence


PR:P34158-1 cystic fibrosis transmembrane conductance regulator isoform 1 (rat)
rCFTR/iso:1

modification


PR:000001048 cftr isoform 1 glycosylated form
CFTR/iso:1/GlycoRes+

modification


PR:000001049 cftr isoform 1 N-glycosylated 1
CFTR/iso:1/NGlyco:1

organism-modification


PR:000036593 cftr isoform 1 N-glycosylated 1 (human)
hCFTR/iso:1/NGlyco:1

modification


PR:000001050 cftr isoform 1 phosphorylated form
CFTR/iso:1/PhosRes+

modification


PR:000001051 cftr isoform 1 phosphorylated 1
CFTR/iso:1/Phos:1

organism-modification


PR:000036594 cftr isoform 1 phosphorylated 1 (human)
hCFTR/iso:1/Phos:1
Yes
modification


PR:000001052 cftr isoform 1 phosphorylated 2
CFTR/iso:1/Phos:2

organism-modification


PR:000036595 cftr isoform 1 phosphorylated 2 (human)
hCFTR/iso:1/Phos:2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036594 hCFTR/iso:1/Phos:1
Example: UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046		 enablesGO:0005260 intracellularly ATP-gated chloride channel activity PMID:1716180
GO:0005260 intracellularly ATP-gated chloride channel activity PMID:1716180