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Protein Ontology report - transient receptor potential cation channel TRPV4
PR:000001068 - http://purl.obolibrary.org/obo/PR_000001068
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001068   
  PRO nametransient receptor potential cation channel TRPV4 
  Synonyms
PRO-Short-label: EXACT:TRPV4
Gene-based: RELATED:VRL2 | VROAC
Other: EXACT:Osm-9-like TRP channel 4 | OTRPC4 | transient receptor potential protein 12 | TRP12 | TrpV4 | vanilloid receptor-like channel 2 | vanilloid receptor-like protein 2 | vanilloid receptor-related osmotically-activated channel | VR-OAC | VRL-2
  Definition"A transient receptor potential cation channel TRPV that is a translation product of the human TRPV4 gene or a 1:1 ortholog thereof. The functional subunits are ion-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification." [PRO:CNA, UniProtKB:Q9HBA0
  PRO Categorygene 
  ParentPR:000000681 transient receptor potential cation channel TRPV
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence5                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:510
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001068

transient receptor potential cation channel TRPV4

TRPV4


"A transient receptor potential cation channel TRPV that is a translation product of the human TRPV4 gene or a 1:1 ortholog thereof. The functional subunits are ion-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification." [PRO:CNA, UniProtKB:Q9HBA0]


organism-gene



PR:A0A1D5PXA5

transient receptor potential cation channel subfamily V member 4 (chicken)

chick-TRPV4


"A transient receptor potential cation channel TRPV4 that is encoded in the genome of chicken." [PRO:CNA]


organism-gene



PR:Q9EPK8

transient receptor potential cation channel subfamily V member 4 (mouse)

mTRPV4


"A transient receptor potential cation channel TRPV4 that is encoded in the genome of mouse." [OMA:Q9EPK8, PRO:DNx]

Yes

organism-sequence



PR:Q9EPK8-1

transient receptor potential cation channel subfamily V member 4 isoform A (mouse)

mTRPV4/iso:A


"A transient receptor potential cation channel TRPV4 isoform A that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000046053

transient receptor potential cation channel subfamily V member 4 phosphorylated 1 (mouse)

mTRPV4/Phos:1


"A transient receptor potential cation channel subfamily V member 4 (mouse) that has been phosphorylated at Tyr-253. UniProtKB:Q9EPK8, Tyr-253, MOD:00048." [iPTMnet:Q9EPK8, PMID:12538589]


organism-gene



PR:Q9ERZ8

transient receptor potential cation channel subfamily V member 4 (rat)

rTRPV4


"A transient receptor potential cation channel TRPV4 that is encoded in the genome of rat." [OMA:Q9ERZ8, PRO:DNx]


organism-gene



PR:Q9HBA0

transient receptor potential cation channel subfamily V member 4 (human)

hTRPV4


"A transient receptor potential cation channel TRPV4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HBA0]


organism-sequence



PR:Q9HBA0-1

transient receptor potential cation channel subfamily V member 4 isoform A (human)

hTRPV4/iso:A


"A transient receptor potential cation channel TRPV4 isoform A that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q9HBA0-2

transient receptor potential cation channel subfamily V member 4 isoform B (human)

hTRPV4/iso:B


"A transient receptor potential cation channel TRPV4 isoform B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]

Yes

organism-sequence



PR:Q9HBA0-3

transient receptor potential cation channel subfamily V member 4 isoform h3 (human)

hTRPV4/iso:h3


"A transient receptor potential cation channel subfamily V member 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-3." [PRO:DNx, UniProtKB:Q9HBA0]


organism-sequence



PR:Q9HBA0-4

transient receptor potential cation channel subfamily V member 4 isoform C (human)

hTRPV4/iso:C


"A transient receptor potential cation channel TRPV4 isoform C that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]

Yes

organism-sequence



PR:Q9HBA0-5

transient receptor potential cation channel subfamily V member 4 isoform D (human)

hTRPV4/iso:D


"A transient receptor potential cation channel TRPV4 isoform D that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]

Yes

organism-sequence



PR:Q9HBA0-6

transient receptor potential cation channel subfamily V member 4 isoform E (human)

hTRPV4/iso:E


"A transient receptor potential cation channel TRPV4 isoform E that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]

Yes

sequence



PR:000001069

transient receptor potential cation channel TRPV4 isoform A

TRPV4/iso:A


"A transient receptor potential cation channel TRPV4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-1 or a 1:1 ortholog thereof." [PMID:11025659, PMID:16293632, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9EPK8-1

transient receptor potential cation channel subfamily V member 4 isoform A (mouse)

mTRPV4/iso:A


"A transient receptor potential cation channel TRPV4 isoform A that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q9HBA0-1

transient receptor potential cation channel subfamily V member 4 isoform A (human)

hTRPV4/iso:A


"A transient receptor potential cation channel TRPV4 isoform A that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000001070

transient receptor potential cation channel TRPV4 isoform B

TRPV4/iso:B


"A transient receptor potential cation channel TRPV4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-2 or a 1:1 ortholog thereof." [PMID:16293632, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9HBA0-2

transient receptor potential cation channel subfamily V member 4 isoform B (human)

hTRPV4/iso:B


"A transient receptor potential cation channel TRPV4 isoform B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]

Yes

sequence



PR:000001071

transient receptor potential cation channel TRPV4 isoform C

TRPV4/iso:C


"A transient receptor potential cation channel TRPV4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-4 or a 1:1 ortholog thereof." [PMID:16293632, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9HBA0-4

transient receptor potential cation channel subfamily V member 4 isoform C (human)

hTRPV4/iso:C


"A transient receptor potential cation channel TRPV4 isoform C that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]

Yes

sequence



PR:000001072

transient receptor potential cation channel TRPV4 isoform D

TRPV4/iso:D


"A transient receptor potential cation channel TRPV4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-5 or a 1:1 ortholog thereof." [PMID:16293632, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9HBA0-5

transient receptor potential cation channel subfamily V member 4 isoform D (human)

hTRPV4/iso:D


"A transient receptor potential cation channel TRPV4 isoform D that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]

Yes

sequence



PR:000001073

transient receptor potential cation channel TRPV4 isoform E

TRPV4/iso:E


"A transient receptor potential cation channel TRPV4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-6 or a 1:1 ortholog thereof." [PMID:16293632, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9HBA0-6

transient receptor potential cation channel subfamily V member 4 isoform E (human)

hTRPV4/iso:E


"A transient receptor potential cation channel TRPV4 isoform E that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q9EPK8 mTRPV4 acts_upstream_of_or_withinGO:0030103 vasopressin secretion PMID:12777254
GO:0042538 hyperosmotic salinity response PMID:12777254
GO:0047484 regulation of response to osmotic stress PMID:12777254
enablesGO:0005034 osmosensor activity PMID:11025659
PR:Q9EPK8-1 mTRPV4/iso:A acts_upstream_of_or_withinGO:0006970 response to osmotic stress PMID:11025659
GO:0007231 osmosensory signaling pathway PMID:11025659
enablescontributes_to GO:0005262 calcium channel activity PMID:11025659
GO:0005515 protein binding PMID:14517216
located_inGO:0005886 plasma membrane PMID:14517216
PR:Q9HBA0-1 hTRPV4/iso:A enablesGO:0042802 identical protein binding with PR:Q9HBA0-1 PMID:16293632
located_inGO:0005886 plasma membrane PMID:16293632
PR:Q9HBA0-2 hTRPV4/iso:B located_inGO:0005783 endoplasmic reticulum PMID:16293632
PR:Q9HBA0-4 hTRPV4/iso:C located_inGO:0005783 endoplasmic reticulum PMID:16293632
PR:Q9HBA0-5 hTRPV4/iso:D enablesGO:0042802 identical protein binding with PR:Q9HBA0-5 PMID:16293632
located_inGO:0005886 plasma membrane PMID:16293632
PR:Q9HBA0-6 hTRPV4/iso:E located_inGO:0005783 endoplasmic reticulum PMID:16293632