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Protein Ontology report - transient receptor potential cation channel TRPV4
PR:000001068 - http://purl.obolibrary.org/obo/PR_000001068
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001068   
  PRO nametransient receptor potential cation channel TRPV4 
  Synonyms
PRO-Short-label: EXACT:TRPV4
Gene-based: RELATED:VRL2 | VROAC
Other: EXACT:Osm-9-like TRP channel 4 | OTRPC4 | transient receptor potential protein 12 | TRP12 | TrpV4 | vanilloid receptor-like channel 2 | vanilloid receptor-like protein 2 | vanilloid receptor-related osmotically-activated channel | VR-OAC | VRL-2
  Definition"A transient receptor potential cation channel TRPV that is a translation product of the human TRPV4 gene or a 1:1 ortholog thereof. The functional subunits are ion-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification." [PRO:CNA, UniProtKB:Q9HBA0] 
  PRO Categorygene 
  ParentPR:000000681 transient receptor potential cation channel TRPV
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence5                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:510
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001068 transient receptor potential cation channel TRPV4
TRPV4

organism-gene


PR:A0A1D5PXA5 transient receptor potential cation channel subfamily V member 4 (chicken)
chick-TRPV4

organism-gene


PR:Q9EPK8 transient receptor potential cation channel subfamily V member 4 (mouse)
mTRPV4
Yes
organism-sequence


PR:Q9EPK8-1 transient receptor potential cation channel subfamily V member 4 isoform A (mouse)
mTRPV4/iso:A
Yes
organism-modification


PR:000046053 transient receptor potential cation channel subfamily V member 4 phosphorylated 1 (mouse)
mTRPV4/Phos:1

organism-gene


PR:Q9ERZ8 transient receptor potential cation channel subfamily V member 4 (rat)
rTRPV4

organism-gene


PR:Q9HBA0 transient receptor potential cation channel subfamily V member 4 (human)
hTRPV4

organism-sequence


PR:Q9HBA0-1 transient receptor potential cation channel subfamily V member 4 isoform A (human)
hTRPV4/iso:A
Yes
organism-sequence


PR:Q9HBA0-2 transient receptor potential cation channel subfamily V member 4 isoform B (human)
hTRPV4/iso:B
Yes
organism-sequence


PR:Q9HBA0-3 transient receptor potential cation channel subfamily V member 4 isoform h3 (human)
hTRPV4/iso:h3

organism-sequence


PR:Q9HBA0-4 transient receptor potential cation channel subfamily V member 4 isoform C (human)
hTRPV4/iso:C
Yes
organism-sequence


PR:Q9HBA0-5 transient receptor potential cation channel subfamily V member 4 isoform D (human)
hTRPV4/iso:D
Yes
organism-sequence


PR:Q9HBA0-6 transient receptor potential cation channel subfamily V member 4 isoform E (human)
hTRPV4/iso:E
Yes
sequence


PR:000001069 transient receptor potential cation channel TRPV4 isoform A
TRPV4/iso:A

organism-sequence


PR:Q9EPK8-1 transient receptor potential cation channel subfamily V member 4 isoform A (mouse)
mTRPV4/iso:A
Yes
organism-sequence


PR:Q9HBA0-1 transient receptor potential cation channel subfamily V member 4 isoform A (human)
hTRPV4/iso:A
Yes
sequence


PR:000001070 transient receptor potential cation channel TRPV4 isoform B
TRPV4/iso:B

organism-sequence


PR:Q9HBA0-2 transient receptor potential cation channel subfamily V member 4 isoform B (human)
hTRPV4/iso:B
Yes
sequence


PR:000001071 transient receptor potential cation channel TRPV4 isoform C
TRPV4/iso:C

organism-sequence


PR:Q9HBA0-4 transient receptor potential cation channel subfamily V member 4 isoform C (human)
hTRPV4/iso:C
Yes
sequence


PR:000001072 transient receptor potential cation channel TRPV4 isoform D
TRPV4/iso:D

organism-sequence


PR:Q9HBA0-5 transient receptor potential cation channel subfamily V member 4 isoform D (human)
hTRPV4/iso:D
Yes
sequence


PR:000001073 transient receptor potential cation channel TRPV4 isoform E
TRPV4/iso:E

organism-sequence


PR:Q9HBA0-6 transient receptor potential cation channel subfamily V member 4 isoform E (human)
hTRPV4/iso:E
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q9EPK8 mTRPV4 acts_upstream_of_or_withinGO:0030103 vasopressin secretion PMID:12777254
GO:0042538 hyperosmotic salinity response PMID:12777254
GO:0047484 regulation of response to osmotic stress PMID:12777254
enablesGO:0005034 osmosensor activity PMID:11025659
PR:Q9EPK8-1 mTRPV4/iso:A acts_upstream_of_or_withinGO:0006970 response to osmotic stress PMID:11025659
GO:0007231 osmosensory signaling pathway PMID:11025659
enablescontributes_to GO:0005262 calcium channel activity PMID:11025659
GO:0005515 protein binding PMID:14517216
located_inGO:0005886 plasma membrane PMID:14517216
PR:Q9HBA0-1 hTRPV4/iso:A enablesGO:0042802 identical protein binding with PR:Q9HBA0-1 PMID:16293632
located_inGO:0005886 plasma membrane PMID:16293632
PR:Q9HBA0-2 hTRPV4/iso:B located_inGO:0005783 endoplasmic reticulum PMID:16293632
PR:Q9HBA0-4 hTRPV4/iso:C located_inGO:0005783 endoplasmic reticulum PMID:16293632
PR:Q9HBA0-5 hTRPV4/iso:D enablesGO:0042802 identical protein binding with PR:Q9HBA0-5 PMID:16293632
located_inGO:0005886 plasma membrane PMID:16293632
PR:Q9HBA0-6 hTRPV4/iso:E located_inGO:0005783 endoplasmic reticulum PMID:16293632