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Protein Ontology report - frizzled-like G-protein coupled receptor

PR:000001315 - http://purl.obolibrary.org/obo/PR_000001315

Protein Forms

Ontology Information

Show OBO stanza

PRO ID

PR:000001315

PRO name

frizzled-like G-protein coupled receptor

Synonyms

PRO-Short-label:	EXACT:	fam:frizzled
Other:	EXACT:	class F G-protein coupled receptor

Definition

"A G-protein coupled receptor with core architecture consisting of an Fz domain (Pfam:PF01392), also known as Frizzled CRD (cysteine rich domain), followed by a Frizzled/Smoothened family membrane region (Pfam:PF01534), which includes 7 transmembrane helices, and a cytoplasmic domain containing the motif Lys-Thr-x-x-x-Trp. They generally function as cell-surface receptors for Wnts." [InterPro:IPR015526, PRO:DAN, PRO:WCB]

Comment

Classification based on GRAFS system. [PMID:12761335].

PRO Category

family

Parent

PR:000030035 G-protein coupled receptor

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Family	1	Organism-Family	0
Gene	11	Organism-Gene	37
Sequence	4	Organism-Sequence	12
Modification	1	Organism-Modification	34

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	PIRSF:PIRSF006696;IUPHARfam:25

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

family

PR:000001315 frizzled-like G-protein coupled receptor

fam:frizzled

gene

PR:000001453 frizzled-10

FZD10

organism-gene

PR:Q8BKG4 frizzled-10 (mouse)

mFZD10

organism-gene

PR:Q9PWH2 frizzled-10 (chicken)

chick-FZD10

organism-gene

PR:Q9ULW2 frizzled-10 (human)

hFZD10

organism-modification

PR:000047470 frizzled-10, signal peptide removed form (human)

hFZD10/SigPep-

gene

PR:000001454 frizzled-4

FZD4

organism-gene

PR:Q61088 frizzled-4 (mouse)

mFZD4

organism-sequence

PR:Q61088-1 frizzled-4 isoform 1 (mouse)

mFZD4/iso:1

organism-gene

PR:Q9IA05 frizzled-4 (chicken)

chick-FZD4

organism-gene

PR:Q9QZH0 frizzled-4 (rat)

rFZD4

organism-gene

PR:Q9ULV1 frizzled-4 (human)

hFZD4

organism-sequence

PR:Q9ULV1-1 frizzled-4 isoform 1 (human)

hFZD4/iso:1

organism-modification

PR:000047473 frizzled-4, signal peptide removed form (human)

hFZD4/SigPep-

organism-modification

PR:000047474 frizzled-4, signal peptide removed ubiquitinated form (human)

hFZD4/SigPep-/UbiqLys+

organism-modification

PR:000047474 frizzled-4, signal peptide removed ubiquitinated form (human)

hFZD4/SigPep-/UbiqLys+

sequence

PR:000044007 frizzled-4 isoform 1

FZD4/iso:1

organism-sequence

PR:Q61088-1 frizzled-4 isoform 1 (mouse)

mFZD4/iso:1

organism-sequence

PR:Q9ULV1-1 frizzled-4 isoform 1 (human)

hFZD4/iso:1

gene

PR:000001455 frizzled-9

FZD9

organism-gene

PR:O00144 frizzled-9 (human)

hFZD9

organism-modification

PR:000047481 frizzled-9, signal peptide removed form (human)

hFZD9/SigPep-

organism-gene

PR:Q8K4C8 frizzled-9 (rat)

rFZD9

organism-gene

PR:Q9R216 frizzled-9 (mouse)

mFZD9

gene

PR:000007718 frizzled-1

FZD1

organism-gene

PR:O57328 frizzled-1 (chicken)

chick-FZD1

organism-gene

PR:O70421 frizzled-1 (mouse)

mFZD1

organism-gene

PR:Q08463 frizzled-1 (rat)

rFZD1

organism-gene

PR:Q9UP38 frizzled-1 (human)

hFZD1

organism-modification

PR:000047469 frizzled-1, signal peptide removed form (human)

hFZD1/SigPep-

organism-modification

PR:000058343 frizzled-1 O-glycosylated 1 (human)

hFZD1/OGlyco:1

organism-modification

PR:000058344 frizzled-1 O-glycosylated 2 (human)

hFZD1/OGlyco:2

gene

PR:000007719 frizzled-2

FZD2

organism-gene

PR:Q08464 frizzled-2 (rat)

rFZD2

organism-gene

PR:Q14332 frizzled-2 (human)

hFZD2

organism-modification

PR:000047471 frizzled-2, signal peptide removed form (human)

hFZD2/SigPep-

organism-modification

PR:000057124 frizzled-2 O-glycosylated 1 (human)

hFZD2/OGlyco:1

organism-modification

PR:000057125 frizzled-2 O-glycosylated 2 (human)

hFZD2/OGlyco:2

organism-gene

PR:Q9JIP6 frizzled-2 (mouse)

mFZD2

gene

PR:000007720 frizzled-3

FZD3

organism-gene

PR:Q61086 frizzled-3 (mouse)

mFZD3

organism-sequence

PR:Q61086-1 frizzled-3 isoform 1 (mouse)

mFZD3/iso:1

organism-modification

PR:000076795 frizzled-3 cysteinylated 1 (mouse)

mFZD3/Cyst:1

organism-gene

PR:Q9NPG1 frizzled-3 (human)

hFZD3

organism-sequence

PR:Q9NPG1-1 frizzled-3 isoform Long (human)

hFZD3/iso:Long

organism-sequence

PR:Q9NPG1-2 frizzled-3 isoform Short (human)

hFZD3/iso:Short

organism-modification

PR:000047472 frizzled-3, signal peptide removed form (human)

hFZD3/SigPep-

sequence

PR:000043476 frizzled-3 isoform 1

FZD3/iso:1

organism-sequence

PR:Q61086-1 frizzled-3 isoform 1 (mouse)

mFZD3/iso:1

organism-sequence

PR:Q9NPG1-1 frizzled-3 isoform Long (human)

hFZD3/iso:Long

modification

PR:000019950 frizzled-3, signal peptide removed form

FZD3/SigPep-

organism-modification

PR:000047472 frizzled-3, signal peptide removed form (human)

hFZD3/SigPep-

gene

PR:000007721 frizzled-5

FZD5

organism-gene

PR:B3DIG4 frizzled-5 (zebrafish)

z-FZD5

organism-gene

PR:Q13467 frizzled-5 (human)

hFZD5

organism-sequence

PR:Q13467-1 frizzled-5 isoform 1 (human)

hFZD5/iso:1

organism-modification

PR:000047475 frizzled-5, signal peptide removed form (human)

hFZD5/SigPep-

organism-modification

PR:000047476 frizzled-5, signal peptide removed ubiquitinated form (human)

hFZD5/SigPep-/UbiqLys+

organism-modification

PR:000047476 frizzled-5, signal peptide removed ubiquitinated form (human)

hFZD5/SigPep-/UbiqLys+

organism-modification

PR:000057033 frizzled-5 O-glycosylated 1 (human)

hFZD5/OGlyco:1

organism-gene

PR:Q1ZXI9 frizzled and smoothened-like protein O (Dictyostelium discoideum)

Dicty-FZD5

organism-gene

PR:Q8CHL0 frizzled-5 (rat)

rFZD5

organism-sequence

PR:Q8CHL0-1 frizzled-5 isoform 1 (rat)

rFZD5/iso:1

organism-gene

PR:Q9EQD0 frizzled-5 (mouse)

mFZD5

organism-sequence

PR:Q9EQD0-1 frizzled-5 isoform 1 (mouse)

mFZD5/iso:1

sequence

PR:000040435 frizzled-5 isoform 1

FZD5/iso:1

organism-sequence

PR:Q13467-1 frizzled-5 isoform 1 (human)

hFZD5/iso:1

organism-sequence

PR:Q8CHL0-1 frizzled-5 isoform 1 (rat)

rFZD5/iso:1

organism-sequence

PR:Q9EQD0-1 frizzled-5 isoform 1 (mouse)

mFZD5/iso:1

gene

PR:000007722 frizzled-6

FZD6

organism-gene

PR:O60353 frizzled-6 (human)

hFZD6

organism-sequence

PR:O60353-1 frizzled-6 isoform h1 (human)

hFZD6/iso:h1

organism-sequence

PR:O60353-2 frizzled-6 isoform h2 (human)

hFZD6/iso:h2

organism-modification

PR:000047477 frizzled-6, signal peptide removed ubiquitinated form (human)

hFZD6/SigPep-/UbiqLys+

organism-modification

PR:000050771 frizzled-6 N-glycosylated 1 (human)

hFZD6/NGlyco:1

organism-modification

PR:000050772 frizzled-6 N-glycosylated 2 (human)

hFZD6/NGlyco:2

organism-modification

PR:000050773 frizzled-6 O-glycosylated 1 (human)

hFZD6/OGlyco:1

organism-modification

PR:000050774 frizzled-6 O-glycosylated 2 (human)

hFZD6/OGlyco:2

organism-modification

PR:000063743 frizzled-6, signal peptide removed form (human)

hFZD6/SigPep-

organism-modification

PR:000047477 frizzled-6, signal peptide removed ubiquitinated form (human)

hFZD6/SigPep-/UbiqLys+

organism-modification

PR:000066533 frizzled-6 cysteinylated 1 (human)

hFZD6/Cyst:1

organism-modification

PR:000080579 frizzled-6 deaminated 1 (human)

hFZD6/Deam:1

organism-gene

PR:Q61089 frizzled-6 (mouse)

mFZD6

gene

PR:000007723 frizzled-7

FZD7

organism-gene

PR:O57329 frizzled-7 (chicken)

chick-FZD7

organism-gene

PR:O75084 frizzled-7 (human)

hFZD7

organism-modification

PR:000047478 frizzled-7, signal peptide removed form (human)

hFZD7/SigPep-

organism-modification

PR:000050815 frizzled-7 O-glycosylated 1 (human)

hFZD7/OGlyco:1

organism-gene

PR:Q61090 frizzled-7 (mouse)

mFZD7

organism-modification

PR:000068087 frizzled-7 cysteinylated 1 (mouse)

mFZD7/Cyst:1

gene

PR:000007724 frizzled-8

FZD8

organism-gene

PR:Q498S8 frizzled-8 (rat)

rFZD8

organism-gene

PR:Q61091 frizzled-8 (mouse)

mFZD8

organism-gene

PR:Q9H461 frizzled-8 (human)

hFZD8

organism-modification

PR:000047479 frizzled-8, signal peptide removed form (human)

hFZD8/SigPep-

organism-modification

PR:000047480 frizzled-8, signal peptide removed ubiquitinated form (human)

hFZD8/SigPep-/UbiqLys+

organism-modification

PR:000047480 frizzled-8, signal peptide removed ubiquitinated form (human)

hFZD8/SigPep-/UbiqLys+

gene

PR:000015288 protein smoothened

SMO

organism-gene

PR:P56726 protein smoothened (mouse)

mSMO

organism-sequence

PR:P56726-1 protein smoothened isoform 1 (mouse)

mSMO/iso:1

organism-gene

PR:P91682 protein smoothened (fruit fly)

fly-SMO

organism-gene

PR:P97698 protein smoothened (rat)

rSMO

organism-sequence

PR:P97698-1 protein smoothened isoform 1 (rat)

rSMO/iso:1

organism-gene

PR:Q5RH73 protein smoothened (zebrafish)

z-SMO

organism-gene

PR:Q99835 protein smoothened (human)

hSMO

organism-modification

PR:000049297 protein smoothened, signal peptide removed form (human)

hSMO/SigPep-

organism-modification

PR:000049298 protein smoothened, signal peptide removed phosphorylated 1 (human)

hSMO/SigPep-/Phos:1

organism-modification

PR:000049299 protein smoothened, signal peptide removed phosphorylated 2 (human)

hSMO/SigPep-/Phos:2

organism-modification

PR:000057979 protein smoothened N-glycosylated 1 (human)

hSMO/NGlyco:1

organism-modification

PR:000057980 protein smoothened O-glycosylated 1 (human)

hSMO/OGlyco:1

organism-modification

PR:000057981 protein smoothened O-glycosylated 2 (human)

hSMO/OGlyco:2

sequence

PR:000039833 protein smoothened isoform 1

SMO/iso:1

organism-sequence

PR:P56726-1 protein smoothened isoform 1 (mouse)

mSMO/iso:1

organism-sequence

PR:P97698-1 protein smoothened isoform 1 (rat)

rSMO/iso:1