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Protein Ontology report - cell adhesion molecule CEACAM1
PR:000001328 - http://purl.obolibrary.org/obo/PR_000001328
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001328   
  PRO namecell adhesion molecule CEACAM1 
  Synonyms
PRO-Short-label: EXACT:CEACAM1
Gene-based: RELATED:BGP | BGP1
Other: EXACT:BGP-1 | biliary glycoprotein 1 | biliary glycoprotein D | carcinoembryonic antigen-related cell adhesion molecule 1 | CD66a | CEA cell adhesion molecule 1 | MHV-R | MHVR1
RELATED:Bgpd | murine hepatitis virus receptor
  Definition"A protein that is a translation product of the human CEACAM1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 29                                        
         Modification1                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001328 cell adhesion molecule CEACAM1
CEACAM1

organism-gene


PR:P13688 cell adhesion molecule CEACAM1 (human)
hCEACAM1

organism-sequence


PR:P13688-1 cell adhesion molecule CEACAM1 isoform h1 (human)
hCEACAM1/iso:h1

organism-sequence


PR:P13688-10 cell adhesion molecule CEACAM1 isoform h10 (human)
hCEACAM1/iso:h10

organism-sequence


PR:P13688-11 cell adhesion molecule CEACAM1 isoform h11 (human)
hCEACAM1/iso:h11

organism-sequence


PR:P13688-2 cell adhesion molecule CEACAM1 isoform h2 (human)
hCEACAM1/iso:h2

organism-sequence


PR:P13688-3 cell adhesion molecule CEACAM1 isoform h3 (human)
hCEACAM1/iso:h3

organism-sequence


PR:P13688-4 cell adhesion molecule CEACAM1 isoform h4 (human)
hCEACAM1/iso:h4

organism-sequence


PR:P13688-5 cell adhesion molecule CEACAM1 isoform h5 (human)
hCEACAM1/iso:h5

organism-sequence


PR:P13688-6 cell adhesion molecule CEACAM1 isoform h6 (human)
hCEACAM1/iso:h6

organism-sequence


PR:P13688-7 cell adhesion molecule CEACAM1 isoform h7 (human)
hCEACAM1/iso:h7

organism-sequence


PR:P13688-8 cell adhesion molecule CEACAM1 isoform h8 (human)
hCEACAM1/iso:h8

organism-sequence


PR:P13688-9 cell adhesion molecule CEACAM1 isoform h9 (human)
hCEACAM1/iso:h9

organism-modification


PR:000046685 cell adhesion molecule CEACAM1, signal peptide removed form (human)
hCEACAM1/SigPep-

organism-modification


PR:000067993 cell adhesion molecule CEACAM1 deaminated 1 (human)
hCEACAM1/Deam:1

organism-modification


PR:000081435 cell adhesion molecule CEACAM1 deaminated 2 (human)
hCEACAM1/Deam:2

organism-gene


PR:P16573 cell adhesion molecule CEACAM1 (rat)
rCEACAM1

organism-sequence


PR:P16573-1 cell adhesion molecule CEACAM1 isoform r1 (rat)
rCEACAM1/iso:r1

organism-sequence


PR:P16573-2 cell adhesion molecule CEACAM1 isoform r2 (rat)
rCEACAM1/iso:r2

organism-gene


PR:P31809 cell adhesion molecule CEACAM1 (mouse)
mCEACAM1

organism-sequence


PR:000044466 cell adhesion molecule CEACAM1 sequence variant CEACAM1a (mouse)
mCEACAM1a
Yes
organism-sequence


PR:P31809-1 CEACAM1a-4L (mouse)
mCEACAM1a/iso:4L
Yes
organism-sequence


PR:P31809-2 CEACAM1a-4S (mouse)
mCEACAM1a/iso:4S

organism-sequence


PR:P31809-3 CEACAM1a-2L (mouse)
mCEACAM1a/iso:3
Yes
organism-sequence


PR:P31809-4 CEACAM1a-2S (mouse)
mCEACAM1a/iso:2S
Yes
organism-modification


PR:000044462 CEACAM1a-2S, signal peptide removed form (mouse)
mCEACAM1a/iso:2S/SigPep-

organism-modification


PR:000044488 CEACAM1a-2S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2S/SigPep-/NGlycoAsn+
Yes
organism-sequence


PR:Q3LFS5 CEACAM1a-4C1 (mouse)
mCEACAM1a/iso:4C1

organism-sequence


PR:Q3LFS6 CEACAM1a-2C1 (mouse)
mCEACAM1a/iso:2C1

organism-sequence


PR:Q3LFS7 CEACAM1a-2 (mouse)
mCEACAM1a/iso:2

organism-sequence


PR:000044467 cell adhesion molecule CEACAM1 sequence variant CEACAM1b (mouse)
mCEACAM1b
Yes
organism-sequence


PR:000044491 CEACAM1b-4C1 (mouse)
mCEACAM1b/iso:4C1

organism-sequence


PR:000044492 CEACAM1b-2C1 (mouse)
mCEACAM1b/iso:2C1

organism-sequence


PR:000044493 CEACAM1b-2 (mouse)
mCEACAM1b/iso:2

organism-seqgroup


PR:000044500 CEACAM1b-4 (mouse)
mCEACAM1b/iso:4

organism-modification


PR:000044501 CEACAM1b-4, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1b/iso:4/SigPep-/NGlycoAsn+
Yes




PR:Q61351 CEACAM1b-4S (mouse)





PR:Q61352 CEACAM1b-4L (mouse)

organism-sequence


PR:Q61351 CEACAM1b-4S (mouse)
mCEACAM1b/iso:4S

organism-sequence


PR:Q61352 CEACAM1b-4L (mouse)
mCEACAM1b/iso:4L

organism-sequence


PR:Q61354 CEACAM1b-2L (mouse)
mCEACAM1b/iso:2L

organism-sequence


PR:Q99232 CEACAM1b-2S (mouse)
mCEACAM1b/iso:2S
Yes
union


PR:000044490 CEACAM1a-2 N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2/NGlycoAsp+
Yes
organism-modification


PR:000044488 CEACAM1a-2S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2S/SigPep-/NGlycoAsn+

organism-modification


PR:000044499 CEACAM1a-2L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2L/SigPep-/NGlycoAsn+

organism-modification


PR:000044463 CEACAM1a-4L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4L/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044464 CEACAM1a-4L, signal peptide removed N-glycosylated and phosphorylated 1 (mouse)
mCEACAM1a/iso:4L/SigPep-/NGlycoPhos:1
Yes
organism-modification


PR:000044465 CEACAM1a-4S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4S/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044468 CEACAM1b-4S, signal peptide removed form (mouse)
mCEACAM1a/iso:4S/SigPep-

organism-modification


PR:000044469 CEACAM1a-4C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4C1/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044470 CEACAM1a-2C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2C1/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044471 CEACAM1a-2, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044472 CEACAM1b-2S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1b/iso:2S/SigPep-/NGlycoAsn+
Yes
union


PR:000044489 CEACAM1a-4 N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4/NGlycoAsp+
Yes
organism-modification


PR:000044463 CEACAM1a-4L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4L/SigPep-/NGlycoAsn+

organism-modification


PR:000044465 CEACAM1a-4S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4S/SigPep-/NGlycoAsn+

organism-modification


PR:000044499 CEACAM1a-2L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2L/SigPep-/NGlycoAsn+

organism-modification


PR:000044502 CEACAM1a-C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:C1/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044469 CEACAM1a-4C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4C1/SigPep-/NGlycoAsn+

organism-modification


PR:000044470 CEACAM1a-2C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2C1/SigPep-/NGlycoAsn+

organism-modification


PR:000044512 CEACAM1a-2L, signal peptide removed and phosphorylated 1 (mouse)
mCEACAM1a/iso:2L/SigPep-/Phos:1

modification


PR:000018399 cell adhesion molecule CEACAM1, signal peptide removed form
CEACAM1/SigPep-

organism-modification


PR:000044462 CEACAM1a-2S, signal peptide removed form (mouse)
mCEACAM1a/iso:2S/SigPep-

organism-modification


PR:000044488 CEACAM1a-2S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2S/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044463 CEACAM1a-4L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4L/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044464 CEACAM1a-4L, signal peptide removed N-glycosylated and phosphorylated 1 (mouse)
mCEACAM1a/iso:4L/SigPep-/NGlycoPhos:1
Yes
organism-modification


PR:000044465 CEACAM1a-4S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4S/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044468 CEACAM1b-4S, signal peptide removed form (mouse)
mCEACAM1a/iso:4S/SigPep-

organism-modification


PR:000044469 CEACAM1a-4C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4C1/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044470 CEACAM1a-2C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2C1/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044471 CEACAM1a-2, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044472 CEACAM1b-2S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1b/iso:2S/SigPep-/NGlycoAsn+
Yes
union


PR:000044489 CEACAM1a-4 N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4/NGlycoAsp+
Yes
organism-modification


PR:000044463 CEACAM1a-4L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4L/SigPep-/NGlycoAsn+

organism-modification


PR:000044465 CEACAM1a-4S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4S/SigPep-/NGlycoAsn+

union


PR:000044490 CEACAM1a-2 N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2/NGlycoAsp+
Yes
organism-modification


PR:000044488 CEACAM1a-2S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2S/SigPep-/NGlycoAsn+

organism-modification


PR:000044499 CEACAM1a-2L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2L/SigPep-/NGlycoAsn+

organism-modification


PR:000044499 CEACAM1a-2L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2L/SigPep-/NGlycoAsn+

organism-modification


PR:000044501 CEACAM1b-4, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1b/iso:4/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044502 CEACAM1a-C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:C1/SigPep-/NGlycoAsn+
Yes
organism-modification


PR:000044469 CEACAM1a-4C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4C1/SigPep-/NGlycoAsn+

organism-modification


PR:000044470 CEACAM1a-2C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2C1/SigPep-/NGlycoAsn+

organism-modification


PR:000044512 CEACAM1a-2L, signal peptide removed and phosphorylated 1 (mouse)
mCEACAM1a/iso:2L/SigPep-/Phos:1

organism-modification


PR:000046685 cell adhesion molecule CEACAM1, signal peptide removed form (human)
hCEACAM1/SigPep-

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044463 mCEACAM1a/iso:4L/SigPep-/NGlycoAsn+
UniProtKB:P31809-1, 35-521, MOD:00160		 acts_upstream_of_or_withinGO:0032703 negative regulation of interleukin-2 production MGI_ref:3693042; PMID:17081782
GO:0042130 negative regulation of T cell proliferation MGI_ref:5451119; PMID:23123061
GO:0042130 negative regulation of T cell proliferation MGI_ref:5451119; PMID:23123061
located_inGO:0009897 external side of plasma membrane MGI_ref:3693042; PMID:17081782
PR:000044464 mCEACAM1a/iso:4L/SigPep-/NGlycoPhos:1
UniProtKB:P31809-1, 35-521, Tyr-488/Tyr-515, MOD:00048|MOD:00160		 enablesGO:0005515 protein binding with PR:P29351 70Z-SHP (mouse) MGI_ref:1326994; PMID:9867848
GO:0005515 protein binding with PR:P29351 70Z-SHP (mouse) MGI_ref:1326994; PMID:9867848
GO:0005515 protein binding with PR:P35235 mPTPN11 MGI_ref:1326994; PMID:9867848
PR:000044465 mCEACAM1a/iso:4S/SigPep-/NGlycoAsn+
UniProtKB:P31809-2, 35-458, MOD:00160		 acts_upstream_of_or_withinGO:0002639 positive regulation of immunoglobulin production MGI_ref:5451119; PMID:23123061
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules MGI_ref:5608586; PMID:1633107
GO:0042102 positive regulation of T cell proliferation MGI_ref:5451119; PMID:23123061
GO:0046718 symbiont entry into host cell MGI_ref:49235; PMID:1719235
GO:0048541 Peyer's patch development MGI_ref:5451119; PMID:23123061
GO:0070237 positive regulation of activation-induced cell death of T cells MGI_ref:5451119; PMID:23123061
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade MGI_ref:5451119; PMID:23123061
GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation MGI_ref:5451119; PMID:23123061
GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation MGI_ref:5451119; PMID:23123061
GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation MGI_ref:5451119; PMID:23123061
enablesGO:0001618 virus receptor activity MGI_ref:49235; PMID:1719235
GO:0046790 virion binding MGI_ref:3053174; PMID:8380065
located_inGO:0009897 external side of plasma membrane MGI_ref:81180; PMID:8896983
GO:0009897 external side of plasma membrane MGI_ref:81180; PMID:8896983
PR:000044466 mCEACAM1a
Example: PR:P31809-1		 acts_upstream_of_or_withinGO:0044794 host-mediated activation of viral process MGI_ref:1098064; PMID:9343248
PR:000044467 mCEACAM1b
The sequence has, minimally, a Thr instead of Ile at position 75, and His instead of Arg at position 81 in comparison to allele CEACAM1a (using the sequence numbering of UniProtKB:P31809-1 for the latter)		 acts_upstream_of_or_withinGO:0044793 host-mediated suppression of viral proces MGI_ref:1098064; PMID:9343248
GO:0044828 host-mediated suppression of viral genome replication MGI_ref:55926; PMID:6327825
PR:000044469 mCEACAM1a/iso:4C1/SigPep-/NGlycoAsn+
UniProtKB:Q3LFS5, 35-458, MOD:00160		 acts_upstream_of_or_withinGO:0044793 host-mediated suppression of viral proces MGI_ref:3848729; PMID:19358828
located_inGO:0005615 extracellular space MGI_ref:3848729; PMID:19358828
PR:000044470 mCEACAM1a/iso:2C1/SigPep-/NGlycoAsn+
UniProtKB:Q3LFS6, 35-270, MOD:00160		 located_inGO:0005615 extracellular space MGI_ref:3848729; PMID:19358828
PR:000044471 mCEACAM1a/iso:2/SigPep-/NGlycoAsn+
UniProtKB:Q3LFS7, 35-236, MOD:00160		 located_inGO:0005615 extracellular space MGI_ref:3848729; PMID:19358828
PR:000044472 mCEACAM1b/iso:2S/SigPep-/NGlycoAsn+
UniProtKB:Q99232, 35-278, MOD:00160		 enablesNOT GO:0046790 virion binding MGI_ref:3053174; PMID:8380065
PR:000044488 mCEACAM1a/iso:2S/SigPep-/NGlycoAsn+
UniProtKB:P31809-4, 35-278, MOD:00160		 enablesGO:0046790 virion binding MGI_ref:3053174; PMID:8380065
PR:000044489 mCEACAM1a/iso:4/NGlycoAsp+ acts_upstream_of_or_withinGO:0044794 host-mediated activation of viral process MGI_ref:2148352; PMID:11483763
enablesNOT GO:0001618 virus receptor activity MGI_ref:5608587; PMID:2164599
located_inGO:0016020 membrane MGI_ref:73162; PMID:1648219
GO:0016020 membrane MGI_ref:73162; PMID:1648219
GO:0016020 membrane MGI_ref:73162; PMID:1648219
GO:0031526 brush border membrane MGI_ref:73162; PMID:1648219
PR:000044490 mCEACAM1a/iso:2/NGlycoAsp+ acts_upstream_of_or_withinGO:0044793 host-mediated suppression of viral proces MGI_ref:2148352; PMID:11483763
enablesNOT GO:0001618 virus receptor activity MGI_ref:5608587; PMID:2164599
located_inGO:0016020 membrane MGI_ref:63233; PMID:8402684
GO:0016020 membrane MGI_ref:63233; PMID:8402684
GO:0031526 brush border membrane MGI_ref:73162; PMID:1648219
PR:000044501 mCEACAM1b/iso:4/SigPep-/NGlycoAsn+ located_inGO:0031526 brush border membrane MGI_ref:73162; PMID:1648219
PR:000044502 mCEACAM1a/iso:C1/SigPep-/NGlycoAsn+ located_inGO:0005615 extracellular space MGI_ref:3848729; PMID:19358828
PR:P31809-1 mCEACAM1a/iso:4L
This form contains the four copies of the Ig domain and is the version with longer cytoplasmic tail		 acts_upstream_of_or_withinGO:0032703 negative regulation of interleukin-2 production MGI_ref:3693042; PMID:17081782
GO:0042130 negative regulation of T cell proliferation MGI_ref:3693042; PMID:17081782
PR:P31809-3 mCEACAM1a/iso:3
This form contains the two copies of the Ig domain and is the version with longer cytoplasmic tail		 acts_upstream_of_or_withinGO:0032703 negative regulation of interleukin-2 production MGI_ref:3693042; PMID:17081782
GO:0046329 negative regulation of JNK cascade MGI_ref:3693042; PMID:17081782
PR:P31809-4 mCEACAM1a/iso:2S
This form contains the two copies of the Ig domain and is the version with shorter cytoplasmic tail		 acts_upstream_of_or_withinGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules MGI_ref:5503958; PMID:10491101
located_inGO:0009897 external side of plasma membrane MGI_ref:81180; PMID:8896983
GO:0009897 external side of plasma membrane MGI_ref:81180; PMID:8896983
PR:Q99232 mCEACAM1b/iso:2S
This form contains the two copies of the Ig domain and is the version with shorter cytoplasmic tail		 acts_upstream_of_or_withinGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules MGI_ref:59357; PMID:1985902