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Protein Ontology report - proteinase-activated receptor 4
PR:000001664 - http://purl.obolibrary.org/obo/PR_000001664
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000001664   
  PRO nameproteinase-activated receptor 4 
  Synonyms
PRO-Short-label: EXACT:F2RL3
Gene-based: RELATED:PAR4
Other: EXACT:coagulation factor II receptor-like 3 | PAR-4 | thrombin receptor-like 3
  Definition"A proteinase-activated receptor that is a translation product of the human F2RL3 gene or a 1:1 ortholog thereof. It is activated by thrombin and cathepsin G, which cleave the mature peptide, exposing a new amino end. The six new N-terminal residues act as a tethered ligand that induces activity." [PMID:10702240, PMID:9618465, PRO:WCB] 
  PRO Categorygene 
  ParentPR:000001550 proteinase-activated receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:350
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001664
proteinase-activated receptor 4
F2RL3
"A proteinase-activated receptor that is a translation product of the human F2RL3 gene or a 1:1 ortholog thereof. It is activated by thrombin and cathepsin G, which cleave the mature peptide, exposing a new amino end. The six new N-terminal residues act as a tethered ligand that induces activity." [PMID:10702240, PMID:9618465, PRO:WCB]

organism-gene


PR:O88634
proteinase-activated receptor 4 (mouse)
mF2RL3
"A proteinase-activated receptor 4 that is encoded in the genome of mouse." [OMA:O88634, PRO:DNx]

organism-gene


PR:Q920E0
proteinase-activated receptor 4 (rat)
rF2RL3
"A proteinase-activated receptor 4 that is encoded in the genome of rat." [OMA:Q920E0, PRO:DNx]

organism-gene


PR:Q96RI0
proteinase-activated receptor 4 (human)
hF2RL3
"A proteinase-activated receptor 4 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q96RI0]

organism-modification


PR:000047351
proteinase-activated receptor 4, signal peptide removed form (human)
hF2RL3/SigPep-
"A proteinase-activated receptor 4 (human) that has had the signal peptide removed. UniProtKB:Q96RI0, 18-385." [PRO:DNx, Reactome:R-HSA-61315]

organism-modification


PR:000084005
proteinase-activated receptor 4, mature form (human)
hF2RL3/mature
"A proteinase-activated receptor 4 (human) that has had the signal peptide and propeptide removed. UniProtKB:Q96RI0, 48-385." [PRO:DNx, Reactome:R-HSA-114533]

organism-modification


PR:000067745
proteinase-activated receptor 4 deaminated 1 (human)
hF2RL3/Deam:1
"A proteinase-activated receptor 4 (human) that has been deaminated on the residue at the position equivalent to Asn-332 of the amino acid sequence represented by UniProtKB:Q96RI0. UniProtKB:Q96RI0, Asn-332, MOD:00684." [IEDB_epitope:1325665, PRO:DNx]

organism-modification


PR:000084005
proteinase-activated receptor 4, mature form (human)
hF2RL3/mature
"A proteinase-activated receptor 4 (human) that has had the signal peptide and propeptide removed. UniProtKB:Q96RI0, 48-385." [PRO:DNx, Reactome:R-HSA-114533]