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Protein Ontology report - transient receptor potential cation channel TRPM8
PR:000001719 - http://purl.obolibrary.org/obo/PR_000001719
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001719   
  PRO nametransient receptor potential cation channel TRPM8 
  Synonyms
PRO-Short-label: EXACT:TRPM8
Gene-based: RELATED:LTRPC6 | TRPP8
Other: EXACT:long transient receptor potential channel 6 | LTrpC-6 | LTrpC6 | transient receptor potential p8 | Trp-p8
  Definition"A transient receptor potential channel protein that is a translation product of the human TRPM8 gene or a 1:1 ortholog thereof. TRPM8 is a member of the subfamily M of the transient receptor potential cation channels (TRPs). In common with other TRPs, these proteins have amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity.TRPM8 forms a nonselective cation channel that is activated by cold and by menthol and other substances that produce the sensation of coolness. These channels exhibit voltage-dependance and regulation by phosphatidylinositol-4,5-bisphosphate (PIP2)." [PMID:15852009, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000044657 transient receptor potential channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 5                                        
         Modification2                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038526;IUPHARobj:500
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001719 transient receptor potential cation channel TRPM8
TRPM8

organism-gene


PR:Q7Z2W7 transient receptor potential cation channel subfamily M member 8 (human)
hTRPM8

organism-sequence


PR:Q7Z2W7-1 transient receptor potential cation channel subfamily M member 8 isoform 1 (human)
hTRPM8/iso:1

organism-sequence


PR:Q7Z2W7-2 transient receptor potential cation channel subfamily M member 8 isoform 2 (human)
hTRPM8/iso:2

organism-sequence


PR:Q7Z2W7-3 transient receptor potential cation channel subfamily M member 8 isoform 3 (human)
hTRPM8/iso:3

organism-sequence


PR:Q7Z2W7-4 transient receptor potential cation channel subfamily M member 8 isoform h4 (human)
hTRPM8/iso:h4

organism-modification


PR:000071823 transient receptor potential cation channel subfamily M member 8 phosphorylated 1 (human)
hTRPM8/Phos:1

organism-modification


PR:000081248 transient receptor potential cation channel subfamily M member 8 phosphorylated 2 (human)
hTRPM8/Phos:2

organism-gene


PR:Q8R455 transient receptor potential cation channel subfamily M member 8 (rat)
rTRPM8

organism-gene


PR:Q8R4D5 transient receptor potential cation channel subfamily M member 8 (mouse)
mTRPM8
Yes
organism-sequence


PR:Q8R4D5-1 transient receptor potential cation channel subfamily M member 8 isoform 1 (mouse)
mTRPM8/iso:1

organism-modification


PR:000036607 transient receptor potential cation channel TRPM8 isoform 1 N-glycosylated 1 (mouse)
mTRPM8/iso:1/NGlyco:1

sequence


PR:000001720 transient receptor potential cation channel TRPM8 isoform 1
TRPM8/iso:1

organism-sequence


PR:Q7Z2W7-1 transient receptor potential cation channel subfamily M member 8 isoform 1 (human)
hTRPM8/iso:1

organism-sequence


PR:Q8R4D5-1 transient receptor potential cation channel subfamily M member 8 isoform 1 (mouse)
mTRPM8/iso:1

organism-modification


PR:000036607 transient receptor potential cation channel TRPM8 isoform 1 N-glycosylated 1 (mouse)
mTRPM8/iso:1/NGlyco:1

modification


PR:000001723 transient receptor potential cation channel TRPM8 isoform 1 glycosylated form
TRPM8/iso:1/GlycoRes+

modification


PR:000001724 transient receptor potential cation channel TRPM8 isoform 1 N-glycosylated 1
TRPM8/iso:1/NGlyco:1

organism-modification


PR:000036607 transient receptor potential cation channel TRPM8 isoform 1 N-glycosylated 1 (mouse)
mTRPM8/iso:1/NGlyco:1

sequence


PR:000001721 transient receptor potential cation channel TRPM8 isoform 2
TRPM8/iso:2

organism-sequence


PR:Q7Z2W7-2 transient receptor potential cation channel subfamily M member 8 isoform 2 (human)
hTRPM8/iso:2

sequence


PR:000001722 transient receptor potential cation channel TRPM8 isoform 3
TRPM8/iso:3

organism-sequence


PR:Q7Z2W7-3 transient receptor potential cation channel subfamily M member 8 isoform 3 (human)
hTRPM8/iso:3

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q8R4D5 mTRPM8 acts_upstream_of_or_withinGO:0006816 calcium ion transport PMID:17015441
GO:0009409 response to cold PMID:17538622
GO:0009409 response to cold PMID:17538622
GO:0009409 response to cold PMID:17538622
GO:0009409 response to cold PMID:17538622
GO:0050955 thermoception PMID:17538622
GO:0050955 thermoception PMID:17538622
GO:0050955 thermoception PMID:17538622
GO:0051289 protein homotetramerization PMID:17015441
GO:0070207 protein homotrimerization PMID:17015441
enablesGO:0005262 calcium channel activity PMID:17538622
GO:0005262 calcium channel activity PMID:17538622
GO:0042803 protein homodimerization activity PMID:17015441
located_inGO:0009897 external side of plasma membrane PMID:17015441