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Protein Ontology report - TIR domain-containing adapter molecule 2

PR:000001750 - http://purl.obolibrary.org/obo/PR_000001750

Protein Forms

Complex

Ontology Information

Show OBO stanza

PRO ID

PR:000001750

PRO name

TIR domain-containing adapter molecule 2

Synonyms

PRO-Short-label:	EXACT:	TICAM2
Gene-based:	RELATED:	TIRAP3 \| TIRP \| TRAM
Other:	EXACT:	putative NF-kappa-B-activating protein 502 \| TICAM-2 \| Toll-like receptor adaptor protein 3 \| Toll/interleukin-1 receptor domain-containing protein \| TRIF-related adapter molecule

Definition

"A protein that is a translation product of the human TICAM2 gene or a 1:1 ortholog thereof." [PRO:CNA]

PRO Category

gene

Parent

PR:000000001 protein

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	2
Sequence	1	Organism-Sequence	3
Modification	2	Organism-Modification	3

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	PIRSF:PIRSF037745

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000001750 TIR domain-containing adapter molecule 2

TICAM2

organism-gene

PR:Q86XR7 TIR domain-containing adapter molecule 2 (human)

hTICAM2

organism-sequence

PR:Q86XR7-1 TIR domain-containing adapter molecule 2 isoform 1 (human)

hTICAM2/iso:1

organism-modification

PR:000027201 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated 1 (human)

hTICAM2/iso:1/InitMet-/Myr:1

organism-modification

PR:000040891 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)

hTICAM2/iso:1/InitMet-/MyrPhos:1

Yes

organism-sequence

PR:Q86XR7-2 TIR domain-containing adapter molecule 2 isoform h2 (human)

hTICAM2/iso:h2

organism-modification

PR:000063665 TIR domain-containing adapter molecule 2, initiator methionine removed myristoylated and phosphorylated 1 (human)

hTICAM2/InitMet-/MyrPhos:1

organism-gene

PR:Q8BJQ4 TIR domain-containing adapter molecule 2 (mouse)

mTICAM2

Yes

organism-sequence

PR:Q8BJQ4-1 TIR domain-containing adapter molecule 2 isoform 1 (mouse)

mTICAM2/iso:1

sequence

PR:000027197 TIR domain-containing adapter molecule 2 isoform 1

TICAM2/iso:1

organism-sequence

PR:Q86XR7-1 TIR domain-containing adapter molecule 2 isoform 1 (human)

hTICAM2/iso:1

organism-modification

PR:000027201 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated 1 (human)

hTICAM2/iso:1/InitMet-/Myr:1

organism-modification

PR:000040891 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)

hTICAM2/iso:1/InitMet-/MyrPhos:1

Yes

organism-sequence

PR:Q8BJQ4-1 TIR domain-containing adapter molecule 2 isoform 1 (mouse)

mTICAM2/iso:1

modification

PR:000027199 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed form

TICAM2/iso:1/InitMet-

modification

PR:000027200 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form

TICAM2/iso:1/InitMet-/MyrRes+

organism-modification

PR:000027201 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated 1 (human)

hTICAM2/iso:1/InitMet-/Myr:1

organism-modification

PR:000040891 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)

hTICAM2/iso:1/InitMet-/MyrPhos:1

Yes

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TICAM2 forms found in complexes

TICAM2 Component	Complexes
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1	PR:000027208 Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000028678 Ticam2:activated TLR4 complex (human)
	PR:000028680 traf6:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000035715 pUbtraf6:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036022 traf3:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036024 Rip1:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036027 sarm:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036030 IRF3:p-tbk1:K63polyUbiq-TRAF3:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036034 IRF7:p-tbk1:K63polyUbiq-TRAF3:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036036 IRF3:p-IKKE:K63polyUbiq-TRAF3:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036038 IRF7:p-IKKE:K63polyUbiq-TRAF3:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036041 K63polyUbiq-TRAF3:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036049 K63-pUb-Rip1:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036053 IKK complex:K63-pUb-Rip1:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036056 rip3:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036058 Rip1:rip3:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036060 pro-caspase-8:fadd:Rip1:Ticam1:Ticam2:activated TLR4 complex (human)
	PR:000036123 p-tbk1:K63polyUbiq-TRAF3:Ticam1:Ticam2:activated TLR4 complex complex (human)
	PR:000036124 p-IKKE:K63polyUbiq-TRAF3:Ticam1:Ticam2:activated TLR4 complex complex (human)
PR:Q8BJQ4 mTICAM2	PR:000027204 Ticam2:activated TLR4 complex (mouse)
	PR:000027207 Ticam1:Ticam2:activated TLR4 complex (mouse)
	PR:000028683 traf3:Ticam1:Ticam2:activated TLR4 complex (mouse)
	PR:000035710 traf6:Ticam1:Ticam2:activated TLR4 complex (mouse)
	PR:000036090 tbk1:tank:ikke:traf3:Ticam1:Ticam2:activated TLR4 complex (mouse)
	PR:000036093 tbk1:K63polyUbiq-tank:Ikke:traf3:Ticam1:Ticam2:activated TLR4 complex (mouse)
	PR:000036095 K63polyUbiq-tank:traf3:Ticam1:Ticam2:activated TLR4 complex (mouse)
	PR:000036097 tbk1:K63polyUbiq-tank:traf3:Ticam1:Ticam2:activated TLR4 complex (mouse)
	PR:000036099 ikke:K63polyUbiq-tank:traf3:Ticam1:Ticam2:activated TLR4 complex (mouse)
	PR:000036101 Rip1:traf6:Ticam1:Ticam2:activated TLR4 complex (mouse)
	PR:000036105 pel1:Rip1:traf6:Ticam1:Ticam2:activated TLR4 complex (mouse)
	PR:000036109 pel1:K63polyUbiq-Rip1:traf6:Ticam1:Ticam2:activated TLR4 complex (mouse)