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Protein Ontology report - NF-kappa-B essential modulator
PR:000001752 - http://purl.obolibrary.org/obo/PR_000001752
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001752   
  PRO nameNF-kappa-B essential modulator 
  Synonyms
PRO-Short-label: EXACT:IKBKG
Gene-based: RELATED:FIP3 | NEMO
Other: EXACT:FIP-3 | I-kappa-B kinase subunit gamma | IkB kinase subunit gamma | IkB kinase-associated protein 1 | IKK-gamma | IKKAP1 | IKKG | inhibitor of nuclear factor kappa-B kinase subunit gamma | NF-kappa-B essential modifier
  Definition"A protein that is a translation product of the human IKBKG gene or a 1:1 ortholog thereof. In response to a large variety of stimuli, among them pro-inflammatory cytokines, growth factors and microbial pathogens, signals emanating from cell surface receptors converge at the IkappaB kinase (IKK) complex. This complex is composed of four subunits, IKKalpha, IKKbeta, ELK, and NEMO. IKKbeta and NEMO subunits are known to be essential for activating NF-kappaB. Activation of NF-kappaB dimers is the result of IKK-mediated, phosphorylation-induced degradation of the IkappaB inhibitor, which enables the NF-kappaB dimers to enter the nucleus and activate specific target gene expression." [PIRSF:PIRSF038160] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification5                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038160
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001752 NF-kappa-B essential modulator
IKBKG

organism-gene


PR:O88522 NF-kappa-B essential modulator (mouse)
mIKBKG

Yes
organism-gene


PR:Q6TMG5 NF-kappa-B essential modulator (rat)
rIKBKG

organism-gene


PR:Q9Y6K9 NF-kappa-B essential modulator (human)
hIKBKG

Yes
organism-sequence


PR:000060620 NF-kappa-B essential modulator sequence variant C417R (human)
hIKBKG/var:C417R

organism-sequence


PR:000061455 NF-kappa-B essential modulator sequence variant R175P (human)
hIKBKG/var:R175P

organism-sequence


PR:000062347 NF-kappa-B essential modulator sequence variant R173G (human)
hIKBKG/var:R173G

organism-sequence


PR:000062826 NF-kappa-B essential modulator sequence variant D406V (human)
hIKBKG/var:D406V

organism-sequence


PR:000062944 NF-kappa-B essential modulator sequence variant L153R (human)
hIKBKG/var:L153R

organism-sequence


PR:000064418 NF-kappa-B essential modulator sequence variant E391* (human)
hIKBKG/var:E391*

organism-sequence


PR:Q9Y6K9-1 NF-kappa-B essential modulator isoform 1 (human)
hIKBKG/iso:1

organism-modification


PR:000036612 NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human)
hIKBKG/iso:1/Phos:1

organism-modification


PR:000036613 NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human)
hIKBKG/iso:1/Phos:2

organism-modification


PR:000036614 NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human)
hIKBKG/iso:1/Phos:3

organism-sequence


PR:Q9Y6K9-2 NF-kappa-B essential modulator isoform h2 (human)
hIKBKG/iso:h2

organism-sequence


PR:Q9Y6K9-3 NF-kappa-B essential modulator isoform h3 (human)
hIKBKG/iso:h3

organism-modification


PR:000047980 NF-kappa-B essential modulator ubiquitinated 1 (human)
hIKBKG/Ubiq:1

organism-modification


PR:000064705 NF-kappa-B essential modulator ubiquitinated 2 (human)
hIKBKG/Ubiq:2

organism-modification


PR:000064734 NF-kappa-B essential modulator sumoylated 1 (human)
hIKBKG/Sumo:1

sequence


PR:000001763 NF-kappa-B essential modulator isoform 1
IKBKG/iso:1

organism-sequence


PR:Q9Y6K9-1 NF-kappa-B essential modulator isoform 1 (human)
hIKBKG/iso:1

organism-modification


PR:000036612 NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human)
hIKBKG/iso:1/Phos:1

organism-modification


PR:000036613 NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human)
hIKBKG/iso:1/Phos:2

organism-modification


PR:000036614 NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human)
hIKBKG/iso:1/Phos:3

modification


PR:000001764 NF-kappa-B essential modulator isoform 1 phosphorylated and ubiquitinated form
IKBKG/iso:1/PhosUbiq+

modification


PR:000001765 NF-kappa-B essential modulator isoform 1 phosphorylated form
IKBKG/iso:1/PhosRes+

modification


PR:000001764 NF-kappa-B essential modulator isoform 1 phosphorylated and ubiquitinated form
IKBKG/iso:1/PhosUbiq+

modification


PR:000001766 NF-kappa-B essential modulator isoform 1 phosphorylated 1
IKBKG/iso:1/Phos:1

organism-modification


PR:000036612 NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human)
hIKBKG/iso:1/Phos:1

modification


PR:000001767 NF-kappa-B essential modulator isoform 1 phosphorylated 2
IKBKG/iso:1/Phos:2

organism-modification


PR:000036613 NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human)
hIKBKG/iso:1/Phos:2

modification


PR:000001768 NF-kappa-B essential modulator isoform 1 phosphorylated 3
IKBKG/iso:1/Phos:3

organism-modification


PR:000036614 NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human)
hIKBKG/iso:1/Phos:3

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IKBKG forms found in complexes   

IKBKG Component
 Complexes
PR:O88522 mIKBKG PR:000036118 IkappaB kinase complex (mouse)
PR:000036119 activated IkappaB kinase complex (mouse)
PR:Q9Y6K9 hIKBKG PR:000026457 IkappaB kinase complex (human)
PR:000035833 activated IkappaB kinase complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)