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Protein Ontology report - NF-kappa-B essential modulator
PR:000001752 - http://purl.obolibrary.org/obo/PR_000001752
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001752   
  PRO nameNF-kappa-B essential modulator 
  Synonyms
PRO-Short-label: EXACT:IKBKG
Gene-based: RELATED:FIP3 | NEMO
Other: EXACT:FIP-3 | I-kappa-B kinase subunit gamma | IkB kinase subunit gamma | IkB kinase-associated protein 1 | IKK-gamma | IKKAP1 | IKKG | inhibitor of nuclear factor kappa-B kinase subunit gamma | NF-kappa-B essential modifier
  Definition"A protein that is a translation product of the human IKBKG gene or a 1:1 ortholog thereof. In response to a large variety of stimuli, among them pro-inflammatory cytokines, growth factors and microbial pathogens, signals emanating from cell surface receptors converge at the IkappaB kinase (IKK) complex. This complex is composed of four subunits, IKKalpha, IKKbeta, ELK, and NEMO. IKKbeta and NEMO subunits are known to be essential for activating NF-kappaB. Activation of NF-kappaB dimers is the result of IKK-mediated, phosphorylation-induced degradation of the IkappaB inhibitor, which enables the NF-kappaB dimers to enter the nucleus and activate specific target gene expression." [PIRSF:PIRSF038160] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification5                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038160
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001752
NF-kappa-B essential modulator
IKBKG
"A protein that is a translation product of the human IKBKG gene or a 1:1 ortholog thereof. In response to a large variety of stimuli, among them pro-inflammatory cytokines, growth factors and microbial pathogens, signals emanating from cell surface receptors converge at the IkappaB kinase (IKK) complex. This complex is composed of four subunits, IKKalpha, IKKbeta, ELK, and NEMO. IKKbeta and NEMO subunits are known to be essential for activating NF-kappaB. Activation of NF-kappaB dimers is the result of IKK-mediated, phosphorylation-induced degradation of the IkappaB inhibitor, which enables the NF-kappaB dimers to enter the nucleus and activate specific target gene expression." [PIRSF:PIRSF038160]

organism-gene


PR:O88522
NF-kappa-B essential modulator (mouse)
mIKBKG
"An NF-kappa-B essential modulator that is encoded in the genome of mouse." [OMA:O88522, PRO:DNx]

Yes
organism-gene


PR:Q6TMG5
NF-kappa-B essential modulator (rat)
rIKBKG
"An NF-kappa-B essential modulator that is encoded in the genome of rat." [OMA:Q6TMG5, PRO:DNx]

organism-gene


PR:Q9Y6K9
NF-kappa-B essential modulator (human)
hIKBKG
"An NF-kappa-B essential modulator that is encoded in the genome of human." [PRO:DNx]

Yes
organism-sequence


PR:000060620
NF-kappa-B essential modulator sequence variant C417R (human)
hIKBKG/var:C417R
"An NF-kappa-B essential modulator (human) that has an Arg residue at the position equivalent to Cys-417 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Cys-417, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-5262858]

organism-sequence


PR:000061455
NF-kappa-B essential modulator sequence variant R175P (human)
hIKBKG/var:R175P
"An NF-kappa-B essential modulator (human) that has a Pro residue at the position equivalent to Arg-175 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Arg-175, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-5262916]

organism-sequence


PR:000062347
NF-kappa-B essential modulator sequence variant R173G (human)
hIKBKG/var:R173G
"An NF-kappa-B essential modulator (human) that has a Gly residue at the position equivalent to Arg-173 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Arg-173, CHEBI:29947." [PRO:DNx, Reactome:R-HSA-5262966]

organism-sequence


PR:000062826
NF-kappa-B essential modulator sequence variant D406V (human)
hIKBKG/var:D406V
"An NF-kappa-B essential modulator (human) that has a Val residue at the position equivalent to Asp-406 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Asp-406, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-5262943]

organism-sequence


PR:000062944
NF-kappa-B essential modulator sequence variant L153R (human)
hIKBKG/var:L153R
"An NF-kappa-B essential modulator (human) that has an Arg residue at the position equivalent to Leu-153 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Leu-153, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-5262879]

organism-sequence


PR:000064418
NF-kappa-B essential modulator sequence variant E391* (human)
hIKBKG/var:E391*
"An NF-kappa-B essential modulator (human) that has has been truncated after the position equivalent to Glu-390 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, 1-390." [PRO:DNx, Reactome:R-HSA-5262924]

organism-sequence


PR:Q9Y6K9-1
NF-kappa-B essential modulator isoform 1 (human)
hIKBKG/iso:1
"An NF-kappa-B essential modulator isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000036612
NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human)
hIKBKG/iso:1/Phos:1
"An NF-kappa-B essential modulator isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6K9-1, Ser-31/Ser-43/Ser-376, MOD:00046." [PMID:12657630, PRO:CNA]

organism-modification


PR:000036613
NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human)
hIKBKG/iso:1/Phos:2
"An NF-kappa-B essential modulator isoform 1 phosphorylated 2 in human. UniProtKB:Q9Y6K9-1, Ser-68, MOD:00046." [PMID:17977820, PRO:CNA]

organism-modification


PR:000036614
NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human)
hIKBKG/iso:1/Phos:3
"An NF-kappa-B essential modulator isoform 1 phosphorylated 3 in human. UniProtKB:Q9Y6K9-1, Ser-85, MOD:00046." [PMID:16497931, PRO:CNA]

organism-sequence


PR:Q9Y6K9-2
NF-kappa-B essential modulator isoform h2 (human)
hIKBKG/iso:h2
"An NF-kappa-B essential modulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6K9-2." [PRO:DNx, UniProtKB:Q9Y6K9]

organism-sequence


PR:Q9Y6K9-3
NF-kappa-B essential modulator isoform h3 (human)
hIKBKG/iso:h3
"An NF-kappa-B essential modulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6K9-3." [PRO:DNx, UniProtKB:Q9Y6K9]

organism-modification


PR:000047980
NF-kappa-B essential modulator ubiquitinated 1 (human)
hIKBKG/Ubiq:1
"An NF-kappa-B essential modulator (human) that has been ubiquitinated on the residue at the position equivalent to Lys-285 of the amino acid sequence represented by UniProtKB:Q9Y6K9. UniProtKB:Q9Y6K9, Lys-285, MOD:01148." [PRO:DNx, Reactome:R-HSA-741397]

organism-modification


PR:000064705
NF-kappa-B essential modulator ubiquitinated 2 (human)
hIKBKG/Ubiq:2
"An NF-kappa-B essential modulator (human) that has been ubiquitinated on the residues at the positions equivalent to Lys-321, Lys-325, and Lys-326 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1 and that includes at least one additional ubiquitinated lysine. Example: UniProtKB:Q9Y6K9-1, Lys-321/Lys-325/Lys-326, MOD:01148|MOD:01148." [PRO:DNx, Reactome:R-HSA-202530]

organism-modification


PR:000064734
NF-kappa-B essential modulator sumoylated 1 (human)
hIKBKG/Sumo:1
"An NF-kappa-B essential modulator (human) that has been sumoylated on the residues at the positions equivalent to Lys-277 and Lys-309 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Lys-277/Lys-309, MOD:01149." [PRO:DNx, Reactome:R-HSA-4755449]

sequence


PR:000001763
NF-kappa-B essential modulator isoform 1
IKBKG/iso:1
"An NF-kappa-B essential modulator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6K9-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q9Y6K9-1
NF-kappa-B essential modulator isoform 1 (human)
hIKBKG/iso:1
"An NF-kappa-B essential modulator isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000036612
NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human)
hIKBKG/iso:1/Phos:1
"An NF-kappa-B essential modulator isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6K9-1, Ser-31/Ser-43/Ser-376, MOD:00046." [PMID:12657630, PRO:CNA]

organism-modification


PR:000036613
NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human)
hIKBKG/iso:1/Phos:2
"An NF-kappa-B essential modulator isoform 1 phosphorylated 2 in human. UniProtKB:Q9Y6K9-1, Ser-68, MOD:00046." [PMID:17977820, PRO:CNA]

organism-modification


PR:000036614
NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human)
hIKBKG/iso:1/Phos:3
"An NF-kappa-B essential modulator isoform 1 phosphorylated 3 in human. UniProtKB:Q9Y6K9-1, Ser-85, MOD:00046." [PMID:16497931, PRO:CNA]

modification


PR:000001764
NF-kappa-B essential modulator isoform 1 phosphorylated and ubiquitinated form
IKBKG/iso:1/PhosUbiq+
"An NF-kappa-B essential modulator isoform 1 that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:JAN]

modification


PR:000001765
NF-kappa-B essential modulator isoform 1 phosphorylated form
IKBKG/iso:1/PhosRes+
"An NF-kappa-B essential modulator isoform 1 that includes at least one phosphorylated residue." [PRO:JAN]

modification


PR:000001764
NF-kappa-B essential modulator isoform 1 phosphorylated and ubiquitinated form
IKBKG/iso:1/PhosUbiq+
"An NF-kappa-B essential modulator isoform 1 that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:JAN]

modification


PR:000001766
NF-kappa-B essential modulator isoform 1 phosphorylated 1
IKBKG/iso:1/Phos:1
"An NF-kappa-B essential modulator isoform 1 phosphorylated form in which the phosphorylation occurs at two Ser residues within the IKK-binding region and at a Ser residue at the C-terminal region by activated IKK beta. Example: UniProtKB:Q9Y6K9-1, Ser-31/Ser-43/Ser-376, MOD:00046." [PMID:12657630, PRO:DAN, PRO:JAN]

organism-modification


PR:000036612
NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human)
hIKBKG/iso:1/Phos:1
"An NF-kappa-B essential modulator isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6K9-1, Ser-31/Ser-43/Ser-376, MOD:00046." [PMID:12657630, PRO:CNA]

modification


PR:000001767
NF-kappa-B essential modulator isoform 1 phosphorylated 2
IKBKG/iso:1/Phos:2
"An NF-kappa-B essential modulator isoform 1 phosphorylated form in which the phosphorylation occurs at a Ser residue of the IKK-binding region by acivated IKK beta. Example: UniProtKB:Q9Y6K9-1, Ser-68, MOD:00046." [PMID:17977820, PRO:DAN, PRO:JAN]

organism-modification


PR:000036613
NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human)
hIKBKG/iso:1/Phos:2
"An NF-kappa-B essential modulator isoform 1 phosphorylated 2 in human. UniProtKB:Q9Y6K9-1, Ser-68, MOD:00046." [PMID:17977820, PRO:CNA]

modification


PR:000001768
NF-kappa-B essential modulator isoform 1 phosphorylated 3
IKBKG/iso:1/Phos:3
"An NF-kappa-B essential modulator isoform 1 phosphorylated form in which the phosphorylation occurs on a Ser residue upon activation by genotoxic signals (through ATM). Example: UniProtKB:Q9Y6K9-1, Ser-85, MOD:00046." [PMID:16497931, PRO:CNA, PRO:DAN]

organism-modification


PR:000036614
NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human)
hIKBKG/iso:1/Phos:3
"An NF-kappa-B essential modulator isoform 1 phosphorylated 3 in human. UniProtKB:Q9Y6K9-1, Ser-85, MOD:00046." [PMID:16497931, PRO:CNA]

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IKBKG forms found in complexes   

IKBKG Component
 Complexes
PR:O88522 mIKBKG PR:000036118 IkappaB kinase complex (mouse)
PR:000036119 activated IkappaB kinase complex (mouse)
PR:Q9Y6K9 hIKBKG PR:000026457 IkappaB kinase complex (human)
PR:000035833 activated IkappaB kinase complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)