back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3
PR:000001769 - http://purl.obolibrary.org/obo/PR_000001769
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001769   
  PRO namemitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 
  Synonyms
PRO-Short-label: EXACT:fam:TAB2-TAB3
  Definition"A protein with core domain architecture consisting of an N-terminal CUE domain (Pfam:PF02845) and a C-terminal zinc-finger domain. TAB2 and TAB3 are receptors that bind preferentially to lysine-linked polyubiquitin chains through the Zn-finger domain." [PMID:15327770, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 2                                        
         Gene2                                                  Organism-Gene 6                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF038187
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000001769

mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3

fam:TAB2-TAB3


"A protein with core domain architecture consisting of an N-terminal CUE domain (Pfam:PF02845) and a C-terminal zinc-finger domain. TAB2 and TAB3 are receptors that bind preferentially to lysine-linked polyubiquitin chains through the Zn-finger domain." [PMID:15327770, PRO:CNA]


gene



PR:000001771

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

TAB3


"A mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 that is a translation product of the human TAB3 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q571K4

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (mouse)

mTAB3


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 that is encoded in the genome of mouse." [OMA:Q571K4, PRO:DNx]


organism-gene



PR:Q8N5C8

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (human)

hTAB3


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 that is a translation product of the TAB3 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8N5C8-1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform h1 (human)

hTAB3/iso:h1


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N5C8-1." [PRO:DNx, UniProtKB:Q8N5C8]


organism-sequence



PR:Q8N5C8-2

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform h2 (human)

hTAB3/iso:h2


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N5C8-2." [PRO:DNx, UniProtKB:Q8N5C8]


organism-modification



PR:000049393

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, initiator methionine removed form (human)

hTAB3/InitMet-


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (human) that has had the initiator methionine removed. UniProtKB:Q8N5C8, 2-712." [PRO:DNx, Reactome:R-HSA-446879, Reactome:R-HSA-450247, Reactome:R-HSA-450264]


gene



PR:000001772

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

TAB2


"A mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 that is a translation product of the human TAB2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q5RFW2

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (zebrafish)

z-TAB2


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 that is encoded in the genome of zebrafish." [OMA:Q5RFW2, PRO:DNx]


organism-sequence



PR:Q5RFW2-1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 (zebrafish)

z-TAB2/iso:1


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5RFW2-1." [PRO:DNx, UniProtKB:Q5RFW2]


organism-sequence



PR:Q5RFW2-2

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 2 (zebrafish)

z-TAB2/iso:2


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5RFW2-2." [PRO:DNx, UniProtKB:Q5RFW2]


organism-gene



PR:Q5U303

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (rat)

rTAB2


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 that is encoded in the genome of rat." [OMA:Q5U303, PRO:DNx]


organism-sequence



PR:Q5U303-1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 (rat)

rTAB2/iso:1


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q5U303-2

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform r2 (rat)

rTAB2/iso:r2


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5U303-2." [PRO:DNx, UniProtKB:Q5U303]


organism-gene



PR:Q99K90

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (mouse)

mTAB2


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 that is encoded in the genome of mouse." [OMA:Q99K90, PRO:CNA]


Yes
organism-sequence



PR:Q99K90-1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 (mouse)

mTAB2/iso:1


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q9NYJ8

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (human)

hTAB2


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 that is encoded in the genome of human." [PRO:CNx, UniProtKB:Q9NYJ8]


Yes
organism-sequence



PR:Q9NYJ8-1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 (human)

hTAB2/iso:1


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9NYJ8-2

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform h2 (human)

hTAB2/iso:h2


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NYJ8-2." [PRO:DNx, UniProtKB:Q9NYJ8]


organism-modification



PR:000070176

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 cysteinylated 1 (human)

hTAB2/Cyst:1


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-608 of the amino acid sequence represented by UniProtKB:Q9NYJ8-1. Example: UniProtKB:Q9NYJ8-1, Cys-608, MOD:00765." [IEDB_epitope:1044903, PRO:DNx]


organism-modification



PR:000081620

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 methylated 1 (human)

hTAB2/Me:1


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (human) that has been methylated on the residue at the position equivalent to Cys-608 of the amino acid sequence represented by UniProtKB:Q9NYJ8-1. Example: UniProtKB:Q9NYJ8-1, Cys-608, MOD:00660." [IEDB_epitope:1044904, PRO:DNx]


sequence



PR:000043660

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1

TAB2/iso:1


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NYJ8-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q5U303-1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 (rat)

rTAB2/iso:1


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q99K90-1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 (mouse)

mTAB2/iso:1


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q9NYJ8-1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 (human)

hTAB2/iso:1


"A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-family



PR:000027101

mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (mouse)

fam:mTAB2-mTAB3


"A mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 that is encoded in the genome of mouse." [PMID:15327770, PRO:CNA]


Yes




PR:Q571K4

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (mouse)











PR:Q99K90

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (mouse)







organism-family



PR:000027103

mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (human)

fam:hTAB2-hTAB3


"A mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 that is encoded in the genome of human." [PMID:15327770, PRO:CNA]


Yes




PR:Q8N5C8

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (human)











PR:Q9NYJ8

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (human)







Back to top
fam:TAB2-TAB3 forms found in complexes   

fam:TAB2-TAB3 Component
Complexes
PR:000027101 fam:mTAB2-mTAB3 PR:000027102 TAK1 kinase complex (mouse)
PR:000036111 K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036114 IkappaB kinase:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036117 pIKBK:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000027103 fam:hTAB2-hTAB3 PR:000035730 TAK1 kinase complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:Q99K90 mTAB2 PR:000027105 TRIKA2 complex (mouse)
PR:Q9NYJ8 hTAB2 PR:000028440 TAB2/TAK1 complex (human)