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family
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PR:000001774 |
inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits
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LBP
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"A protein with core domain architecture consisting of an N-terminal Protein kinase domain (Pfam:PF00069), and a C-terminus that is involved in the interaction with NEMO (PR:000001752). In response to a large variety of stimuli, among them pro-inflammatory cytokines, growth factors and microbial pathogens, signals emanating from cell surface receptors converge at the IkappaB kinase (IKK) complex. This complex is composed of four subunits, IKKalpha, IKKbeta, ELK, and NEMO. IKKbeta and NEMO subunits are known to be essential for activating NF-kappaB. Activation of NF-kappaB dimers is the result of IKK-mediated, phosphorylation-induced degradation of the IkappaB inhibitor, which enables the NF-kappaB dimers to enter the nucleus and activate specific target gene expression." [PIRSF:PIRSF000581, PMID:10359587, PMID:18462684, PRO:CNA]
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gene
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PR:000001775 |
inhibitor of nuclear factor kappa-B kinase subunit alpha
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CHUK
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"An inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits that is a translation product of the human CHUK gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:O15111 |
inhibitor of nuclear factor kappa-B kinase subunit alpha (human)
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hCHUK
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15111]
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Yes |
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organism-sequence
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PR:O15111-1 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (human)
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hCHUK/iso:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of human." [PRO:CNx]
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organism-modification
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PR:000026823 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human)
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hCHUK/iso:1/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in human. UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]
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Yes |
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organism-modification
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PR:000045576 |
inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 2 (human)
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hCHUK/Phos:2
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been phosphorylated at Thr-23. UniProtKB:O15111, Thr-23, MOD:00047." [iPTMnet:O15111, PMID:10485710, Reactome:R-HSA-177667, Reactome:R-HSA-198615]
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organism-modification
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PR:000062311 |
inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 1 (human)
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hCHUK/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been phosphorylated on the residues at the positions equivalent to Ser-176 and Ser-180 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Ser-176/Ser-180, MOD:00046." [PRO:DNx, Reactome:R-HSA-177667]
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organism-modification
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PR:000065276 |
inhibitor of nuclear factor kappa-B kinase subunit alpha methylated 1 (human)
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hCHUK/Me:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been methylated on the residue at the position equivalent to Thr-319 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Thr-319, MOD:01418." [IEDB_epitope:1319554, PRO:DNx]
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organism-modification
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PR:000085410 |
inhibitor of nuclear factor kappa-B kinase subunit alpha deaminated 1 (human)
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hCHUK/Deam:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been deaminated on the residue at the position equivalent to Gln-63 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Gln-63, MOD:00685." [IEDB_epitope:1778644, PRO:DNx]
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organism-modification
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PR:000085871 |
inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 3 (human)
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hCHUK/Phos:3
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-187 and Tyr-198 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Tyr-187/Tyr-198, MOD:00048." [PRO:DNx, Reactome:R-HSA-9861501]
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organism-gene
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PR:Q4G3H4 |
inhibitor of nuclear factor kappa-B kinase subunit alpha (zebrafish)
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z-CHUK
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of zebrafish." [PRO:CNA]
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organism-gene
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PR:Q5ZJB4 |
inhibitor of nuclear factor kappa-B kinase subunit alpha (chicken)
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chick-CHUK
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of chicken." [PRO:CNA]
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organism-gene
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PR:Q60680 |
inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse)
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mCHUK
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of mouse." [OMA:Q60680, PRO:DNx]
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organism-sequence
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PR:Q60680-1 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (mouse)
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mCHUK/iso:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNx]
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Yes |
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organism-modification
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PR:000036121 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse)
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mCHUK/iso:1/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q60680-1, Ser-176/Ser-180, MOD:00046." [PMID:16751795, PRO:CNA]
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Yes |
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organism-sequence
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PR:Q60680-2 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform m2 (mouse)
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mCHUK/iso:m2
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60680-2." [PRO:DNx, UniProtKB:Q60680]
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organism-sequence
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PR:Q60680-3 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform m3 (mouse)
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mCHUK/iso:m3
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60680-3." [PRO:DNx, UniProtKB:Q60680]
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sequence
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PR:000026820 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1
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CHUK/iso:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15111-1 or a 1:1 ortholog thereof." [PRO:CNx]
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organism-sequence
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PR:O15111-1 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (human)
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hCHUK/iso:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of human." [PRO:CNx]
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organism-modification
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PR:000026823 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human)
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hCHUK/iso:1/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in human. UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]
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Yes |
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organism-sequence
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PR:Q60680-1 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (mouse)
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mCHUK/iso:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNx]
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Yes |
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organism-modification
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PR:000036121 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse)
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mCHUK/iso:1/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q60680-1, Ser-176/Ser-180, MOD:00046." [PMID:16751795, PRO:CNA]
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Yes |
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modification
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PR:000026822 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1
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CHUK/iso:1/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that has been phosphorylated in the two Ser residues within the activation loop. Example: UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]
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organism-modification
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PR:000026823 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human)
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hCHUK/iso:1/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in human. UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]
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Yes |
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organism-modification
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PR:000036121 |
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse)
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mCHUK/iso:1/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q60680-1, Ser-176/Ser-180, MOD:00046." [PMID:16751795, PRO:CNA]
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Yes |
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gene
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PR:000001776 |
inhibitor of nuclear factor kappa-B kinase subunit beta
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IKBKB
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"An inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits that is a translation product of the human IKBKB gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:O14920 |
inhibitor of nuclear factor kappa-B kinase subunit beta (human)
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hIKBKB
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"An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:O14920]
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Yes |
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organism-sequence
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PR:O14920-1 |
inhibitor of nuclear factor kappa-B kinase subunit beta isoform h1 (human)
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hIKBKB/iso:h1
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"An inhibitor of nuclear factor kappa-B kinase subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14920-1." [PRO:DNx, UniProtKB:O14920]
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organism-sequence
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PR:O14920-2 |
inhibitor of nuclear factor kappa-B kinase subunit beta isoform h2 (human)
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hIKBKB/iso:h2
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"An inhibitor of nuclear factor kappa-B kinase subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14920-2." [PRO:DNx, UniProtKB:O14920]
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organism-sequence
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PR:O14920-3 |
inhibitor of nuclear factor kappa-B kinase subunit beta isoform h3 (human)
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hIKBKB/iso:h3
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"An inhibitor of nuclear factor kappa-B kinase subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14920-3." [PRO:DNx, UniProtKB:O14920]
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organism-sequence
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PR:O14920-4 |
inhibitor of nuclear factor kappa-B kinase subunit beta isoform h4 (human)
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hIKBKB/iso:h4
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"An inhibitor of nuclear factor kappa-B kinase subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14920-4." [PRO:DNx, UniProtKB:O14920]
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organism-modification
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PR:000035831 |
inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (human)
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hIKBKB/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 in human. UniProtKB:O14920, Ser-177/Ser-181, MOD:00046." [PRO:DNx, UniProtKB:O14920]
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Yes |
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organism-modification
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PR:000077358 |
inhibitor of nuclear factor kappa-B kinase subunit beta deaminated 1 (human)
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hIKBKB/Deam:1
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"An inhibitor of nuclear factor kappa-B kinase subunit beta (human) that has been deaminated on the residue at the position equivalent to Asn-250 of the amino acid sequence represented by UniProtKB:O14920-1. Example: UniProtKB:O14920-1, Asn-250, MOD:00684." [IEDB_epitope:1800760, PRO:DNx]
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organism-gene
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PR:O88351 |
inhibitor of nuclear factor kappa-B kinase subunit beta (mouse)
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mIKBKB
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"An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of mouse." [OMA:O88351, PRO:DNx]
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Yes |
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organism-modification
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PR:000036115 |
inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (mouse)
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mIKBKB/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 in mouse. Phosphorylation is necessary for activation, and occurs on two Ser residues in the activation loop. UniProtKB:O88351, Ser-177/Ser-181, MOD:00046." [PMID:16751795, PMID:18202307, PRO:CNA, PRO:DAN]
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Yes |
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organism-gene
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PR:Q5ZI83 |
uncharacterized protein, RCJMB04_29g15 translation product (chicken)
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chick-IKBKB
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"An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of chicken." [PANTHER:PTHR22969:SF7, PRO:DNx]
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organism-gene
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PR:Q84M95 |
probable serine/threonine-protein kinase PBL28 (Arabidopsis thaliana)
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At-IKBKB
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"An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of Arabidopsis thaliana." [PRO:CNA]
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organism-sequence
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PR:Q84M95-1 |
probable serine/threonine-protein kinase PBL28 isoform 1 (Arabidopsis thaliana)
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At-IKBKB/iso:1
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"A probable serine/threonine-protein kinase PBL28 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q84M95-1." [PRO:DNx, UniProtKB:Q84M95]
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organism-gene
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PR:Q9QY78 |
inhibitor of nuclear factor kappa-B kinase subunit beta (rat)
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rIKBKB
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"An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of rat." [PRO:DAN]
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modification
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PR:000035830 |
inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1
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IKBKB/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit beta that has been phosphorylated at two Ser residues within the activation loop in the protein kinase domain. Example: UniProtKB:O14920, Ser-177/Ser-181, MOD:00046." [PRO:DNx, Reactome:R-HSA-202506]
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organism-modification
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PR:000035831 |
inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (human)
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hIKBKB/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 in human. UniProtKB:O14920, Ser-177/Ser-181, MOD:00046." [PRO:DNx, UniProtKB:O14920]
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Yes |
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organism-modification
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PR:000036115 |
inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (mouse)
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mIKBKB/Phos:1
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"An inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 in mouse. Phosphorylation is necessary for activation, and occurs on two Ser residues in the activation loop. UniProtKB:O88351, Ser-177/Ser-181, MOD:00046." [PMID:16751795, PMID:18202307, PRO:CNA, PRO:DAN]
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Yes |
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