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Protein Ontology report - IKK-related kinase
PR:000001777 - http://purl.obolibrary.org/obo/PR_000001777
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001777   
  PRO nameIKK-related kinase 
  Definition"A protein that has a core domain composition consisting of one copy of the Protein kinase domain (Pfam:PF00069) at the N terminus, and with average length of about 720 residues. Members of this class have essential roles in innate immunity through signal-induced activation of IRF3 and IRF7." [PMID:18353649, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038348
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000001777 IKK-related kinase
IKBKB

gene


PR:000001778 inhibitor of nuclear factor kappa-B kinase subunit epsilon
IKBKE

organism-gene


PR:Q14164 inhibitor of nuclear factor kappa-B kinase subunit epsilon (human)
hIKBKE

organism-sequence


PR:Q14164-1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1 (human)
hIKBKE/iso:1

organism-sequence


PR:Q14164-2 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform h2 (human)
hIKBKE/iso:h2

organism-modification


PR:000028691 inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human)
hIKBKE/Phos:1

Yes
organism-modification


PR:000064755 inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated and sumoylated 1 (human)
hIKBKE/PhosSumo:1

organism-gene


PR:Q9R0T8 inhibitor of nuclear factor kappa-B kinase subunit epsilon (mouse)
mIKBKE

Yes
sequence


PR:000028688 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1
IKBKE/iso:1

organism-sequence


PR:Q14164-1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1 (human)
hIKBKE/iso:1

modification


PR:000028690 inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1
IKBKE/Phos:1

organism-modification


PR:000028691 inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human)
hIKBKE/Phos:1

Yes
gene


PR:000001779 serine/threonine-protein kinase TBK1
TBK1

organism-gene


PR:Q9UHD2 serine/threonine-protein kinase TBK1 (human)
hTBK1

organism-sequence


PR:Q9UHD2-1 serine/threonine-protein kinase TBK1 isoform 1 (human)
hTBK1/iso:1

organism-modification


PR:000028695 serine/threonine-protein kinase TBK1 phosphorylated 1 (human)
hTBK1/Phos:1

Yes
organism-modification


PR:000045519 serine/threonine-protein kinase TBK1 phosphorylated 2 (human)
hTBK1/Phos:2

organism-modification


PR:000064841 serine/threonine-protein kinase TBK1 phosphorylated and ubiquitinated 1 (human)
hTBK1/PhosUbiq:1

organism-modification


PR:000066943 serine/threonine-protein kinase TBK1 methylated 1 (human)
hTBK1/Me:1

organism-modification


PR:000068123 serine/threonine-protein kinase TBK1 deaminated 1 (human)
hTBK1/Deam:1

organism-modification


PR:000070007 serine/threonine-protein kinase TBK1 cysteinylated 1 (human)
hTBK1/Cyst:1

organism-modification


PR:000075441 serine/threonine-protein kinase TBK1 deaminated 2 (human)
hTBK1/Deam:2

organism-modification


PR:000077131 serine/threonine-protein kinase TBK1 deaminated 3 (human)
hTBK1/Deam:3

organism-gene


PR:Q9WUN2 serine/threonine-protein kinase TBK1 (mouse)
mTBK1

Yes
organism-modification


PR:000080978 serine/threonine-protein kinase TBK1 cysteinylated 1 (mouse)
mTBK1/Cyst:1

sequence


PR:000028692 serine/threonine-protein kinase TBK1 isoform 1
TBK1/iso:1

organism-sequence


PR:Q9UHD2-1 serine/threonine-protein kinase TBK1 isoform 1 (human)
hTBK1/iso:1

modification


PR:000028694 serine/threonine-protein kinase TBK1 phosphorylated 1
TBK1/Phos:1

organism-modification


PR:000028695 serine/threonine-protein kinase TBK1 phosphorylated 1 (human)
hTBK1/Phos:1

Yes
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IKBKB forms found in complexes   

IKBKB Component
 Complexes
PR:000028691 hIKBKE/Phos:1 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000028695 hTBK1/Phos:1 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q9R0T8 mIKBKE PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036149 tbk1:tank:ikke complex (mouse)
PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)
PR:Q9WUN2 mTBK1 PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036149 tbk1:tank:ikke complex (mouse)
PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)