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Protein Ontology report - interleukin-1 receptor-associated kinase 4
PR:000001780 - http://purl.obolibrary.org/obo/PR_000001780
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001780   
  PRO nameinterleukin-1 receptor-associated kinase 4 
  Synonyms
PRO-Short-label: EXACT:IRAK4
Other: EXACT:IRAK-4 | renal carcinoma antigen NY-REN-64
  Definition"A protein that is a translation product of the human IRAK4 gene or a 1:1 ortholog thereof. The archetypical form consists of an N-terminal Death domain (Pfam:PF00531) and a C-terminal Protein kinase domain (Pfam:PF00069). This protein is an essential component of innate immunity." [PMID:11960013, PMID:16177054, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 7                                        
         Modification3                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038189;IUPHARobj:2045
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001780 interleukin-1 receptor-associated kinase 4
IRAK4

Yes
organism-gene


PR:P27450 probable serine/threonine-protein kinase CST (Arabidopsis thaliana)
At-IRAK4

organism-sequence


PR:P27450-1 probable serine/threonine-protein kinase CST isoform 1 (Arabidopsis thaliana)
At-IRAK4/iso:1

organism-gene


PR:Q05652 serine/threonine-protein kinase pelle (fruit fly)
fly-IRAK4

organism-gene


PR:Q8R4K2 interleukin-1 receptor-associated kinase 4 (mouse)
mIRAK4

Yes
organism-sequence


PR:Q8R4K2-1 interleukin-1 receptor-associated kinase 4 isoform 1 (mouse)
mIRAK4/iso:1

organism-modification


PR:000027177 interleukin-1 receptor-associated kinase 4 phosphorylated form (mouse)
mIRAK4/PhosRes+

organism-modification


PR:000027181 interleukin-1 receptor-associated kinase 4 unmodified form (mouse)
mIRAK4/UnMod

Yes
organism-gene


PR:Q9NWZ3 interleukin-1 receptor-associated kinase 4 (human)
hIRAK4

organism-sequence


PR:000060515 interleukin-1 receptor-associated kinase 4 sequence variant Q293* (human)
hIRAK4/var:Q293*

organism-sequence


PR:000061705 interleukin-1 receptor-associated kinase 4 sequence variant R12C (human)
hIRAK4/var:R12C

organism-sequence


PR:000062041 interleukin-1 receptor-associated kinase 4 sequence variant E402* (human)
hIRAK4/var:E402*

organism-sequence


PR:Q9NWZ3-1 interleukin-1 receptor-associated kinase 4 isoform 1 (human)
hIRAK4/iso:1

organism-modification


PR:000027191 interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)
hIRAK4/iso:1/Phos:1

Yes
organism-sequence


PR:Q9NWZ3-2 interleukin-1 receptor-associated kinase 4 isoform h2 (human)
hIRAK4/iso:h2

organism-modification


PR:000027184 interleukin-1 receptor-associated kinase 4 unmodified form (human)
hIRAK4/UnMod

Yes
organism-modification


PR:000048046 interleukin-1 receptor-associated kinase 4 phosphorylated 1 (human)
hIRAK4/Phos:1

sequence


PR:000027188 interleukin-1 receptor-associated kinase 4 isoform 1
IRAK4/iso:1

organism-sequence


PR:Q8R4K2-1 interleukin-1 receptor-associated kinase 4 isoform 1 (mouse)
mIRAK4/iso:1

organism-sequence


PR:Q9NWZ3-1 interleukin-1 receptor-associated kinase 4 isoform 1 (human)
hIRAK4/iso:1

organism-modification


PR:000027191 interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)
hIRAK4/iso:1/Phos:1

Yes
modification


PR:000027190 interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1
IRAK4/iso:1/Phos:1

organism-modification


PR:000027191 interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)
hIRAK4/iso:1/Phos:1

Yes
modification


PR:000027176 interleukin-1 receptor-associated kinase 4 phosphorylated form
IRAK4/PhosRes+

organism-modification


PR:000027177 interleukin-1 receptor-associated kinase 4 phosphorylated form (mouse)
mIRAK4/PhosRes+

modification


PR:000027180 interleukin-1 receptor-associated kinase 4 unmodified form
IRAK4/UnMod

organism-modification


PR:000027181 interleukin-1 receptor-associated kinase 4 unmodified form (mouse)
mIRAK4/UnMod

Yes
organism-modification


PR:000027184 interleukin-1 receptor-associated kinase 4 unmodified form (human)
hIRAK4/UnMod

Yes
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IRAK4 forms found in complexes   

IRAK4 Component
 Complexes
PR:000001780 IRAK4 PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:000027181 mIRAK4/UnMod PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse)
PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027184 hIRAK4/UnMod PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027191 hIRAK4/iso:1/Phos:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:Q8R4K2 mIRAK4 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)