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gene
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PR:000001780 |
interleukin-1 receptor-associated kinase 4
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IRAK4
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"A protein that is a translation product of the human IRAK4 gene or a 1:1 ortholog thereof. The archetypical form consists of an N-terminal Death domain (Pfam:PF00531) and a C-terminal Protein kinase domain (Pfam:PF00069). This protein is an essential component of innate immunity." [PMID:11960013, PMID:16177054, PRO:CNA]
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Yes |
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organism-gene
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PR:P27450 |
probable serine/threonine-protein kinase CST (Arabidopsis thaliana)
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At-IRAK4
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"An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of Arabidopsis thaliana." [PRO:CNA]
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organism-sequence
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PR:P27450-1 |
probable serine/threonine-protein kinase CST isoform 1 (Arabidopsis thaliana)
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At-IRAK4/iso:1
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"A probable serine/threonine-protein kinase CST (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27450-1." [PRO:DNx, UniProtKB:P27450]
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organism-gene
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PR:Q05652 |
serine/threonine-protein kinase pelle (fruit fly)
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fly-IRAK4
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"An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of fruit fly." [OMA:Q05652, PRO:DNx]
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organism-gene
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PR:Q8R4K2 |
interleukin-1 receptor-associated kinase 4 (mouse)
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mIRAK4
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"An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of mouse." [OMA:Q8R4K2, PRO:CNA]
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Yes |
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organism-sequence
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PR:Q8R4K2-1 |
interleukin-1 receptor-associated kinase 4 isoform 1 (mouse)
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mIRAK4/iso:1
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"An interleukin-1 receptor-associated kinase 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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organism-modification
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PR:000027177 |
interleukin-1 receptor-associated kinase 4 phosphorylated form (mouse)
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mIRAK4/PhosRes+
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"An interleukin-1 receptor-associated kinase 4 phosphorylated form in mouse. UniProtKB:Q8R4K2, MOD:00696." [PMID:17312103, PRO:CNA]
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organism-modification
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PR:000027181 |
interleukin-1 receptor-associated kinase 4 unmodified form (mouse)
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mIRAK4/UnMod
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"An interleukin-1 receptor-associated kinase 4 unmodified form in mouse." [PRO:CNA]
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Yes |
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organism-gene
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PR:Q9NWZ3 |
interleukin-1 receptor-associated kinase 4 (human)
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hIRAK4
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"An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of human." [PRO:CNA]
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organism-sequence
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PR:000060515 |
interleukin-1 receptor-associated kinase 4 sequence variant Q293* (human)
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hIRAK4/var:Q293*
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"An interleukin-1 receptor-associated kinase 4 (human) that has has been truncated after the position equivalent to Ala-292 of the amino acid sequence represented by UniProtKB:Q9NWZ3-1. Example: UniProtKB:Q9NWZ3-1, 1-292." [PRO:DNx, Reactome:R-HSA-5602426]
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organism-sequence
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PR:000061705 |
interleukin-1 receptor-associated kinase 4 sequence variant R12C (human)
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hIRAK4/var:R12C
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"An interleukin-1 receptor-associated kinase 4 (human) that has a Cys residue at the position equivalent to Arg-12 of the amino acid sequence represented by UniProtKB:Q9NWZ3-1. Example: UniProtKB:Q9NWZ3-1, Arg-12, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-5602511]
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organism-sequence
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PR:000062041 |
interleukin-1 receptor-associated kinase 4 sequence variant E402* (human)
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hIRAK4/var:E402*
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"An interleukin-1 receptor-associated kinase 4 (human) that has has been truncated after the position equivalent to Glu-401 of the amino acid sequence represented by UniProtKB:Q9NWZ3-1. Example: UniProtKB:Q9NWZ3-1, 1-401." [PRO:DNx, Reactome:R-HSA-5602517]
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organism-sequence
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PR:Q9NWZ3-1 |
interleukin-1 receptor-associated kinase 4 isoform 1 (human)
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hIRAK4/iso:1
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"An interleukin-1 receptor-associated kinase 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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organism-modification
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PR:000027191 |
interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)
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hIRAK4/iso:1/Phos:1
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"An interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 in human. UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PMID:17141195, PRO:CNA]
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Yes |
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organism-sequence
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PR:Q9NWZ3-2 |
interleukin-1 receptor-associated kinase 4 isoform h2 (human)
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hIRAK4/iso:h2
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"An interleukin-1 receptor-associated kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NWZ3-2." [PRO:DNx, UniProtKB:Q9NWZ3]
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organism-modification
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PR:000027184 |
interleukin-1 receptor-associated kinase 4 unmodified form (human)
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hIRAK4/UnMod
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"An interleukin-1 receptor-associated kinase 4 unmodified form in human." [PRO:CNA]
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Yes |
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organism-modification
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PR:000048046 |
interleukin-1 receptor-associated kinase 4 phosphorylated 1 (human)
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hIRAK4/Phos:1
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"An interleukin-1 receptor-associated kinase 4 (human) that has been post-translationally modified to include phosphothreonine at positions 342 and 345, and phosphoserine at position 346 of the amino acid sequence represented by UniProtKB:Q9NWZ3. UniProtKB:Q9NWZ3, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PRO:DNx, Reactome:R-HSA-446649, Reactome:R-HSA-936957, Reactome:R-HSA-975149]
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sequence
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PR:000027188 |
interleukin-1 receptor-associated kinase 4 isoform 1
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IRAK4/iso:1
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"An interleukin-1 receptor-associated kinase 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NWZ3-1 or a 1:1 ortholog thereof." [PRO:CNA]
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organism-sequence
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PR:Q8R4K2-1 |
interleukin-1 receptor-associated kinase 4 isoform 1 (mouse)
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mIRAK4/iso:1
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"An interleukin-1 receptor-associated kinase 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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organism-sequence
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PR:Q9NWZ3-1 |
interleukin-1 receptor-associated kinase 4 isoform 1 (human)
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hIRAK4/iso:1
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"An interleukin-1 receptor-associated kinase 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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organism-modification
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PR:000027191 |
interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)
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hIRAK4/iso:1/Phos:1
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"An interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 in human. UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PMID:17141195, PRO:CNA]
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Yes |
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modification
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PR:000027190 |
interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1
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IRAK4/iso:1/Phos:1
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"An interleukin-1 receptor-associated kinase 4 isoform 1 that has been phosphorylated by autocatalysis within the kinase activation loop following activation of the Toll-like receptor pathways. Example: UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PRO:CNA]
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organism-modification
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PR:000027191 |
interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)
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hIRAK4/iso:1/Phos:1
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"An interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 in human. UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PMID:17141195, PRO:CNA]
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Yes |
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modification
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PR:000027176 |
interleukin-1 receptor-associated kinase 4 phosphorylated form
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IRAK4/PhosRes+
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"An interleukin-1 receptor-associated kinase 4 that includes at least one phosphorylated residued after IL-1 stimulation." [PMID:17312103, PRO:CNA]
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organism-modification
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PR:000027177 |
interleukin-1 receptor-associated kinase 4 phosphorylated form (mouse)
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mIRAK4/PhosRes+
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"An interleukin-1 receptor-associated kinase 4 phosphorylated form in mouse. UniProtKB:Q8R4K2, MOD:00696." [PMID:17312103, PRO:CNA]
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modification
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PR:000027180 |
interleukin-1 receptor-associated kinase 4 unmodified form
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IRAK4/UnMod
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"An interleukin-1 receptor-associated kinase 4 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]
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organism-modification
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PR:000027181 |
interleukin-1 receptor-associated kinase 4 unmodified form (mouse)
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mIRAK4/UnMod
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"An interleukin-1 receptor-associated kinase 4 unmodified form in mouse." [PRO:CNA]
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Yes |
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organism-modification
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PR:000027184 |
interleukin-1 receptor-associated kinase 4 unmodified form (human)
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hIRAK4/UnMod
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"An interleukin-1 receptor-associated kinase 4 unmodified form in human." [PRO:CNA]
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Yes |
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