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Protein Ontology report - interleukin-1 receptor-associated kinase IRAK1/3
PR:000001781 - http://purl.obolibrary.org/obo/PR_000001781
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001781   
  PRO nameinterleukin-1 receptor-associated kinase IRAK1/3 
  Definition"A protein with core domain architecture consisting of an N-terminal Death domain (Pfam:PF00531) followed by a Protein kinase domain (Pfam:PF00069). This class is closely related to IRAK-4 (PR:000001780), but it contains an extra C-terminal region of about 200 residues." [PMID:12620219
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 9                                        
         Sequence2                                                  Organism-Sequence 14                                        
         Modification5                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038190
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000001781

interleukin-1 receptor-associated kinase IRAK1/3

IRAK4


"A protein with core domain architecture consisting of an N-terminal Death domain (Pfam:PF00531) followed by a Protein kinase domain (Pfam:PF00069). This class is closely related to IRAK-4 (PR:000001780), but it contains an extra C-terminal region of about 200 residues." [PMID:12620219]


gene



PR:000001782

interleukin-1 receptor-associated kinase 1

IRAK1


"An interleukin-1 receptor-associated kinase IRAK1/3 that is a translation product of the human IRAK1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P51617

interleukin-1 receptor-associated kinase 1 (human)

hIRAK1


"An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P51617-1

interleukin-1 receptor-associated kinase 1 isoform 1 (human)

hIRAK1/iso:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000027492

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)

hIRAK1/iso:1/Phos:3


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA]

Yes

organism-modification



PR:000027493

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)

hIRAK1/iso:1/Phos:4


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046." [PMID:14625308, PRO:CNA]

Yes

organism-modification



PR:000027494

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)

hIRAK1/iso:1/Phos:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P51617-1, Thr-209, MOD:00047." [PRO:DNx, UniProtKB:P51617]

Yes

Yes
organism-modification



PR:000061935

interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)

hIRAK1/iso:1/pSerThr+


"An interleukin-1 receptor-associated kinase 1 isoform 1 (human) that includes at least one phosphorylated serine and at least one phosphorylated threonine. UniProtKB:P51617-1, MOD:00046|MOD:00047." [PRO:DNx, Reactome:R-HSA-193904]


organism-sequence



PR:P51617-2

interleukin-1 receptor-associated kinase 1 isoform h2 (human)

hIRAK1/iso:h2


"An interleukin-1 receptor-associated kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-2." [PRO:DNx, UniProtKB:P51617]


organism-sequence



PR:P51617-3

interleukin-1 receptor-associated kinase 1 isoform h3 (human)

hIRAK1/iso:h3


"An interleukin-1 receptor-associated kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-3." [PRO:DNx, UniProtKB:P51617]


organism-sequence



PR:P51617-4

interleukin-1 receptor-associated kinase 1 isoform h4 (human)

hIRAK1/iso:h4


"An interleukin-1 receptor-associated kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-4." [PRO:DNx, UniProtKB:P51617]


organism-modification



PR:000048042

interleukin-1 receptor-associated kinase 1 phosphorylated 5 (human)

hIRAK1/Phos:5


"An interleukin-1 receptor-associated kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-376, and phosphothreonine at position 387 of the amino acid sequence represented by UniProtKB:P51617. UniProtKB:P51617, Ser-376, MOD:00046|Thr-387, MOD:00047." [PRO:DNx, Reactome:R-HSA-446687]


organism-modification



PR:000048043

interleukin-1 receptor-associated kinase 1 phosphorylated 1 (human)

hIRAK1/Phos:1


"An interleukin-1 receptor-associated kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-209 of the amino acid sequence represented by UniProtKB:P51617. UniProtKB:P51617, Thr-209, MOD:00047." [PRO:DNx, Reactome:R-HSA-937031, Reactome:R-HSA-975189]


organism-modification



PR:000048044

interleukin-1 receptor-associated kinase 1 phosphorylated 3 (human)

hIRAK1/Phos:3


"An interleukin-1 receptor-associated kinase 1 (human) that has been post-translationally modified to include phosphothreonine at positions 209 and 387 of the amino acid sequence represented by UniProtKB:P51617. UniProtKB:P51617, Thr-209/Thr-387, MOD:00047." [PRO:DNx, Reactome:R-HSA-166279, Reactome:R-HSA-975117]


organism-modification



PR:000062298

interleukin-1 receptor-associated kinase 1 phosphorylated 2 (human)

hIRAK1/Phos:2


"An interleukin-1 receptor-associated kinase 1 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-209, Ser-376, and Thr-387 of the amino acid sequence represented by UniProtKB:P51617-1 and that includes at least one additional phosphorylated threonine and at least two additional phosphorylated serines. Example: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|Ser-376, MOD:00046|MOD:00046(2+)|MOD:00047." [PRO:DNx, Reactome:R-HSA-446682, Reactome:R-HSA-937011, Reactome:R-HSA-975157]


organism-modification



PR:000064197

interleukin-1 receptor-associated kinase 1 phosphoserine and phosphothreonine form (human)

hIRAK1/pSerThr+


"An interleukin-1 receptor-associated kinase 1 (human) that includes at least one phosphorylated serine and at least one phosphorylated threonine. UniProtKB:P51617, MOD:00046|MOD:00047." [PRO:DNx, Reactome:R-HSA-3149574]


organism-modification



PR:000064772

interleukin-1 receptor-associated kinase 1 phosphorylated and ubiquitinated 1 (human)

hIRAK1/PhosUbiq:1


"An interleukin-1 receptor-associated kinase 1 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-209, Ser-376 and Thr-387, and ubiquitinated on the residues at the positions equivalent to Lys-134 and Lys-180 of the amino acid sequence represented by UniProtKB:P51617-1 and that includes at least one additional phosphorylated threonine and at least two additional phosphorylated serines. Example: UniProtKB:P51617-1, Lys-134/Lys-180, MOD:01148|Thr-209/Thr-387, MOD:00047|Ser-376, MOD:00046|MOD:00046(2+)|MOD:00047." [PRO:DNx, Reactome:R-HSA-975112]


organism-gene



PR:Q62406

interleukin-1 receptor-associated kinase 1 (mouse)

mIRAK1


"An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of mouse." [OMA:Q62406, PRO:CNA]


Yes
organism-sequence



PR:Q62406-1

interleukin-1 receptor-associated kinase 1 isoform 1 (mouse)

mIRAK1/iso:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000027178

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)

mIRAK1/iso:1/Phos:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q62406-1, Thr-209, MOD:00047." [PMID:12538665, TLR:AMM]


Yes
organism-modification



PR:000027179

interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)

mIRAK1/iso:1/UnMod


"An interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form in mouse." [PRO:CNA]


Yes
organism-sequence



PR:Q62406-2

interleukin-1 receptor-associated kinase 1 isoform m2 (mouse)

mIRAK1/iso:m2


"An interleukin-1 receptor-associated kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q62406-2." [PRO:DNx, UniProtKB:Q62406]


sequence



PR:000021973

interleukin-1 receptor-associated kinase 1 isoform 1

IRAK1/iso:1


"An interleukin-1 receptor-associated kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P51617-1

interleukin-1 receptor-associated kinase 1 isoform 1 (human)

hIRAK1/iso:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000027492

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)

hIRAK1/iso:1/Phos:3


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA]

Yes

organism-modification



PR:000027493

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)

hIRAK1/iso:1/Phos:4


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046." [PMID:14625308, PRO:CNA]

Yes

organism-modification



PR:000027494

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)

hIRAK1/iso:1/Phos:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P51617-1, Thr-209, MOD:00047." [PRO:DNx, UniProtKB:P51617]

Yes

Yes
organism-modification



PR:000061935

interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)

hIRAK1/iso:1/pSerThr+


"An interleukin-1 receptor-associated kinase 1 isoform 1 (human) that includes at least one phosphorylated serine and at least one phosphorylated threonine. UniProtKB:P51617-1, MOD:00046|MOD:00047." [PRO:DNx, Reactome:R-HSA-193904]


organism-sequence



PR:Q62406-1

interleukin-1 receptor-associated kinase 1 isoform 1 (mouse)

mIRAK1/iso:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000027178

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)

mIRAK1/iso:1/Phos:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q62406-1, Thr-209, MOD:00047." [PMID:12538665, TLR:AMM]


Yes
organism-modification



PR:000027179

interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)

mIRAK1/iso:1/UnMod


"An interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form in mouse." [PRO:CNA]


Yes
modification



PR:000021971

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form

IRAK1/iso:1/PhosRes+


"An interleukin-1 receptor-associated kinase 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000021975

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1

IRAK1/iso:1/Phos:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located at the N terminus of the kinase domain. This is the first step following the activation of the TLR/IL-1 receptor complex. This phosphorylation results in a conformational change of the kinase domain. Example: UniProtKB:P51617-1, Thr-209, MOD:00047." [PMID:11960013, PMID:14625308, PRO:CNA, TLR:AMM]


organism-modification



PR:000027178

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)

mIRAK1/iso:1/Phos:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q62406-1, Thr-209, MOD:00047." [PMID:12538665, TLR:AMM]


Yes
organism-modification



PR:000027494

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)

hIRAK1/iso:1/Phos:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P51617-1, Thr-209, MOD:00047." [PRO:DNx, UniProtKB:P51617]

Yes

Yes
modification



PR:000021977

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3

IRAK1/iso:1/Phos:3


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located near the N terminus of the kinase domain, and on a Thr residue located in the activation loop (Thr-387 in human). The latter phosphorylation is the second step following the activation of the TLR/IL-1 receptor complex. Example: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA, PRO:DAN]


organism-modification



PR:000027492

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)

hIRAK1/iso:1/Phos:3


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA]

Yes

modification



PR:000021978

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4

IRAK1/iso:1/Phos:4


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation occurs by interleukin-1 receptor-associated kinase 4 (IRAK-4) and extensively autophosphorylated in the Pro-, Ser-, and Thr-rich ProST region between the N-terminal death domain and kinase domain. Example: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046." [PMID:14625308, PRO:CNA, PRO:DAN]


organism-modification



PR:000027493

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)

hIRAK1/iso:1/Phos:4


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046." [PMID:14625308, PRO:CNA]

Yes

organism-modification



PR:000061935

interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)

hIRAK1/iso:1/pSerThr+


"An interleukin-1 receptor-associated kinase 1 isoform 1 (human) that includes at least one phosphorylated serine and at least one phosphorylated threonine. UniProtKB:P51617-1, MOD:00046|MOD:00047." [PRO:DNx, Reactome:R-HSA-193904]


modification



PR:000021974

interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form

IRAK1/iso:1/UnMod


"An interleukin-1 receptor-associated kinase 1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]


organism-modification



PR:000027179

interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)

mIRAK1/iso:1/UnMod


"An interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form in mouse." [PRO:CNA]


Yes
gene



PR:000001783

interleukin-1 receptor-associated kinase-like 2

IRAK2


"An interleukin-1 receptor-associated kinase IRAK1/3 that is a translation product of the human IRAK2 gene or a 1:1 ortholog thereof. This protein class is inactive as a kinase due to a change of an Asn instead of an Asp redisue in a catalytic site." [PMID:9374458, PRO:CNA]


organism-gene



PR:F1N826

uncharacterized protein, IRAK2 translation product (chicken)

chick-IRAK2


"An interleukin-1 receptor-associated kinase-like 2 that is encoded in the genome of chicken." [OMA:F1N826, PRO:DNx]


organism-gene



PR:O43187

interleukin-1 receptor-associated kinase-like 2 (human)

hIRAK2


"An interleukin-1 receptor-associated kinase-like 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O43187]


organism-modification



PR:000048045

interleukin-1 receptor-associated kinase-like 2 phosphorylated form (human)

hIRAK2/PhosRes+


"An interleukin-1 receptor-associated kinase-like 2 (human) that includes at least one phosphorylated residue. UniProtKB:O43187, MOD:00696." [PRO:DNx, Reactome:R-HSA-446636, Reactome:R-HSA-936949, Reactome:R-HSA-975187]


organism-modification



PR:000081167

interleukin-1 receptor-associated kinase-like 2 cysteinylated 1 (human)

hIRAK2/Cyst:1


"An interleukin-1 receptor-associated kinase-like 2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-470 of the amino acid sequence represented by UniProtKB:O43187. UniProtKB:O43187, Cys-470, MOD:00765." [IEDB_epitope:1578132, PRO:DNx]


organism-modification



PR:000081833

interleukin-1 receptor-associated kinase-like 2 cysteinylated 2 (human)

hIRAK2/Cyst:2


"An interleukin-1 receptor-associated kinase-like 2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-261 of the amino acid sequence represented by UniProtKB:O43187. UniProtKB:O43187, Cys-261, MOD:00765." [IEDB_epitope:1857096, PRO:DNx]


organism-modification



PR:000082521

interleukin-1 receptor-associated kinase-like 2 cysteinylated 3 (human)

hIRAK2/Cyst:3


"An interleukin-1 receptor-associated kinase-like 2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-79 of the amino acid sequence represented by UniProtKB:O43187. UniProtKB:O43187, Cys-79, MOD:00765." [IEDB_epitope:1333187, PRO:DNx]


organism-gene



PR:Q4QQS0

interleukin-1 receptor-associated kinase-like 2 (rat)

rIRAK2


"An interleukin-1 receptor-associated kinase-like 2 that is encoded in the genome of rat." [OMA:Q4QQS0, PRO:DNx]


organism-gene



PR:Q8CFA1

interleukin-1 receptor-associated kinase-like 2 (mouse)

mIRAK2


"An interleukin-1 receptor-associated kinase-like 2 that is encoded in the genome of mouse." [OMA:Q8CFA1, PRO:DNx]


organism-sequence



PR:Q8CFA1-1

interleukin-1 receptor-associated kinase-like 2 isoform m1 (mouse)

mIRAK2/iso:m1


"An interleukin-1 receptor-associated kinase-like 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFA1-1." [PRO:DNx, UniProtKB:Q8CFA1]


organism-sequence



PR:Q8CFA1-2

interleukin-1 receptor-associated kinase-like 2 isoform m2 (mouse)

mIRAK2/iso:m2


"An interleukin-1 receptor-associated kinase-like 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFA1-2." [PRO:DNx, UniProtKB:Q8CFA1]


organism-sequence



PR:Q8CFA1-3

interleukin-1 receptor-associated kinase-like 2 isoform m3 (mouse)

mIRAK2/iso:m3


"An interleukin-1 receptor-associated kinase-like 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFA1-3." [PRO:DNx, UniProtKB:Q8CFA1]


organism-sequence



PR:Q8CFA1-4

interleukin-1 receptor-associated kinase-like 2 isoform m4 (mouse)

mIRAK2/iso:m4


"An interleukin-1 receptor-associated kinase-like 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFA1-4." [PRO:DNx, UniProtKB:Q8CFA1]


gene



PR:000001784

interleukin-1 receptor-associated kinase 3

IRAK3


"An interleukin-1 receptor-associated kinase IRAK1/3 that is a translation product of the human IRAK3 gene or a 1:1 ortholog thereof." [PMID:12150927, PRO:CNA]


organism-gene



PR:Q8K4B2

interleukin-1 receptor-associated kinase 3 (mouse)

mIRAK3


"An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of mouse." [OMA:Q8K4B2, PMID:12150927, PRO:CNA]

Yes

Yes
organism-gene



PR:Q9Y616

interleukin-1 receptor-associated kinase 3 (human)

hIRAK3


"An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y616]


organism-sequence



PR:Q9Y616-1

interleukin-1 receptor-associated kinase 3 isoform 1 (human)

hIRAK3/iso:1


"An interleukin-1 receptor-associated kinase 3 isoform 1 that is encoded in the genome of human." [GenBank:AF113136, PMID:10383454, PRO:CNA]

Yes

organism-sequence



PR:Q9Y616-2

interleukin-1 receptor-associated kinase 3 isoform h2 (human)

hIRAK3/iso:h2


"An interleukin-1 receptor-associated kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y616-2." [PRO:DNx, UniProtKB:Q9Y616]


organism-modification



PR:000073219

interleukin-1 receptor-associated kinase 3 phosphorylated 1 (human)

hIRAK3/Phos:1


"An interleukin-1 receptor-associated kinase 3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-335 of the amino acid sequence represented by UniProtKB:Q9Y616-1. Example: UniProtKB:Q9Y616-1, Ser-335, MOD:00046." [IEDB_epitope:912152, PRO:DNx]


sequence



PR:000027241

interleukin-1 receptor-associated kinase 3 isoform 1

IRAK3/iso:1


"An interleukin-1 receptor-associated kinase 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y616-1 or a 1:1 ortholog thereof." [GenBank:AF113136, PMID:10383454, PRO:CNA]


organism-sequence



PR:Q9Y616-1

interleukin-1 receptor-associated kinase 3 isoform 1 (human)

hIRAK3/iso:1


"An interleukin-1 receptor-associated kinase 3 isoform 1 that is encoded in the genome of human." [GenBank:AF113136, PMID:10383454, PRO:CNA]

Yes

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IRAK4 forms found in complexes   

IRAK4 Component
Complexes
PR:000027178 mIRAK1/iso:1/Phos:1 PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027179 mIRAK1/iso:1/UnMod PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027253 IRAK1:tollip complex (mouse)
PR:000027494 hIRAK1/iso:1/Phos:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:Q62406 mIRAK1 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:Q8K4B2 mIRAK3 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027492 hIRAK1/iso:1/Phos:3
UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047
acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0004674 protein serine/threonine kinase activity PMID:14625308
PR:000027493 hIRAK1/iso:1/Phos:4
UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046
acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0004674 protein serine/threonine kinase activity PMID:14625308
NOT GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
NOT GO:0005515 protein binding PMID:14625308
PR:000027494 hIRAK1/iso:1/Phos:1
UniProtKB:P51617-1, Thr-209, MOD:00047
enablesGO:0005515 protein binding with PR:Q9NWZ3 hIRAK4 PMID:11960013
GO:0016301 kinase activity PMID:11960013
PR:P51617-1 hIRAK1/iso:1 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
GO:0005515 protein binding with PR:Q9Y4K3 E3 ubiquitin-protein ligase TRAF6 (human) PMID:14625308
PR:Q8K4B2 mIRAK3 acts_upstream_of_or_withinGO:0034122 negative regulation of toll-like receptor signaling pathway PMID:12150927
PR:Q9Y616-1 hIRAK3/iso:1 acts_upstream_of_or_withinGO:0034122 negative regulation of toll-like receptor signaling pathway PMID:10383454
enablesGO:0005515 protein binding with PR:Q99836 hMYD88 PMID:10383454