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Protein Ontology report - fractalkine
PR:000001855 - http://purl.obolibrary.org/obo/PR_000001855
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001855   
  PRO namefractalkine 
  Synonyms
PRO-Short-label: EXACT:CX3CL1
Gene-based: RELATED:A-152E5.2 | Cx3c | FKN | NTT | SCYD1
Other: EXACT:C-X3-C motif chemokine 1 | CX3C membrane-anchored chemokine | neurotactin | small-inducible cytokine D1
  Definition"A protein that is a translation product of the human CX3CL1 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 1                                        
         Modification3                                                  Organism-Modification 12                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038029
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001855

fractalkine

CX3CL1


"A protein that is a translation product of the human CX3CL1 gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:O35188

fractalkine (mouse)

mCX3CL1


"A fractalkine that is encoded in the genome of mouse." [OMA:O35188, PRO:DNx]


organism-sequence



PR:Q9Z0D9-1

CX3C chemokine receptor 1 isoform 1 (mouse)

mCX3CR1/iso:1


"A fractalkine isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-gene



PR:O55145

fractalkine (rat)

rCX3CL1


"A fractalkine that is encoded in the genome of rat." [PRO:WCB]


organism-gene



PR:P78423

fractalkine (human)

hCX3CL1


"A fractalkine that is encoded in the genome of human." [PRO:WCB, UniProtKB:P78423]


organism-modification



PR:000047104

fractalkine, signal peptide removed form (human)

hCX3CL1/SigPep-


"A fractalkine (human) that has had the signal peptide removed. UniProtKB:P78423, 25-397." [PRO:DNx, Reactome:R-HSA-373368]


organism-modification



PR:000056679

fractalkine O-glycosylated 1 (human)

hCX3CL1/OGlyco:1


"A fractalkine (human) that has been O-glycosylated at the residue equivalent to Ser-199 of the amino acid sequence represented by UniProtKB:P78423-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P78423-1, Ser-199, MOD:00002~GNO:G43417UB." [GlyGen:P78423-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056680

fractalkine O-glycosylated 2 (human)

hCX3CL1/OGlyco:2


"A fractalkine (human) that has been O-glycosylated at the residue equivalent to Ser-199 of the amino acid sequence represented by UniProtKB:P78423-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P78423-1, Ser-199, MOD:00002~GNO:G53434XO." [GlyGen:P78423-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056681

fractalkine O-glycosylated 3 (human)

hCX3CL1/OGlyco:3


"A fractalkine (human) that has been O-glycosylated at the residue equivalent to Ser-208 of the amino acid sequence represented by UniProtKB:P78423-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P78423-1, Ser-208, MOD:00002~GNO:G43417UB." [GlyGen:P78423-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056682

fractalkine O-glycosylated 4 (human)

hCX3CL1/OGlyco:4


"A fractalkine (human) that has been O-glycosylated at the residue equivalent to Ser-253 of the amino acid sequence represented by UniProtKB:P78423-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P78423-1, Ser-253, MOD:00002~GNO:G29068FM." [GlyGen:P78423-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056683

fractalkine O-glycosylated 5 (human)

hCX3CL1/OGlyco:5


"A fractalkine (human) that has been O-glycosylated at the residue equivalent to Ser-253 of the amino acid sequence represented by UniProtKB:P78423-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P78423-1, Ser-253, MOD:00002~GNO:G43417UB." [GlyGen:P78423-1, PMID:22171320, PMID:30459171, PRO:DNx]


organism-modification



PR:000056684

fractalkine O-glycosylated 6 (human)

hCX3CL1/OGlyco:6


"A fractalkine (human) that has been O-glycosylated at the residue equivalent to Thr-153 of the amino acid sequence represented by UniProtKB:P78423-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P78423-1, Thr-153, MOD:00005~GNO:G53434XO." [GlyGen:P78423-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056685

fractalkine O-glycosylated 7 (human)

hCX3CL1/OGlyco:7


"A fractalkine (human) that has been O-glycosylated at the residue equivalent to Thr-183 of the amino acid sequence represented by UniProtKB:P78423-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P78423-1, Thr-183, MOD:00005~GNO:G43417UB." [GlyGen:P78423-1, PMID:22171320, PRO:DNx]


organism-modification



PR:000056686

fractalkine O-glycosylated 8 (human)

hCX3CL1/OGlyco:8


"A fractalkine (human) that has been O-glycosylated at the residue equivalent to Thr-272 of the amino acid sequence represented by UniProtKB:P78423-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P78423-1, Thr-272, MOD:00005~GNO:G43417UB." [GlyGen:P78423-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056687

fractalkine O-glycosylated 9 (human)

hCX3CL1/OGlyco:9


"A fractalkine (human) that has been O-glycosylated at the residue equivalent to Thr-329 of the amino acid sequence represented by UniProtKB:P78423-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P78423-1, Thr-329, MOD:00005~GNO:G43417UB." [GlyGen:P78423-1, PMID:22171320, PMID:30459171, PRO:DNx]


organism-modification



PR:000056688

fractalkine O-glycosylated 10 (human)

hCX3CL1/OGlyco:10


"A fractalkine (human) that has been O-glycosylated at the residue equivalent to Thr-338 of the amino acid sequence represented by UniProtKB:P78423-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P78423-1, Thr-338, MOD:00005~GNO:G43417UB." [GlyGen:P78423-1, PMID:22171320, PRO:DNx]


organism-modification



PR:000069531

fractalkine cysteinylated 1 (human)

hCX3CL1/Cyst:1


"A fractalkine (human) that has been cysteinylated on the residue at the position equivalent to Cys-58 of the amino acid sequence represented by UniProtKB:P78423. UniProtKB:P78423, Cys-58, MOD:00765." [IEDB_epitope:1574792, IEDB_epitope:1577488, IEDB_epitope:1577490, PRO:DNx]


sequence



PR:000002982

fractalkine isoform 1

CX3CL1/iso:1


"A fractalkine that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z0D9-1 or a 1:1 ortholog thereof." [PRO:HJD]


organism-sequence



PR:Q9Z0D9-1

CX3C chemokine receptor 1 isoform 1 (mouse)

mCX3CR1/iso:1


"A fractalkine isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

modification



PR:000021941

fractalkine isoform 1, signal peptide removed form

CX3CL1/iso:1/SigPep-


"A fractalkine isoform 1 that has had the signal peptide removed." [PRO:DAN]


modification



PR:000018549

fractalkine, signal peptide removed form

CX3CL1/SigPep-


"A fractalkine that has had the signal peptide removed." [PRO:DNx]


modification



PR:000021941

fractalkine isoform 1, signal peptide removed form

CX3CL1/iso:1/SigPep-


"A fractalkine isoform 1 that has had the signal peptide removed." [PRO:DAN]


organism-modification



PR:000047104

fractalkine, signal peptide removed form (human)

hCX3CL1/SigPep-


"A fractalkine (human) that has had the signal peptide removed. UniProtKB:P78423, 25-397." [PRO:DNx, Reactome:R-HSA-373368]


modification



PR:000018550

fractalkine proteolytic cleavage product

CX3CL1/ClvPrd


"A fractalkine that has been processed by proteolytic cleavage." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q9Z0D9-1 mCX3CR1/iso:1 acts_upstream_of_or_withinGO:0002282 microglial cell activation involved in immune response MGI_ref:3639805; PMID:16732273
GO:0019221 cytokine-mediated signaling pathway MGI_ref:3833195; PMID:18971423
GO:0021795 cerebral cortex cell migration MGI_ref:3639805; PMID:16732273
GO:0048246 macrophage chemotaxis MGI_ref:3777228; PMID:18322241
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand MGI_ref:3833195; PMID:18971423