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Protein Ontology report - receptor-type tyrosine-protein kinase Tie
PR:000001923 - http://purl.obolibrary.org/obo/PR_000001923
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001923   
  PRO namereceptor-type tyrosine-protein kinase Tie 
  Definition"A protein with core architecture consisting of an extracellular region containing an Ig-like domain (Pfam:PF00047 or Pfam:PF10430), followed by 3 EGF-like domains (Pfam:PF07947 or Pfam:PF00053), another Ig-like domain, and 3 Fibronectin type III domains (Pfam:PF00041), and a cytoplasmic region containing the Protein tyrosine kinase domain (Pfam:PF07714)." [PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF000630
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000001923

receptor-type tyrosine-protein kinase Tie

CD164


"A protein with core architecture consisting of an extracellular region containing an Ig-like domain (Pfam:PF00047 or Pfam:PF10430), followed by 3 EGF-like domains (Pfam:PF07947 or Pfam:PF00053), another Ig-like domain, and 3 Fibronectin type III domains (Pfam:PF00041), and a cytoplasmic region containing the Protein tyrosine kinase domain (Pfam:PF07714)." [PRO:WCB]


gene



PR:000002032

angiopoietin-1 receptor

TEK


"A receptor-type tyrosine-protein kinase Tie that is a translation product of the human TEK gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:O73791

angiopoietin-1 receptor (zebrafish)

z-TEK


"An angiopoietin-1 receptor that is encoded in the genome of zebrafish." [PANTHER:PTHR24416:SF90, PRO:DNx]


organism-gene



PR:Q02763

angiopoietin-1 receptor (human)

hTEK


"An angiopoietin-1 receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q02763]


organism-sequence



PR:000002131

angiopoietin-1 receptor sequence variant R849W (human)

hTEK/var:R849W


"An angiopoietin-1 receptor (human) that has a Trp residue at the position equivalent to Arg-849 of the amino acid sequence represented by UniProtKB:Q02763-1. Example: UniProtKB:Q02763-1, Arg-849, CHEBI:29954." [PMID:10369874, PMID:8980225, PMID:99199243, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000002132

angiopoietin-1 receptor sequence variant Y897S (human)

hTEK/var:Y897S


"An angiopoietin-1 receptor (human) that has a Ser residue at the position equivalent to Tyr-897 of the amino acid sequence represented by UniProtKB:Q02763-1. Example: UniProtKB:Q02763-1, Tyr-897, CHEBI:29999." [PMID:10369874, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q02763-1

angiopoietin-1 receptor isoform 1 (human)

hTEK/iso:1


"An angiopoietin-1 receptor isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q02763-2

angiopoietin-1 receptor isoform h2 (human)

hTEK/iso:h2


"An angiopoietin-1 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02763-2." [PRO:DNx, UniProtKB:Q02763]


organism-sequence



PR:Q02763-3

angiopoietin-1 receptor isoform h3 (human)

hTEK/iso:h3


"An angiopoietin-1 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02763-3." [PRO:DNx, UniProtKB:Q02763]


organism-modification



PR:000049418

angiopoietin-1 receptor, signal peptide removed form (human)

hTEK/SigPep-


"An angiopoietin-1 receptor (human) that has had the signal peptide removed. UniProtKB:Q02763, 23-1124." [PRO:DNx, Reactome:R-HSA-197755]


organism-modification



PR:000049419

angiopoietin-1 receptor, signal peptide removed phosphorylated 1 (human)

hTEK/SigPep-/Phos:1


"An angiopoietin-1 receptor (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 816, 992, 1102, 1108 and 1113, and phosphoserine at position 1119 of the amino acid sequence represented by UniProtKB:Q02763. UniProtKB:Q02763, 23-1124, Tyr-816/Tyr-992/Tyr-1102/Tyr-1108/Tyr-1113, MOD:00048|Ser-1119, MOD:00046." [PRO:DNx, Reactome:R-HSA-204772]


organism-modification



PR:000056851

angiopoietin-1 receptor N-glycosylated 1 (human)

hTEK/NGlyco:1


"An angiopoietin-1 receptor (human) that has been N-glycosylated at the residue equivalent to Asn-649 of the amino acid sequence represented by UniProtKB:Q02763-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:Q02763-1, Asn-649, MOD:00160~GNO:G58001LT." [GlyGen:Q02763-1, PMID:23345538, PRO:DNx]


organism-modification



PR:000081311

angiopoietin-1 receptor deaminated 1 (human)

hTEK/Deam:1


"An angiopoietin-1 receptor (human) that has been deaminated on the residue at the position equivalent to Asn-975 of the amino acid sequence represented by UniProtKB:Q02763-1. Example: UniProtKB:Q02763-1, Asn-975, MOD:00684." [IEDB_epitope:1990091, PRO:DNx]


organism-gene



PR:Q02858

angiopoietin-1 receptor (mouse)

mTEK


"An angiopoietin-1 receptor that is encoded in the genome of mouse." [OMA:Q02858, PRO:DNx]


organism-sequence



PR:Q02858-1

angiopoietin-1 receptor isoform 1 (mouse)

mTEK/iso:1


"An angiopoietin-1 receptor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000002130

angiopoietin-1 receptor isoform 1

TEK/iso:1


"An angiopoietin-1 receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02763-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q02763-1

angiopoietin-1 receptor isoform 1 (human)

hTEK/iso:1


"An angiopoietin-1 receptor isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q02858-1

angiopoietin-1 receptor isoform 1 (mouse)

mTEK/iso:1


"An angiopoietin-1 receptor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000026692

angiopoietin-1 receptor isoform 1, signal peptide removed form

TEK/iso:1/SigPep-


"An angiopoietin-1 receptor isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018700

angiopoietin-1 receptor, signal peptide removed form

TEK/SigPep-


"An angiopoietin-1 receptor that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026692

angiopoietin-1 receptor isoform 1, signal peptide removed form

TEK/iso:1/SigPep-


"An angiopoietin-1 receptor isoform 1 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000049418

angiopoietin-1 receptor, signal peptide removed form (human)

hTEK/SigPep-


"An angiopoietin-1 receptor (human) that has had the signal peptide removed. UniProtKB:Q02763, 23-1124." [PRO:DNx, Reactome:R-HSA-197755]


organism-modification



PR:000049419

angiopoietin-1 receptor, signal peptide removed phosphorylated 1 (human)

hTEK/SigPep-/Phos:1


"An angiopoietin-1 receptor (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 816, 992, 1102, 1108 and 1113, and phosphoserine at position 1119 of the amino acid sequence represented by UniProtKB:Q02763. UniProtKB:Q02763, 23-1124, Tyr-816/Tyr-992/Tyr-1102/Tyr-1108/Tyr-1113, MOD:00048|Ser-1119, MOD:00046." [PRO:DNx, Reactome:R-HSA-204772]


gene



PR:000016330

tyrosine-protein kinase receptor Tie-1

TIE1


"A receptor-type tyrosine-protein kinase Tie that is a translation product of the human TIE1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P35590

tyrosine-protein kinase receptor Tie-1 (human)

hTIE1


"A tyrosine-protein kinase receptor Tie-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P35590]


organism-sequence



PR:P35590-1

tyrosine-protein kinase receptor Tie-1 isoform h1 (human)

hTIE1/iso:h1


"A tyrosine-protein kinase receptor Tie-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35590-1." [PRO:DNx, UniProtKB:P35590]


organism-sequence



PR:P35590-2

tyrosine-protein kinase receptor Tie-1 isoform h2 (human)

hTIE1/iso:h2


"A tyrosine-protein kinase receptor Tie-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35590-2." [PRO:DNx, UniProtKB:P35590]


organism-sequence



PR:P35590-3

tyrosine-protein kinase receptor Tie-1 isoform h3 (human)

hTIE1/iso:h3


"A tyrosine-protein kinase receptor Tie-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35590-3." [PRO:DNx, UniProtKB:P35590]


organism-gene



PR:Q06806

tyrosine-protein kinase receptor Tie-1 (mouse)

mTIE1


"A tyrosine-protein kinase receptor Tie-1 that is encoded in the genome of mouse." [OMA:Q06806, PRO:DNx]


modification



PR:000021667

tyrosine-protein kinase receptor Tie-1, signal peptide removed form

TIE1/SigPep-


"A tyrosine-protein kinase receptor Tie-1 that has had the signal peptide removed." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000002131 hTEK/var:R849W
Example: UniProtKB:Q02763-1, Arg-849, CHEBI:29954
associated_with_disease_progressionDO:0050792 multiple cutaneous and mucosal venous malformations PMID:10369874; PMID:8980225
enablesGO:0005515 protein binding with PR:P27986-1 PMID:10369874
PR:000002132 hTEK/var:Y897S
Example: UniProtKB:Q02763-1, Tyr-897, CHEBI:29999
associated_with_disease_progressionDO:0050792 multiple cutaneous and mucosal venous malformations PMID:10369874
enablesGO:0005515 protein binding with PR:P27986-1 PMID:10369874