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Protein Ontology report - beta-type platelet-derived growth factor receptor
PR:000002035 - http://purl.obolibrary.org/obo/PR_000002035
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002035   
  PRO namebeta-type platelet-derived growth factor receptor 
  Synonyms
PRO-Short-label: EXACT:PDGFRB
Gene-based: RELATED:PDGFR1
Other: EXACT:beta platelet-derived growth factor receptor | CD140 antigen-like family member B | CD140b | PDGF-R-beta | PDGFR-1 | PDGFR-beta | platelet-derived growth factor receptor 1
RELATED:Pdgfr
  Definition"A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human PDGFRB gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000001810 CSF-1/PDGF receptor-type tyrosine-protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 4                                        
         Modification4                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500948;IUPHARobj:1804
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000002035

beta-type platelet-derived growth factor receptor

PDGFRB


"A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human PDGFRB gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P05622

platelet-derived growth factor receptor beta (mouse)

mPDGFRB


"A beta-type platelet-derived growth factor receptor that is encoded in the genome of mouse." [OMA:P05622, PRO:DNx]


organism-sequence



PR:P05622-1

platelet-derived growth factor receptor beta isoform 1 (mouse)

mPDGFRB/iso:1


"A beta-type platelet-derived growth factor receptor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:P05622-2

platelet-derived growth factor receptor beta isoform m2 (mouse)

mPDGFRB/iso:m2


"A platelet-derived growth factor receptor beta (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05622-2." [PRO:DNx, UniProtKB:P05622]


organism-gene



PR:P09619

platelet-derived growth factor receptor beta (human)

hPDGFRB


"A beta-type platelet-derived growth factor receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P09619]


organism-sequence



PR:P09619-1

platelet-derived growth factor receptor beta isoform 1 (human)

hPDGFRB/iso:1


"A beta-type platelet-derived growth factor receptor isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P09619-2

platelet-derived growth factor receptor beta isoform h2 (human)

hPDGFRB/iso:h2


"A platelet-derived growth factor receptor beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09619-2." [PRO:DNx, UniProtKB:P09619]


organism-modification



PR:000048725

platelet-derived growth factor receptor beta, signal peptide removed form (human)

hPDGFRB/SigPep-


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed. UniProtKB:P09619, 33-1106." [PRO:DNx, Reactome:R-HSA-186767]


organism-modification



PR:000048726

platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 1 (human)

hPDGFRB/SigPep-/Phos:1


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 579, 581, 716, 740, 751, 763, 771, 775, 778, 857, 1009 and 1021 of the amino acid sequence represented by UniProtKB:P09619. UniProtKB:P09619, 33-1106, Tyr-579/Tyr-581/Tyr-716/Tyr-740/Tyr-751/Tyr-763/Tyr-771/Tyr-775/Tyr-778/Tyr-857/Tyr-1009/Tyr-1021, MOD:00048." [PRO:DNx, Reactome:R-HSA-186803]


organism-modification



PR:000049846

platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 2 (human)

hPDGFRB/SigPep-/Phos:2


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Tyr-857 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048." [PMID:1653029, PMID:9642269, PRO:KER]

Yes

organism-modification



PR:000049847

platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 3 (human)

hPDGFRB/SigPep-/Phos:3


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that has been phosphorylated on residues at positions equivalent to Tyr-857 and Ser-1104 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046." [PMID:15271984, PMID:15994317, PRO:KER]

Yes

organism-modification



PR:000049848

platelet-derived growth factor receptor beta, signal peptide removed unphosphorylated 2 (human)

hPDGFRB/SigPep-/UnPhos:2


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that lacks phosphorylation on the residue at the position equivalent to Tyr-857 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, PR:000026291." [PMID:1653029, PMID:9642269, PRO:KER]

Yes

organism-modification



PR:000064602

platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 4 (human)

hPDGFRB/SigPep-/Phos:4


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-579, Tyr-581, Tyr-716, Tyr-740, Tyr-751, Tyr-763, Tyr-771, Tyr-775, Tyr-778, Tyr-857, and Tyr-1009 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-579/Tyr-581/Tyr-716/Tyr-740/Tyr-751/Tyr-763/Tyr-771/Tyr-775/Tyr-778/Tyr-857/Tyr-1009, MOD:00048." [PRO:DNx, Reactome:R-HSA-8864039]


organism-gene



PR:Q05030

platelet-derived growth factor receptor beta (rat)

rPDGFRB


"A beta-type platelet-derived growth factor receptor that is encoded in the genome of rat." [OMA:Q05030, PRO:DNx]


sequence



PR:000002136

beta-type platelet-derived growth factor receptor isoform 1

PDGFRB/iso:1


"A beta-type platelet-derived growth factor receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05622-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P05622-1

platelet-derived growth factor receptor beta isoform 1 (mouse)

mPDGFRB/iso:1


"A beta-type platelet-derived growth factor receptor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000026683

beta-type platelet-derived growth factor receptor isoform 1, signal peptide removed form

PDGFRB/iso:1/SigPep-


"A beta-type platelet-derived growth factor receptor isoform 1 that has had the signal peptide removed." [PRO:DNx]


sequence



PR:000002137

beta-type platelet-derived growth factor receptor isoform 2

PDGFRB/iso:2


"A beta-type platelet-derived growth factor receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09619-1 or a 1:1 ortholog thereof." [PMID:2850496, PRO:CNA]


organism-sequence



PR:P09619-1

platelet-derived growth factor receptor beta isoform 1 (human)

hPDGFRB/iso:1


"A beta-type platelet-derived growth factor receptor isoform 2 that is encoded in the genome of human." [PRO:CNA]


modification



PR:000002143

beta-type platelet-derived growth factor receptor isoform 2, signal peptide removed form

PDGFRB/iso:2/SigPep-


"A beta-type platelet-derived growth factor receptor isoform 2 that has had the signal peptide removed." [PMID:15340161, PRO:CNA]


modification



PR:000018702

beta-type platelet-derived growth factor receptor, signal peptide removed form

PDGFRB/SigPep-


"A beta-type platelet-derived growth factor receptor that has had the signal peptide removed." [PRO:DNx]


modification



PR:000002143

beta-type platelet-derived growth factor receptor isoform 2, signal peptide removed form

PDGFRB/iso:2/SigPep-


"A beta-type platelet-derived growth factor receptor isoform 2 that has had the signal peptide removed." [PMID:15340161, PRO:CNA]


modification



PR:000026683

beta-type platelet-derived growth factor receptor isoform 1, signal peptide removed form

PDGFRB/iso:1/SigPep-


"A beta-type platelet-derived growth factor receptor isoform 1 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000048725

platelet-derived growth factor receptor beta, signal peptide removed form (human)

hPDGFRB/SigPep-


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed. UniProtKB:P09619, 33-1106." [PRO:DNx, Reactome:R-HSA-186767]


organism-modification



PR:000048726

platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 1 (human)

hPDGFRB/SigPep-/Phos:1


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 579, 581, 716, 740, 751, 763, 771, 775, 778, 857, 1009 and 1021 of the amino acid sequence represented by UniProtKB:P09619. UniProtKB:P09619, 33-1106, Tyr-579/Tyr-581/Tyr-716/Tyr-740/Tyr-751/Tyr-763/Tyr-771/Tyr-775/Tyr-778/Tyr-857/Tyr-1009/Tyr-1021, MOD:00048." [PRO:DNx, Reactome:R-HSA-186803]


organism-modification



PR:000049846

platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 2 (human)

hPDGFRB/SigPep-/Phos:2


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Tyr-857 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048." [PMID:1653029, PMID:9642269, PRO:KER]

Yes

organism-modification



PR:000049847

platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 3 (human)

hPDGFRB/SigPep-/Phos:3


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that has been phosphorylated on residues at positions equivalent to Tyr-857 and Ser-1104 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046." [PMID:15271984, PMID:15994317, PRO:KER]

Yes

organism-modification



PR:000049848

platelet-derived growth factor receptor beta, signal peptide removed unphosphorylated 2 (human)

hPDGFRB/SigPep-/UnPhos:2


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that lacks phosphorylation on the residue at the position equivalent to Tyr-857 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, PR:000026291." [PMID:1653029, PMID:9642269, PRO:KER]

Yes

organism-modification



PR:000064602

platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 4 (human)

hPDGFRB/SigPep-/Phos:4


"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-579, Tyr-581, Tyr-716, Tyr-740, Tyr-751, Tyr-763, Tyr-771, Tyr-775, Tyr-778, Tyr-857, and Tyr-1009 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-579/Tyr-581/Tyr-716/Tyr-740/Tyr-751/Tyr-763/Tyr-771/Tyr-775/Tyr-778/Tyr-857/Tyr-1009, MOD:00048." [PRO:DNx, Reactome:R-HSA-8864039]


modification



PR:000025415

beta-type platelet-derived growth factor receptor proteolytic cleavage product

PDGFRB/ClvPrd


"A beta-type platelet-derived growth factor receptor that has been processed by proteolytic cleavage." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000049846 hPDGFRB/SigPep-/Phos:2
Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048
acts_upstream_of_or_withinincreased GO:0018108 peptidyl-tyrosine phosphorylation relative to PR:000049848 hPDGFRB/SigPep-/UnPhos:2 PMID:1653029; PMID:9642269
enablesGO:0004713 protein tyrosine kinase activity PMID:15994317; PMID:9642269
increased GO:0005515 protein binding relative to PR:000049848 hPDGFRB/SigPep-/UnPhos:2 PMID:1653029
PR:000049847 hPDGFRB/SigPep-/Phos:3
Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046
acts_upstream_of_or_withindecreased GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 PMID:15271984
enablesdecreased GO:0004713 protein tyrosine kinase activity relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 PMID:15271984
decreased GO:0005515 protein binding relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 PMID:15271984
PR:000049848 hPDGFRB/SigPep-/UnPhos:2
Example: UniProtKB:P09619-1, 33-1106, Tyr-857, PR:000026291
acts_upstream_of_or_withinGO:0038083 peptidyl-tyrosine autophosphorylation PMID:9642269