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Protein Ontology report - integrin beta-1
PR:000002040 - http://purl.obolibrary.org/obo/PR_000002040
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002040   
  PRO nameintegrin beta-1 
  Synonyms
PRO-Short-label: EXACT:ITGB1
Gene-based: RELATED:FNRB | MDF2 | MSK12
Other: EXACT:CD29 | fibronectin receptor subunit beta | VLA-4 subunit beta
  Definition"An integrin beta that is a translation product of the human ITGB1 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000001861 integrin beta
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence5                                                  Organism-Sequence 7                                        
         Modification1                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2455
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000002040

integrin beta-1

ITGB1


"An integrin beta that is a translation product of the human ITGB1 gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P05556

integrin beta-1 (human)

hITGB1


"An integrin beta-1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P05556]


organism-sequence



PR:P05556-1

integrin beta-1 isoform beta-1A (human)

hITGB1/iso:beta-1A


"An integrin beta-1 isoform beta-1A that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P05556-2

integrin beta-1 isoform beta-1B (human)

hITGB1/iso:beta-1B


"An integrin beta-1 isoform beta-1B that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P05556-3

integrin beta-1 isoform beta-1C (human)

hITGB1/iso:beta-1C


"An integrin beta-1 isoform beta-1C that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P05556-4

integrin beta-1 isoform beta-1C-2 (human)

hITGB1/iso:beta-1C-2


"An integrin beta-1 isoform beta-1C-2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P05556-5

integrin beta-1 isoform beta-1D (human)

hITGB1/iso:beta-1D


"An integrin beta-1 isoform beta-1D that is encoded in the genome of human." [PRO:CNA, UniProtKB:P05556]


organism-modification



PR:000028415

integrin beta-1, signal peptide removed form (human)

hITGB1/SigPep-


"An integrin beta-1, signal peptide removed form in human. Example: UniProtKB:P05556-1, 21-798." [PRO:DNx]


Yes
organism-modification



PR:000053565

integrin beta-1 N-glycosylated 1 (human)

hITGB1/NGlyco:1


"An integrin beta-1 (human) that has been N-glycosylated at the residue equivalent to Asn-212 of the amino acid sequence represented by UniProtKB:P05556-1, in which the glycan composition is represented by GlyTouCan:G25079LO. Example: UniProtKB:P05556-1, Asn-212, MOD:00160~GNO:G25079LO." [GlyGen:P05556-1, PMID:29741879, PRO:DNx]


organism-modification



PR:000053566

integrin beta-1 N-glycosylated 2 (human)

hITGB1/NGlyco:2


"An integrin beta-1 (human) that has been N-glycosylated at the residue equivalent to Asn-212 of the amino acid sequence represented by UniProtKB:P05556-1, in which the glycan composition is represented by GlyTouCan:G43769HG. Example: UniProtKB:P05556-1, Asn-212, MOD:00160~GNO:G43769HG." [GlyGen:P05556-1, PMID:29741879, PRO:DNx]


organism-modification



PR:000053567

integrin beta-1 N-glycosylated 3 (human)

hITGB1/NGlyco:3


"An integrin beta-1 (human) that has been N-glycosylated at the residue equivalent to Asn-669 of the amino acid sequence represented by UniProtKB:P05556-1, in which the glycan composition is represented by GlyTouCan:G25079LO. Example: UniProtKB:P05556-1, Asn-669, MOD:00160~GNO:G25079LO." [GlyGen:P05556-1, PMID:29741879, PRO:DNx]


organism-modification



PR:000053568

integrin beta-1 N-glycosylated 4 (human)

hITGB1/NGlyco:4


"An integrin beta-1 (human) that has been N-glycosylated at the residue equivalent to Asn-97 of the amino acid sequence represented by UniProtKB:P05556-1, in which the glycan composition is represented by GlyTouCan:G25987BV. Example: UniProtKB:P05556-1, Asn-97, MOD:00160~GNO:G25987BV." [GlyGen:P05556-1, PMID:23345538, PRO:DNx]


organism-modification



PR:000066244

integrin beta-1 deaminated 1 (human)

hITGB1/Deam:1


"An integrin beta-1 (human) that has been deaminated on the residue at the position equivalent to Asn-386 of the amino acid sequence represented by UniProtKB:P05556-1. Example: UniProtKB:P05556-1, Asn-386, MOD:00684." [IEDB_epitope:1994650, PRO:DNx]


organism-modification



PR:000066932

integrin beta-1 methylated 1 (human)

hITGB1/Me:1


"An integrin beta-1 (human) that has been methylated on the residue at the position equivalent to Cys-301 of the amino acid sequence represented by UniProtKB:P05556-1. Example: UniProtKB:P05556-1, Cys-301, MOD:00660." [IEDB_epitope:1016149, PRO:DNx]


organism-modification



PR:000070391

integrin beta-1 cysteinylated 1 (human)

hITGB1/Cyst:1


"An integrin beta-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-261 of the amino acid sequence represented by UniProtKB:P05556-1. Example: UniProtKB:P05556-1, Cys-261, MOD:00765." [IEDB_epitope:1331071, PRO:DNx]


organism-modification



PR:000072780

integrin beta-1 cysteinylated 2 (human)

hITGB1/Cyst:2


"An integrin beta-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-435 of the amino acid sequence represented by UniProtKB:P05556-1. Example: UniProtKB:P05556-1, Cys-435, MOD:00765." [IEDB_epitope:2120158, IEDB_epitope:2122640, IEDB_epitope:2122641, IEDB_epitope:2130035, PRO:DNx]


organism-modification



PR:000075713

integrin beta-1 cysteinylated 3 (human)

hITGB1/Cyst:3


"An integrin beta-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-415 of the amino acid sequence represented by UniProtKB:P05556-1. Example: UniProtKB:P05556-1, Cys-415, MOD:00765." [IEDB_epitope:2121254, PRO:DNx]


organism-modification



PR:000083387

integrin beta-1 cysteinylated 4 (human)

hITGB1/Cyst:4


"An integrin beta-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-207 of the amino acid sequence represented by UniProtKB:P05556-1. Example: UniProtKB:P05556-1, Cys-207, MOD:00765." [IEDB_epitope:2126186, PRO:DNx]


organism-gene



PR:P09055

integrin beta-1 (mouse)

mITGB1


"An integrin beta-1 that is encoded in the genome of mouse." [OMA:P09055, PRO:DNx]


organism-sequence



PR:P09055-1

integrin beta-1 isoform beta-1A (mouse)

mITGB1/iso:beta-1A


"An integrin beta-1 isoform beta-1A that is encoded in the genome of mouse." [PMID:8870969, PMID:9553049, PRO:KRC]

Yes

organism-sequence



PR:P09055-2

integrin beta-1 isoform beta-1D (mouse)

mITGB1/iso:beta-1D


"An integrin beta-1 isoform beta-1D that is encoded in the genome of mouse. This isoform contains a unique alternatively spliced cytoplasmic domain of 50 amino acids, with the last 24 amino acids encoded by an additional exon, 11 of these are in common with the isoform beta-1A." [PMID:8567725, PMID:8870969, PMID:9553049, PRO:KRC]

Yes

organism-gene



PR:P11584

integrin beta-PS (fruit fly)

fly-ITGB1


"An integrin beta-1 that is encoded in the genome of fruit fly." [OMA:P11584, PRO:DNx]


organism-gene



PR:P49134

integrin beta-1 (rat)

rITGB1


"An integrin beta-1 that is encoded in the genome of rat." [OMA:P49134, PRO:DNx]


organism-gene



PR:Q27874

integrin beta pat-3 (worm)

ITGB1 (worm)


"An integrin beta-1 that is encoded in the genome of worm." [OMA:Q27874, PRO:WCB]


sequence



PR:000037153

integrin beta-1 isoform beta-1A

ITGB1/iso:beta-1A


"An integrin beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05556-1 or a 1:1 ortholog thereof." [PRO:CNA, UniProtKB:P05556]


organism-sequence



PR:P05556-1

integrin beta-1 isoform beta-1A (human)

hITGB1/iso:beta-1A


"An integrin beta-1 isoform beta-1A that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P09055-1

integrin beta-1 isoform beta-1A (mouse)

mITGB1/iso:beta-1A


"An integrin beta-1 isoform beta-1A that is encoded in the genome of mouse." [PMID:8870969, PMID:9553049, PRO:KRC]

Yes

sequence



PR:000037155

integrin beta-1 isoform beta-1B

ITGB1/iso:beta-1B


"An integrin beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05556-2 or a 1:1 ortholog thereof." [PRO:CNA, UniProtKB:P05556]


organism-sequence



PR:P05556-2

integrin beta-1 isoform beta-1B (human)

hITGB1/iso:beta-1B


"An integrin beta-1 isoform beta-1B that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000037157

integrin beta-1 isoform beta-1C

ITGB1/iso:beta-1C


"An integrin beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05556-3 or a 1:1 ortholog thereof." [PRO:CNA, UniProtKB:P05556]


organism-sequence



PR:P05556-3

integrin beta-1 isoform beta-1C (human)

hITGB1/iso:beta-1C


"An integrin beta-1 isoform beta-1C that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000037159

integrin beta-1 isoform beta-1C-2

ITGB1/iso:beta-1C-2


"An integrin beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05556-4 or a 1:1 ortholog thereof." [PRO:CNA, UniProtKB:P05556]


organism-sequence



PR:P05556-4

integrin beta-1 isoform beta-1C-2 (human)

hITGB1/iso:beta-1C-2


"An integrin beta-1 isoform beta-1C-2 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000037161

integrin beta-1 isoform beta-1D

ITGB1/iso:beta-1D


"An integrin beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05556-5 or a 1:1 ortholog thereof." [PRO:CNA, UniProtKB:P05556]


organism-sequence



PR:P05556-5

integrin beta-1 isoform beta-1D (human)

hITGB1/iso:beta-1D


"An integrin beta-1 isoform beta-1D that is encoded in the genome of human." [PRO:CNA, UniProtKB:P05556]


organism-sequence



PR:P09055-2

integrin beta-1 isoform beta-1D (mouse)

mITGB1/iso:beta-1D


"An integrin beta-1 isoform beta-1D that is encoded in the genome of mouse. This isoform contains a unique alternatively spliced cytoplasmic domain of 50 amino acids, with the last 24 amino acids encoded by an additional exon, 11 of these are in common with the isoform beta-1A." [PMID:8567725, PMID:8870969, PMID:9553049, PRO:KRC]

Yes

modification



PR:000018706

integrin beta-1, signal peptide removed form

ITGB1/SigPep-


"An integrin beta-1 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000028415

integrin beta-1, signal peptide removed form (human)

hITGB1/SigPep-


"An integrin beta-1, signal peptide removed form in human. Example: UniProtKB:P05556-1, 21-798." [PRO:DNx]


Yes
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ITGB1 forms found in complexes   

ITGB1 Component
Complexes
PR:000028415 hITGB1/SigPep- PR:000028448 ILK:integrin beta-1 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P09055-1 mITGB1/iso:beta-1A acts_upstream_of_or_withinGO:0016477 cell migration MGI_ref:1203253; PMID:9553049
PR:P09055-2 mITGB1/iso:beta-1D
This isoform contains a unique alternatively spliced cytoplasmic domain of 50 amino acids, with the last 24 amino acids encoded by an additional exon, 11 of these are in common with the isoform beta-1A
acts_upstream_of_or_withinGO:0048738 cardiac muscle tissue development MGI_ref:1203253; PMID:9553049