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Protein Ontology report - interferon regulatory factor 3
PR:000002045 - http://purl.obolibrary.org/obo/PR_000002045
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002045   
  PRO nameinterferon regulatory factor 3 
  Synonyms
PRO-Short-label: EXACT:IRF3
Other: EXACT:IRF-3
  Definition"An interferon regulatory factor 3-9 that is a translation product of the human IRF3 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000001863 interferon regulatory factor 3-9
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 7                                        
         Modification3                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000002045 interferon regulatory factor 3
IRF3

organism-gene


PR:P70671 interferon regulatory factor 3 (mouse)
mIRF3

organism-sequence


PR:C0IXK2 interferon regulatory factor 3 isoform 2 (mouse)
mIRF3/iso:2

organism-sequence


PR:P70671-1 interferon regulatory factor 3 isoform 1 (mouse)
mIRF3/iso:1
Yes
organism-modification


PR:000027097 interferon regulatory factor 3 isoform 1 phosphorylated 1 (mouse)
mIRF3/iso:1/Phos:1

Yes
organism-gene


PR:Q14653 interferon regulatory factor 3 (human)
hIRF3

Yes
organism-sequence


PR:Q14653-1 interferon regulatory factor 3 isoform 1 (human)
hIRF3/iso:1

organism-modification


PR:000025763 interferon regulatory factor 3 isoform 1 phosphorylated 1 (human)
hIRF3/iso:1/Phos:1
Yes
Yes
organism-modification


PR:000045489 interferon regulatory factor 3 isoform 1 phosphorylated 2 (human)
hIRF3/iso:1/Phos:2

Yes
organism-sequence


PR:Q14653-2 interferon regulatory factor 3 isoform h2 (human)
hIRF3/iso:h2

organism-sequence


PR:Q14653-3 interferon regulatory factor 3 isoform h3 (human)
hIRF3/iso:h3

organism-sequence


PR:Q14653-4 interferon regulatory factor 3 isoform h4 (human)
hIRF3/iso:h4

organism-sequence


PR:Q14653-5 interferon regulatory factor 3 isoform h5 (human)
hIRF3/iso:h5

organism-modification


PR:000028702 interferon regulatory factor 3 unmodified form (human)
hIRF3/UnMod

Yes
organism-modification


PR:000045488 interferon regulatory factor 3 phosphorylated 1 (human)
hIRF3/Phos:1

Yes
organism-modification


PR:000065516 interferon regulatory factor 3 methylated 1 (human)
hIRF3/Me:1

organism-modification


PR:000075605 interferon regulatory factor 3 cysteinylated 1 (human)
hIRF3/Cyst:1

sequence


PR:000003257 interferon regulatory factor 3 isoform 1
IRF3/iso:1

organism-sequence


PR:P70671-1 interferon regulatory factor 3 isoform 1 (mouse)
mIRF3/iso:1
Yes
organism-modification


PR:000027097 interferon regulatory factor 3 isoform 1 phosphorylated 1 (mouse)
mIRF3/iso:1/Phos:1

Yes
organism-sequence


PR:Q14653-1 interferon regulatory factor 3 isoform 1 (human)
hIRF3/iso:1

organism-modification


PR:000025763 interferon regulatory factor 3 isoform 1 phosphorylated 1 (human)
hIRF3/iso:1/Phos:1
Yes
Yes
organism-modification


PR:000045489 interferon regulatory factor 3 isoform 1 phosphorylated 2 (human)
hIRF3/iso:1/Phos:2

Yes
modification


PR:000003259 interferon regulatory factor 3 isoform 1 phosphorylated form
IRF3/iso:1/PhosRes+

modification


PR:000003260 interferon regulatory factor 3 isoform 1 phosphorylated 1
IRF3/iso:1/Phos:1

organism-modification


PR:000025763 interferon regulatory factor 3 isoform 1 phosphorylated 1 (human)
hIRF3/iso:1/Phos:1
Yes
Yes
organism-modification


PR:000027097 interferon regulatory factor 3 isoform 1 phosphorylated 1 (mouse)
mIRF3/iso:1/Phos:1

Yes
organism-modification


PR:000045489 interferon regulatory factor 3 isoform 1 phosphorylated 2 (human)
hIRF3/iso:1/Phos:2

Yes
modification


PR:000028701 interferon regulatory factor 3 unmodified form
IRF3/UnMod

organism-modification


PR:000028702 interferon regulatory factor 3 unmodified form (human)
hIRF3/UnMod

Yes
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IRF3 forms found in complexes   

IRF3 Component
 Complexes
PR:000025763 hIRF3/iso:1/Phos:1 PR:000036002 IRF3-P:IRF3-P:KPNA4 complex (human)
PR:000027097 mIRF3/iso:1/Phos:1 PR:000027098 IRF3-P:IRF3-P complex (mouse)
PR:000036043 IRF3-P:p65 complex (mouse)
PR:000036047 IRF3-P:p65:ISRE complex (mouse)
PR:000028702 hIRF3/UnMod PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000045488 hIRF3/Phos:1 PR:000025765 IRF3-P:IRF3-P complex (human)
PR:000045489 hIRF3/iso:1/Phos:2 PR:000027084 IRF3-P:IRF7-P complex (human)
PR:Q14653 hIRF3 PR:000036045 IRF3:XPO1 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025763 hIRF3/iso:1/Phos:1
UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046		 enablesGO:0005515 protein binding with PR:O14980 chromosome region maintenance 1 protein homolog (human) PMID:10805757
located_inGO:0005829 cytosol Reactome:REACT_7149
PR:P70671-1 mIRF3/iso:1 located_inGO:0005737 cytoplasm MGI_ref:3828224; PMID:18851954