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Protein Ontology report - signal transducer and activator of transcription 1
PR:000002087 - http://purl.obolibrary.org/obo/PR_000002087
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002087   
  PRO namesignal transducer and activator of transcription 1 
  Synonyms
PRO-Short-label: EXACT:STAT1
Other: EXACT:Signal transducer and activator of transcription 1-alpha/beta | transcription factor ISGF-3 components p91/p84
  Definition"A signal transducer and transcription activator STAT that is a translation product of the human STAT1 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000001933 signal transducer and transcription activator STAT
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence2                                                  Organism-Sequence 4                                        
         Modification5                                                  Organism-Modification 21                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000002087

signal transducer and activator of transcription 1

STAT1


"A signal transducer and transcription activator STAT that is a translation product of the human STAT1 gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P42224

signal transducer and activator of transcription 1-alpha/beta (human)

hSTAT1


"A signal transducer and activator of transcription 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P42224]


organism-sequence



PR:P42224-1

signal transducer and activator of transcription 1 isoform 1 (human)

hSTAT1/iso:1


"A signal transducer and activator of transcription 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000026858

signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 (human)

hSTAT1/iso:1/Phos:1


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 in human. UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7657660, PRO:CNA, Reactome:R-HSA-873791, Reactome:R-HSA-909684]


organism-modification



PR:000027889

signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 (human)

hSTAT1/iso:1/Phos:3


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 in human. UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]

Yes

organism-modification



PR:000027891

signal transducer and activator of transcription 1 isoform 1 sumoylated 1 (human)

hSTAT1/iso:1/Sumo:1


"A signal transducer and activator of transcription 1 isoform 1 sumoylated 1 in human. UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]


organism-modification



PR:000028637

signal transducer and activator of transcription 1 isoform 1 acetylated 1 (human)

hSTAT1/iso:1/Ac:1


"A signal transducer and activator of transcription 1 isoform 1 acetylated 1 in human. UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]


organism-modification



PR:000061402

signal transducer and activator of transcription 1 isoform 1 phosphorylated 2 (human)

hSTAT1/iso:1/Phos:2


"A signal transducer and activator of transcription 1 isoform 1 (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-701 and Ser-727 of the amino acid sequence represented by UniProtKB:P42224-1. UniProtKB:P42224-1, Tyr-701, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-873792, Reactome:R-HSA-909563]


organism-sequence



PR:P42224-2

signal transducer and activator of transcription 1-alpha/beta isoform Beta (human)

hSTAT1/iso:Beta


"A signal transducer and activator of transcription 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000064269

signal transducer and activator of transcription 1-alpha/beta isoform Beta phosphorylated 1 (human)

hSTAT1/iso:Beta/Phos:1


"A signal transducer and activator of transcription 1-alpha/beta isoform Beta (human) that has been phosphorylated on the residue at the position equivalent to Tyr-701 of the amino acid sequence represented by UniProtKB:P42224-2. UniProtKB:P42224-2, Tyr-701, MOD:00048." [PRO:DNx, Reactome:R-HSA-909676, Reactome:R-HSA-909686]


organism-modification



PR:000049364

signal transducer and activator of transcription 1-alpha/beta phosphorylated 1 (human)

hSTAT1/Phos:1


"A signal transducer and activator of transcription 1-alpha/beta (human) that has been phosphorylated on the residue at the position equivalent to Tyr-701 of the amino acid sequence represented by UniProtKB:P42224. UniProtKB:P42224, Tyr-701, MOD:00048." [PRO:DNx, Reactome:R-HSA-3132766]


organism-modification



PR:000061490

signal transducer and activator of transcription 1-alpha/beta, initiator methionine removed phosphorylated form (human)

hSTAT1/InitMet-/PhosRes+


"A signal transducer and activator of transcription 1-alpha/beta (human) that has had the initiator methionine removed and that includes at least one phosphorylated residue. Example: UniProtKB:P42224-1, 2-750, MOD:00696." [PRO:DNx, Reactome:R-HSA-8950418, Reactome:R-HSA-8987140]


organism-modification



PR:000062150

signal transducer and activator of transcription 1-alpha/beta, initiator methionine removed phosphorylated 1 (human)

hSTAT1/InitMet-/Phos:1


"A signal transducer and activator of transcription 1-alpha/beta (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Tyr-701 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, 2-750, Tyr-701, MOD:00048." [PRO:DNx, Reactome:R-HSA-8951202, Reactome:R-HSA-8985905]


organism-modification



PR:000085877

signal transducer and activator of transcription 1-alpha/beta, initiator methionine removed phosphorylated 2 (human)

hSTAT1/InitMet-/Phos:2


"A signal transducer and activator of transcription 1-alpha/beta (human) that has had the initiator methionine removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-701 and Ser-727 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, 2-750, Tyr-701, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-9850842]


organism-modification



PR:000063461

signal transducer and activator of transcription 1-alpha/beta, initiator methionine removed form (human)

hSTAT1/InitMet-


"A signal transducer and activator of transcription 1-alpha/beta (human) that has had the initiator methionine removed. Example: UniProtKB:P42224-1, 2-750." [PRO:DNx, Reactome:R-HSA-629622]


organism-modification



PR:000061490

signal transducer and activator of transcription 1-alpha/beta, initiator methionine removed phosphorylated form (human)

hSTAT1/InitMet-/PhosRes+


"A signal transducer and activator of transcription 1-alpha/beta (human) that has had the initiator methionine removed and that includes at least one phosphorylated residue. Example: UniProtKB:P42224-1, 2-750, MOD:00696." [PRO:DNx, Reactome:R-HSA-8950418, Reactome:R-HSA-8987140]


organism-modification



PR:000062150

signal transducer and activator of transcription 1-alpha/beta, initiator methionine removed phosphorylated 1 (human)

hSTAT1/InitMet-/Phos:1


"A signal transducer and activator of transcription 1-alpha/beta (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Tyr-701 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, 2-750, Tyr-701, MOD:00048." [PRO:DNx, Reactome:R-HSA-8951202, Reactome:R-HSA-8985905]


organism-modification



PR:000085877

signal transducer and activator of transcription 1-alpha/beta, initiator methionine removed phosphorylated 2 (human)

hSTAT1/InitMet-/Phos:2


"A signal transducer and activator of transcription 1-alpha/beta (human) that has had the initiator methionine removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-701 and Ser-727 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, 2-750, Tyr-701, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-9850842]


organism-modification



PR:000068262

signal transducer and activator of transcription 1-alpha/beta methylated 1 (human)

hSTAT1/Me:1


"A signal transducer and activator of transcription 1-alpha/beta (human) that has been methylated on the residue at the position equivalent to Cys-492 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, Cys-492, MOD:00660." [IEDB_epitope:1011569, IEDB_epitope:1011570, PRO:DNx]


organism-modification



PR:000069794

signal transducer and activator of transcription 1-alpha/beta cysteinylated 1 (human)

hSTAT1/Cyst:1


"A signal transducer and activator of transcription 1-alpha/beta (human) that has been cysteinylated on the residue at the position equivalent to Cys-174 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, Cys-174, MOD:00765." [IEDB_epitope:925069, PRO:DNx]


organism-modification



PR:000070511

signal transducer and activator of transcription 1-alpha/beta deaminated 1 (human)

hSTAT1/Deam:1


"A signal transducer and activator of transcription 1-alpha/beta (human) that has been deaminated on the residue at the position equivalent to Asn-372 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, Asn-372, MOD:00684." [IEDB_epitope:1333005, PRO:DNx]


organism-modification



PR:000072847

signal transducer and activator of transcription 1-alpha/beta methylated 2 (human)

hSTAT1/Me:2


"A signal transducer and activator of transcription 1-alpha/beta (human) that has been methylated on the residue at the position equivalent to Cys-174 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, Cys-174, MOD:00660." [IEDB_epitope:1004917, PRO:DNx]


organism-modification



PR:000074495

signal transducer and activator of transcription 1-alpha/beta deaminated 2 (human)

hSTAT1/Deam:2


"A signal transducer and activator of transcription 1-alpha/beta (human) that has been deaminated on the residue at the position equivalent to Asn-357 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, Asn-357, MOD:00684." [IEDB_epitope:775753, PRO:DNx]


organism-modification



PR:000080708

signal transducer and activator of transcription 1-alpha/beta methylated 3 (human)

hSTAT1/Me:3


"A signal transducer and activator of transcription 1-alpha/beta (human) that has been methylated on the residue at the position equivalent to Cys-155 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, Cys-155, MOD:00660." [IEDB_epitope:1027712, PRO:DNx]


organism-modification



PR:000081707

signal transducer and activator of transcription 1-alpha/beta deaminated 3 (human)

hSTAT1/Deam:3


"A signal transducer and activator of transcription 1-alpha/beta (human) that has been deaminated on the residue at the position equivalent to Gln-285 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, Gln-285, MOD:00685." [IEDB_epitope:771803, IEDB_epitope:894150, PRO:DNx]


organism-modification



PR:000084260

signal transducer and activator of transcription 1-alpha/beta deaminated 4 (human)

hSTAT1/Deam:4


"A signal transducer and activator of transcription 1-alpha/beta (human) that has been deaminated on the residue at the position equivalent to Gln-352 of the amino acid sequence represented by UniProtKB:P42224-1. Example: UniProtKB:P42224-1, Gln-352, MOD:00685." [IEDB_epitope:774229, PRO:DNx]


organism-gene



PR:P42225

signal transducer and activator of transcription 1 (mouse)

mSTAT1


"A signal transducer and activator of transcription 1 that is encoded in the genome of mouse." [OMA:P42225, PRO:DNx]


organism-sequence



PR:P42225-1

signal transducer and activator of transcription 1 isoform 1 (mouse)

mSTAT1/iso:1


"A signal transducer and activator of transcription 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q99K94

signal transducer and activator of transcription isoform 2 (mouse)

mSTAT1/iso:2


"A signal transducer and activator of transcription 1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000049976

signal transducer and activator of transcription 1 phosphorylated 1 (mouse)

mSTAT1/Phos:1


"A signal transducer and activator of transcription 1 (mouse) that has been phosphorylated at Tyr-701 within the conserved GYI sequence following the SH2 domain. UniProtKB:P42225, Tyr-701, MOD:00048." [PMID:27671227, PRO:LN]


organism-modification



PR:000049977

signal transducer and activator of transcription 1 unphosphorylated 1 (mouse)

mSTAT1/UnPhos:1


"A signal transducer and activator of transcription 1 (mouse) that lacks phosphorylation at Tyr-701 within the conserved GYI sequence following the SH2 domain. UniProtKB:P42225, Tyr-701, PR:000026291." [PMID:27671227, PRO:LN]


sequence



PR:000003073

signal transducer and activator of transcription 1 isoform 1

STAT1/iso:1


"A signal transducer and activator of transcription 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42224-1 or a 1:1 ortholog thereof." [PMID:1502203, PRO:CNA]


organism-sequence



PR:P42224-1

signal transducer and activator of transcription 1 isoform 1 (human)

hSTAT1/iso:1


"A signal transducer and activator of transcription 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000026858

signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 (human)

hSTAT1/iso:1/Phos:1


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 in human. UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7657660, PRO:CNA, Reactome:R-HSA-873791, Reactome:R-HSA-909684]


organism-modification



PR:000027889

signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 (human)

hSTAT1/iso:1/Phos:3


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 in human. UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]

Yes

organism-modification



PR:000027891

signal transducer and activator of transcription 1 isoform 1 sumoylated 1 (human)

hSTAT1/iso:1/Sumo:1


"A signal transducer and activator of transcription 1 isoform 1 sumoylated 1 in human. UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]


organism-modification



PR:000028637

signal transducer and activator of transcription 1 isoform 1 acetylated 1 (human)

hSTAT1/iso:1/Ac:1


"A signal transducer and activator of transcription 1 isoform 1 acetylated 1 in human. UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]


organism-modification



PR:000061402

signal transducer and activator of transcription 1 isoform 1 phosphorylated 2 (human)

hSTAT1/iso:1/Phos:2


"A signal transducer and activator of transcription 1 isoform 1 (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-701 and Ser-727 of the amino acid sequence represented by UniProtKB:P42224-1. UniProtKB:P42224-1, Tyr-701, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-873792, Reactome:R-HSA-909563]


organism-sequence



PR:P42225-1

signal transducer and activator of transcription 1 isoform 1 (mouse)

mSTAT1/iso:1


"A signal transducer and activator of transcription 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000003075

signal transducer and activator of transcription 1 isoform 1 phosphorylated form

STAT1/iso:1/PhosRes+


"A signal transducer and activator of transcription 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003076

signal transducer and activator of transcription 1 isoform 1 phosphorylated 1

STAT1/iso:1/Phos:1


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the conserved GYI sequence following the SH2 domain. Example: UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7543024, PRO:CNA]


organism-modification



PR:000026858

signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 (human)

hSTAT1/iso:1/Phos:1


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 in human. UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7657660, PRO:CNA, Reactome:R-HSA-873791, Reactome:R-HSA-909684]


modification



PR:000027888

signal transducer and activator of transcription 1 isoform 1 phosphorylated 3

STAT1/iso:1/Phos:3


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated form that has been modified on a Ser residue located in the conserved PMSP sequence at the C-terminal transactivation domain. Example: UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]


organism-modification



PR:000027889

signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 (human)

hSTAT1/iso:1/Phos:3


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 in human. UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]

Yes

organism-modification



PR:000061402

signal transducer and activator of transcription 1 isoform 1 phosphorylated 2 (human)

hSTAT1/iso:1/Phos:2


"A signal transducer and activator of transcription 1 isoform 1 (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-701 and Ser-727 of the amino acid sequence represented by UniProtKB:P42224-1. UniProtKB:P42224-1, Tyr-701, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-873792, Reactome:R-HSA-909563]


modification



PR:000027890

signal transducer and activator of transcription 1 isoform 1 sumoylated 1

STAT1/iso:1/Sumo:1


"A signal transducer and activator of transcription 1 isoform 1 that has been modified on a Lys residue located right after the conserved GYI sequence in the C-terminal region. PIAS proteins promote this modification in response to IFN-gamma signaling. Example: UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]


organism-modification



PR:000027891

signal transducer and activator of transcription 1 isoform 1 sumoylated 1 (human)

hSTAT1/iso:1/Sumo:1


"A signal transducer and activator of transcription 1 isoform 1 sumoylated 1 in human. UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]


modification



PR:000028636

signal transducer and activator of transcription 1 isoform 1 acetylated 1

STAT1/iso:1/Ac:1


"A signal transducer and activator of transcription 1 isoform 1 that has been acetylated on Lys residues within the DNA binding domain. Example: UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]


organism-modification



PR:000028637

signal transducer and activator of transcription 1 isoform 1 acetylated 1 (human)

hSTAT1/iso:1/Ac:1


"A signal transducer and activator of transcription 1 isoform 1 acetylated 1 in human. UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]


sequence



PR:000003077

signal transducer and activator of transcription 1 isoform 2

STAT1/iso:2


"A signal transducer and activator of transcription 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42224-2 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P42224-2

signal transducer and activator of transcription 1-alpha/beta isoform Beta (human)

hSTAT1/iso:Beta


"A signal transducer and activator of transcription 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000064269

signal transducer and activator of transcription 1-alpha/beta isoform Beta phosphorylated 1 (human)

hSTAT1/iso:Beta/Phos:1


"A signal transducer and activator of transcription 1-alpha/beta isoform Beta (human) that has been phosphorylated on the residue at the position equivalent to Tyr-701 of the amino acid sequence represented by UniProtKB:P42224-2. UniProtKB:P42224-2, Tyr-701, MOD:00048." [PRO:DNx, Reactome:R-HSA-909676, Reactome:R-HSA-909686]


organism-sequence



PR:Q99K94

signal transducer and activator of transcription isoform 2 (mouse)

mSTAT1/iso:2


"A signal transducer and activator of transcription 1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027889 hSTAT1/iso:1/Phos:3
UniProtKB:P42224-1, Ser-727, MOD:00046
acts_upstream_of_or_withinGO:0043065 positive regulation of apoptotic process PMID:15322115
located_inGO:0005634 nucleus PMID:15322115