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Protein Ontology report - zinc finger protein Helios
PR:000002172 - http://purl.obolibrary.org/obo/PR_000002172
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002172   
  PRO namezinc finger protein Helios 
  Synonyms
PRO-Short-label: EXACT:IKZF2
Gene-based: RELATED:HELIOS | Zfpn1a2 | ZNFN1A2
Other: EXACT:Ikaros family zinc finger protein 2
  Definition"An Ikaros-like zinc finger transcription factor that is a translation product of the human IKZF2 gene or a 1:1 ortholog thereof." [PRO:HJD] 
  PRO Categorygene 
  ParentPR:000002986 Ikaros-like zinc finger transcription factor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 12                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000002172
zinc finger protein Helios
IKZF2
"An Ikaros-like zinc finger transcription factor that is a translation product of the human IKZF2 gene or a 1:1 ortholog thereof." [PRO:HJD]

organism-gene


PR:H2L008
zinc finger protein ztf-16 (worm)
IKZF2 (worm)
"A zinc finger protein Helios that is encoded in the genome of worm." [PRO:HJD]

organism-sequence


PR:H2L008-1
zinc finger protein ztf-16 isoform b (worm)
IKZF2/iso:b (worm)
"A zinc finger protein ztf-16 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:H2L008-1." [PRO:DNx, UniProtKB:H2L008]

organism-sequence


PR:H2L008-2
zinc finger protein ztf-16 isoform a (worm)
IKZF2/iso:a (worm)
"A zinc finger protein ztf-16 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:H2L008-2." [PRO:DNx, UniProtKB:H2L008]

organism-gene


PR:P81183
zinc finger protein Helios (mouse)
mIKZF2
"A zinc finger protein Helios that is encoded in the genome of mouse." [OMA:P81183, PRO:DNx]
Yes
organism-sequence


PR:P81183-1
zinc finger protein Helios isoform B (mouse)
mIKZF2/iso:B
"A zinc finger protein Helios isoform 1 that is encoded in the genome of mouse." [PRO:HJD]
Yes
organism-sequence


PR:P81183-2
zinc finger protein Helios isoform A (mouse)
mIKZF2/iso:A
"A zinc finger protein Helios isoform 2 that is encoded in the genome of mouse." [PRO:HJD]
Yes
organism-gene


PR:Q9UKS7
zinc finger protein Helios (human)
hIKZF2
"A zinc finger protein Helios that is encoded in the genome of human." [PRO:HJD, UniProtKB:Q9UKS7]

organism-sequence


PR:Q9UKS7-1
zinc finger protein Helios isoform 1 (human)
hIKZF2/iso:1
"A zinc finger protein Helios isoform 1 that is encoded in the genome of human." [PRO:HJD]

organism-sequence


PR:Q9UKS7-2
zinc finger protein Helios isoform 2 (human)
hIKZF2/iso:2
"A zinc finger protein Helios isoform 2 that is encoded in the genome of human." [PRO:HJD]

organism-sequence


PR:Q9UKS7-3
zinc finger protein Helios isoform h3 (human)
hIKZF2/iso:h3
"A zinc finger protein Helios (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UKS7-3." [PRO:DNx, UniProtKB:Q9UKS7]

organism-sequence


PR:Q9UKS7-4
zinc finger protein Helios isoform h4 (human)
hIKZF2/iso:h4
"A zinc finger protein Helios (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UKS7-4." [PRO:DNx, UniProtKB:Q9UKS7]

organism-sequence


PR:Q9UKS7-5
zinc finger protein Helios isoform h5 (human)
hIKZF2/iso:h5
"A zinc finger protein Helios (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UKS7-5." [PRO:DNx, UniProtKB:Q9UKS7]

organism-sequence


PR:Q9UKS7-6
zinc finger protein Helios isoform h6 (human)
hIKZF2/iso:h6
"A zinc finger protein Helios (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UKS7-6." [PRO:DNx, UniProtKB:Q9UKS7]

organism-sequence


PR:Q9UKS7-7
zinc finger protein Helios isoform h7 (human)
hIKZF2/iso:h7
"A zinc finger protein Helios (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UKS7-7." [PRO:DNx, UniProtKB:Q9UKS7]

organism-sequence


PR:Q9UKS7-8
zinc finger protein Helios isoform h8 (human)
hIKZF2/iso:h8
"A zinc finger protein Helios (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UKS7-8." [PRO:DNx, UniProtKB:Q9UKS7]

organism-modification


PR:000081230
zinc finger protein Helios methylated 1 (human)
hIKZF2/Me:1
"A zinc finger protein Helios (human) that has been methylated on the residue at the position equivalent to Cys-404 of the amino acid sequence represented by UniProtKB:Q9UKS7-1. Example: UniProtKB:Q9UKS7-1, Cys-404, MOD:00660." [IEDB_epitope:1040696, PRO:DNx]

organism-modification


PR:000081486
zinc finger protein Helios phosphorylated 1 (human)
hIKZF2/Phos:1
"A zinc finger protein Helios (human) that has been phosphorylated on the residue at the position equivalent to Ser-23 of the amino acid sequence represented by UniProtKB:Q9UKS7-1. Example: UniProtKB:Q9UKS7-1, Ser-23, MOD:00046." [IEDB_epitope:610815, PRO:DNx]

sequence


PR:000002173
zinc finger protein Helios isoform 1
IKZF2/iso:1
"A zinc finger protein Helios that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P81183-1 or a 1:1 ortholog thereof." [PRO:HJD]
Yes
organism-sequence


PR:P81183-1
zinc finger protein Helios isoform B (mouse)
mIKZF2/iso:B
"A zinc finger protein Helios isoform 1 that is encoded in the genome of mouse." [PRO:HJD]
Yes
organism-sequence


PR:Q9UKS7-1
zinc finger protein Helios isoform 1 (human)
hIKZF2/iso:1
"A zinc finger protein Helios isoform 1 that is encoded in the genome of human." [PRO:HJD]

sequence


PR:000002174
zinc finger protein Helios isoform 2
IKZF2/iso:2
"A zinc finger protein Helios that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P81183-2 or a 1:1 ortholog thereof." [PRO:HJD]
Yes
organism-sequence


PR:P81183-2
zinc finger protein Helios isoform A (mouse)
mIKZF2/iso:A
"A zinc finger protein Helios isoform 2 that is encoded in the genome of mouse." [PRO:HJD]
Yes
organism-sequence


PR:Q9UKS7-2
zinc finger protein Helios isoform 2 (human)
hIKZF2/iso:2
"A zinc finger protein Helios isoform 2 that is encoded in the genome of human." [PRO:HJD]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000002173 IKZF2/iso:1 enablesGO:0046982 protein heterodimerization activity with PR:O08900|PR:Q03267-1 MGI_ref:1203354; PMID:9560339
PR:000002174 IKZF2/iso:2 enablesGO:0046982 protein heterodimerization activity with PR:P81183-1|PR:P81183-2 MGI_ref:1203354; PMID:9560339
PR:P81183 mIKZF2 acts_upstream_of_or_withinGO:0045944 positive regulation of transcription by RNA polymerase II PMID:9560339
enablesGO:0042803 protein homodimerization activity with PR:P81183 Helios PMID:9560339
PR:P81183-1 mIKZF2/iso:B enablesGO:0046982 protein heterodimerization activity with PR:O08900 Ikaros family zinc finger protein 3 (mouse) MGI_ref:1203354; PMID:9560339
GO:0046982 protein heterodimerization activity with PR:O08900-1|PR:Q03267-1 MGI_ref:1203354; PMID:9560339
GO:0046982 protein heterodimerization activity with PR:Q03267-1 MGI_ref:1203354; PMID:9560339
located_inGO:0005634 nucleus PMID:9560339
PR:P81183-2 mIKZF2/iso:A enablesGO:0046982 protein heterodimerization activity with PR:O08900-1|PR:Q03267-1 MGI_ref:1203354; PMID:9560339
GO:0046982 protein heterodimerization activity with PR:P81183-1 MGI_ref:1203354; PMID:9560339
GO:0046982 protein heterodimerization activity with PR:P81183-2 MGI_ref:1203354; PMID:9560339
located_inGO:0005634 nucleus PMID:9560339