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Protein Ontology report - caspase-3-like protease
PR:000002196 - http://purl.obolibrary.org/obo/PR_000002196
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000002196   
  PRO namecaspase-3-like protease 
  Definition"A protein that is a translation product of a gene family that includes CASP3, CASP6, and CASP7 genes. The core architecture consists of a Caspase domain (Pfam:PF00656). Encoded as zymogens, the activated proteins are cysteine proteases typically involved in apoptosis." [PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 14                                        
         Sequence7                                                  Organism-Sequence 12                                        
         Modification11                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF015839
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000002196

caspase-3-like protease

APAF1


"A protein that is a translation product of a gene family that includes CASP3, CASP6, and CASP7 genes. The core architecture consists of a Caspase domain (Pfam:PF00656). Encoded as zymogens, the activated proteins are cysteine proteases typically involved in apoptosis." [PRO:WCB]


gene



PR:000002312

caspase-3

CASP3


"A caspase-3-like protease that is a translation product of the human CASP3 gene or a 1:1 ortholog thereof." [PRO:JAN]


organism-gene



PR:P42574

caspase-3 (human)

hCASP3


"A caspase-3 that is encoded in the genome of human." [PRO:JAN, UniProtKB:P42574]


organism-sequence



PR:P42574-1

caspase-3 isoform 1 (human)

hCASP3/iso:1


"A caspase-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000026876

caspase-3 isoform 1 cleaved 1 (human)

hCASP3/iso:1/Clv:1


"A caspase-3 isoform 1 cleaved 1 in human. UniProtKB:P42574-1, 176-277." [PMID:11931755, PRO:CNA]


Yes
organism-modification



PR:000026877

caspase-3 isoform 1 cleaved 2 (human)

hCASP3/iso:1/Clv:2


"A caspase-3 isoform 1 cleaved 2 in human. UniProtKB:P42574-1, 29-175." [PRO:CNA]


Yes
organism-modification



PR:000082245

caspase-3 cysteinylated 1 (human)

hCASP3/Cyst:1


"A caspase-3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-148 of the amino acid sequence represented by UniProtKB:P42574. UniProtKB:P42574, Cys-148, MOD:00765." [IEDB_epitope:925902, PRO:DNx]


organism-gene



PR:P55213

caspase-3 (rat)

rCASP3


"A caspase-3 that is encoded in the genome of rat." [OMA:P55213, PRO:DNx]


organism-gene



PR:P70677

caspase-3 (mouse)

mCASP3


"A caspase-3 that is encoded in the genome of mouse." [OMA:P70677, PRO:DNx]


organism-sequence



PR:P70677-1

caspase-3 isoform 1 (mouse)

mCASP3/iso:1


"A caspase-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q8MKI5

caspase-3 (dog)

dog-CASP3


"A caspase-3 that is encoded in the genome of dog." [OMA:Q8MKI5, PRO:DNx]


sequence



PR:000002402

caspase-3 isoform 1

CASP3/iso:1


"A caspase-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70677-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P42574-1

caspase-3 isoform 1 (human)

hCASP3/iso:1


"A caspase-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000026876

caspase-3 isoform 1 cleaved 1 (human)

hCASP3/iso:1/Clv:1


"A caspase-3 isoform 1 cleaved 1 in human. UniProtKB:P42574-1, 176-277." [PMID:11931755, PRO:CNA]


Yes
organism-modification



PR:000026877

caspase-3 isoform 1 cleaved 2 (human)

hCASP3/iso:1/Clv:2


"A caspase-3 isoform 1 cleaved 2 in human. UniProtKB:P42574-1, 29-175." [PRO:CNA]


Yes
organism-sequence



PR:P70677-1

caspase-3 isoform 1 (mouse)

mCASP3/iso:1


"A caspase-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000002454

caspase-3 isoform 1 cleaved 1

CASP3/iso:1/Clv:1


"A caspase-3 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-3 subunit p12." [PRO:CNA]


Yes
organism-modification



PR:000026876

caspase-3 isoform 1 cleaved 1 (human)

hCASP3/iso:1/Clv:1


"A caspase-3 isoform 1 cleaved 1 in human. UniProtKB:P42574-1, 176-277." [PMID:11931755, PRO:CNA]


Yes
modification



PR:000002455

caspase-3 isoform 1 cleaved 2

CASP3/iso:1/Clv:2


"A caspase-3 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-3 subunit p17." [PRO:CNA]


Yes
organism-modification



PR:000026877

caspase-3 isoform 1 cleaved 2 (human)

hCASP3/iso:1/Clv:2


"A caspase-3 isoform 1 cleaved 2 in human. UniProtKB:P42574-1, 29-175." [PRO:CNA]


Yes
modification



PR:000018762

caspase-3 proteolytic cleavage product

CASP3/ClvPrd


"A caspase-3 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000002454

caspase-3 isoform 1 cleaved 1

CASP3/iso:1/Clv:1


"A caspase-3 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-3 subunit p12." [PRO:CNA]


Yes
organism-modification



PR:000026876

caspase-3 isoform 1 cleaved 1 (human)

hCASP3/iso:1/Clv:1


"A caspase-3 isoform 1 cleaved 1 in human. UniProtKB:P42574-1, 176-277." [PMID:11931755, PRO:CNA]


Yes
modification



PR:000002455

caspase-3 isoform 1 cleaved 2

CASP3/iso:1/Clv:2


"A caspase-3 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-3 subunit p17." [PRO:CNA]


Yes
organism-modification



PR:000026877

caspase-3 isoform 1 cleaved 2 (human)

hCASP3/iso:1/Clv:2


"A caspase-3 isoform 1 cleaved 2 in human. UniProtKB:P42574-1, 29-175." [PRO:CNA]


Yes
gene



PR:000002315

caspase-6

CASP6


"A caspase-3-like protease that is a translation product of the human CASP6 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:A0A1D5PPP7

caspase-6 (chicken)

chick-CASP6


"A caspase-6 that is encoded in the genome of chicken." [PRO:CNA]


organism-gene



PR:O08738

caspase-6 (mouse)

mCASP6


"A caspase-6 that is encoded in the genome of mouse." [OMA:O08738, PRO:DNx]


organism-sequence



PR:O08738-1

caspase-6 isoform 1 (mouse)

mCASP6/iso:1


"A caspase-6 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]


organism-gene



PR:O35397

caspase-6 (rat)

rCASP6


"A caspase-6 that is encoded in the genome of rat." [OMA:O35397, PRO:DNx]


organism-gene



PR:P55212

caspase-6 (human)

hCASP6


"A caspase-6 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P55212]


organism-sequence



PR:P55212-1

caspase-6 isoform Alpha (human)

hCASP6/iso:Alpha


"A caspase-6 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P55212]


organism-modification



PR:000050093

caspase-6 subunit p18 (human)

hCASP6/p18


"A caspase-6 subunit p18 in human. Example: UniProtKB:P55212-1, 24-179." [PRO:DNx, UniProtKB:P55212]


organism-modification



PR:000050094

caspase-6 subunit p11 (human)

hCASP6/p11


"A caspase-6 subunit p11 in human. Example: UniProtKB:P55212-1, 194-293." [PRO:DNx, UniProtKB:P55212]


organism-sequence



PR:P55212-2

caspase-6 isoform Beta (human)

hCASP6/iso:Beta


"A caspase-6 isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000045840

caspase-6 phosphorylated 1 (human)

hCASP6/Phos:1


"A caspase-6 (human) that has been phosphorylated on the residue at the position equivalent to Ser-257 of the amino acid sequence represented by UniProtKB:P55212-1. Example: UniProtKB:P55212-1, Ser-257, MOD:00046." [iPTMnet:P55212, PMID:15273717]


organism-modification



PR:000067313

caspase-6 cysteinylated 1 (human)

hCASP6/Cyst:1


"A caspase-6 (human) that has been cysteinylated on the residue at the position equivalent to Cys-87 of the amino acid sequence represented by UniProtKB:P55212-1. Example: UniProtKB:P55212-1, Cys-87, MOD:00765." [IEDB_epitope:2127366, PRO:DNx]


sequence



PR:000002406

caspase-6 isoform 1

CASP6/iso:1


"A caspase-6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55212-1 or a 1:1 ortholog thereof." [PMID:7796396]


organism-sequence



PR:P55212-1

caspase-6 isoform Alpha (human)

hCASP6/iso:Alpha


"A caspase-6 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P55212]


organism-modification



PR:000050093

caspase-6 subunit p18 (human)

hCASP6/p18


"A caspase-6 subunit p18 in human. Example: UniProtKB:P55212-1, 24-179." [PRO:DNx, UniProtKB:P55212]


organism-modification



PR:000050094

caspase-6 subunit p11 (human)

hCASP6/p11


"A caspase-6 subunit p11 in human. Example: UniProtKB:P55212-1, 194-293." [PRO:DNx, UniProtKB:P55212]


modification



PR:000002456

caspase-6 subunit p11

CASP6/p11


"A caspase-6 isoform 1 that corresponds to the C-terminal portion after removal of the propeptides. UniProtKB:P55212-1, 194-293." [PMID:8900201, PRO:CNA, PRO:DAN]


organism-modification



PR:000050094

caspase-6 subunit p11 (human)

hCASP6/p11


"A caspase-6 subunit p11 in human. Example: UniProtKB:P55212-1, 194-293." [PRO:DNx, UniProtKB:P55212]


modification



PR:000002457

caspase-6 subunit p18

CASP6/p18


"A caspase-6 isoform 1 that corresponds to the N-terminal portion after removal of the propeptides. Example: UniProtKB:P55212-1, 24-179." [PMID:8900201, PRO:CNA, PRO:DAN]


organism-modification



PR:000050093

caspase-6 subunit p18 (human)

hCASP6/p18


"A caspase-6 subunit p18 in human. Example: UniProtKB:P55212-1, 24-179." [PRO:DNx, UniProtKB:P55212]


sequence



PR:000002407

caspase-6 isoform 2

CASP6/iso:2


"A caspase-6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O08738-1 or a 1:1 ortholog thereof." [PRO:DAN, PRO:JAN]


organism-sequence



PR:O08738-1

caspase-6 isoform 1 (mouse)

mCASP6/iso:1


"A caspase-6 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002408

caspase-6 isoform 3

CASP6/iso:3


"A caspase-6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55212-2 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P55212-2

caspase-6 isoform Beta (human)

hCASP6/iso:Beta


"A caspase-6 isoform 3 that is encoded in the genome of human." [PRO:CNA]


modification



PR:000018765

caspase-6 proteolytic cleavage product

CASP6/ClvPrd


"A caspase-6 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000002456

caspase-6 subunit p11

CASP6/p11


"A caspase-6 isoform 1 that corresponds to the C-terminal portion after removal of the propeptides. UniProtKB:P55212-1, 194-293." [PMID:8900201, PRO:CNA, PRO:DAN]


organism-modification



PR:000050094

caspase-6 subunit p11 (human)

hCASP6/p11


"A caspase-6 subunit p11 in human. Example: UniProtKB:P55212-1, 194-293." [PRO:DNx, UniProtKB:P55212]


modification



PR:000002457

caspase-6 subunit p18

CASP6/p18


"A caspase-6 isoform 1 that corresponds to the N-terminal portion after removal of the propeptides. Example: UniProtKB:P55212-1, 24-179." [PMID:8900201, PRO:CNA, PRO:DAN]


organism-modification



PR:000050093

caspase-6 subunit p18 (human)

hCASP6/p18


"A caspase-6 subunit p18 in human. Example: UniProtKB:P55212-1, 24-179." [PRO:DNx, UniProtKB:P55212]


gene



PR:000002316

caspase-7

CASP7


"A caspase-3-like protease that is a translation product of the human CASP7 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:F1NV61

caspase-7 (chicken)

chick-CASP7


"A caspase-7 that is encoded in the genome of chicken." [PRO:CNA]


organism-gene



PR:O01382

caspase drICE (fruit fly)

fly-CASP7


"A caspase-7 that is encoded in the genome of fruit fly." [OMA:O01382, PRO:DNx]


organism-gene



PR:P55210

caspase-7 (human)

hCASP7


"A caspase-7 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P55210]


organism-sequence



PR:P55210-1

caspase-7 isoform Alpha (human)

hCASP7/iso:Alpha


"A caspase-7 isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-modification



PR:000050105

caspase-7 subunit p20 (human)

hCASP7/p20


"A caspase-7 subunit p20 in human. Example: UniProtKB:P55210-1, 24-198." [PRO:DNx, UniProtKB:P55210]


organism-modification



PR:000050106

caspase-7 subunit p11 (human)

hCASP7/p11


"A caspase-7 subunit p11 in human. Example: UniProtKB:P55210-1, 207-303." [PRO:DNx, UniProtKB:P55210]


organism-sequence



PR:P55210-2

caspase-7 isoform Beta (human)

hCASP7/iso:Beta


"A caspase-7 isoform 2 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:P55210-3

caspase-7 isoform Alpha' (human)

hCASP7/iso:Alpha'


"A caspase-7 isoform 3 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:P55210-4

caspase-7 isoform h4 (human)

hCASP7/iso:h4


"A caspase-7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55210-4." [PRO:DNx, UniProtKB:P55210]


organism-gene



PR:P97864

caspase-7 (mouse)

mCASP7


"A caspase-7 that is encoded in the genome of mouse." [OMA:P97864, PRO:DNx]


organism-sequence



PR:P97864-1

caspase-7 isoform 1 (mouse)

mCASP7/iso:1


"A caspase-7 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002409

caspase-7 isoform 1

CASP7/iso:1


"A caspase-7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55210-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P55210-1

caspase-7 isoform Alpha (human)

hCASP7/iso:Alpha


"A caspase-7 isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-modification



PR:000050105

caspase-7 subunit p20 (human)

hCASP7/p20


"A caspase-7 subunit p20 in human. Example: UniProtKB:P55210-1, 24-198." [PRO:DNx, UniProtKB:P55210]


organism-modification



PR:000050106

caspase-7 subunit p11 (human)

hCASP7/p11


"A caspase-7 subunit p11 in human. Example: UniProtKB:P55210-1, 207-303." [PRO:DNx, UniProtKB:P55210]


organism-sequence



PR:P97864-1

caspase-7 isoform 1 (mouse)

mCASP7/iso:1


"A caspase-7 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


modification



PR:000002458

caspase-7 subunit p11

CASP7/p11


"A caspase-7 isoform 1 that corresponds to the C-terminal portion after removal of the propeptides. Example: UniProtKB:P55210-1, 207-303." [PMID:8755496, PRO:CNA, PRO:DAN]


organism-modification



PR:000050106

caspase-7 subunit p11 (human)

hCASP7/p11


"A caspase-7 subunit p11 in human. Example: UniProtKB:P55210-1, 207-303." [PRO:DNx, UniProtKB:P55210]


modification



PR:000002459

caspase-7 subunit p20

CASP7/p20


"A caspase-7 isoform 1 that corresponds to the N-terminal portion after removal of the propeptides. Example: UniProtKB:P55210-1, 24-198." [PMID:8755496, PRO:CNA, PRO:DAN]


organism-modification



PR:000050105

caspase-7 subunit p20 (human)

hCASP7/p20


"A caspase-7 subunit p20 in human. Example: UniProtKB:P55210-1, 24-198." [PRO:DNx, UniProtKB:P55210]


sequence



PR:000002410

caspase-7 isoform 2

CASP7/iso:2


"A caspase-7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55210-2 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P55210-2

caspase-7 isoform Beta (human)

hCASP7/iso:Beta


"A caspase-7 isoform 2 that is encoded in the genome of human." [PRO:JAN]


sequence



PR:000002411

caspase-7 isoform 3

CASP7/iso:3


"A caspase-7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55210-3 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P55210-3

caspase-7 isoform Alpha' (human)

hCASP7/iso:Alpha'


"A caspase-7 isoform 3 that is encoded in the genome of human." [PRO:JAN]


modification



PR:000018766

caspase-7, initiator methionine removed form

CASP7/InitMet-


"A caspase-7 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000018767

caspase-7 proteolytic cleavage product

CASP7/ClvPrd


"A caspase-7 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000002458

caspase-7 subunit p11

CASP7/p11


"A caspase-7 isoform 1 that corresponds to the C-terminal portion after removal of the propeptides. Example: UniProtKB:P55210-1, 207-303." [PMID:8755496, PRO:CNA, PRO:DAN]


organism-modification



PR:000050106

caspase-7 subunit p11 (human)

hCASP7/p11


"A caspase-7 subunit p11 in human. Example: UniProtKB:P55210-1, 207-303." [PRO:DNx, UniProtKB:P55210]


modification



PR:000002459

caspase-7 subunit p20

CASP7/p20


"A caspase-7 isoform 1 that corresponds to the N-terminal portion after removal of the propeptides. Example: UniProtKB:P55210-1, 24-198." [PMID:8755496, PRO:CNA, PRO:DAN]


organism-modification



PR:000050105

caspase-7 subunit p20 (human)

hCASP7/p20


"A caspase-7 subunit p20 in human. Example: UniProtKB:P55210-1, 24-198." [PRO:DNx, UniProtKB:P55210]


gene



PR:000005054

caspase-14

CASP14


"A caspase-3-like protease that is a translation product of the human CASP14 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O89094

caspase-14 (mouse)

mCASP14


"A caspase-14 that is encoded in the genome of mouse." [OMA:O89094, PRO:DNx]


organism-sequence



PR:O89094-1

caspase-14 isoform m1 (mouse)

mCASP14/iso:m1


"A caspase-14 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O89094-1." [PRO:DNx, UniProtKB:O89094]


organism-sequence



PR:O89094-2

caspase-14 isoform m2 (mouse)

mCASP14/iso:m2


"A caspase-14 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O89094-2." [PRO:DNx, UniProtKB:O89094]


organism-gene



PR:P31944

caspase-14 (human)

hCASP14


"A caspase-14 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P31944]


modification



PR:000019242

caspase-14 proteolytic cleavage product

CASP14/ClvPrd


"A caspase-14 that has been processed by proteolytic cleavage." [PRO:DNx]


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APAF1 forms found in complexes   

APAF1 Component
Complexes
PR:000002454 CASP3/iso:1/Clv:1 PR:000026878 caspase-3 complex
PR:000002455 CASP3/iso:1/Clv:2 PR:000026878 caspase-3 complex
PR:000026876 hCASP3/iso:1/Clv:1 PR:000026879 caspase-3 complex (human)
PR:000026877 hCASP3/iso:1/Clv:2 PR:000026879 caspase-3 complex (human)