back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - Bcl2-associated agonist of cell death isoform 1
PR:000002280 - http://purl.obolibrary.org/obo/PR_000002280
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002280   
  PRO nameBcl2-associated agonist of cell death isoform 1 
  Synonyms
PRO-Short-label: EXACT:BAD/iso:1
Other: EXACT:BAD isoform alpha | bcl-xL/Bcl-2-associated death promoter
  Definition"A Bcl2-associated agonist of cell death that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61337-1 or a 1:1 ortholog thereof." [PRO:JAN] 
  PRO Categorysequence 
  ParentPR:000002184 Bcl2-associated agonist of cell death
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification10                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000002280
Bcl2-associated agonist of cell death isoform 1
BAD/iso:1
"A Bcl2-associated agonist of cell death that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61337-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:O35147-1
Bcl2-associated agonist of cell death isoform Alpha (rat)
rBAD/iso:Alpha
"A Bcl2-associated agonist of cell death isoform 1 that is encoded in the genome of rat." [PRO:JAN]
Yes
organism-modification


PR:000026134
Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 (rat)
rBAD/iso:1/Phos:3
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 in rat. UniProtKB:O35147-1, Ser-112, MOD:00046." [PMID:10195903, PMID:10597268, PRO:JAN]
Yes
organism-modification


PR:000044748
Bcl2-associated agonist of cell death isoform 1 unmodified form (rat)
rBAD/iso:1/UnMod
"A Bcl2-associated agonist of cell death isoform 1 unmodified form in rat." [PRO:DNx]
Yes
organism-sequence


PR:Q61337-1
Bcl2-associated agonist of cell death isoform 1 (mouse)
mBAD/iso:1
"A Bcl2-associated agonist of cell death isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-modification


PR:000026133
Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 (mouse)
mBAD/iso:1/Phos:2
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046." [PMID:10880354, PMID:10949026, PRO:JAN]
Yes
organism-modification


PR:000026135
Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 (mouse)
mBAD/iso:1/Phos:4
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 in mouse. UniProtKB:Q61337-1, Thr-201, MOD:00047." [PMID:14967141, PRO:JAN]
Yes
organism-modification


PR:000026136
Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 (mouse)
mBAD/iso:1/Phos:5
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 in mouse. UniProtKB:Q61337-1, Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]
Yes
organism-modification


PR:000026137
Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 (mouse)
mBAD/iso:1/Phos:6
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 in mouse. UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]
Yes
organism-modification


PR:000026138
Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 (mouse)
mBAD/iso:1/Phos:7
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]

organism-modification


PR:000026139
Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 (mouse)
mBAD/iso:1/Phos:8
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 in mouse. UniProtKB:Q61337-1, Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]
Yes
organism-modification


PR:000026167
Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 (mouse)
mBAD/iso:1/Phos:1
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046." [PMID:10949026, PMID:8929531, PMID:9346240, PRO:JAN]
Yes
organism-modification


PR:000037809
Bcl2-associated agonist of cell death isoform 1 unphosphorylated 1 (mouse)
mBAD/iso:1/UnPhos:1
"A Bcl2-associated agonist of cell death isoform 1 (mouse) that lacks phosphorylation on the indicated Ser residues located within each of two RxRxxSxP motifs, and the indicated Ser residue within the motif RRxS in the BH3 domain, which is the major PKA phosphorylation site. Example: UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, PR:000026291." [PMID:16403219, PRO:DAN, PRO:KER]

organism-modification


PR:000044747
Bcl2-associated agonist of cell death isoform 1 unmodified form (mouse)
mBAD/iso:1/UnMod
"A Bcl2-associated agonist of cell death isoform 1 unmodified form in mouse." [PRO:DNx]
Yes
modification


PR:000002843
Bcl2-associated agonist of cell death isoform 1 unmodified form
BAD/iso:1/UnMod
"A Bcl2-associated agonist of cell death isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]

organism-modification


PR:000044747
Bcl2-associated agonist of cell death isoform 1 unmodified form (mouse)
mBAD/iso:1/UnMod
"A Bcl2-associated agonist of cell death isoform 1 unmodified form in mouse." [PRO:DNx]
Yes
organism-modification


PR:000044748
Bcl2-associated agonist of cell death isoform 1 unmodified form (rat)
rBAD/iso:1/UnMod
"A Bcl2-associated agonist of cell death isoform 1 unmodified form in rat." [PRO:DNx]
Yes
modification


PR:000003084
Bcl2-associated agonist of cell death isoform 1 phosphorylated form
BAD/iso:1/PhosRes+
"A Bcl2-associated agonist of cell death isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000003085
Bcl2-associated agonist of cell death isoform 1 phosphorylated 1
BAD/iso:1/Phos:1
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at two Ser residues which are the major sites of phosphorylation by PKA and AKT signaling. The sites are the indicated serines within the RxRxxSxP motifs. Phosphorylation on these residues favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046." [PMID:10949026, PMID:8929531, PMID:9346240, PRO:CNA, PRO:DAN, PRO:JAN]

organism-modification


PR:000026167
Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 (mouse)
mBAD/iso:1/Phos:1
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046." [PMID:10949026, PMID:8929531, PMID:9346240, PRO:JAN]
Yes
modification


PR:000003086
Bcl2-associated agonist of cell death isoform 1 phosphorylated 2
BAD/iso:1/Phos:2
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at the indicated Ser residues within each of two RxRxxSxP motifs, and within the RRxS motif located in the BH3 domain. Example: UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046." [PMID:10880354, PMID:10949026, PRO:CNA, PRO:DAN, PRO:JAN]

organism-modification


PR:000026133
Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 (mouse)
mBAD/iso:1/Phos:2
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046." [PMID:10880354, PMID:10949026, PRO:JAN]
Yes
modification


PR:000003087
Bcl2-associated agonist of cell death isoform 1 phosphorylated 3
BAD/iso:1/Phos:3
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs upon activation of the MAPK pathway. Phosphorylation on this residue favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-112, MOD:00046." [PMID:10195903, PMID:10597268, PMID:10880354, PRO:JAN]

organism-modification


PR:000026134
Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 (rat)
rBAD/iso:1/Phos:3
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 in rat. UniProtKB:O35147-1, Ser-112, MOD:00046." [PMID:10195903, PMID:10597268, PRO:JAN]
Yes
modification


PR:000003233
Bcl2-associated agonist of cell death isoform 1 phosphorylated 4
BAD/iso:1/Phos:4
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at a Thr residue by the action of JNK1. Example: UniProtKB:Q61337-1, Thr-201, MOD:00047." [PMID:14967141, PRO:JAN]

organism-modification


PR:000026135
Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 (mouse)
mBAD/iso:1/Phos:4
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 in mouse. UniProtKB:Q61337-1, Thr-201, MOD:00047." [PMID:14967141, PRO:JAN]
Yes
modification


PR:000003238
Bcl2-associated agonist of cell death isoform 1 phosphorylated 5
BAD/iso:1/Phos:5
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at one of the two Ser residues which are the major sites of phosphorylation by MAPK and AKT signaling. Phosphorylation on this residue favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]

organism-modification


PR:000026136
Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 (mouse)
mBAD/iso:1/Phos:5
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 in mouse. UniProtKB:Q61337-1, Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]
Yes
modification


PR:000003269
Bcl2-associated agonist of cell death isoform 1 phosphorylated 6
BAD/iso:1/Phos:6
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs by the action of cdc-2. Example: UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]

organism-modification


PR:000026137
Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 (mouse)
mBAD/iso:1/Phos:6
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 in mouse. UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]
Yes
modification


PR:000025849
Bcl2-associated agonist of cell death isoform 1 phosphorylated 7
BAD/iso:1/Phos:7
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at two Ser residues by activation of RSK. Phosphorylation on these residues favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-112/Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]

organism-modification


PR:000026138
Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 (mouse)
mBAD/iso:1/Phos:7
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]

modification


PR:000025850
Bcl2-associated agonist of cell death isoform 1 phosphorylated 8
BAD/iso:1/Phos:8
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at a Ser residue at the PKA/RSK consensus sequence RRxS. Phosphorylation on this residue favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]

organism-modification


PR:000026139
Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 (mouse)
mBAD/iso:1/Phos:8
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 in mouse. UniProtKB:Q61337-1, Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]
Yes
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026133 mBAD/iso:1/Phos:2
UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:10949026
enablesNOT GO:0005515 protein binding with PR:000003237 fam:14-3-3 PMID:10949026
NOT GO:0005515 protein binding with PR:P63101-1 PMID:10949026
NOT GO:0005515 protein binding with PR:Q64373-1 PMID:10949026
NOT GO:0005515 protein binding with PR:Q07817-1 PMID:10949026
PR:000026134 rBAD/iso:1/Phos:3
UniProtKB:O35147-1, Ser-112, MOD:00046		 enablesdecreased GO:0005515 protein binding with PR:P53563-1 PMID:10195903
GO:0019902 phosphatase binding PMID:10195903
located_inGO:0005829 cytosol PMID:10195903
PR:000026135 mBAD/iso:1/Phos:4
UniProtKB:Q61337-1, Thr-201, MOD:00047		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:14967141
enablesdecreased GO:0005515 protein binding with PR:Q64373-1 PMID:14967141
PR:000026136 mBAD/iso:1/Phos:5
UniProtKB:Q61337-1, Ser-136, MOD:00046		 enablesGO:0005515 protein binding with PR:P63101 KCIP-1 (mouse) PMID:12049737
PR:000026137 mBAD/iso:1/Phos:6
UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046		 acts_upstream_of_or_withinGO:0051402 neuron apoptotic process PMID:12049737
PR:000026139 mBAD/iso:1/Phos:8
UniProtKB:Q61337-1, Ser-155, MOD:00046		 enablesGO:0071889 14-3-3 protein binding with PR:P61982 mYWHAG PMID:10880354
PR:000026167 mBAD/iso:1/Phos:1
UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046		 enablesdecreased GO:0005515 protein binding with PR:P62258-1 PMID:12049737
decreased GO:0005515 protein binding with PR:Q07817-1 PMID:12049737
decreased GO:0005515 protein binding with PR:Q9CQV8 KCIP-1 (mouse) PMID:12049737
decreased GO:0005515 protein binding with PR:P63101 KCIP-1 (mouse) PMID:12049737
PR:000044747 mBAD/iso:1/UnMod acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:15280015
enablesGO:0005515 protein binding with PR:P04049 cRaf (human) PMID:17011751
GO:0005515 protein binding with PR:P06803-2 PMID:17011751
GO:0005515 protein binding with PR:P15056 BRAF PMID:17011751
GO:0005515 protein binding with PR:Q04759 hPRKCQ PMID:17011751
located_inGO:0031966 mitochondrial membrane PMID:15280015
PR:000044748 rBAD/iso:1/UnMod enablesGO:0005515 protein binding with PR:P53563-1 PMID:10195903
decreased GO:0019902 phosphatase binding relative to PR:000026134 rBAD/iso:1/Phos:3 PMID:10195903
located_inGO:0005739 mitochondrion PMID:10195903
PR:O35147-1 rBAD/iso:Alpha acts_upstream_of_or_withinGO:0043525 positive regulation of neuron apoptotic process PMID:11161472
enablesGO:0005515 protein binding with PR:O88996-1 PMID:11161472