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Protein Ontology report - RAC-alpha serine/threonine-protein kinase isoform 1
PR:000002286 - http://purl.obolibrary.org/obo/PR_000002286
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002286   
  PRO nameRAC-alpha serine/threonine-protein kinase isoform 1 
  Synonyms
PRO-Short-label: EXACT:AKT1/iso:1
  Definition"A RAC-alpha serine/threonine-protein kinase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P31749-1 or a 1:1 ortholog thereof." [PRO:JAN] 
  PRO Categorysequence 
  ParentPR:000002190 RAC-alpha serine/threonine-protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification3                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000002286 RAC-alpha serine/threonine-protein kinase isoform 1
AKT1/iso:1

organism-sequence


PR:P31749-1 RAC-alpha serine/threonine-protein kinase isoform 1 (human)
hAKT1/iso:1

organism-modification


PR:000027473 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)
hAKT1/iso:1/Phos:2
Yes
organism-modification


PR:000028994 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)
hAKT1/iso:1/Phos:1
Yes
organism-sequence


PR:P31750-1 RAC-alpha serine/threonine-protein kinase isoform 1 (mouse)
mAKT1/iso:1

modification


PR:000003102 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form
AKT1/iso:1/PhosRes+

modification


PR:000003103 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1
AKT1/iso:1/Phos:1

organism-modification


PR:000028994 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)
hAKT1/iso:1/Phos:1
Yes
modification


PR:000027472 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2
AKT1/iso:1/Phos:2

organism-modification


PR:000027473 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)
hAKT1/iso:1/Phos:2
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027473 hAKT1/iso:1/Phos:2
UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:16549426
PR:000028994 hAKT1/iso:1/Phos:1
UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046		 acts_upstream_of_or_withinGO:0032869 cellular response to insulin stimulus PMID:8978681
GO:0051092 positive regulation of NF-kappaB transcription factor activity PMID:12138205
enablesGO:0004672 protein kinase activity PMID:8978681
GO:0004674 protein serine/threonine kinase activity PMID:12138205
GO:0005515 protein binding PMID:12138205
GO:0005515 protein binding PMID:12138205