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Protein Ontology report - apoptosis regulator Bcl-2
PR:000002307 - http://purl.obolibrary.org/obo/PR_000002307
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002307   
  PRO nameapoptosis regulator Bcl-2 
  Synonyms
PRO-Short-label: EXACT:BCL2
Gene-based: RELATED:Bcl-2
  Definition"A Bcl-2-like apoptosis inhibitor that is a translation product of the human BCL2 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000002186 Bcl-2-like apoptosis inhibitor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 4                                        
         Modification6                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2844
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000002307

apoptosis regulator Bcl-2

BCL2


"A Bcl-2-like apoptosis inhibitor that is a translation product of the human BCL2 gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P10415

apoptosis regulator Bcl-2 (human)

hBCL2


"An apoptosis regulator Bcl-2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P10415]


organism-sequence



PR:P10415-1

apoptosis regulator Bcl-2 isoform Alpha (human)

hBCL2/iso:Alpha


"An apoptosis regulator Bcl-2 isoform 1 that is encoded in the genome of human." [PRO:JAN]

Yes

organism-modification



PR:000027461

apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)

hBCL2/iso:1/Phos:2


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 in human. UniProtKB:P10415-1, Thr-74, MOD:00047." [PMID:12039864, PRO:PD]

Yes

organism-modification



PR:000027463

apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)

hBCL2/iso:1/Phos:3


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046." [PMID:18570871, PMID:19029119, PRO:PD]

Yes

organism-modification



PR:000027465

apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)

hBCL2/iso:1/Phos:4


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046." [PMID:15703383, PRO:PD]

Yes

organism-modification



PR:000027467

apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)

hBCL2/iso:1/Phos:5


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 in human. UniProtKB:P10415-1, Thr-56, MOD:00047." [PMID:10766756, PRO:PD]

Yes

organism-sequence



PR:P10415-2

apoptosis regulator Bcl-2 isoform Beta (human)

hBCL2/iso:Beta


"An apoptosis regulator Bcl-2 isoform 2 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


organism-modification



PR:000070038

apoptosis regulator Bcl-2 methylated 1 (human)

hBCL2/Me:1


"An apoptosis regulator Bcl-2 (human) that has been methylated on the residue at the position equivalent to Cys-229 of the amino acid sequence represented by UniProtKB:P10415-1. Example: UniProtKB:P10415-1, Cys-229, MOD:00660." [IEDB_epitope:1032350, PRO:DNx]


organism-modification



PR:000082889

apoptosis regulator Bcl-2 cysteinylated 1 (human)

hBCL2/Cyst:1


"An apoptosis regulator Bcl-2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-158 of the amino acid sequence represented by UniProtKB:P10415-1. Example: UniProtKB:P10415-1, Cys-158, MOD:00765." [IEDB_epitope:1569724, PRO:DNx]


organism-gene



PR:P10417

apoptosis regulator Bcl-2 (mouse)

mBCL2


"An apoptosis regulator Bcl-2 that is encoded in the genome of mouse." [OMA:P10417, PRO:DNx]


organism-sequence



PR:P10417-1

apoptosis regulator Bcl-2 isoform Alpha (mouse)

mBCL2/iso:Alpha


"An apoptosis regulator Bcl-2 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

Yes

organism-modification



PR:000036633

apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 (mouse)

mBCL2/iso:1/Phos:1


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 in mouse. UniProtKB:P10417-1, Ser-70, MOD:00046." [PMID:9115213, PMID:9852076, PRO:JAN]

Yes

organism-sequence



PR:P10417-2

apoptosis regulator Bcl-2 isoform Beta (mouse)

mBCL2/iso:Beta


"An apoptosis regulator Bcl-2 isoform 2 that is encoded in the genome of mouse." [PRO:JAN, PRO:SY]


organism-gene



PR:P49950

apoptosis regulator Bcl-2 (rat)

rBCL2


"An apoptosis regulator Bcl-2 that is encoded in the genome of rat." [OMA:P49950, PRO:DNx]


organism-gene



PR:Q00709

apoptosis regulator Bcl-2 (chicken)

chick-BCL2


"An apoptosis regulator Bcl-2 that is encoded in the genome of chicken." [PRO:WCB]


sequence



PR:000002383

apoptosis regulator Bcl-2 isoform 1

BCL2/iso:1


"An apoptosis regulator Bcl-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10417-1 or a 1:1 ortholog thereof." [PMID:2834197, PMID:2875799, PRO:JAN]


organism-sequence



PR:P10415-1

apoptosis regulator Bcl-2 isoform Alpha (human)

hBCL2/iso:Alpha


"An apoptosis regulator Bcl-2 isoform 1 that is encoded in the genome of human." [PRO:JAN]

Yes

organism-modification



PR:000027461

apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)

hBCL2/iso:1/Phos:2


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 in human. UniProtKB:P10415-1, Thr-74, MOD:00047." [PMID:12039864, PRO:PD]

Yes

organism-modification



PR:000027463

apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)

hBCL2/iso:1/Phos:3


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046." [PMID:18570871, PMID:19029119, PRO:PD]

Yes

organism-modification



PR:000027465

apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)

hBCL2/iso:1/Phos:4


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046." [PMID:15703383, PRO:PD]

Yes

organism-modification



PR:000027467

apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)

hBCL2/iso:1/Phos:5


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 in human. UniProtKB:P10415-1, Thr-56, MOD:00047." [PMID:10766756, PRO:PD]

Yes

organism-sequence



PR:P10417-1

apoptosis regulator Bcl-2 isoform Alpha (mouse)

mBCL2/iso:Alpha


"An apoptosis regulator Bcl-2 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

Yes

organism-modification



PR:000036633

apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 (mouse)

mBCL2/iso:1/Phos:1


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 in mouse. UniProtKB:P10417-1, Ser-70, MOD:00046." [PMID:9115213, PMID:9852076, PRO:JAN]

Yes

modification



PR:000003088

apoptosis regulator Bcl-2 isoform 1 phosphorylated form

BCL2/iso:1/PhosRes+


"An apoptosis regulator Bcl-2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003089

apoptosis regulator Bcl-2 isoform 1 phosphorylated 1

BCL2/iso:1/Phos:1


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs by the action of PKC. Example: UniProtKB:P10417-1, Ser-70, MOD:00046." [PMID:9115213, PMID:9852076, PRO:JAN]


organism-modification



PR:000036633

apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 (mouse)

mBCL2/iso:1/Phos:1


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 in mouse. UniProtKB:P10417-1, Ser-70, MOD:00046." [PMID:9115213, PMID:9852076, PRO:JAN]

Yes

modification



PR:000027460

apoptosis regulator Bcl-2 isoform 1 phosphorylated 2

BCL2/iso:1/Phos:2


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs on a Thr residue within the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-74, MOD:00047." [PMID:12039864, PRO:PD]


organism-modification



PR:000027461

apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)

hBCL2/iso:1/Phos:2


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 in human. UniProtKB:P10415-1, Thr-74, MOD:00047." [PMID:12039864, PRO:PD]

Yes

modification



PR:000027462

apoptosis regulator Bcl-2 isoform 1 phosphorylated 3

BCL2/iso:1/Phos:3


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs at the three major phosphorylation sites (Thr and two conserved Ser residues) within the motif TSPLx(7-10)GPxLS, which is part of the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046." [PMID:18570871, PMID:19029119, PRO:PD]


organism-modification



PR:000027463

apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)

hBCL2/iso:1/Phos:3


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046." [PMID:18570871, PMID:19029119, PRO:PD]

Yes

modification



PR:000027464

apoptosis regulator Bcl-2 isoform 1 phosphorylated 4

BCL2/iso:1/Phos:4


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Thr and second Ser residue within the motif TSPLx(7-10)GPxLS, which is part of the the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046." [PMID:15703383, PRO:PD]


organism-modification



PR:000027465

apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)

hBCL2/iso:1/Phos:4


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046." [PMID:15703383, PRO:PD]

Yes

modification



PR:000027466

apoptosis regulator Bcl-2 isoform 1 phosphorylated 5

BCL2/iso:1/Phos:5


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser or Thr of the [TS]PxP motif, which is part of the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-56, MOD:00047." [PMID:10766756, PRO:PD]


organism-modification



PR:000027467

apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)

hBCL2/iso:1/Phos:5


"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 in human. UniProtKB:P10415-1, Thr-56, MOD:00047." [PMID:10766756, PRO:PD]

Yes

sequence



PR:000002384

apoptosis regulator Bcl-2 isoform 2

BCL2/iso:2


"An apoptosis regulator Bcl-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10415-2 or a 1:1 ortholog thereof." [PMID:3523487, PRO:DAN, PRO:JAN, PRO:SY]


organism-sequence



PR:P10415-2

apoptosis regulator Bcl-2 isoform Beta (human)

hBCL2/iso:Beta


"An apoptosis regulator Bcl-2 isoform 2 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


organism-sequence



PR:P10417-2

apoptosis regulator Bcl-2 isoform Beta (mouse)

mBCL2/iso:Beta


"An apoptosis regulator Bcl-2 isoform 2 that is encoded in the genome of mouse." [PRO:JAN, PRO:SY]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027461 hBCL2/iso:1/Phos:2
UniProtKB:P10415-1, Thr-74, MOD:00047
acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:12039864
PR:000027463 hBCL2/iso:1/Phos:3
UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046
acts_upstream_of_or_withinGO:0016239 positive regulation of macroautophagy PMID:18570871; PMID:19029119
enablesNOT GO:0005515 protein binding with PR:Q14457 BECN1 PMID:18570871; PMID:19029119
PR:000027465 hBCL2/iso:1/Phos:4
UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046
acts_upstream_of_or_withinGO:0043065 positive regulation of apoptotic process PMID:15703383
PR:000027467 hBCL2/iso:1/Phos:5
UniProtKB:P10415-1, Thr-56, MOD:00047
acts_upstream_of_or_withinGO:0045839 negative regulation of mitotic nuclear division PMID:10766756
PR:000036633 mBCL2/iso:1/Phos:1
UniProtKB:P10417-1, Ser-70, MOD:00046
acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:9115213; PMID:9852076
enablesGO:0005515 protein binding with PR:Q07813 Bax PMID:9115213; PMID:9852076
GO:0019902 phosphatase binding PMID:9115213; PMID:9852076
located_inGO:0016020 membrane PMID:9115213; PMID:9852076
PR:P10415-1 hBCL2/iso:Alpha acts_upstream_of_or_withinGO:0070885 negative regulation of calcineurin-NFAT signaling cascade PMID:9109491
enablesGO:0005515 protein binding with PR:P63328 calcineurin A alpha (mouse) PMID:9109491
GO:0005515 protein binding with PR:Q07813 Bax PMID:9109491
located_inGO:0005886 plasma membrane PMID:9109491
PR:P10417-1 mBCL2/iso:Alpha acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:11583631
enablesGO:0005515 protein binding with PR:000026785 mBID/iso:1/Clv:1 PMID:11583631